EMX2

Empty spiracles homeobox 2
Identifiers
Symbols	EMX2 ;
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3023
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Empty spiracles homeobox 2, also known as EMX2, is a human gene.

The homeodomain transcription factor EMX2 is critical for central nervous system and urogenital development. EMX1 (MIM 600034) and EMX2 are related to the 'empty spiracles' gene expressed in the developing Drosophila head.[supplied by OMIM]

Further reading

• Guerrini R, Carrozzo R (2002). "Epileptogenic brain malformations: clinical presentation, malformative patterns and indications for genetic testing". Seizure : the journal of the British Epilepsy Association. 11 Suppl A: 532–43, quiz 544-7. PMID 12185771.
• Simeone A, Gulisano M, Acampora D; et al. (1992). "Two vertebrate homeobox genes related to the Drosophila empty spiracles gene are expressed in the embryonic cerebral cortex". EMBO J. 11 (7): 2541–50. PMID 1352754.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kastury K, Druck T, Huebner K; et al. (1994). "Chromosome locations of human EMX and OTX genes". Genomics. 22 (1): 41–5. doi:10.1006/geno.1994.1343. PMID 7959790.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brunelli S, Faiella A, Capra V; et al. (1996). "Germline mutations in the homeobox gene EMX2 in patients with severe schizencephaly". Nat. Genet. 12 (1): 94–6. doi:10.1038/ng0196-94. PMID 8528262.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wiemann S, Weil B, Wellenreuther R; et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Noonan FC, Mutch DG, Ann Mallon M, Goodfellow PJ (2001). "Characterization of the homeodomain gene EMX2: sequence conservation, expression analysis, and a search for mutations in endometrial cancers". Genomics. 76 (1–3): 37–44. doi:10.1006/geno.2001.6590. PMID 11549315.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Troy PJ, Daftary GS, Bagot CN, Taylor HS (2003). "Transcriptional repression of peri-implantation EMX2 expression in mammalian reproduction by HOXA10". Mol. Cell. Biol. 23 (1): 1–13. PMID 12482956.CS1 maint: Multiple names: authors list (link)
• Noonan FC, Goodfellow PJ, Staloch LJ; et al. (2003). "Antisense transcripts at the EMX2 locus in human and mouse". Genomics. 81 (1): 58–66. PMID 12573261.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Daftary GS, Taylor HS (2004). "EMX2 gene expression in the female reproductive tract and aberrant expression in the endometrium of patients with endometriosis". J. Clin. Endocrinol. Metab. 89 (5): 2390–6. PMID 15126568.
• Nédélec S, Foucher I, Brunet I; et al. (2004). "Emx2 homeodomain transcription factor interacts with eukaryotic translation initiation factor 4E (eIF4E) in the axons of olfactory sensory neurons". Proc. Natl. Acad. Sci. U.S.A. 101 (29): 10815–20. doi:10.1073/pnas.0403824101. PMID 15247416.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hamasaki T, Leingärtner A, Ringstedt T, O'Leary DD (2004). "EMX2 regulates sizes and positioning of the primary sensory and motor areas in neocortex by direct specification of cortical progenitors". Neuron. 43 (3): 359–72. doi:10.1016/j.neuron.2004.07.016. PMID 15294144.CS1 maint: Multiple names: authors list (link)
• Treloar SA, Zhao ZZ, Le L; et al. (2007). "Variants in EMX2 and PTEN do not contribute to risk of endometriosis". Mol. Hum. Reprod. 13 (8): 587–94. doi:10.1093/molehr/gam023. PMID 17563403.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• EMX2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.