ELAV-like protein 3: Difference between revisions
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'''ELAV-like protein 3''' is a [[protein]] that in humans is encoded by the ''ELAVL3'' [[gene]].<ref name="pmid9799595">{{cite journal | vauthors = Van Tine BA, Knops JF, Butler A, Deloukas P, Shaw GM, King PH | title = Localization of HuC (ELAVL3) to chromosome 19p13.2 by fluorescence in situ hybridization utilizing a novel tyramide labeling technique | journal = Genomics | volume = 53 | issue = 3 | pages = 296–9 |date=Dec 1998 | pmid = 9799595 | pmc = | doi = 10.1006/geno.1998.5468 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ELAVL3 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1995| accessdate = }}</ref> | '''ELAV-like protein 3''' is a [[protein]] that in humans is encoded by the ''ELAVL3'' [[gene]].<ref name="pmid9799595">{{cite journal | vauthors = Van Tine BA, Knops JF, Butler A, Deloukas P, Shaw GM, King PH | title = Localization of HuC (ELAVL3) to chromosome 19p13.2 by fluorescence in situ hybridization utilizing a novel tyramide labeling technique | journal = Genomics | volume = 53 | issue = 3 | pages = 296–9 |date=Dec 1998 | pmid = 9799595 | pmc = | doi = 10.1006/geno.1998.5468 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ELAVL3 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1995| accessdate = }}</ref> | ||
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| summary_text = A member of the ELAVL protein family, ELAV-like 3 is a neural-specific [[RNA-binding protein]] which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.<ref name="entrez"/> | | summary_text = A member of the ELAVL protein family, ELAV-like 3 is a [[neural]]-specific [[RNA-binding protein]] which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu [[antigens]] (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum [[antibody]] present in sera from patients with paraneoplastic [[encephalomyelitis]] and sensory [[neuronopathy]] ([[PEM/PSN]]) suggests it has a role in [[neurogenesis]]. Two alternatively spliced [[transcript variants]] encoding distinct [[isoforms]] have been found for this gene.<ref name="entrez"/> | ||
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Latest revision as of 17:08, 21 February 2018
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ELAV-like protein 3 is a protein that in humans is encoded by the ELAVL3 gene.[1][2]
A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[2]
References
- ↑ Van Tine BA, Knops JF, Butler A, Deloukas P, Shaw GM, King PH (Dec 1998). "Localization of HuC (ELAVL3) to chromosome 19p13.2 by fluorescence in situ hybridization utilizing a novel tyramide labeling technique". Genomics. 53 (3): 296–9. doi:10.1006/geno.1998.5468. PMID 9799595.
- ↑ 2.0 2.1 "Entrez Gene: ELAVL3 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)".
Further reading
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Behrends U, Jandl T, Golbeck A, et al. (2002). "Novel products of the HUD, HUC, NNP-1 and alpha-internexin genes identified by autologous antibody screening of a pediatric neuroblastoma library". Int. J. Cancer. 100 (6): 669–77. doi:10.1002/ijc.10550. PMID 12209604.
- Park S, Myszka DG, Yu M, et al. (2000). "HuD RNA recognition motifs play distinct roles in the formation of a stable complex with AU-rich RNA". Mol. Cell. Biol. 20 (13): 4765–72. doi:10.1128/MCB.20.13.4765-4772.2000. PMC 85909. PMID 10848602.
- Sakai K, Kitagawa Y, Hirose G (1999). "Analysis of the RNA recognition motifs of human neuronal ELAV-like proteins in binding to a cytokine mRNA". Biochem. Biophys. Res. Commun. 256 (2): 263–8. doi:10.1006/bbrc.1999.0282. PMID 10079173.
- Sakai K, Gofuku M, Kitagawa Y, et al. (1994). "A hippocampal protein associated with paraneoplastic neurologic syndrome and small cell lung carcinoma". Biochem. Biophys. Res. Commun. 199 (3): 1200–8. doi:10.1006/bbrc.1994.1358. PMID 7511893.
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