Dutasteride

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Dutasteride
Systematic (IUPAC) name
(5α, 17β)-N-{2,5 bis(trifluoromethyl) phenyl}-3-oxo-4-azaandrost-1-ene-17-carboxamide
Identifiers
CAS number 164656-23-9
ATC code G04CB02
PubChem 152945
DrugBank APRD00385
Chemical data
Formula C27H30F6N2O2 
Mol. mass 528.53 g/mol
Pharmacokinetic data
Bioavailability 60%
Protein binding 99%
Metabolism Hepatic (CYP3A4-mediated)
Half life 5 weeks
Excretion Fecal
Therapeutic considerations
Pregnancy cat.

X(US) Not to be handled by pregnant women

Legal status

POM(UK) -only(US)

Routes Oral

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Overview

Dutasteride (marketed as Avodart, Avidart, Avolve, Duagen, Dutas, Dutagen, Duprost) is a 5-alpha-reductase inhibitor, a drug which inhibits the conversion of testosterone into dihydrotestosterone (DHT). It is used to treat conditions caused by DHT, such as benign prostatic hyperplasia (BPH).

Classification and Method of Action

Dutasteride belongs to a class of drugs called 5-alpha-reductase inhibitors, which block the action of the 5-alpha-reductase enzymes that convert testosterone into dihydrotestosterone (DHT). Finasteride also belongs to this group. Dutasteride inhibits both isoforms of 5-alpha reductase, while finasteride inhibits only one. But a clinical study done by GlaxoSmithKline, the EPICS trial, did not find dutasteride to be more effective than finasteride in treating BPH.

Uses

While dutasteride is officially approved to treat enlargement of the prostate gland. Clinical trials for dutasteride as a hair loss drug were undertaken, but called off in late 2002. The reason the trials were called off is not publicly known. Industry sources speculate that Avodart would have been seen as too similar to Propecia to have proved profitable as a hair loss treatment.

In December 2006, Avodart manufacturer GlaxoSmithKline embarked on a new Phase III, six month study in Korea to test the safety, tolerability and effectiveness of a once-daily dose of dutasteride (0.5mg) for the treatment of male pattern baldness in the vertex region of the scalp (types IIIv, IV and V on the Hamilton-Norwood scale).[1] The future impact that this study will have on the FDA's approval or disapproval of Avodart for the treatment of male pattern baldness in the United States is yet to be determined.

See also

External links

References

  1. ClinicalTrials.gov NCT00441116
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| group5 = Clinical Trials Involving Dutasteride | list5 = Ongoing Trials on Dutasteride at Clinical Trials.govTrial results on DutasterideClinical Trials on Dutasteride at Google


| group6 = Guidelines / Policies / Government Resources (FDA/CDC) Regarding Dutasteride | list6 = US National Guidelines Clearinghouse on DutasterideNICE Guidance on DutasterideNHS PRODIGY GuidanceFDA on DutasterideCDC on Dutasteride


| group7 = Textbook Information on Dutasteride | list7 = Books and Textbook Information on Dutasteride


| group8 = Pharmacology Resources on Dutasteride | list8 = AND (Dose)}} Dosing of DutasterideAND (drug interactions)}} Drug interactions with DutasterideAND (side effects)}} Side effects of DutasterideAND (Allergy)}} Allergic reactions to DutasterideAND (overdose)}} Overdose information on DutasterideAND (carcinogenicity)}} Carcinogenicity information on DutasterideAND (pregnancy)}} Dutasteride in pregnancyAND (pharmacokinetics)}} Pharmacokinetics of Dutasteride


| group9 = Genetics, Pharmacogenomics, and Proteinomics of Dutasteride | list9 = AND (pharmacogenomics)}} Genetics of DutasterideAND (pharmacogenomics)}} Pharmacogenomics of DutasterideAND (proteomics)}} Proteomics of Dutasteride


| group10 = Newstories on Dutasteride | list10 = Dutasteride in the newsBe alerted to news on DutasterideNews trends on Dutasteride</small>


| group11 = Commentary on Dutasteride | list11 = Blogs on Dutasteride

| group12 = Patient Resources on Dutasteride | list12 = Patient resources on DutasterideDiscussion groups on DutasteridePatient Handouts on DutasterideDirections to Hospitals Treating DutasterideRisk calculators and risk factors for Dutasteride


| group13 = Healthcare Provider Resources on Dutasteride | list13 = Symptoms of DutasterideCauses & Risk Factors for DutasterideDiagnostic studies for DutasterideTreatment of Dutasteride

| group14 = Continuing Medical Education (CME) Programs on Dutasteride | list14 = CME Programs on Dutasteride

| group15 = International Resources on Dutasteride | list15 = Dutasteride en EspanolDutasteride en Francais

| group16 = Business Resources on Dutasteride | list16 = Dutasteride in the MarketplacePatents on Dutasteride

| group17 = Informatics Resources on Dutasteride | list17 = List of terms related to Dutasteride


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