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==Overview==
'''Dopexamine''' is a synthetic analogue of dopamine. Despite this, it is a [[Beta1-adrenergic agonist|β<sub>1</sub>]] and [[beta2-adrenergic receptor agonist|β<sub>2</sub>-adrenergic receptor agonist]].<ref name="PMID7902685">{{cite journal |author=Perrin G, Papazian L, Martin C. |title=Dopexamine: a new dopaminergic agonist |journal=Ann Fr Anesth Reanim. |volume=12 |issue=3 |pages=308–320 |year=1993 |month=|pmid=7902685 |pmc= |doi= |url=}}</ref> Its action at [[dopamine receptor]] D1 mediates relaxation of vascular smooth muscle in renal, mesenteric, cerebral and coronary arteries. Mild action at D2 receptors decreases noradrenaline release.<ref name="pmid2862944">{{cite journal |author=Brown RA, Dixon J, Farmer JB, ''et al.'' |title=Dopexamine: a novel agonist at peripheral dopamine receptors and beta 2-adrenoceptors |journal=Br. J. Pharmacol. |volume=85 |issue=3 |pages=599–608 |date=July 1985 |pmid=2862944 |pmc=1916510 |doi= 10.1111/j.1476-5381.1985.tb10554.x|url=}}</ref>
Use in [[sepsis]] has been proposed.<ref name="pmid16893450">{{cite journal |author=Birnbaum J, Klotz E, Spies CD, ''et al.'' |title=Effects of dopexamine on the intestinal microvascular blood flow and leucocyte activation in a sepsis model in rats |journal=Crit Care |volume=10 |issue=4 |pages=R117 |year=2006 |pmid=16893450 |pmc=1750974 |doi=10.1186/cc5011 |url=http://ccforum.com/content/10/4/R117}}</ref>
It is used as an [[inotropic]] agent in cardiac failure.<ref name="pmid12740229">{{cite journal |author=Lisbon A |title=Dopexamine, dobutamine, and dopamine increase splanchnic blood flow: what is the evidence? |journal=Chest |volume=123 |issue=5 Suppl |pages=460S–3S |date=May 2003 |pmid=12740229 |doi= 10.1378/chest.123.5_suppl.460S|url=http://www.chestjournal.org/cgi/pmidlookup?view=long&pmid=12740229}}</ref> Side effects include arrhythmia, tremor, angina and flushing.


==References==
{{reflist|2}}


==Overview==
{{Cardiac stimulants excluding cardiac glycosides}}
'''Dopexamine''' is a [[beta2-adrenergic receptor agonist|β<sub>2</sub>-adrenergic receptor agonist]].


[[Category:Beta-adrenergic agonists]]
[[Category:Catecholamines]]
[[Category:Catecholamines]]
[[Category:Phenethylamines]]
[[Category:Dopamine agonists]]
[[Category:Drugs]]
[[Category:Inotropic agents]]
 
[[Category:Cardiovascular Drugs]]
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Latest revision as of 00:27, 24 July 2014

Dopexamine
Clinical data
ATC code
Identifiers
CAS Number
PubChem CID
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC22H32N2O2
Molar mass429.43 g/mol

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Dopexamine is a synthetic analogue of dopamine. Despite this, it is a β1 and β2-adrenergic receptor agonist.[1] Its action at dopamine receptor D1 mediates relaxation of vascular smooth muscle in renal, mesenteric, cerebral and coronary arteries. Mild action at D2 receptors decreases noradrenaline release.[2]

Use in sepsis has been proposed.[3]

It is used as an inotropic agent in cardiac failure.[4] Side effects include arrhythmia, tremor, angina and flushing.

References

  1. Perrin G, Papazian L, Martin C. (1993). "Dopexamine: a new dopaminergic agonist". Ann Fr Anesth Reanim. 12 (3): 308–320. PMID 7902685.
  2. Brown RA, Dixon J, Farmer JB; et al. (July 1985). "Dopexamine: a novel agonist at peripheral dopamine receptors and beta 2-adrenoceptors". Br. J. Pharmacol. 85 (3): 599–608. doi:10.1111/j.1476-5381.1985.tb10554.x. PMC 1916510. PMID 2862944.
  3. Birnbaum J, Klotz E, Spies CD; et al. (2006). "Effects of dopexamine on the intestinal microvascular blood flow and leucocyte activation in a sepsis model in rats". Crit Care. 10 (4): R117. doi:10.1186/cc5011. PMC 1750974. PMID 16893450.
  4. Lisbon A (May 2003). "Dopexamine, dobutamine, and dopamine increase splanchnic blood flow: what is the evidence?". Chest. 123 (5 Suppl): 460S–3S. doi:10.1378/chest.123.5_suppl.460S. PMID 12740229.

Template:Cardiac stimulants excluding cardiac glycosides