Diverticulitis natural history, complications and prognosis: Difference between revisions

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==Overview==
==Overview==
Diverticulitis natural history is not well understood, but some studies have shown the disease to take a benign course if left untreated. Diverticulitis can cause many [[complications]] that can sometimes be fatal. These [[complications]] include [[abscess]], [[Bowel perforation|perforation]], [[peritonitis]], and [[fistula]] formation. Prognosis of diverticulitis is excellent and conservative treatment is successful in 70 to 100 percent of patients.
Diverticulitis natural history is not well understood, but some studies have shown the disease to take a benign course if left untreated. Diverticulitis can cause many [[complications]] that can sometimes be fatal. These [[complications]] include [[abscess]], [[Bowel perforation|perforation]], [[peritonitis]], and [[fistula]] formation. [[Prognosis]] of diverticulitis is excellent and conservative treatment is successful in 70 to 100 percent of patients.


==Natural History==
==Natural History==
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==Complications==
==Complications==
In complicated diverticulitis, [[bacteria]] may subsequently infect the outside of the [[Colon (anatomy)|colon]] if an [[inflamed]] diverticulum bursts open. If the [[infection]] spreads to the lining of the [[abdominal cavity]] ([[peritoneum]]), this can cause potentially fatal [[peritonitis]]. Sometimes, inflamed diverticula can cause narrowing of the [[bowel]], causing an [[obstruction]]. Also, the affected part of the colon could adhere to the [[Urinary bladder|bladder]] or other adjacent [[organ (anatomy)|organ]]<nowiki/>s, causing a [[fistula]]. These complications always require treatment to prevent them from progressing and causing serious illness.<ref name="pmid24430321">{{cite journal| author=Morris AM, Regenbogen SE, Hardiman KM, Hendren S| title=Sigmoid diverticulitis: a systematic review. | journal=JAMA | year= 2014 | volume= 311 | issue= 3 | pages= 287-97 | pmid=24430321 | doi=10.1001/jama.2013.282025 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24430321  }} </ref>
In complicated diverticulitis, [[bacteria]] may subsequently infect the outside of the [[Colon (anatomy)|colon]] if an [[inflamed]] diverticulum bursts open. If the [[infection]] spreads to the lining of the [[abdominal cavity]] ([[peritoneum]]), this can cause potentially fatal [[peritonitis]]. Sometimes, inflamed diverticula can cause narrowing of the [[bowel]], causing an [[obstruction]]. Also, the affected part of the [[Colon (anatomy)|colon]] could adhere to the [[Urinary bladder|bladder]] or other adjacent [[organ (anatomy)|organ]]<nowiki/>s, causing a [[fistula]]. These complications always require treatment to prevent them from progressing and causing serious illness.<ref name="pmid24430321">{{cite journal| author=Morris AM, Regenbogen SE, Hardiman KM, Hendren S| title=Sigmoid diverticulitis: a systematic review. | journal=JAMA | year= 2014 | volume= 311 | issue= 3 | pages= 287-97 | pmid=24430321 | doi=10.1001/jama.2013.282025 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24430321  }} </ref>


===Abscess===
===Abscess===
*[[Abscess]] formation may take place in cases of diverticulitis.<ref name="pmid14672782">{{cite journal| author=Bahadursingh AM, Virgo KS, Kaminski DL, Longo WE| title=Spectrum of disease and outcome of complicated diverticular disease. | journal=Am J Surg | year= 2003 | volume= 186 | issue= 6 | pages= 696-701 | pmid=14672782 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=14672782  }} </ref>  
*[[Abscess]] formation may take place in cases of diverticulitis.<ref name="pmid14672782">{{cite journal| author=Bahadursingh AM, Virgo KS, Kaminski DL, Longo WE| title=Spectrum of disease and outcome of complicated diverticular disease. | journal=Am J Surg | year= 2003 | volume= 186 | issue= 6 | pages= 696-701 | pmid=14672782 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=14672782  }} </ref>  
*The [[abscess]] can be detected by CT scan and can be resolved with [[antibiotics]]. If the [[abscess]] persists, cutaneous drainage is recommended.
*The [[abscess]] can be detected by [[Computed tomography|CT scan]] and can be resolved with [[antibiotics]]. If the [[abscess]] persists, cutaneous drainage is recommended.


=== Perforation and peritonitis ===
=== Perforation and peritonitis ===

Latest revision as of 17:09, 24 November 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Cafer Zorkun, M.D., Ph.D. [2]

Overview

Diverticulitis natural history is not well understood, but some studies have shown the disease to take a benign course if left untreated. Diverticulitis can cause many complications that can sometimes be fatal. These complications include abscess, perforation, peritonitis, and fistula formation. Prognosis of diverticulitis is excellent and conservative treatment is successful in 70 to 100 percent of patients.

Natural History

The natural history of diverticulitis is still not well understood. However, some studies have shown the disease to take a benign course with a low incidence of complications if left untreated.[1][2]

Complications

In complicated diverticulitis, bacteria may subsequently infect the outside of the colon if an inflamed diverticulum bursts open. If the infection spreads to the lining of the abdominal cavity (peritoneum), this can cause potentially fatal peritonitis. Sometimes, inflamed diverticula can cause narrowing of the bowel, causing an obstruction. Also, the affected part of the colon could adhere to the bladder or other adjacent organs, causing a fistula. These complications always require treatment to prevent them from progressing and causing serious illness.[3]

Abscess

Perforation and peritonitis

Fistula

Prognosis

In patients with acute uncomplicated diverticulitis, conservative treatment is successful in 70 to 100 percent of patients and mortality is negligible.[7]

References

  1. Salem TA, Molloy RG, O'Dwyer PJ (2007). "Prospective, five-year follow-up study of patients with symptomatic uncomplicated diverticular disease". Dis Colon Rectum. 50 (9): 1460–4. doi:10.1007/s10350-007-0226-5. PMID 17431721. Review in: J Fam Pract. 2007 Dec;56(12):992
  2. Floch MH, Bina I (2004). "The natural history of diverticulitis: fact and theory". J Clin Gastroenterol. 38 (5 Suppl 1): S2–7. PMID 15115921.
  3. Morris AM, Regenbogen SE, Hardiman KM, Hendren S (2014). "Sigmoid diverticulitis: a systematic review". JAMA. 311 (3): 287–97. doi:10.1001/jama.2013.282025. PMID 24430321.
  4. Bahadursingh AM, Virgo KS, Kaminski DL, Longo WE (2003). "Spectrum of disease and outcome of complicated diverticular disease". Am J Surg. 186 (6): 696–701. PMID 14672782.
  5. Nagorney DM, Adson MA, Pemberton JH (1985). "Sigmoid diverticulitis with perforation and generalized peritonitis". Dis Colon Rectum. 28 (2): 71–5. PMID 3971809.
  6. Woods RJ, Lavery IC, Fazio VW, Jagelman DG, Weakley FL (1988). "Internal fistulas in diverticular disease". Dis Colon Rectum. 31 (8): 591–6. PMID 3402284.
  7. Rafferty J, Shellito P, Hyman NH, Buie WD (2006). "Practice parameters for sigmoid diverticulitis". Dis. Colon Rectum. 49 (7): 939–44. doi:10.1007/s10350-006-0578-2. PMID 16741596.

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