Dimenhydrinate: Difference between revisions

Dimenhydrinate
Combination of
diphenhydramine	antiemetic
8-chlorotheophylline	stimulant
[[{{{component3}}}]]	? Class
[[{{{component4}}}]]	? Class
[[{{{component5}}}]]	? Class
Clinical data
Trade names	Dramamine
AHFS/Drugs.com	Monograph
MedlinePlus	a607046
Pregnancy; category	AU: A ; US: B (No risk in non-human studies) ; ;
Routes of; administration	Oral, Rectal, I.V.
ATC code	R06AA52 ;
Legal status
Legal status	AU: S2 (Pharmacy only) ; US: OTC ;
Identifiers
CAS Number	523-87-5 ;
PubChem CID	10660;
DrugBank	DB00985 ;
ChemSpider	10210 ;
UNII	JB937PER5C;
KEGG	D00520 ;
ChEMBL	ChEMBL1200406 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
3D model (JSmol)	Interactive image;
	SMILES O=C2N(c1nc(Cl)nc1C(=O)N2C)C.O(CCN(C)C)C(c1ccccc1)c2ccccc2;
	InChI InChI=1S/C17H21NO.C7H7ClN4O2/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;1-11-4-3(9-6(8)10-4)5(13)12(2)7(11)14/h3-12,17H,13-14H2,1-2H3;1-2H3,(H,9,10) ; Key:NFLLKCVHYJRNRH-UHFFFAOYSA-N ;
(what is this?) (verify)

Dimenhydrinate
	Adult Indications & Dosage
	Pediatric Indications & Dosage
	Contraindications
	Warnings & Precautions
	Adverse Reactions
	Drug Interactions
	Use in Specific Populations
	Administration & Monitoring
	Overdosage
	Pharmacology
	Clinical Studies
	How Supplied
	Images
	Patient Counseling Information
	Precautions with Alcohol
	Brand Names
	Look-Alike Names

VisualWikitext

Revision as of 18:09, 20 April 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Turky Alkathery, M.D. [2]

Disclaimer

WikiDoc MAKES NO GUARANTEE OF VALIDITY. WikiDoc is not a professional health care provider, nor is it a suitable replacement for a licensed healthcare provider. WikiDoc is intended to be an educational tool, not a tool for any form of healthcare delivery. The educational content on WikiDoc drug pages is based upon the FDA package insert, National Library of Medicine content and practice guidelines / consensus statements. WikiDoc does not promote the administration of any medication or device that is not consistent with its labeling. Please read our full disclaimer here.
NOTE: Most over the counter (OTC) are not reviewed and approved by the FDA. However, they may be marketed if they comply with applicable regulations and policies. FDA has not evaluated whether this product complies.

Overview

Dimenhydrinate is an antiemetic that is FDA approved for the treatment of these symptoms associated with motion sickness:

nausea.
vomiting.
dizziness.. Common adverse reactions include nausea, vomiting, xerostomia and sedation..

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Indications

Uses for prevention and treatment of these symptoms associated with motion sickness:

Dosage

To prevent motion sickness, the first dose should be taken 1/2 to 1 hour before starting activity.
To prevent or treat motion sickness, use the following dosing.

This image is provided by the National Library of Medicine.

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Dimenhydrinate in adult patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Dimenhydrinate in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

Indications

Uses for prevention and treatment of these symptoms associated with motion sickness:

Do not use in children under 2 years of age unless directed by a doctor

Dosage

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Dimenhydrinate in pediatric patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Dimenhydrinate in pediatric patients.

Contraindications

None

Warnings

None.

Precautions

ASK A DOCTOR BEFORE USE IF YOU HAVE

A breathing problem such as emphysema or chronic bronchitis.
Glaucoma.
Difficulty in urination due to enlargement of the prostate gland.

Adverse Reactions

Clinical Trials Experience

WHEN USING THIS PRODUCT

Marked drowsiness may occur.
Alcohol, sedatives and tranquilizers may increase drowsiness.
Avoid alcoholic drinks.
Be careful when driving a motor vehicle or operating machinery*

Postmarketing Experience

There is limited information regarding postmarketing experience.

Drug Interactions

ASK DOCTOR/PHARMACIST

Ask a doctor or pharmacist before use if you are taking sedatives or tranquilizers.

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA):

If pregnant or breast-feeding, ask a health professional before use.

Pregnancy Category (AUS): There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Dimenhydrinate in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Dimenhydrinate during labor and delivery.

Nursing Mothers

If pregnant or breast-feeding, ask a health professional before use.

Pediatric Use

There is no FDA guidance on the use of Dimenhydrinate in pediatric settings.

Geriatic Use

There is no FDA guidance on the use of Dimenhydrinate in geriatric settings.

Gender

There is no FDA guidance on the use of Dimenhydrinate with respect to specific gender populations.

Race

There is no FDA guidance on the use of Dimenhydrinate with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Dimenhydrinate in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Dimenhydrinate in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Dimenhydrinate in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Dimenhydrinate in patients who are immunocompromised.

Administration and Monitoring

Administration

Oral.

Monitoring

There is limited information regarding Monitoring.

IV Compatibility

There is limited information regarding IV Compatibility.

Overdosage

In case of overdose, get medical help or contact a Poison Control Center right away. (1-800-222-1222).

Pharmacology

Mechanism of Action

There is limited information regarding Mechanism of action.

Structure

Pharmacodynamics

There is limited information regarding Pharmacodynamics.

Pharmacokinetics

There is limited information regarding Pharmacokinetics.

Nonclinical Toxicology

There is limited information regarding Nonclinical toxicology.

Clinical Studies

There is limited information regarding Clinical Studies.

How Supplied

There is limited information regarding Dimenhydrinate How Supplied in the drug label.

Storage

Store at 15° to 30°C (59° to 86°F)

Images

Drug Images

{{#ask: Page Name::Dimenhydrinate |?Pill Name |?Drug Name |?Pill Ingred |?Pill Imprint |?Pill Dosage |?Pill Color |?Pill Shape |?Pill Size (mm) |?Pill Scoring |?NDC |?Drug Author |format=template |template=DrugPageImages |mainlabel=- |sort=Pill Name }}

Package and Label Display Panel

{{#ask: Label Page::Dimenhydrinate |?Label Name |format=template |template=DrugLabelImages |mainlabel=- |sort=Label Page }}

Patient Counseling Information

There is limited information regarding Dimenhydrinate Patient Counseling Information in the drug label.

Precautions with Alcohol

Avoid alcoholic drinks.

Brand Names

DIMENHYDRINATE ®^[1]

Look-Alike Drug Names

dimenhyDRINATE - diphenhydrAMINE^[2]

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

↑ "DIMENHYDRINATE- dimenhydrinate tablet".
↑ "http://www.ismp.org". External link in |title= (help)

[1] "DIMENHYDRINATE- dimenhydrinate tablet".

[www.ismp.org-2] "http://www.ismp.org". External link in |title= (help)

[1]

[2]

@@ Line 16: / Line 16: @@
 *Uses for prevention and treatment of these symptoms associated with motion sickness:
-::*nausea
+::*[[nausea]]
-::*vomiting
+::*[[vomiting]]
-::*dizziness
+::*[[dizziness]]
 ===Dosage===
@@ Line 28: / Line 28: @@
 |fdaLIADPed====Indications===
 *Uses for prevention and treatment of these symptoms associated with [[motion sickness]]:
-::*nausea
+::*[[nausea]]
-::*vomiting
+::*[[vomiting]]
-::*dizziness
+::*[[dizziness]]
 *Do not use in children under 2 years of age unless directed by a doctor
@@ Line 41: / Line 41: @@
 ===Precautions===
 ====ASK A DOCTOR BEFORE USE IF YOU HAVE====
-:*A breathing problem such as emphysema or chronic bronchitis.
+:*A breathing problem such as [[emphysema]] or [[chronic bronchitis]].
-:*Glaucoma.
+:*[[Glaucoma]].
-:*Difficulty in urination due to enlargement of the prostate gland.
+:*Difficulty in urination due to [[BPH|enlargement of the prostate gland]].
 |clinicalTrials=====WHEN USING THIS PRODUCT====
 *Marked drowsiness may occur.
@@ Line 51: / Line 51: @@
 |postmarketing=*There is limited information regarding <i>postmarketing experience</i>.
 |drugInteractions=====ASK DOCTOR/PHARMACIST====
-*Ask a doctor or pharmacist before use if you are taking sedatives or tranquilizers.
+*Ask a doctor or pharmacist before use if you are taking [[sedatives]] or [[tranquilizers]].
 |useInPregnancyFDA=*If pregnant or breast-feeding, ask a health professional before use.
 |useInNursing=*If pregnant or breast-feeding, ask a health professional before use.
@@ Line 58: / Line 58: @@
 |IVCompat=*There is limited information regarding <i>IV Compatibility</i>.
 |overdose=*In case of overdose, get medical help or contact a Poison Control Center right away. (1-800-222-1222).
-|drugBox=
+|drugBox={{Drugbox
-{{Drugbox
 | Verifiedfields = changed
 | Watchedfields = changed
@@ Line 110: / Line 109: @@
 | StdInChIKey = NFLLKCVHYJRNRH-UHFFFAOYSA-N
 }}
+|mechAction=*There is limited information regarding <i>Mechanism of action</i>.
+|structure=[[File:Diphenhydramine-trans.png|thumb|none|400px|This image is provided by the National Library of Medicine.]]
+|PD=*There is limited information regarding <i>Pharmacodynamics</i>.
+|PK=*There is limited information regarding <i>Pharmacokinetics</i>.
+|nonClinToxic=*There is limited information regarding <i>Nonclinical toxicology</i>.
+|clinicalStudies=*There is limited information regarding <i>Clinical Studies</i>.
 |storage=*Store at 15° to 30°C (59° to 86°F)
 |packLabel=[[File:Dimenhydrinate2.jpeg|thumb|none|400px|This image is provided by the National Library of Medicine.]][[File:Dimenhydrinate3.png|thumb|none|400px|This image is provided by the National Library of Medicine.]]
 |alcohol=*Avoid alcoholic drinks.
-|brandNames=* ®<ref>{{Cite web | title =  | url = }}</ref>
+|brandNames=*DIMENHYDRINATE ®<ref>{{Cite web | title = DIMENHYDRINATE- dimenhydrinate tablet   | url = http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b4e1e0e9-a7cf-4c10-9e1b-0f4110be0767}}</ref>
 |lookAlike=* dimenhyDRINATE - diphenhydrAMINE<ref name="www.ismp.org">{{Cite web  | last =  | first =  | title = http://www.ismp.org | url = http://www.ismp.org | publisher =  | date =  }}</ref>
 }}

Dimenhydrinate: Difference between revisions

Revision as of 18:09, 20 April 2015

Disclaimer

Overview

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Indications

Dosage

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

Non–Guideline-Supported Use

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

Indications

Dosage

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

Non–Guideline-Supported Use

Contraindications

Warnings

Precautions

ASK A DOCTOR BEFORE USE IF YOU HAVE

Adverse Reactions

Clinical Trials Experience

WHEN USING THIS PRODUCT

Postmarketing Experience

Drug Interactions

ASK DOCTOR/PHARMACIST

Use in Specific Populations

Pregnancy

Labor and Delivery

Nursing Mothers

Pediatric Use

Geriatic Use

Gender

Race

Renal Impairment

Hepatic Impairment

Females of Reproductive Potential and Males

Immunocompromised Patients

Administration and Monitoring

Administration

Monitoring

IV Compatibility

Overdosage

Pharmacology

Mechanism of Action

Structure

Pharmacodynamics

Pharmacokinetics

Nonclinical Toxicology

Clinical Studies

How Supplied

Storage

Images

Drug Images

Package and Label Display Panel

Patient Counseling Information

Precautions with Alcohol

Brand Names

Look-Alike Drug Names

Drug Shortage Status

Price

References

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