Dimenhydrinate: Difference between revisions

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|useInPregnancyFDA=*If pregnant or breast-feeding, ask a health professional before use.
|useInPregnancyFDA=*If pregnant or breast-feeding, ask a health professional before use.
|useInNursing=*If pregnant or breast-feeding, ask a health professional before use.
|useInNursing=*If pregnant or breast-feeding, ask a health professional before use.
|administration=*Oral.
|monitoring=*There is limited information regarding <i>Monitoring</i>.
|IVCompat=*There is limited information regarding <i>IV Compatibility</i>.
|overdose=*In case of overdose, get medical help or contact a Poison Control Center right away. (1-800-222-1222).
|drugBox=
{{Drugbox
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 459441657
| image = Diphenhydramine-trans.png
| width = 150
<!--Combo data-->
| type = combo
| component1 = diphenhydramine
| class1 = [[antiemetic]]
| component2 = 8-chlorotheophylline
| class2 = [[stimulant]]
<!--Clinical data-->
| tradename = Dramamine
| Drugs.com = {{drugs.com|monograph|dimenhydrinate}}
| MedlinePlus = a607046
| pregnancy_AU = A
| pregnancy_US = B
| legal_AU = S2
| legal_US = OTC
| routes_of_administration = Oral, Rectal, I.V.
<!--Identifiers-->
| CASNo_Ref = {{cascite|correct|CAS}}
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 523-87-5
| ATC_prefix = R06AA52
| PubChem = 10660
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB00985
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 10210
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = JB937PER5C
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D00520
| ChEMBL_Ref = {{ebicite|changed|EBI}}
| ChEMBL = 1200406
<!--Chemical data-->
| smiles = O=C2N(c1nc(Cl)nc1C(=O)N2C)C.O(CCN(C)C)C(c1ccccc1)c2ccccc2
| InChI = 1/C17H21NO.C7H7ClN4O2/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;1-11-4-3(9-6(8)10-4)5(13)12(2)7(11)14/h3-12,17H,13-14H2,1-2H3;1-2H3,(H,9,10)
| InChIKey = NFLLKCVHYJRNRH-UHFFFAOYAO
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C17H21NO.C7H7ClN4O2/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;1-11-4-3(9-6(8)10-4)5(13)12(2)7(11)14/h3-12,17H,13-14H2,1-2H3;1-2H3,(H,9,10)
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = NFLLKCVHYJRNRH-UHFFFAOYSA-N
}}
|storage=*Store at 15° to 30°C (59° to 86°F)
|storage=*Store at 15° to 30°C (59° to 86°F)
|packLabel=[[File:Dimenhydrinate2.jpeg|thumb|none|400px|This image is provided by the National Library of Medicine.]][[File:Dimenhydrinate3.png|thumb|none|400px|This image is provided by the National Library of Medicine.]]
|packLabel=[[File:Dimenhydrinate2.jpeg|thumb|none|400px|This image is provided by the National Library of Medicine.]][[File:Dimenhydrinate3.png|thumb|none|400px|This image is provided by the National Library of Medicine.]]

Revision as of 18:01, 20 April 2015

Dimenhydrinate
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Turky Alkathery, M.D. [2]

Disclaimer

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NOTE: Most over the counter (OTC) are not reviewed and approved by the FDA. However, they may be marketed if they comply with applicable regulations and policies. FDA has not evaluated whether this product complies.

Overview

Dimenhydrinate is an antiemetic that is FDA approved for the treatment of these symptoms associated with motion sickness:

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Indications

  • Uses for prevention and treatment of these symptoms associated with motion sickness:
  • nausea
  • vomiting
  • dizziness

Dosage

  • To prevent motion sickness, the first dose should be taken 1/2 to 1 hour before starting activity.
  • To prevent or treat motion sickness, use the following dosing.
This image is provided by the National Library of Medicine.

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

  • There is limited information regarding Off-Label Guideline-Supported Use of Dimenhydrinate in adult patients.

Non–Guideline-Supported Use

  • There is limited information regarding Off-Label Non–Guideline-Supported Use of Dimenhydrinate in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

Indications

  • Uses for prevention and treatment of these symptoms associated with motion sickness:
  • nausea
  • vomiting
  • dizziness
  • Do not use in children under 2 years of age unless directed by a doctor

Dosage

This image is provided by the National Library of Medicine.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Dimenhydrinate in pediatric patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Dimenhydrinate in pediatric patients.

Contraindications

  • None

Warnings

  • None.

Precautions

ASK A DOCTOR BEFORE USE IF YOU HAVE

  • A breathing problem such as emphysema or chronic bronchitis.
  • Glaucoma.
  • Difficulty in urination due to enlargement of the prostate gland.

Adverse Reactions

Clinical Trials Experience

WHEN USING THIS PRODUCT

  • Marked drowsiness may occur.
  • Alcohol, sedatives and tranquilizers may increase drowsiness.
  • Avoid alcoholic drinks.
  • Be careful when driving a motor vehicle or operating machinery*

Postmarketing Experience

  • There is limited information regarding postmarketing experience.

Drug Interactions

ASK DOCTOR/PHARMACIST

  • Ask a doctor or pharmacist before use if you are taking sedatives or tranquilizers.

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA):

  • If pregnant or breast-feeding, ask a health professional before use.


Pregnancy Category (AUS): There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Dimenhydrinate in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Dimenhydrinate during labor and delivery.

Nursing Mothers

  • If pregnant or breast-feeding, ask a health professional before use.

Pediatric Use

There is no FDA guidance on the use of Dimenhydrinate in pediatric settings.

Geriatic Use

There is no FDA guidance on the use of Dimenhydrinate in geriatric settings.

Gender

There is no FDA guidance on the use of Dimenhydrinate with respect to specific gender populations.

Race

There is no FDA guidance on the use of Dimenhydrinate with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Dimenhydrinate in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Dimenhydrinate in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Dimenhydrinate in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Dimenhydrinate in patients who are immunocompromised.

Administration and Monitoring

Administration

  • Oral.

Monitoring

  • There is limited information regarding Monitoring.

IV Compatibility

  • There is limited information regarding IV Compatibility.

Overdosage

  • In case of overdose, get medical help or contact a Poison Control Center right away. (1-800-222-1222).

Pharmacology

Dimenhydrinate
Combination of
diphenhydramineantiemetic
8-chlorotheophyllinestimulant
[[{{{component3}}}]]? Class
[[{{{component4}}}]]? Class
[[{{{component5}}}]]? Class
Clinical data
Trade namesDramamine
AHFS/Drugs.comMonograph
MedlinePlusa607046
Pregnancy
category
  • AU: A
  • US: B (No risk in non-human studies)
Routes of
administration
Oral, Rectal, I.V.
ATC code
Legal status
Legal status
  • AU: S2 (Pharmacy only)
  • US: OTC
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
3D model (JSmol)
 ☒N☑Y (what is this?)  (verify)

Mechanism of Action

There is limited information regarding Dimenhydrinate Mechanism of Action in the drug label.

Structure

There is limited information regarding Dimenhydrinate Structure in the drug label.

Pharmacodynamics

There is limited information regarding Dimenhydrinate Pharmacodynamics in the drug label.

Pharmacokinetics

There is limited information regarding Dimenhydrinate Pharmacokinetics in the drug label.

Nonclinical Toxicology

There is limited information regarding Dimenhydrinate Nonclinical Toxicology in the drug label.

Clinical Studies

There is limited information regarding Dimenhydrinate Clinical Studies in the drug label.

How Supplied

There is limited information regarding Dimenhydrinate How Supplied in the drug label.

Storage

  • Store at 15° to 30°C (59° to 86°F)

Images

Drug Images

{{#ask: Page Name::Dimenhydrinate |?Pill Name |?Drug Name |?Pill Ingred |?Pill Imprint |?Pill Dosage |?Pill Color |?Pill Shape |?Pill Size (mm) |?Pill Scoring |?NDC |?Drug Author |format=template |template=DrugPageImages |mainlabel=- |sort=Pill Name }}

Package and Label Display Panel

This image is provided by the National Library of Medicine.
This image is provided by the National Library of Medicine.

{{#ask: Label Page::Dimenhydrinate |?Label Name |format=template |template=DrugLabelImages |mainlabel=- |sort=Label Page }}

Patient Counseling Information

There is limited information regarding Dimenhydrinate Patient Counseling Information in the drug label.

Precautions with Alcohol

  • Avoid alcoholic drinks.

Brand Names

Look-Alike Drug Names

  • dimenhyDRINATE - diphenhydrAMINE[2]

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

  1. Empty citation (help)
  2. "http://www.ismp.org". External link in |title= (help)