Digoxin

Jump to navigation Jump to search


Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Abdurahman Khalil, M.D. [2]

Synonyms / Brand Names: Digox, Digoxin, Lanoxin

Digoxin tablet

Digoxin injection

Digoxin solution

Overview

Digoxin INN is a purified cardiac glycoside similar to Digitoxin extracted from the foxglove plant, Digitalis lanata,[1] which was discovered by William Withering. Its corresponding aglycone is digoxigenin, and its acetyl derivative is acetyldigoxin. Digoxin is widely used in the treatment of various heart conditions, namely atrial fibrillation, atrial flutter and sometimes heart failure that cannot be controlled by other medication.

Category

Cardiac glycoside

Digoxin
Clinical data
Trade namesLanoxin
AHFS/Drugs.comMonograph
MedlinePlusa682301
Pregnancy
category
Routes of
administration
Oral, Intravenous
ATC code
Legal status
Legal status
  • S4 (Au), POM (UK), ℞-only (U.S.)
Pharmacokinetic data
Bioavailability60 to 80% (Oral)
Protein binding25%
MetabolismHepatic (16%)
Elimination half-life36 to 48 hours
(patients with normal renal function)
3.5 to 5 days
(patients with impaired renal function)
ExcretionRenal
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC41H64O14
Molar mass780.938 g/mol
3D model (JSmol)
Melting point249.3 °C (480.74 °F)
Solubility in water0.0648 mg/mL (20 °C)
  (verify)

References

  1. Hollman A (1996). "Digoxin comes from Digitalis lanata". British Medical Journal. 312 (7035): 912.

http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=58f45aba-ff6f-43cc-bb88-be40a9f7beda

http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=41c16cff-b03e-405e-a617-d6f45d3ce2bd

Template:Cardiac glycosides

Template:Antiarrhythmic agents