Dezocine

Revision as of 15:32, 13 April 2015 by Rabin Bista (talk | contribs)
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to navigation Jump to search
Dezocine
Clinical data
SynonymsDezocine, Dalgan
Routes of
administration
intramuscular injection
ATC code
Pharmacokinetic data
MetabolismHepatic
Elimination half-life2.2 hours
Identifiers
CAS Number
PubChem CID
DrugBank
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC16H23NO
Molar mass245.36 g/mol

WikiDoc Resources for Dezocine

Articles

Most recent articles on Dezocine

Most cited articles on Dezocine

Review articles on Dezocine

Articles on Dezocine in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Dezocine

Images of Dezocine

Photos of Dezocine

Podcasts & MP3s on Dezocine

Videos on Dezocine

Evidence Based Medicine

Cochrane Collaboration on Dezocine

Bandolier on Dezocine

TRIP on Dezocine

Clinical Trials

Ongoing Trials on Dezocine at Clinical Trials.gov

Trial results on Dezocine

Clinical Trials on Dezocine at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Dezocine

NICE Guidance on Dezocine

NHS PRODIGY Guidance

FDA on Dezocine

CDC on Dezocine

Books

Books on Dezocine

News

Dezocine in the news

Be alerted to news on Dezocine

News trends on Dezocine

Commentary

Blogs on Dezocine

Definitions

Definitions of Dezocine

Patient Resources / Community

Patient resources on Dezocine

Discussion groups on Dezocine

Patient Handouts on Dezocine

Directions to Hospitals Treating Dezocine

Risk calculators and risk factors for Dezocine

Healthcare Provider Resources

Symptoms of Dezocine

Causes & Risk Factors for Dezocine

Diagnostic studies for Dezocine

Treatment of Dezocine

Continuing Medical Education (CME)

CME Programs on Dezocine

International

Dezocine en Espanol

Dezocine en Francais

Business

Dezocine in the Marketplace

Patents on Dezocine

Experimental / Informatics

List of terms related to Dezocine

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Dezocine (Dalgan, WY-16225) is an opioid analgesic related to pentazocine, with a similar profile of effects that include analgesic action and euphoria at low doses,[1] but produces dysphoria and hallucinations at high doses, most likely due to action at κ-opioid receptors.[2][3]

Dezocine has been found to be an effective painkiller comparable to meperidine (pethidine),[4] and so is a more effective analgesic than pentazocine, but causes relatively more respiratory depression than pentazocine.[5] It is a useful drug for the treatment of pain,[6] but side effects such as dizziness limit its clinical application,[7] and it can produce opioid withdrawal syndrome in patients already dependent on other opioids.[8]

Dezocine is unusual among opioids as it is the only primary amine known to be an active opioid. It is a mixed agonist-antagonist as with other drugs in this class,[9] and despite having a stronger respiratory depressant effect than morphine, dezocine shows a ceiling effect on its respiratory depressive action so above a certain dose this effect does not get any more severe.[10]


Template:Pharm-stub

References

  1. Zacny JP, Lichtor JL, de Wit H. Subjective, behavioral, and physiologic responses to intravenous dezocine in healthy volunteers. Anesthesia and Analgesia. 1992 Apr;74(4):523-30.
  2. Jacobs AM, Youngblood F. Opioid receptor affinity for agonist-antagonist analgesics. Journal of the American Podiatric Medical Association. 1992 Oct;82(10):520-4.
  3. Gharagozlou P, Hashemi E, DeLorey TM, Clark JD, Lameh J. Pharmacological profiles of opioid ligands at kappa opioid receptors. BMC Pharmacology. 2006 Jan 25;6:3.
  4. Camu F, Gepts E. Analgesic properties of dezocine for relief of postoperative pain. Acta Anaesthesiologica Belgica. 1979;30 Suppl:183-91.
  5. Wuest HP, Bellville JW. The respiratory effects of dezocine and pentazocine in man. Journal of Clinical Pharmacology. 1979 Apr;19(4):205-10.
  6. O'Brien JJ, Benfield P. Dezocine. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy. Drugs. 1989 Aug;38(2):226-48.
  7. Oosterlinck W, Verbaeys A. Preliminary clinical experience with dezocine, a new potent analgesic. Current Medical Research and Opinion. 1980;6(7):472-4.
  8. Strain EC, Preston KL, Liebson IA, Bigelow GE. Opioid antagonist effects of dezocine in opioid-dependent humans. Clinical Pharmacology and Therapeutics. 1996 Aug;60(2):206-17.
  9. Young AM, Stephens KR, Hein DW, Woods JH. Reinforcing and discriminative stimulus properties of mixed agonist-antagonist opioids. Journal Pharmacology and Experimental Therapeutics. 1984 Apr;229(1):118-26.
  10. Romagnoli A, Keats AS. Ceiling respiratory depression by dezocine. Clinical Pharmacology and Therapeutics. 1984 Mar;35(3):367-73.

Template:Opioids