Desflurane

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Desflurane
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Chetan Lokhande, M.B.B.S [2]

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Overview

Desflurane is a general anesthetics that is FDA approved for the {{{indicationType}}} of General anesthesia. Common adverse reactions include gastrointestinal: nausea (27% ), vomiting (16% ), respiratory: cough ( adult induction, 22% to 34% ), interrupted breathing (adult induction, 30% to 39%; adult and intubated pediatric maintenance, greater than 1% ).

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

General anesthesia: induction, initial INHALED concentration of 3% in oxygen or nitrous oxide/oxygen, increased by 0.5% to 1% increments every 2 to 3 breaths or as tolerated (end tidal concentrations 4% to 11%) inspired concentrations greater than 12% have been safely administered during induction and may require a reduction of nitrous oxide or air General anesthesia: maintenance, INHALED concentrations of 2.5% to 8.5% with or without concomitant nitrous oxide; dosage must be individualized based on patient response

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

There is limited information about Off-Label Guideline-Supported Use of Desflurane in adult patients.

Non–Guideline-Supported Use

There is limited information about Off-Label Non–Guideline-Supported Use of Desflurane in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

General anesthesia: maintenance, INHALED in concentrations of 5.2% to 10% with or without concomitant nitrous oxide; dosage must be individualized based on patient response

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

There is limited information about Off-Label Guideline-Supported Use of Desflurane in pediatric patients.

Non–Guideline-Supported Use

There is limited information about Off-Label Non–Guideline-Supported Use of Desflurane in pediatric patients.

Contraindications

The use of SUPRANE (desflurane, USP) is contraindicated in the following conditions:

   Known or suspected genetic susceptibility to malignant hyperthermia.
   Patients in whom general anesthesia is contraindicated.
   Induction of anesthesia in pediatric patients.
   Patients with known sensitivity to SUPRANE (desflurane, USP) or to other halogenated agents [see Warnings and Precautions (5.5)].
   Patients with a history of confirmed hepatitis or with a history of unexplained moderate to severe hepatic dysfunction (e.g., jaundice associated with fever and/or eosinophilia) after anesthesia with SUPRANE (desflurane, USP) or other halogenated agents [see Warnings and Precautions].

Warnings

There is limited information regarding Desflurane Warnings' in the drug label.

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Desflurane Clinical Trials Experience in the drug label.

Postmarketing Experience

There is limited information regarding Desflurane Postmarketing Experience in the drug label.

Drug Interactions

There is limited information regarding Desflurane Drug Interactions in the drug label.

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA): There is no FDA guidance on usage of Desflurane in women who are pregnant.
Pregnancy Category (AUS): There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Desflurane in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Desflurane during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Desflurane in women who are nursing.

Pediatric Use

There is no FDA guidance on the use of Desflurane in pediatric settings.

Geriatic Use

There is no FDA guidance on the use of Desflurane in geriatric settings.

Gender

There is no FDA guidance on the use of Desflurane with respect to specific gender populations.

Race

There is no FDA guidance on the use of Desflurane with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Desflurane in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Desflurane in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Desflurane in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Desflurane in patients who are immunocompromised.

Administration and Monitoring

Administration

There is limited information regarding Desflurane Administration in the drug label.

Monitoring

There is limited information regarding Desflurane Monitoring in the drug label.

IV Compatibility

There is limited information regarding the compatibility of Desflurane and IV administrations.

Overdosage

There is limited information regarding Desflurane overdosage. If you suspect drug poisoning or overdose, please contact the National Poison Help hotline (1-800-222-1222) immediately.

Pharmacology

There is limited information regarding Desflurane Pharmacology in the drug label.

Mechanism of Action

There is limited information regarding Desflurane Mechanism of Action in the drug label.

Structure

There is limited information regarding Desflurane Structure in the drug label.

Pharmacodynamics

There is limited information regarding Desflurane Pharmacodynamics in the drug label.

Pharmacokinetics

There is limited information regarding Desflurane Pharmacokinetics in the drug label.

Nonclinical Toxicology

There is limited information regarding Desflurane Nonclinical Toxicology in the drug label.

Clinical Studies

There is limited information regarding Desflurane Clinical Studies in the drug label.

How Supplied

There is limited information regarding Desflurane How Supplied in the drug label.

Storage

There is limited information regarding Desflurane Storage in the drug label.

Images

Drug Images

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Package and Label Display Panel

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Patient Counseling Information

There is limited information regarding Desflurane Patient Counseling Information in the drug label.

Precautions with Alcohol

Alcohol-Desflurane interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

There is limited information regarding Desflurane Brand Names in the drug label.

Look-Alike Drug Names

There is limited information regarding Desflurane Look-Alike Drug Names in the drug label.

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.