Delta-like 1

Delta-like 1 (Drosophila)
Identifiers
Symbols	DLL1 ; DELTA1; Delta
External IDs	Template:OMIM5 Template:MGI HomoloGene: 4104
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Delta-like 1 (Drosophila), also known as DLL1, is a human gene.

DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication.

Further reading

• Watt FM (2002). "The stem cell compartment in human interfollicular epidermis". J. Dermatol. Sci. 28 (3): 173–80. PMID 11912004.
• Lewis AK, Frantz GD, Carpenter DA; et al. (1999). "Distinct expression patterns of notch family receptors and ligands during development of the mammalian inner ear". Mech. Dev. 78 (1–2): 159–63. PMID 9858718.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mitsiadis TA, Hirsinger E, Lendahl U, Goridis C (1999). "Delta-notch signaling in odontogenesis: correlation with cytodifferentiation and evidence for feedback regulation". Dev. Biol. 204 (2): 420–31. doi:10.1006/dbio.1998.9092. PMID 9882480.CS1 maint: Multiple names: authors list (link)
• Gray GE, Mann RS, Mitsiadis E; et al. (1999). "Human ligands of the Notch receptor". Am. J. Pathol. 154 (3): 785–94. PMID 10079256.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Beckers J, Clark A, Wünsch K; et al. (1999). "Expression of the mouse Delta1 gene during organogenesis and fetal development". Mech. Dev. 84 (1–2): 165–8. PMID 10473134.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Morrison A, Hodgetts C, Gossler A; et al. (1999). "Expression of Delta1 and Serrate1 (Jagged1) in the mouse inner ear". Mech. Dev. 84 (1–2): 169–72. PMID 10473135.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Han W, Ye Q, Moore MA (2000). "A soluble form of human Delta-like-1 inhibits differentiation of hematopoietic progenitor cells". Blood. 95 (5): 1616–25. PMID 10688816.CS1 maint: Multiple names: authors list (link)
• Shimizu K, Chiba S, Hosoya N; et al. (2000). "Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2". Mol. Cell. Biol. 20 (18): 6913–22. PMID 10958687.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shimizu K, Chiba S, Saito T; et al. (2000). "Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors". Biochem. Biophys. Res. Commun. 276 (1): 385–9. doi:10.1006/bbrc.2000.3469. PMID 11006133.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jaleco AC, Neves H, Hooijberg E; et al. (2001). "Differential effects of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation". J. Exp. Med. 194 (7): 991–1002. PMID 11581320.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shimizu K, Chiba S, Saito T; et al. (2002). "Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain". EMBO J. 21 (3): 294–302. doi:10.1093/emboj/21.3.294. PMID 11823422.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Panin VM, Shao L, Lei L; et al. (2002). "Notch ligands are substrates for protein O-fucosyltransferase-1 and Fringe". J. Biol. Chem. 277 (33): 29945–52. doi:10.1074/jbc.M204445200. PMID 12036964.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sakamoto K, Yamaguchi S, Ando R; et al. (2002). "The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway". J. Biol. Chem. 277 (33): 29399–405. doi:10.1074/jbc.M203727200. PMID 12050162.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ohishi K, Varnum-Finney B, Bernstein ID (2002). "Delta-1 enhances marrow and thymus repopulating ability of human CD34(+)CD38(-) cord blood cells". J. Clin. Invest. 110 (8): 1165–74. PMID 12393852.CS1 maint: Multiple names: authors list (link)
• Karlström H, Beatus P, Dannaeus K; et al. (2003). "A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 17119–24. doi:10.1073/pnas.252624099. PMID 12482954.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tohda S, Murata-Ohsawa M, Sakano S, Nara N (2003). "Notch ligands, Delta-1 and Delta-4 suppress the self-renewal capacity and long-term growth of two myeloblastic leukemia cell lines". Int. J. Oncol. 22 (5): 1073–9. PMID 12684674.CS1 maint: Multiple names: authors list (link)
• Six E, Ndiaye D, Laabi Y; et al. (2003). "The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase". Proc. Natl. Acad. Sci. U.S.A. 100 (13): 7638–43. doi:10.1073/pnas.1230693100. PMID 12794186.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• LaVoie MJ, Selkoe DJ (2003). "The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments". J. Biol. Chem. 278 (36): 34427–37. doi:10.1074/jbc.M302659200. PMID 12826675.
• Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)