Defensin, beta 1

Defensin, beta 1
PDB rendering based on 1e4s.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1e4s​, 1iju​, 1ijv​, 1kj5​, 2nlb​, 2nlc​, 2nld​, 2nle​, 2nlf​, 2nlg​, 2nlh​, 2nlp​, 2nlq​, 2nls​
Identifiers
Symbols	DEFB1 ; BD1; DEFB-1; DEFB101; HBD1; MGC51822
External IDs	Template:OMIM5 HomoloGene: 88476
Gene ontology Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Defensin, beta 1, also known as DEFB1, is a human gene.

Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 1, an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. This gene maps in close proximity to defensin family member defensin, alpha 1, and has been implicated in the pathogenesis of cystic fibrosis.

Further reading

• Ganz T, Lehrer RI (1995). "Defensins". Pharmacol. Ther. 66 (2): 191–205. PMID 7667395.
• Bensch KW, Raida M, Mägert HJ; et al. (1995). "hBD-1: a novel beta-defensin from human plasma". FEBS Lett. 368 (2): 331–5. PMID 7628632.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Goldman MJ, Anderson GM, Stolzenberg ED; et al. (1997). "Human beta-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis". Cell. 88 (4): 553–60. PMID 9038346.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• McCray PB, Bentley L (1997). "Human airway epithelia express a beta-defensin". Am. J. Respir. Cell Mol. Biol. 16 (3): 343–9. PMID 9070620.
• Liu L, Zhao C, Heng HH, Ganz T (1997). "The human beta-defensin-1 and alpha-defensins are encoded by adjacent genes: two peptide families with differing disulfide topology share a common ancestry". Genomics. 43 (3): 316–20. doi:10.1006/geno.1997.4801. PMID 9268634.CS1 maint: Multiple names: authors list (link)
• Valore EV, Park CH, Quayle AJ; et al. (1998). "Human beta-defensin-1: an antimicrobial peptide of urogenital tissues". J. Clin. Invest. 101 (8): 1633–42. PMID 9541493.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Schnapp D, Reid CJ, Harris A (1999). "Localization of expression of human beta defensin-1 in the pancreas and kidney". J. Pathol. 186 (1): 99–103. doi:10.1002/(SICI)1096-9896(199809)186:1<99::AID-PATH133>3.0.CO;2-#. PMID 9875146.CS1 maint: Multiple names: authors list (link)
• Hiratsuka T, Nakazato M, Ashitani J, Matsukura S (1999). "[A study of human beta-defensin-1 and human beta-defensin-2 in airway mucosal defense]". Kansenshogaku Zasshi. 73 (2): 156–62. PMID 10213993.CS1 maint: Multiple names: authors list (link)
• Gropp R, Frye M, Wagner TO, Bargon J (1999). "Epithelial defensins impair adenoviral infection: implication for adenovirus-mediated gene therapy". Hum. Gene Ther. 10 (6): 957–64. doi:10.1089/10430349950018355. PMID 10223729.CS1 maint: Multiple names: authors list (link)
• Mathews M, Jia HP, Guthmiller JM; et al. (1999). "Production of beta-defensin antimicrobial peptides by the oral mucosa and salivary glands". Infect. Immun. 67 (6): 2740–5. PMID 10338476.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bøe R, Silvola J, Yang J; et al. (1999). "Human beta-defensin-1 mRNA is transcribed in tympanic membrane and adjacent auditory canal epithelium". Infect. Immun. 67 (9): 4843–6. PMID 10456939.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang D, Chertov O, Bykovskaia SN; et al. (1999). "Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6". Science. 286 (5439): 525–8. PMID 10521347.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tunzi CR, Harper PA, Bar-Oz B; et al. (2000). "Beta-defensin expression in human mammary gland epithelia". Pediatr. Res. 48 (1): 30–5. PMID 10879797.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sahasrabudhe KS, Kimball JR, Morton TH; et al. (2000). "Expression of the antimicrobial peptide, human beta-defensin 1, in duct cells of minor salivary glands and detection in saliva". J. Dent. Res. 79 (9): 1669–74. PMID 11023262.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jia HP, Starner T, Ackermann M; et al. (2001). "Abundant human beta-defensin-1 expression in milk and mammary gland epithelium". J. Pediatr. 138 (1): 109–12. doi:10.1067/mpd.2001.109375. PMID 11148522.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ali RS, Falconer A, Ikram M; et al. (2001). "Expression of the peptide antibiotics human beta defensin-1 and human beta defensin-2 in normal human skin". J. Invest. Dermatol. 117 (1): 106–11. doi:10.1046/j.0022-202x.2001.01401.x. PMID 11442756.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Carothers DG, Graham SM, Jia HP; et al. (2001). "Production of beta-defensin antimicrobial peptides by maxillary sinus mucosa". American journal of rhinology. 15 (3): 175–9. PMID 11453504.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hoover DM, Chertov O, Lubkowski J (2001). "The structure of human beta-defensin-1: new insights into structural properties of beta-defensins". J. Biol. Chem. 276 (42): 39021–6. doi:10.1074/jbc.M103830200. PMID 11486002.CS1 maint: Multiple names: authors list (link)