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'''Dynein light chain 2, cytoplasmic''' is a [[protein]] that in humans is encoded by the ''DYNLL2'' [[gene]].<ref name="pmid16260502">{{cite journal | vauthors = Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB | title = Cytoplasmic dynein nomenclature | journal = J Cell Biol | volume = 171 | issue = 3 | pages = 411–3 |date=November 2005 | pmid = 16260502 | pmc = 2171247 | doi = 10.1083/jcb.200508078 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DYNLL2 dynein, light chain, LC8-type 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=140735| accessdate = }}</ref><br />
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==Interactions==<br />
DYNLL2 has been shown to [[Protein-protein interaction|interact]] with [[DLG4]],<ref name=pmid10844022>{{cite journal |last=Naisbitt |first=S |author2=Valtschanoff J |author3=Allison D W |author4=Sala C |author5=Kim E |author6=Craig A M |author7=Weinberg R J |author8=Sheng M |date=June 2000 |title=Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein |journal=J. Neurosci. |volume=20 |issue=12 |pages=4524–34 |publisher= |location = UNITED STATES| issn = 0270-6474| pmid = 10844022 }}</ref> [[C12orf40]],<ref>{{cite journal|last1=Rolland|first1=Thomas|last2=Taşan|first2=Murat|last3=Charloteaux|first3=Benoit|last4=Pevzner|first4=Samuel J.|last5=Zhong|first5=Quan|last6=Sahni|first6=Nidhi|last7=Yi|first7=Song|last8=Lemmens|first8=Irma|last9=Fontanillo|first9=Celia|last10=Mosca|first10=Roberto|last11=Kamburov|first11=Atanas|last12=Ghiassian|first12=Susan D.|last13=Yang|first13=Xinping|last14=Ghamsari|first14=Lila|last15=Balcha|first15=Dawit|last16=Begg|first16=Bridget E.|last17=Braun|first17=Pascal|last18=Brehme|first18=Marc|last19=Broly|first19=Martin P.|last20=Carvunis|first20=Anne-Ruxandra|last21=Convery-Zupan|first21=Dan|last22=Corominas|first22=Roser|last23=Coulombe-Huntington|first23=Jasmin|last24=Dann|first24=Elizabeth|last25=Dreze|first25=Matija|last26=Dricot|first26=Amélie|last27=Fan|first27=Changyu|last28=Franzosa|first28=Eric|last29=Gebreab|first29=Fana|last30=Gutierrez|first30=Bryan J.|last31=Hardy|first31=Madeleine F.|last32=Jin|first32=Mike|last33=Kang|first33=Shuli|last34=Kiros|first34=Ruth|last35=Lin|first35=Guan Ning|last36=Luck|first36=Katja|last37=MacWilliams|first37=Andrew|last38=Menche|first38=Jörg|last39=Murray|first39=Ryan R.|last40=Palagi|first40=Alexandre|last41=Poulin|first41=Matthew M.|last42=Rambout|first42=Xavier|last43=Rasla|first43=John|last44=Reichert|first44=Patrick|last45=Romero|first45=Viviana|last46=Ruyssinck|first46=Elien|last47=Sahalie|first47=Julie M.|last48=Scholz|first48=Annemarie|last49=Shah|first49=Akash A.|last50=Sharma|first50=Amitabh|last51=Shen|first51=Yun|last52=Spirohn|first52=Kerstin|last53=Tam|first53=Stanley|last54=Tejeda|first54=Alexander O.|last55=Trigg|first55=Shelly A.|last56=Twizere|first56=Jean-Claude|last57=Vega|first57=Kerwin|last58=Walsh|first58=Jennifer|last59=Cusick|first59=Michael E.|last60=Xia|first60=Yu|last61=Barabási|first61=Albert-László|last62=Iakoucheva|first62=Lilia M.|last63=Aloy|first63=Patrick|last64=De Las Rivas|first64=Javier|last65=Tavernier|first65=Jan|last66=Calderwood|first66=Michael A.|last67=Hill|first67=David E.|last68=Hao|first68=Tong|last69=Roth|first69=Frederick P.|last70=Vidal|first70=Marc|title=A Proteome-Scale Map of the Human Interactome Network|journal=Cell|date=November 2014|volume=159|issue=5|pages=1212–1226|doi=10.1016/j.cell.2014.10.050|pmid=25416956|pmc=4266588}}</ref> [[DLGAP1]],<ref name=pmid10844022/> [[MYO5A]]<ref name=pmid10844022/><ref name=pmid11546872>{{cite journal |last=Puthalakath |first=H |author2=Villunger A |author3=O'Reilly L A |author4=Beaumont J G |author5=Coultas L |author6=Cheney R E |author7=Huang D C |author8=Strasser A |date=September 2001 |title=Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis |journal=[[Science (journal)|Science]] |volume=293 |issue=5536 |pages=1829–32 |publisher= |location = United States| issn = 0036-8075| pmid = 11546872 |doi = 10.1126/science.1062257 }}</ref> and [[BMF (gene)|BMF]].<ref name=pmid11546872/><ref name=pmid14561217>{{cite journal |last=Day |first=Catherine L |author2=Puthalakath Hamsa |author3=Skea Gretchen |author4=Strasser Andreas |author5=Barsukov Igor |author6=Lian Lu-Yun |author7=Huang David C S |author8=Hinds Mark G |date=February 2004 |title=Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands |journal=Biochem. J. |volume=377 |issue=Pt 3 |pages=597–605 |publisher= |location = England| issn = | pmid = 14561217 |doi = 10.1042/BJ20031251 |pmc=1223895 }}</ref><br />
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==References==<br />
{{reflist}}<br />
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==Further reading==<br />
{{refbegin | 2}}<br />
{{PBB_Further_reading <br />
| citations = <br />
*{{cite journal | vauthors=Naisbitt S, Valtschanoff J, Allison DW |title=Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein. |journal=J. Neurosci. |volume=20 |issue= 12 |pages= 4524–34 |year= 2000 |pmid= 10844022 |doi= |display-authors=etal}}<br />
*{{cite journal | vauthors=Haraguchi K, Satoh K, Yanai H |title=The hDLG-associated protein DAP interacts with dynein light chain and neuronal nitric oxide synthase. |journal=Genes Cells |volume=5 |issue= 11 |pages= 905–911 |year= 2001 |pmid= 11122378 |doi=10.1046/j.1365-2443.2000.00374.x |display-authors=etal}}<br />
*{{cite journal | vauthors=Puthalakath H, Villunger A, O'Reilly LA |title=Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis. |journal=Science |volume=293 |issue= 5536 |pages= 1829–32 |year= 2001 |pmid= 11546872 |doi= 10.1126/science.1062257 |display-authors=etal}}<br />
*{{cite journal | vauthors=Fuhrmann JC, Kins S, Rostaing P |title=Gephyrin interacts with Dynein light chains 1 and 2, components of motor protein complexes. |journal=J. Neurosci. |volume=22 |issue= 13 |pages= 5393–402 |year= 2002 |pmid= 12097491 |display-authors=etal}}<br />
*{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}<br />
*{{cite journal | vauthors=Day CL, Puthalakath H, Skea G |title=Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands. |journal=Biochem. J. |volume=377 |issue= Pt 3 |pages= 597–605 |year= 2004 |pmid= 14561217 |doi= 10.1042/BJ20031251 | pmc=1223895 |display-authors=etal}}<br />
*{{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}<br />
*{{cite journal | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}<br />
}}<br />
{{refend}}<br />
{{PDB Gallery|geneid=140735}}<br />
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DYNLL2 associations with risk for generalized anxiety disorder: Donner et al. An Association Analysis of Murine Anxiety Genes in Humans Implicates Novel Candidate Genes for Anxiety Disorders. Biological Psychiatry, 2008; 64 (8): 672 {{doi|10.1016/j.biopsych.2008.06.002}}<br />
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