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{{Infobox_gene}}
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'''Dihydropyrimidinase-related protein 2''' is an [[enzyme]] that in humans is encoded by the ''DPYSL2'' [[gene]].<ref name="pmid8973361">{{cite journal | vauthors = Hamajima N, Matsuda K, Sakata S, Tamaki N, Sasaki M, Nonaka M | title = A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution | journal = Gene | volume = 180 | issue = 1–2 | pages = 157–63 |date=Jan 1997 | pmid = 8973361 | pmc =  | doi =10.1016/S0378-1119(96)00445-3 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DPYSL2 dihydropyrimidinase-like 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1808| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_DPYSL2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2gse.
| PDB = {{PDB2|2gse}}
| Name = Dihydropyrimidinase-like 2
| HGNCid = 3014
| Symbol = DPYSL2
| AltSymbols =; CRMP2; DHPRP2; DRP-2; DRP2
| OMIM = 602463
| ECnumber = 
| Homologene = 74392
| MGIid = 1349763
| GeneAtlas_image1 = PBB_GE_DPYSL2_200762_at_tn.png
| Function = {{GNF_GO|id=GO:0004157 |text = dihydropyrimidinase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0030424 |text = axon}} {{GNF_GO|id=GO:0030425 |text = dendrite}} {{GNF_GO|id=GO:0043025 |text = cell soma}}
| Process = {{GNF_GO|id=GO:0006139 |text = nucleobase, nucleoside, nucleotide and nucleic acid metabolic process}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007399 |text = nervous system development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1808
    | Hs_Ensembl = ENSG00000092964
    | Hs_RefseqProtein = NP_001377
    | Hs_RefseqmRNA = NM_001386
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 26491327
    | Hs_GenLoc_end = 26571611
    | Hs_Uniprot = Q16555
    | Mm_EntrezGene = 12934
    | Mm_Ensembl = ENSMUSG00000022048
    | Mm_RefseqmRNA = NM_009955
    | Mm_RefseqProtein = NP_034085
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 65756972
    | Mm_GenLoc_end = 65822710
    | Mm_Uniprot = O08553
  }}
}}
'''Dihydropyrimidinase-like 2''', also known as '''DPYSL2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DPYSL2 dihydropyrimidinase-like 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1808| accessdate = }}</ref>


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==Interactions==
DPYSL2 has been shown to [[Protein-protein interaction|interact]] with [[CRMP1]],<ref name=pmid12482610>{{cite journal |last=Leung |first=Thomas |author2=Ng Yvonne |author3=Cheong Albert |author4=Ng Chong Han |author5=Tan Ivan |author6=Hall Christine |author7=Lim Louis  |date=Dec 2002 |title=p80 ROKalpha binding protein is a novel splice variant of CRMP-1 which associates with CRMP-2 and modulates RhoA-induced neuronal morphology |journal=FEBS Lett. |volume=532 |issue=3 |pages=445–9 |publisher= |location = Netherlands| issn = 0014-5793| pmid = 12482610 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = | doi = 10.1016/S0014-5793(02)03736-5 }}</ref> [[Adaptor-related protein complex 2, alpha 1]]<ref name=pmid12942088>{{cite journal |last=Nishimura |first=Takashi |author2=Fukata Yuko |author3=Kato Katsuhiro |author4=Yamaguchi Tomoya |author5=Matsuura Yoshiharu |author6=Kamiguchi Hiroyuki |author7=Kaibuchi Kozo  |date=Sep 2003 |title=CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth |journal=Nat. Cell Biol. |volume=5 |issue=9 |pages=819–26 |publisher= |location = England| issn = 1465-7392| pmid = 12942088 |doi = 10.1038/ncb1039 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[NUMB (gene)|NUMB]].<ref name=pmid12942088/>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Dawson SJ, White LA |title=Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin. |journal=J. Infect. |volume=24 |issue= 3 |pages= 317-20 |year= 1992 |pmid= 1602151 |doi=  }}
*{{cite journal  | vauthors=Dawson SJ, White LA |title=Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin |journal=J. Infect. |volume=24 |issue= 3 |pages= 317–20 |year= 1992 |pmid= 1602151 |doi=10.1016/S0163-4453(05)80037-4 }}
*{{cite journal  | author=Goshima Y, Nakamura F, Strittmatter P, Strittmatter SM |title=Collapsin-induced growth cone collapse mediated by an intracellular protein related to UNC-33. |journal=Nature |volume=376 |issue= 6540 |pages= 509-14 |year= 1995 |pmid= 7637782 |doi= 10.1038/376509a0 }}
*{{cite journal  | vauthors=Goshima Y, Nakamura F, Strittmatter P, Strittmatter SM |title=Collapsin-induced growth cone collapse mediated by an intracellular protein related to UNC-33 |journal=Nature |volume=376 |issue= 6540 |pages= 509–14 |year= 1995 |pmid= 7637782 |doi= 10.1038/376509a0 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
*{{cite journal  | author=Roberts RG, Freeman TC, Kendall E, ''et al.'' |title=Characterization of DRP2, a novel human dystrophin homologue. |journal=Nat. Genet. |volume=13 |issue= 2 |pages= 223-6 |year= 1996 |pmid= 8640231 |doi= 10.1038/ng0696-223 }}
*{{cite journal  | vauthors=Roberts RG, Freeman TC, Kendall E |title=Characterization of DRP2, a novel human dystrophin homologue |journal=Nat. Genet. |volume=13 |issue= 2 |pages= 223–6 |year= 1996 |pmid= 8640231 |doi= 10.1038/ng0696-223 |display-authors=etal}}
*{{cite journal  | author=Hamajima N, Matsuda K, Sakata S, ''et al.'' |title=A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution. |journal=Gene |volume=180 |issue= 1-2 |pages= 157-63 |year= 1997 |pmid= 8973361 |doi= }}
*{{cite journal  | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  |display-authors=etal}}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal  | vauthors=Kitamura K, Takayama M, Hamajima N |title=Characterization of the human dihydropyrimidinase-related protein 2 (DRP-2) gene |journal=DNA Res. |volume=6 |issue= 5 |pages= 291–7 |year= 2000 |pmid= 10574455 |doi=10.1093/dnares/6.5.291  |display-authors=etal}}
*{{cite journal  | author=Kitamura K, Takayama M, Hamajima N, ''et al.'' |title=Characterization of the human dihydropyrimidinase-related protein 2 (DRP-2) gene. |journal=DNA Res. |volume=6 |issue= 5 |pages= 291-7 |year= 2000 |pmid= 10574455 |doi=  }}
*{{cite journal  | vauthors=Gu Y, Hamajima N, Ihara Y |title=Neurofibrillary tangle-associated collapsin response mediator protein-2 (CRMP-2) is highly phosphorylated on Thr-509, Ser-518, and Ser-522 |journal=Biochemistry |volume=39 |issue= 15 |pages= 4267–75 |year= 2000 |pmid= 10757975 |doi=10.1021/bi992323h }}
*{{cite journal  | author=Gu Y, Hamajima N, Ihara Y |title=Neurofibrillary tangle-associated collapsin response mediator protein-2 (CRMP-2) is highly phosphorylated on Thr-509, Ser-518, and Ser-522. |journal=Biochemistry |volume=39 |issue= 15 |pages= 4267-75 |year= 2000 |pmid= 10757975 |doi= }}
*{{cite journal  | vauthors=Gu Y, Ihara Y |title=Evidence that collapsin response mediator protein-2 is involved in the dynamics of microtubules |journal=J. Biol. Chem. |volume=275 |issue= 24 |pages= 17917–20 |year= 2000 |pmid= 10770920 |doi= 10.1074/jbc.C000179200 }}
*{{cite journal  | author=Gu Y, Ihara Y |title=Evidence that collapsin response mediator protein-2 is involved in the dynamics of microtubules. |journal=J. Biol. Chem. |volume=275 |issue= 24 |pages= 17917-20 |year= 2000 |pmid= 10770920 |doi= 10.1074/jbc.C000179200 }}
*{{cite journal  | vauthors=Arimura N, Inagaki N, Chihara K |title=Phosphorylation of collapsin response mediator protein-2 by Rho-kinase. Evidence for two separate signaling pathways for growth cone collapse |journal=J. Biol. Chem. |volume=275 |issue= 31 |pages= 23973–80 |year= 2000 |pmid= 10818093 |doi= 10.1074/jbc.M001032200 |display-authors=etal}}
*{{cite journal  | author=Arimura N, Inagaki N, Chihara K, ''et al.'' |title=Phosphorylation of collapsin response mediator protein-2 by Rho-kinase. Evidence for two separate signaling pathways for growth cone collapse. |journal=J. Biol. Chem. |volume=275 |issue= 31 |pages= 23973-80 |year= 2000 |pmid= 10818093 |doi= 10.1074/jbc.M001032200 }}
*{{cite journal  | vauthors=Fukada M, Watakabe I, Yuasa-Kawada J |title=Molecular characterization of CRMP5, a novel member of the collapsin response mediator protein family |journal=J. Biol. Chem. |volume=275 |issue= 48 |pages= 37957–65 |year= 2001 |pmid= 10956643 |doi= 10.1074/jbc.M003277200 |display-authors=etal}}
*{{cite journal  | author=Fukada M, Watakabe I, Yuasa-Kawada J, ''et al.'' |title=Molecular characterization of CRMP5, a novel member of the collapsin response mediator protein family. |journal=J. Biol. Chem. |volume=275 |issue= 48 |pages= 37957-65 |year= 2001 |pmid= 10956643 |doi= 10.1074/jbc.M003277200 }}
*{{cite journal  | vauthors=Santolini E, Puri C, Salcini AE |title=Numb Is an Endocytic Protein |journal=J. Cell Biol. |volume=151 |issue= 6 |pages= 1345–52 |year= 2001 |pmid= 11121447 |doi=10.1083/jcb.151.6.1345  | pmc=2190585  |display-authors=etal}}
*{{cite journal  | author=Santolini E, Puri C, Salcini AE, ''et al.'' |title=Numb is an endocytic protein. |journal=J. Cell Biol. |volume=151 |issue= 6 |pages= 1345-52 |year= 2001 |pmid= 11121447 |doi= }}
*{{cite journal  | vauthors=Lee S, Kim JH, Lee CS |title=Collapsin response mediator protein-2 inhibits neuronal phospholipase D(2) activity by direct interaction |journal=J. Biol. Chem. |volume=277 |issue= 8 |pages= 6542–9 |year= 2002 |pmid= 11741937 |doi= 10.1074/jbc.M108047200 |display-authors=etal}}
*{{cite journal  | author=Lee S, Kim JH, Lee CS, ''et al.'' |title=Collapsin response mediator protein-2 inhibits neuronal phospholipase D(2) activity by direct interaction. |journal=J. Biol. Chem. |volume=277 |issue= 8 |pages= 6542-9 |year= 2002 |pmid= 11741937 |doi= 10.1074/jbc.M108047200 }}
*{{cite journal  | vauthors=Weitzdoerfer R, Fountoulakis M, Lubec G |title=Aberrant expression of dihydropyrimidinase related proteins-2,-3 and -4 in fetal Down syndrome brain |journal=J. Neural Transm. Suppl. |volume= |issue= 61 |pages= 95–107 |year= 2002 |pmid= 11771764 |doi= 10.1007/978-3-7091-6262-0_8}}
*{{cite journal  | author=Weitzdoerfer R, Fountoulakis M, Lubec G |title=Aberrant expression of dihydropyrimidinase related proteins-2,-3 and -4 in fetal Down syndrome brain. |journal=J. Neural Transm. Suppl. |volume= |issue= 61 |pages= 95-107 |year= 2002 |pmid= 11771764 |doi= }}
*{{cite journal  | vauthors=Fukata Y, Itoh TJ, Kimura T |title=CRMP-2 binds to tubulin heterodimers to promote microtubule assembly |journal=Nat. Cell Biol. |volume=4 |issue= 8 |pages= 583–91 |year= 2002 |pmid= 12134159 |doi= 10.1038/ncb825 |display-authors=etal}}
*{{cite journal  | author=Fukata Y, Itoh TJ, Kimura T, ''et al.'' |title=CRMP-2 binds to tubulin heterodimers to promote microtubule assembly. |journal=Nat. Cell Biol. |volume=4 |issue= 8 |pages= 583-91 |year= 2002 |pmid= 12134159 |doi= 10.1038/ncb825 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Leung T, Ng Y, Cheong A |title=p80 ROKalpha binding protein is a novel splice variant of CRMP-1 which associates with CRMP-2 and modulates RhoA-induced neuronal morphology |journal=FEBS Lett. |volume=532 |issue= 3 |pages= 445–9 |year= 2003 |pmid= 12482610 |doi=10.1016/S0014-5793(02)03736-5  |display-authors=etal}}
*{{cite journal  | author=Leung T, Ng Y, Cheong A, ''et al.'' |title=p80 ROKalpha binding protein is a novel splice variant of CRMP-1 which associates with CRMP-2 and modulates RhoA-induced neuronal morphology. |journal=FEBS Lett. |volume=532 |issue= 3 |pages= 445-9 |year= 2003 |pmid= 12482610 |doi= }}
*{{cite journal  | vauthors=Nishimura T, Fukata Y, Kato K |title=CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth |journal=Nat. Cell Biol. |volume=5 |issue= 9 |pages= 819–26 |year= 2003 |pmid= 12942088 |doi= 10.1038/ncb1039 |display-authors=etal}}
*{{cite journal  | author=Nishimura T, Fukata Y, Kato K, ''et al.'' |title=CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth. |journal=Nat. Cell Biol. |volume=5 |issue= 9 |pages= 819-26 |year= 2003 |pmid= 12942088 |doi= 10.1038/ncb1039 }}
*{{cite journal  | vauthors=Nakata K, Ujike H, Tanaka Y |title=No association between the dihydropyrimidinase-related protein 2 (DRP-2) gene and bipolar disorder in humans |journal=Neurosci. Lett. |volume=349 |issue= 3 |pages= 171–4 |year= 2003 |pmid= 12951196 |doi=10.1016/S0304-3940(03)00824-3  |display-authors=etal}}
*{{cite journal  | author=Nakata K, Ujike H, Tanaka Y, ''et al.'' |title=No association between the dihydropyrimidinase-related protein 2 (DRP-2) gene and bipolar disorder in humans. |journal=Neurosci. Lett. |volume=349 |issue= 3 |pages= 171-4 |year= 2003 |pmid= 12951196 |doi= }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=1808}}
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Revision as of 18:42, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Dihydropyrimidinase-related protein 2 is an enzyme that in humans is encoded by the DPYSL2 gene.[1][2]


Interactions

DPYSL2 has been shown to interact with CRMP1,[3] Adaptor-related protein complex 2, alpha 1[4] and NUMB.[4]

References

  1. ↑ Hamajima N, Matsuda K, Sakata S, Tamaki N, Sasaki M, Nonaka M (Jan 1997). "A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution". Gene. 180 (1–2): 157–63. doi:10.1016/S0378-1119(96)00445-3. PMID 8973361.
  2. ↑ "Entrez Gene: DPYSL2 dihydropyrimidinase-like 2".
  3. ↑ Leung, Thomas; Ng Yvonne; Cheong Albert; Ng Chong Han; Tan Ivan; Hall Christine; Lim Louis (Dec 2002). "p80 ROKalpha binding protein is a novel splice variant of CRMP-1 which associates with CRMP-2 and modulates RhoA-induced neuronal morphology". FEBS Lett. Netherlands. 532 (3): 445–9. doi:10.1016/S0014-5793(02)03736-5. ISSN 0014-5793. PMID 12482610.
  4. ↑ 4.0 4.1 Nishimura, Takashi; Fukata Yuko; Kato Katsuhiro; Yamaguchi Tomoya; Matsuura Yoshiharu; Kamiguchi Hiroyuki; Kaibuchi Kozo (Sep 2003). "CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth". Nat. Cell Biol. England. 5 (9): 819–26. doi:10.1038/ncb1039. ISSN 1465-7392. PMID 12942088.

Further reading



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