DLX2: Difference between revisions
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*{{cite journal | vauthors=Qiu M, Bulfone A, Martinez S |title=Null mutation of Dlx-2 results in abnormal morphogenesis of proximal first and second branchial arch derivatives and abnormal differentiation in the forebrain |journal=Genes Dev. |volume=9 |issue= 20 |pages= 2523–38 |year= 1995 |pmid= 7590232 |doi=10.1101/gad.9.20.2523 |display-authors=etal}} | *{{cite journal | vauthors=Qiu M, Bulfone A, Martinez S |title=Null mutation of Dlx-2 results in abnormal morphogenesis of proximal first and second branchial arch derivatives and abnormal differentiation in the forebrain |journal=Genes Dev. |volume=9 |issue= 20 |pages= 2523–38 |year= 1995 |pmid= 7590232 |doi=10.1101/gad.9.20.2523 |display-authors=etal}} | ||
*{{cite journal | vauthors=Selski DJ, Thomas NE, Coleman PD, Rogers KE |title=The human brain homeogene, DLX-2: cDNA sequence and alignment with the murine homologue |journal=Gene |volume=132 |issue= 2 |pages= 301–3 |year= 1993 |pmid= 7901126 |doi=10.1016/0378-1119(93)90212-L }} | *{{cite journal | vauthors=Selski DJ, Thomas NE, Coleman PD, Rogers KE |title=The human brain homeogene, DLX-2: cDNA sequence and alignment with the murine homologue |journal=Gene |volume=132 |issue= 2 |pages= 301–3 |year= 1993 |pmid= 7901126 |doi=10.1016/0378-1119(93)90212-L }} | ||
*{{cite journal | vauthors=Simeone A, Acampora D, Pannese M |title=Cloning and characterization of two members of the vertebrate Dlx gene family |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 6 |pages= 2250–4 |year= 1994 |pmid= 7907794 |doi=10.1073/pnas.91.6.2250 | pmc=43348 |display-authors=etal}} | *{{cite journal | vauthors=Simeone A, Acampora D, Pannese M |title=Cloning and characterization of two members of the vertebrate Dlx gene family |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 6 |pages= 2250–4 |year= 1994 |pmid= 7907794 |doi=10.1073/pnas.91.6.2250 | pmc=43348 |display-authors=etal|bibcode=1994PNAS...91.2250S}} | ||
*{{cite journal | vauthors=McGuinness T, Porteus MH, Smiga S |title=Sequence, organization, and transcription of the Dlx-1 and Dlx-2 locus |journal=Genomics |volume=35 |issue= 3 |pages= 473–85 |year= 1996 |pmid= 8812481 |doi= 10.1006/geno.1996.0387 |display-authors=etal}} | *{{cite journal | vauthors=McGuinness T, Porteus MH, Smiga S |title=Sequence, organization, and transcription of the Dlx-1 and Dlx-2 locus |journal=Genomics |volume=35 |issue= 3 |pages= 473–85 |year= 1996 |pmid= 8812481 |doi= 10.1006/geno.1996.0387 |display-authors=etal}} | ||
*{{cite journal | vauthors=Zhang H, Hu G, Wang H |title=Heterodimerization of Msx and Dlx homeoproteins results in functional antagonism |journal=Mol. Cell. Biol. |volume=17 |issue= 5 |pages= 2920–32 |year= 1997 |pmid= 9111364 |doi= 10.1128/mcb.17.5.2920| pmc=232144 |display-authors=etal}} | *{{cite journal | vauthors=Zhang H, Hu G, Wang H |title=Heterodimerization of Msx and Dlx homeoproteins results in functional antagonism |journal=Mol. Cell. Biol. |volume=17 |issue= 5 |pages= 2920–32 |year= 1997 |pmid= 9111364 |doi= 10.1128/mcb.17.5.2920| pmc=232144 |display-authors=etal}} | ||
*{{cite journal | vauthors=Yu G, Zerucha T, Ekker M, Rubenstein JL |title=Evidence that GRIP, a PDZ-domain protein which is expressed in the embryonic forebrain, co-activates transcription with DLX homeodomain proteins |journal=Brain Res. Dev. Brain Res. |volume=130 |issue= 2 |pages= 217–30 |year= 2002 |pmid= 11675124 |doi=10.1016/S0165-3806(01)00239-5 }} | *{{cite journal | vauthors=Yu G, Zerucha T, Ekker M, Rubenstein JL |title=Evidence that GRIP, a PDZ-domain protein which is expressed in the embryonic forebrain, co-activates transcription with DLX homeodomain proteins |journal=Brain Res. Dev. Brain Res. |volume=130 |issue= 2 |pages= 217–30 |year= 2002 |pmid= 11675124 |doi=10.1016/S0165-3806(01)00239-5 }} | ||
*{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}} | *{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M }} | ||
*{{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}} | *{{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}} | ||
*{{cite journal | vauthors=Espinoza HM, Ganga M, Vadlamudi U |title=Protein kinase C phosphorylation modulates N- and C-terminal regulatory activities of the PITX2 homeodomain protein |journal=Biochemistry |volume=44 |issue= 10 |pages= 3942–54 |year= 2005 |pmid= 15751970 |doi= 10.1021/bi048362x |display-authors=etal}} | *{{cite journal | vauthors=Espinoza HM, Ganga M, Vadlamudi U |title=Protein kinase C phosphorylation modulates N- and C-terminal regulatory activities of the PITX2 homeodomain protein |journal=Biochemistry |volume=44 |issue= 10 |pages= 3942–54 |year= 2005 |pmid= 15751970 |doi= 10.1021/bi048362x |display-authors=etal}} | ||
Latest revision as of 07:20, 23 June 2018
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Homeobox protein DLX-2 is a protein that in humans is encoded by the DLX2 gene.[1][2]
Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 2.[2]
Interactions
DLX2 has been shown to interact with DLX5,[3] MSX1[3] and Msh homeobox 2.[3]
References
- ↑ Ozcelik T, Porteus MH, Rubenstein JL, Francke U (Sep 1992). "DLX2 (TES1), a homeobox gene of the Distal-less family, assigned to conserved regions on human and mouse chromosomes 2". Genomics. 13 (4): 1157–61. doi:10.1016/0888-7543(92)90031-M. PMID 1354641.
- ↑ 2.0 2.1 "Entrez Gene: DLX2 distal-less homeobox 2".
- ↑ 3.0 3.1 3.2 Zhang, H; Hu G; Wang H; Sciavolino P; Iler N; Shen M M; Abate-Shen C (May 1997). "Heterodimerization of Msx and Dlx homeoproteins results in functional antagonism". Mol. Cell. Biol. UNITED STATES. 17 (5): 2920–32. doi:10.1128/mcb.17.5.2920. ISSN 0270-7306. PMC 232144. PMID 9111364.
Further reading
- Harris SE, Guo D, Harris MA, et al. (2003). "Transcriptional regulation of BMP-2 activated genes in osteoblasts using gene expression microarray analysis: role of Dlx2 and Dlx5 transcription factors". Front. Biosci. 8: s1249–65. doi:10.2741/1170. PMID 12957859.
- Qiu M, Bulfone A, Martinez S, et al. (1995). "Null mutation of Dlx-2 results in abnormal morphogenesis of proximal first and second branchial arch derivatives and abnormal differentiation in the forebrain". Genes Dev. 9 (20): 2523–38. doi:10.1101/gad.9.20.2523. PMID 7590232.
- Selski DJ, Thomas NE, Coleman PD, Rogers KE (1993). "The human brain homeogene, DLX-2: cDNA sequence and alignment with the murine homologue". Gene. 132 (2): 301–3. doi:10.1016/0378-1119(93)90212-L. PMID 7901126.
- Simeone A, Acampora D, Pannese M, et al. (1994). "Cloning and characterization of two members of the vertebrate Dlx gene family". Proc. Natl. Acad. Sci. U.S.A. 91 (6): 2250–4. Bibcode:1994PNAS...91.2250S. doi:10.1073/pnas.91.6.2250. PMC 43348. PMID 7907794.
- McGuinness T, Porteus MH, Smiga S, et al. (1996). "Sequence, organization, and transcription of the Dlx-1 and Dlx-2 locus". Genomics. 35 (3): 473–85. doi:10.1006/geno.1996.0387. PMID 8812481.
- Zhang H, Hu G, Wang H, et al. (1997). "Heterodimerization of Msx and Dlx homeoproteins results in functional antagonism". Mol. Cell. Biol. 17 (5): 2920–32. doi:10.1128/mcb.17.5.2920. PMC 232144. PMID 9111364.
- Yu G, Zerucha T, Ekker M, Rubenstein JL (2002). "Evidence that GRIP, a PDZ-domain protein which is expressed in the embryonic forebrain, co-activates transcription with DLX homeodomain proteins". Brain Res. Dev. Brain Res. 130 (2): 217–30. doi:10.1016/S0165-3806(01)00239-5. PMID 11675124.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Espinoza HM, Ganga M, Vadlamudi U, et al. (2005). "Protein kinase C phosphorylation modulates N- and C-terminal regulatory activities of the PITX2 homeodomain protein". Biochemistry. 44 (10): 3942–54. doi:10.1021/bi048362x. PMID 15751970.
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