DKK3: Difference between revisions

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{{PBB_Summary
{{PBB_Summary
| section_title =  
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| summary_text = This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two [[cysteine]] rich regions and is involved in [[embryonic]] development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein.<ref name="entrez">{{cite web | title = Entrez Gene: DKK3 dickkopf homolog 3 (Xenopus laevis)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27122| accessdate = }}</ref>
| summary_text = This gene encodes a protein that is a member of the [[dickkopf]] family. The secreted protein contains two [[cysteine]] rich regions and is involved in [[embryonic]] development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein.<ref name="entrez">{{cite web | title = Entrez Gene: DKK3 dickkopf homolog 3 (Xenopus laevis)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27122| accessdate = }}</ref>
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*{{cite journal  | vauthors=Kuphal S, Lodermeyer S, Bataille F |title=Expression of Dickkopf genes is strongly reduced in malignant melanoma |journal=Oncogene |volume=25 |issue= 36 |pages= 5027–36 |year= 2006 |pmid= 16568085 |doi= 10.1038/sj.onc.1209508 |display-authors=etal}}
*{{cite journal  | vauthors=Kuphal S, Lodermeyer S, Bataille F |title=Expression of Dickkopf genes is strongly reduced in malignant melanoma |journal=Oncogene |volume=25 |issue= 36 |pages= 5027–36 |year= 2006 |pmid= 16568085 |doi= 10.1038/sj.onc.1209508 |display-authors=etal}}
*{{cite journal  | vauthors=Urakami S, Shiina H, Enokida H |title=Combination analysis of hypermethylated Wnt-antagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection |journal=Clin. Cancer Res. |volume=12 |issue= 7 Pt 1 |pages= 2109–16 |year= 2006 |pmid= 16609023 |doi= 10.1158/1078-0432.CCR-05-2468 |display-authors=etal}}
*{{cite journal  | vauthors=Urakami S, Shiina H, Enokida H |title=Combination analysis of hypermethylated Wnt-antagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection |journal=Clin. Cancer Res. |volume=12 |issue= 7 Pt 1 |pages= 2109–16 |year= 2006 |pmid= 16609023 |doi= 10.1158/1078-0432.CCR-05-2468 |display-authors=etal}}
*{{cite journal  | vauthors=Veeck J, Bektas N, Hartmann A |title=Wnt signalling in human breast cancer: expression of the putative Wnt inhibitor Dickkopf-3 (DKK3) is frequently suppressed by promoter hypermethylation in mammary tumours |journal=Breast. Cancer Res. |volume=10 |issue= R82  |year= 2008 |pmid= 18826564 |doi= 10.1186/bcr2151  | pages=R82  | pmc=2614517 |display-authors=etal}}
*{{cite journal  | vauthors=Veeck J, Bektas N, Hartmann A |title=Wnt signalling in human breast cancer: expression of the putative Wnt inhibitor Dickkopf-3 (DKK3) is frequently suppressed by promoter hypermethylation in mammary tumours |journal=Breast Cancer Res. |volume=10 |issue= R82  |year= 2008 |pmid= 18826564 |doi= 10.1186/bcr2151  | pages=R82  | pmc=2614517 |display-authors=etal}}
*{{cite journal  | vauthors=Veeck J, Wild PJ, Fuchs T |title=Prognostic relevance of Wnt-inhibitory factor-1 (WIF1) and Dickkopf-3 (DKK3) promoter methylation in human breast cancer |journal=BMC Cancer |volume=9  |year= 2009 |pmid= 19570204 |doi= 10.1186/1471-2407-9-217  | pages=217  | pmc=2717119 |display-authors=etal}}
*{{cite journal  | vauthors=Veeck J, Wild PJ, Fuchs T |title=Prognostic relevance of Wnt-inhibitory factor-1 (WIF1) and Dickkopf-3 (DKK3) promoter methylation in human breast cancer |journal=BMC Cancer |volume=9  |year= 2009 |pmid= 19570204 |doi= 10.1186/1471-2407-9-217  | pages=217  | pmc=2717119 |display-authors=etal}}
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Latest revision as of 02:13, 15 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Dickkopf-related protein 3 is a protein that in humans is encoded by the DKK3 gene.[1][2]

This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein.[2]

References

  1. Krupnik VE, Sharp JD, Jiang C, Robison K, Chickering TW, Amaravadi L, Brown DE, Guyot D, Mays G, Leiby K, Chang B, Duong T, Goodearl AD, Gearing DP, Sokol SY, McCarthy SA (Dec 1999). "Functional and structural diversity of the human Dickkopf gene family". Gene. 238 (2): 301–13. doi:10.1016/S0378-1119(99)00365-0. PMID 10570958.
  2. 2.0 2.1 "Entrez Gene: DKK3 dickkopf homolog 3 (Xenopus laevis)".

Further reading