DAZ associated protein 1: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''DAZ-associated protein 1''' is a [[protein]] that in humans is encoded by the ''DAZAP1'' [[gene]].<ref name="pmid10857750">{{cite journal | vauthors = Tsui S, Dai T, Roettger S, Schempp W, Salido EC, Yen PH | title = Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1 | journal = Genomics | volume = 65 | issue = 3 | pages = 266–73 | date = August 2000 | pmid = 10857750 | pmc =  | doi = 10.1006/geno.2000.6169 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DAZAP1 DAZ associated protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26528| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_DAZAP1_image.jpg
| image_source = [[Protein Data Bank|PDB]] rendering based on 2dgs.
| PDB = {{PDB2|2dgs}}, {{PDB2|2dh8}}
| Name = DAZ associated protein 1
| HGNCid = 2683
| Symbol = DAZAP1
| AltSymbols =; MGC19907
| OMIM = 607430
| ECnumber = 
| Homologene = 23129
| MGIid = 1917498
| GeneAtlas_image1 = PBB_GE_DAZAP1_218443_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007283 |text = spermatogenesis}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 26528
    | Hs_Ensembl = ENSG00000071626
    | Hs_RefseqProtein = NP_061832
    | Hs_RefseqmRNA = NM_018959
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 1358584
    | Hs_GenLoc_end = 1386683
    | Hs_Uniprot = Q96EP5
    | Mm_EntrezGene = 70248
    | Mm_Ensembl = ENSMUSG00000069565
    | Mm_RefseqmRNA = XM_986609
    | Mm_RefseqProtein = XP_991703
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 79668203
    | Mm_GenLoc_end = 79691535
    | Mm_Uniprot = Q0VDX2
  }}
}}
'''DAZ associated protein 1''', also known as '''DAZAP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DAZAP1 DAZ associated protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26528| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
In mammals, the [[Y chromosome]] directs the development of the [[testes]] and plays an important role in [[spermatogenesis]]. A high percentage of infertile men have deletions that map to regions of the Y chromosome. The [[DAZ1]] (Deleted in [[Azoospermia]]) gene cluster maps to the AZFc region of the Y chromosome and is deleted in many azoospermic and severely oligospermic men. It is thought that the DAZ gene cluster arose from the transposition, amplification, and pruning of the ancestral autosomal gene [[DAZL]] also involved in germ cell development and gametogenesis. This gene encodes an RNA-binding protein with two RNP motifs that was originally identified by its interaction with the infertility factors DAZ and DAZL. Two isoforms are encoded by transcript variants of this gene.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infertile men have deletions that map to regions of the Y chromosome. The DAZ (deleted in azoospermia) gene cluster maps to the AZFc region of the Y chromosome and is deleted in many azoospermic and severely oligospermic men. It is thought that the DAZ gene cluster arose from the transposition, amplification, and pruning of the ancestral autosomal gene DAZL also involved in germ cell development and gametogenesis. This gene encodes an RNA-binding protein with two RNP motifs that was originally identified by its interaction with the infertility factors DAZ and DAZL. Two isoforms are encoded by transcript variants of this gene.<ref name="entrez">{{cite web | title = Entrez Gene: DAZAP1 DAZ associated protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26528| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
DAZ associated protein 1 has been shown to [[Protein-protein interaction|interact]] with [[DAZ1]].<ref name=autogenerated1>{{cite journal | vauthors = Tsui S, Dai T, Roettger S, Schempp W, Salido EC, Yen PH | title = Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1 | journal = Genomics | volume = 65 | issue = 3 | pages = 266–73 | date = May 2000 | pmid = 10857750 | doi = 10.1006/geno.2000.6169 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Dai T, Vera Y, Salido EC, Yen PH | title = Characterization of the mouse Dazap1 gene encoding an RNA-binding protein that interacts with infertility factors DAZ and DAZL. | journal = BMC Genomics | volume = 2 | pages = 6 | year = 2003 | pmid = 11604102 | pmc = 57980 | doi = 10.1186/1471-2164-2-6 }}
| citations =
* {{cite journal | vauthors = Vera Y, Dai T, Hikim AP, Lue Y, Salido EC, Swerdloff RS, Yen PH | title = Deleted in azoospermia associated protein 1 shuttles between nucleus and cytoplasm during normal germ cell maturation | journal = J. Androl. | volume = 23 | issue = 5 | pages = 622–8 | year = 2003 | pmid = 12185095 | doi =  }}
*{{cite journal  | author=Tsui S, Dai T, Roettger S, ''et al.'' |title=Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1. |journal=Genomics |volume=65 |issue= 3 |pages= 266-73 |year= 2000 |pmid= 10857750 |doi= 10.1006/geno.2000.6169 }}
* {{cite journal | vauthors = Prima V, Gore L, Caires A, Boomer T, Yoshinari M, Imaizumi M, Varella-Garcia M, Hunger SP | title = Cloning and functional characterization of MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins created by a variant t(1;19)(q23;p13.3) in acute lymphoblastic leukemia | journal = Leukemia | volume = 19 | issue = 5 | pages = 806–13 | year = 2005 | pmid = 15744350 | doi = 10.1038/sj.leu.2403684 }}
*{{cite journal | author=Dai T, Vera Y, Salido EC, Yen PH |title=Characterization of the mouse Dazap1 gene encoding an RNA-binding protein that interacts with infertility factors DAZ and DAZL. |journal=BMC Genomics |volume=2 |issue= 1 |pages= 6 |year= 2003 |pmid= 11604102 |doi= }}
* {{cite journal | vauthors = Pan HA, Lin YS, Lee KH, Huang JR, Lin YH, Kuo PL | title = Expression patterns of the DAZ-associated protein DAZAP1 in rat and human ovaries | journal = Fertil. Steril. | volume = 84 Suppl 2 | issue =  | pages = 1089–94 | year = 2006 | pmid = 16209998 | doi = 10.1016/j.fertnstert.2005.03.075 }}
*{{cite journal | author=Vera Y, Dai T, Hikim AP, ''et al.'' |title=Deleted in azoospermia associated protein 1 shuttles between nucleus and cytoplasm during normal germ cell maturation. |journal=J. Androl. |volume=23 |issue= 5 |pages= 622-8 |year= 2003 |pmid= 12185095 |doi=  }}
* {{cite journal | vauthors = Morton S, Yang HT, Moleleki N, Campbell DG, Cohen P, Rousseau S | title = Phosphorylation of the ARE-binding protein DAZAP1 by ERK2 induces its dissociation from DAZ | journal = Biochem. J. | volume = 399 | issue = 2 | pages = 265–73 | year = 2006 | pmid = 16848763 | pmc = 1609909 | doi = 10.1042/BJ20060681 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Prima V, Gore L, Caires A, ''et al.'' |title=Cloning and functional characterization of MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins created by a variant t(1;19)(q23;p13.3) in acute lymphoblastic leukemia. |journal=Leukemia |volume=19 |issue= 5 |pages= 806-13 |year= 2005 |pmid= 15744350 |doi= 10.1038/sj.leu.2403684 }}
*{{cite journal | author=Pan HA, Lin YS, Lee KH, ''et al.'' |title=Expression patterns of the DAZ-associated protein DAZAP1 in rat and human ovaries. |journal=Fertil. Steril. |volume=84 Suppl 2 |issue=  |pages= 1089-94 |year= 2006 |pmid= 16209998 |doi= 10.1016/j.fertnstert.2005.03.075 }}
*{{cite journal | author=Morton S, Yang HT, Moleleki N, ''et al.'' |title=Phosphorylation of the ARE-binding protein DAZAP1 by ERK2 induces its dissociation from DAZ. |journal=Biochem. J. |volume=399 |issue= 2 |pages= 265-73 |year= 2006 |pmid= 16848763 |doi= 10.1042/BJ20060681 }}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=26528}}


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Latest revision as of 02:14, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

DAZ-associated protein 1 is a protein that in humans is encoded by the DAZAP1 gene.[1][2]

Function

In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infertile men have deletions that map to regions of the Y chromosome. The DAZ1 (Deleted in Azoospermia) gene cluster maps to the AZFc region of the Y chromosome and is deleted in many azoospermic and severely oligospermic men. It is thought that the DAZ gene cluster arose from the transposition, amplification, and pruning of the ancestral autosomal gene DAZL also involved in germ cell development and gametogenesis. This gene encodes an RNA-binding protein with two RNP motifs that was originally identified by its interaction with the infertility factors DAZ and DAZL. Two isoforms are encoded by transcript variants of this gene.[2]

Interactions

DAZ associated protein 1 has been shown to interact with DAZ1.[3]

References

  1. ↑ Tsui S, Dai T, Roettger S, Schempp W, Salido EC, Yen PH (August 2000). "Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1". Genomics. 65 (3): 266–73. doi:10.1006/geno.2000.6169. PMID 10857750.
  2. ↑ 2.0 2.1 "Entrez Gene: DAZAP1 DAZ associated protein 1".
  3. ↑ Tsui S, Dai T, Roettger S, Schempp W, Salido EC, Yen PH (May 2000). "Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1". Genomics. 65 (3): 266–73. doi:10.1006/geno.2000.6169. PMID 10857750.

Further reading


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