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{{Infobox_gene}}
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'''Disabled homolog 2-interacting protein''' is a [[protein]] that in humans is encoded by the ''DAB2IP'' [[gene]].<ref name="pmid11944990">{{cite journal | vauthors = Chen H, Pong RC, Wang Z, Hsieh JT | title = Differential regulation of the human gene DAB2IP in normal and malignant prostatic epithelia: cloning and characterization | journal = Genomics | volume = 79 | issue = 4 | pages = 573–81 |date=April 2002 | pmid = 11944990 | pmc =  | doi = 10.1006/geno.2002.6739 }}</ref><ref name="pmid11812785">{{cite journal | vauthors = Wang Z, Tseng CP, Pong RC, Chen H, McConnell JD, Navone N, Hsieh JT | title = The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2 | journal = J Biol Chem | volume = 277 | issue = 15 | pages = 12622–31 |date=April 2002 | pmid = 11812785 | pmc =  | doi = 10.1074/jbc.M110568200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DAB2IP DAB2 interacting protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=153090| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = DAB2 interacting protein
| HGNCid = 17294
| Symbol = DAB2IP
| AltSymbols =; AIP1; AF9Q34; DIP1/2; FLJ39072; KIAA1743
| OMIM = 609205
| ECnumber =
| Homologene = 13058
| MGIid = 1916851
| Function = {{GNF_GO|id=GO:0005096 |text = GTPase activator activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
  | Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0045786 |text = negative regulation of progression through cell cycle}} {{GNF_GO|id=GO:0051056 |text = regulation of small GTPase mediated signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 153090
    | Hs_Ensembl = ENSG00000136848
    | Hs_RefseqProtein = NP_115941
    | Hs_RefseqmRNA = NM_032552
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 9
    | Hs_GenLoc_start = 123368983
    | Hs_GenLoc_end = 123587630
    | Hs_Uniprot = Q5VWQ8
    | Mm_EntrezGene = 69601
    | Mm_Ensembl = ENSMUSG00000026883
    | Mm_RefseqmRNA = NM_001001602
    | Mm_RefseqProtein = NP_001001602
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 35404851
    | Mm_GenLoc_end = 35553001
    | Mm_Uniprot = Q3UHC7
  }}
}}
'''DAB2 interacting protein''', also known as '''DAB2IP''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DAB2IP DAB2 interacting protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=153090| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor gene and is inactivated by methylation in prostate and breast cancers (Yano et al., 2005).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: DAB2IP DAB2 interacting protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=153090| accessdate = }}</ref>
| summary_text = DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor gene and is inactivated by methylation in prostate and breast cancers (Yano et al., 2005).[supplied by OMIM]<ref name="entrez" />
}}
}}
==Interactions==
DAB2IP has been shown to [[Protein-protein interaction|interact]] with [[DAB2]].<ref name=autogenerated1>{{cite journal |last=Wang |first=Zhi |author2=Tseng Ching-Ping |author3=Pong Rey-Chen |author4=Chen Hong |author5=McConnell John D |author6=Navone Nora |author7=Hsieh Jer-Tsong  |date=April 2002  |title=The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2 |journal=J. Biol. Chem. |volume=277 |issue=15 |pages=12622–31 | issn = 0021-9258| pmid = 11812785 |doi = 10.1074/jbc.M110568200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99-106 |year= 2003 |pmid= 12168954 |doi=  }}
*{{cite journal  | vauthors=Nakajima D, Okazaki N, Yamakawa H |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=10.1093/dnares/9.3.99 |display-authors=etal}}
*{{cite journal  | author=Nagase T, Kikuno R, Hattori A, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 6 |pages= 347-55 |year= 2001 |pmid= 11214970 |doi= }}
*{{cite journal  | vauthors=Nagase T, Kikuno R, Hattori A |title=Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro |journal=DNA Res. |volume=7 |issue= 6 |pages= 347–55 |year= 2001 |pmid= 11214970 |doi=10.1093/dnares/7.6.347 |display-authors=etal}}
*{{cite journal  | author=Wang Z, Tseng CP, Pong RC, ''et al.'' |title=The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2. |journal=J. Biol. Chem. |volume=277 |issue= 15 |pages= 12622-31 |year= 2002 |pmid= 11812785 |doi= 10.1074/jbc.M110568200 }}
*{{cite journal  | vauthors=Chen H, Toyooka S, Gazdar AF, Hsieh JT |title=Epigenetic regulation of a novel tumor suppressor gene (hDAB2IP) in prostate cancer cell lines |journal=J. Biol. Chem. |volume=278 |issue= 5 |pages= 3121–30 |year= 2003 |pmid= 12446720 |doi= 10.1074/jbc.M208230200 }}
*{{cite journal | author=Chen H, Pong RC, Wang Z, Hsieh JT |title=Differential regulation of the human gene DAB2IP in normal and malignant prostatic epithelia: cloning and characterization. |journal=Genomics |volume=79 |issue= 4 |pages= 573-81 |year= 2002 |pmid= 11944990 |doi= 10.1006/geno.2002.6739 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M }}
*{{cite journal  | author=Chen H, Toyooka S, Gazdar AF, Hsieh JT |title=Epigenetic regulation of a novel tumor suppressor gene (hDAB2IP) in prostate cancer cell lines. |journal=J. Biol. Chem. |volume=278 |issue= 5 |pages= 3121-30 |year= 2003 |pmid= 12446720 |doi= 10.1074/jbc.M208230200 }}
*{{cite journal  | vauthors=Zhang R, He X, Liu W |title=AIP1 mediates TNF-α–induced ASK1 activation by facilitating dissociation of ASK1 from its inhibitor 14-3-3 |journal=J. Clin. Invest. |volume=111 |issue= 12 |pages= 1933–43 |year= 2003 |pmid= 12813029 |doi=10.1172/JCI17790  | pmc=161425 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Zhang R, He X, Liu W, ''et al.'' |title=AIP1 mediates TNF-alpha-induced ASK1 activation by facilitating dissociation of ASK1 from its inhibitor 14-3-3. |journal=J. Clin. Invest. |volume=111 |issue= 12 |pages= 1933-43 |year= 2003 |pmid= 12813029 |doi=  }}
*{{cite journal  | vauthors=von Bergh AR, Wijers PM, Groot AJ |title=Identification of a novel RAS GTPase-activating protein (RASGAP) gene at 9q34 as an MLL fusion partner in a patient with de novo acute myeloid leukemia |journal=Genes Chromosomes Cancer |volume=39 |issue= 4 |pages= 324–34 |year= 2004 |pmid= 14978793 |doi= 10.1002/gcc.20004 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Dote H, Toyooka S, Tsukuda K |title=Aberrant promoter methylation in human DAB2 interactive protein (hDAB2IP) gene in breast cancer |journal=Clin. Cancer Res. |volume=10 |issue= 6 |pages= 2082–9 |year= 2004 |pmid= 15041729 |doi=10.1158/1078-0432.CCR-03-0236 |display-authors=etal}}
*{{cite journal  | author=von Bergh AR, Wijers PM, Groot AJ, ''et al.'' |title=Identification of a novel RAS GTPase-activating protein (RASGAP) gene at 9q34 as an MLL fusion partner in a patient with de novo acute myeloid leukemia. |journal=Genes Chromosomes Cancer |volume=39 |issue= 4 |pages= 324-34 |year= 2004 |pmid= 14978793 |doi= 10.1002/gcc.20004 }}
*{{cite journal  | vauthors=Humphray SJ, Oliver K, Hunt AR |title=DNA sequence and analysis of human chromosome 9 |journal=Nature |volume=429 |issue= 6990 |pages= 369–74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 | pmc=2734081 |display-authors=etal|bibcode=2004Natur.429..369H }}
*{{cite journal  | author=Dote H, Toyooka S, Tsukuda K, ''et al.'' |title=Aberrant promoter methylation in human DAB2 interactive protein (hDAB2IP) gene in breast cancer. |journal=Clin. Cancer Res. |volume=10 |issue= 6 |pages= 2082-9 |year= 2004 |pmid= 15041729 |doi=  }}
*{{cite journal  | vauthors=Zhang H, Zhang R, Luo Y |title=AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation |journal=J. Biol. Chem. |volume=279 |issue= 43 |pages= 44955–65 |year= 2004 |pmid= 15310755 |doi= 10.1074/jbc.M407617200 |display-authors=etal}}
*{{cite journal  | author=Humphray SJ, Oliver K, Hunt AR, ''et al.'' |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369-74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 }}
*{{cite journal  | vauthors=Yano M, Toyooka S, Tsukuda K |title=Aberrant promoter methylation of human DAB2 interactive protein (hDAB2IP) gene in lung cancers |journal=Int. J. Cancer |volume=113 |issue= 1 |pages= 59–66 |year= 2004 |pmid= 15386433 |doi= 10.1002/ijc.20531 |display-authors=etal}}
*{{cite journal  | author=Zhang H, Zhang R, Luo Y, ''et al.'' |title=AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation. |journal=J. Biol. Chem. |volume=279 |issue= 43 |pages= 44955-65 |year= 2004 |pmid= 15310755 |doi= 10.1074/jbc.M407617200 }}
*{{cite journal  | vauthors=Chen H, Tu SW, Hsieh JT |title=Down-regulation of human DAB2IP gene expression mediated by polycomb Ezh2 complex and histone deacetylase in prostate cancer |journal=J. Biol. Chem. |volume=280 |issue= 23 |pages= 22437–44 |year= 2005 |pmid= 15817459 |doi= 10.1074/jbc.M501379200 }}
*{{cite journal  | author=Yano M, Toyooka S, Tsukuda K, ''et al.'' |title=Aberrant promoter methylation of human DAB2 interactive protein (hDAB2IP) gene in lung cancers. |journal=Int. J. Cancer |volume=113 |issue= 1 |pages= 59-66 |year= 2004 |pmid= 15386433 |doi= 10.1002/ijc.20531 }}
*{{cite journal  | vauthors=Kunze E, Von Bonin F, Werner C |title=Transitional cell carcinomas and nonurothelial carcinomas of the urinary bladder differ in the promoter methylation status of the caveolin-1, hDAB2IP and p53 genes, but not in the global methylation of Alu elements |journal=Int. J. Mol. Med. |volume=17 |issue= 1 |pages= 3–13 |year= 2006 |pmid= 16328005 |doi=  10.3892/ijmm.17.1.3|display-authors=etal}}
*{{cite journal  | author=Chen H, Tu SW, Hsieh JT |title=Down-regulation of human DAB2IP gene expression mediated by polycomb Ezh2 complex and histone deacetylase in prostate cancer. |journal=J. Biol. Chem. |volume=280 |issue= 23 |pages= 22437-44 |year= 2005 |pmid= 15817459 |doi= 10.1074/jbc.M501379200 }}
*{{cite journal  | vauthors=Beausoleil SA, Villén J, Gerber SA |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 |display-authors=etal}}
*{{cite journal  | author=Kunze E, Von Bonin F, Werner C, ''et al.'' |title=Transitional cell carcinomas and nonurothelial carcinomas of the urinary bladder differ in the promoter methylation status of the caveolin-1, hDAB2IP and p53 genes, but not in the global methylation of Alu elements. |journal=Int. J. Mol. Med. |volume=17 |issue= 1 |pages= 3-13 |year= 2006 |pmid= 16328005 |doi=  }}
*{{cite journal  | author=Beausoleil SA, Villén J, Gerber SA, ''et al.'' |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285-92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 07:36, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Disabled homolog 2-interacting protein is a protein that in humans is encoded by the DAB2IP gene.[1][2][3]

DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor gene and is inactivated by methylation in prostate and breast cancers (Yano et al., 2005).[supplied by OMIM][3]

Interactions

DAB2IP has been shown to interact with DAB2.[4]

References

  1. ↑ Chen H, Pong RC, Wang Z, Hsieh JT (April 2002). "Differential regulation of the human gene DAB2IP in normal and malignant prostatic epithelia: cloning and characterization". Genomics. 79 (4): 573–81. doi:10.1006/geno.2002.6739. PMID 11944990.
  2. ↑ Wang Z, Tseng CP, Pong RC, Chen H, McConnell JD, Navone N, Hsieh JT (April 2002). "The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2". J Biol Chem. 277 (15): 12622–31. doi:10.1074/jbc.M110568200. PMID 11812785.
  3. ↑ 3.0 3.1 "Entrez Gene: DAB2IP DAB2 interacting protein".
  4. ↑ Wang, Zhi; Tseng Ching-Ping; Pong Rey-Chen; Chen Hong; McConnell John D; Navone Nora; Hsieh Jer-Tsong (April 2002). "The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2". J. Biol. Chem. 277 (15): 12622–31. doi:10.1074/jbc.M110568200. ISSN 0021-9258. PMID 11812785.

Further reading



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