Cyclin B2: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
m (Bot: HTTP→HTTPS)
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''G2/mitotic-specific cyclin-B2''' is a [[protein]] that in humans is encoded by the ''CCNB2'' [[gene]].
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cyclin B2
| HGNCid = 1580
| Symbol = CCNB2
| AltSymbols =; HsT17299
| OMIM = 602755
| ECnumber = 
| Homologene = 74359
| MGIid = 88311
| GeneAtlas_image1 = PBB_GE_CCNB2_202705_at_tn.png
| GeneAtlas_image2 = PBB_GE_CCNB2_gnf1h06136_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_CCNB2_gnf1h06137_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0015630 |text = microtubule cytoskeleton}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007067 |text = mitosis}} {{GNF_GO|id=GO:0051301 |text = cell division}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9133
    | Hs_Ensembl = ENSG00000157456
    | Hs_RefseqProtein = NP_004692
    | Hs_RefseqmRNA = NM_004701
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 15
    | Hs_GenLoc_start = 57184612
    | Hs_GenLoc_end = 57204535
    | Hs_Uniprot = O95067
    | Mm_EntrezGene = 12442
    | Mm_Ensembl = ENSMUSG00000032218
    | Mm_RefseqmRNA = NM_007630
    | Mm_RefseqProtein = NP_031656
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 70206853
    | Mm_GenLoc_end = 70220718
    | Mm_Uniprot = Q922E9
  }}
}}
'''Cyclin B2''', also known as '''CCNB2''', is a human [[gene]].


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control.<ref name="entrez">{{cite web | title = Entrez Gene: CCNB2 cyclin B2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9133| accessdate = }}</ref>
{{PBB_Summary
| section_title =
| summary_text = Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control.<ref name="entrez">{{cite web | title = Entrez Gene: CCNB2 cyclin B2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9133| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}


==Further reading==
Cyclin B2 has been shown to [[Protein-protein interaction|interact]] with [[TGF beta receptor 2]].<ref name=pmid9926943>{{cite journal | vauthors = Liu JH, Wei S, Burnette PK, Gamero AM, Hutton M, Djeu JY | title = Functional association of TGF-beta receptor II with cyclin B | journal = Oncogene | volume = 18 | issue = 1 | pages = 269–75  | date = Jan 1999 | pmid = 9926943 | doi = 10.1038/sj.onc.1202263 }}</ref>
 
== See also ==
* [[Cyclin B]]
 
== References ==
{{Reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = He J, Choe S, Walker R, Di Marzio P, Morgan DO, Landau NR | title = Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity | journal = J. Virol. | volume = 69 | issue = 11 | pages = 6705–11 | year = 1995 | pmid = 7474080 | pmc = 189580 | doi =  }}
| citations =
* {{cite journal | vauthors = Re F, Braaten D, Franke EK, Luban J | title = Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B | journal = J. Virol. | volume = 69 | issue = 11 | pages = 6859–64 | year = 1995 | pmid = 7474100 | pmc = 189600 | doi =  }}
*{{cite journal | author=He J, Choe S, Walker R, ''et al.'' |title=Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity. |journal=J. Virol. |volume=69 |issue= 11 |pages= 6705-11 |year= 1995 |pmid= 7474080 |doi=  }}
* {{cite journal | vauthors = Di Marzio P, Choe S, Ebright M, Knoblauch R, Landau NR | title = Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr | journal = J. Virol. | volume = 69 | issue = 12 | pages = 7909–16 | year = 1995 | pmid = 7494303 | pmc = 189735 | doi =  }}
*{{cite journal | author=Re F, Braaten D, Franke EK, Luban J |title=Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B. |journal=J. Virol. |volume=69 |issue= 11 |pages= 6859-64 |year= 1995 |pmid= 7474100 |doi=  }}
* {{cite journal | vauthors = Jowett JB, Planelles V, Poon B, Shah NP, Chen ML, Chen IS | title = The human immunodeficiency virus type 1 vpr gene arrests infected T cells in the G2 + M phase of the cell cycle | journal = J. Virol. | volume = 69 | issue = 10 | pages = 6304–13 | year = 1995 | pmid = 7666531 | pmc = 189529 | doi =  }}
*{{cite journal | author=Di Marzio P, Choe S, Ebright M, ''et al.'' |title=Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr. |journal=J. Virol. |volume=69 |issue= 12 |pages= 7909-16 |year= 1996 |pmid= 7494303 |doi=  }}
* {{cite journal | vauthors = Jackman M, Firth M, Pines J | title = Human cyclins B1 and B2 are localized to strikingly different structures: B1 to microtubules, B2 primarily to the Golgi apparatus | journal = EMBO J. | volume = 14 | issue = 8 | pages = 1646–54 | year = 1995 | pmid = 7737117 | pmc = 398257 | doi =  }}
*{{cite journal | author=Jowett JB, Planelles V, Poon B, ''et al.'' |title=The human immunodeficiency virus type 1 vpr gene arrests infected T cells in the G2 + M phase of the cell cycle. |journal=J. Virol. |volume=69 |issue= 10 |pages= 6304-13 |year= 1995 |pmid= 7666531 |doi=  }}
* {{cite journal | vauthors = Pines J, Hunter T | title = The differential localization of human cyclins A and B is due to a cytoplasmic retention signal in cyclin B | journal = EMBO J. | volume = 13 | issue = 16 | pages = 3772–81 | year = 1994 | pmid = 8070405 | pmc = 395290 | doi =  }}
*{{cite journal | author=Jackman M, Firth M, Pines J |title=Human cyclins B1 and B2 are localized to strikingly different structures: B1 to microtubules, B2 primarily to the Golgi apparatus. |journal=EMBO J. |volume=14 |issue= 8 |pages= 1646-54 |year= 1995 |pmid= 7737117 |doi=  }}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Pines J, Hunter T |title=The differential localization of human cyclins A and B is due to a cytoplasmic retention signal in cyclin B. |journal=EMBO J. |volume=13 |issue= 16 |pages= 3772-81 |year= 1994 |pmid= 8070405 |doi=  }}
* {{cite journal | vauthors = Poon B, Jowett JB, Stewart SA, Armstrong RW, Rishton GM, Chen IS | title = Human immunodeficiency virus type 1 vpr gene induces phenotypic effects similar to those of the DNA alkylating agent, nitrogen mustard | journal = J. Virol. | volume = 71 | issue = 5 | pages = 3961–71 | year = 1997 | pmid = 9094673 | pmc = 191548 | doi =  }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Poon B, Jowett JB, Stewart SA, ''et al.'' |title=Human immunodeficiency virus type 1 vpr gene induces phenotypic effects similar to those of the DNA alkylating agent, nitrogen mustard. |journal=J. Virol. |volume=71 |issue= 5 |pages= 3961-71 |year= 1997 |pmid= 9094673 |doi=  }}
* {{cite journal | vauthors = Mahalingam S, Ayyavoo V, Patel M, Kieber-Emmons T, Kao GD, Muschel RJ, Weiner DB | title = HIV-1 Vpr interacts with a human 34-kDa mov34 homologue, a cellular factor linked to the G2/M phase transition of the mammalian cell cycle | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 95 | issue = 7 | pages = 3419–24 | year = 1998 | pmid = 9520381 | pmc = 19851 | doi = 10.1073/pnas.95.7.3419 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Brandeis M, Rosewell I, Carrington M, Crompton T, Jacobs MA, Kirk J, Gannon J, Hunt T | title = Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 95 | issue = 8 | pages = 4344–9 | year = 1998 | pmid = 9539739 | pmc = 22491 | doi = 10.1073/pnas.95.8.4344 }}
*{{cite journal | author=Mahalingam S, Ayyavoo V, Patel M, ''et al.'' |title=HIV-1 Vpr interacts with a human 34-kDa mov34 homologue, a cellular factor linked to the G2/M phase transition of the mammalian cell cycle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 7 |pages= 3419-24 |year= 1998 |pmid= 9520381 |doi= }}
* {{cite journal | vauthors = Felzien LK, Woffendin C, Hottiger MO, Subbramanian RA, Cohen EA, Nabel GJ | title = HIV transcriptional activation by the accessory protein, VPR, is mediated by the p300 co-activator | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 95 | issue = 9 | pages = 5281–6 | year = 1998 | pmid = 9560267 | pmc = 20252 | doi = 10.1073/pnas.95.9.5281 }}
*{{cite journal | author=Brandeis M, Rosewell I, Carrington M, ''et al.'' |title=Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 8 |pages= 4344-9 |year= 1998 |pmid= 9539739 |doi= }}
* {{cite journal | vauthors = Liu JH, Wei S, Burnette PK, Gamero AM, Hutton M, Djeu JY | title = Functional association of TGF-beta receptor II with cyclin B | journal = Oncogene | volume = 18 | issue = 1 | pages = 269–75 | year = 1999 | pmid = 9926943 | doi = 10.1038/sj.onc.1202263 }}
*{{cite journal | author=Felzien LK, Woffendin C, Hottiger MO, ''et al.'' |title=HIV transcriptional activation by the accessory protein, VPR, is mediated by the p300 co-activator. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 9 |pages= 5281-6 |year= 1998 |pmid= 9560267 |doi= }}
* {{cite journal | vauthors = Elder RT, Yu M, Chen M, Edelson S, Zhao Y | title = Cell cycle G2 arrest induced by HIV-1 Vpr in fission yeast (Schizosaccharomyces pombe) is independent of cell death and early genes in the DNA damage checkpoint | journal = Virus Res. | volume = 68 | issue = 2 | pages = 161–73 | year = 2000 | pmid = 10958988 | doi = 10.1016/S0168-1702(00)00167-2 }}
*{{cite journal | author=Liu JH, Wei S, Burnette PK, ''et al.'' |title=Functional association of TGF-beta receptor II with cyclin B. |journal=Oncogene |volume=18 |issue= 1 |pages= 269-75 |year= 1999 |pmid= 9926943 |doi= 10.1038/sj.onc.1202263 }}
* {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Res. | volume = 10 | issue = 11 | pages = 1788–95 | year = 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}
*{{cite journal | author=Hrimech M, Yao XJ, Branton PE, Cohen EA |title=Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A. |journal=EMBO J. |volume=19 |issue= 15 |pages= 3956-67 |year= 2000 |pmid= 10921877 |doi= 10.1093/emboj/19.15.3956 }}
* {{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs | journal = Genome Res. | volume = 11 | issue = 3 | pages = 422–35 | year = 2001 | pmid = 11230166 | pmc = 311072 | doi =  10.1101/gr.GR1547R }}
*{{cite journal | author=Elder RT, Yu M, Chen M, ''et al.'' |title=Cell cycle G2 arrest induced by HIV-1 Vpr in fission yeast (Schizosaccharomyces pombe) is independent of cell death and early genes in the DNA damage checkpoint. |journal=Virus Res. |volume=68 |issue= 2 |pages= 161-73 |year= 2000 |pmid= 10958988 |doi= }}
* {{cite journal | vauthors = Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S | title = Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing | journal = EMBO Rep. | volume = 1 | issue = 3 | pages = 287–92 | year = 2000 | pmid = 11256614 | pmc = 1083732 | doi = 10.1093/embo-reports/kvd058 }}
*{{cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
* {{cite journal | vauthors = Elder RT, Yu M, Chen M, Zhu X, Yanagida M, Zhao Y | title = HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25 | journal = Virology | volume = 287 | issue = 2 | pages = 359–70 | year = 2001 | pmid = 11531413 | doi = 10.1006/viro.2001.1007 }}
*{{cite journal | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
* {{cite journal | vauthors = Mouland AJ, Coady M, Yao XJ, Cohen EA | title = Hypophosphorylation of poly(A) polymerase and increased polyadenylation activity are associated with human immunodeficiency virus type 1 Vpr expression | journal = Virology | volume = 292 | issue = 2 | pages = 321–30 | year = 2002 | pmid = 11878934 | doi = 10.1006/viro.2001.1261 }}
*{{cite journal | author=Simpson JC, Wellenreuther R, Poustka A, ''et al.'' |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287-92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 }}
*{{cite journal  | author=Elder RT, Yu M, Chen M, ''et al.'' |title=HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25. |journal=Virology |volume=287 |issue= 2 |pages= 359-70 |year= 2001 |pmid= 11531413 |doi= 10.1006/viro.2001.1007 }}
*{{cite journal | author=Mouland AJ, Coady M, Yao XJ, Cohen EA |title=Hypophosphorylation of poly(A) polymerase and increased polyadenylation activity are associated with human immunodeficiency virus type 1 Vpr expression. |journal=Virology |volume=292 |issue= 2 |pages= 321-30 |year= 2002 |pmid= 11878934 |doi= 10.1006/viro.2001.1261 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{Cell cycle proteins}}
 
 
{{Gene-15-stub}}

Latest revision as of 17:57, 30 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

G2/mitotic-specific cyclin-B2 is a protein that in humans is encoded by the CCNB2 gene.

Function

Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control.[1]

Interactions

Cyclin B2 has been shown to interact with TGF beta receptor 2.[2]

See also

References

  1. ↑ "Entrez Gene: CCNB2 cyclin B2".
  2. ↑ Liu JH, Wei S, Burnette PK, Gamero AM, Hutton M, Djeu JY (Jan 1999). "Functional association of TGF-beta receptor II with cyclin B". Oncogene. 18 (1): 269–75. doi:10.1038/sj.onc.1202263. PMID 9926943.

Further reading


Retrieved from "https://www.wikidoc.org/index.php?title=Cyclin_B2&oldid=1416843"