Cryptococcosis: Difference between revisions

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==Treatment==
==Treatment==
[[Cryptococcosis medical therapy|Medical therapy]] | [[Cryptococcosis surgery|Surgical options]] | [[Cryptococcosis primary prevention|Primary prevention]]  | [[Cryptococcosis secondary prevention|Secondary prevention]] | [[Cryptococcosis cost-effectiveness of therapy|Financial costs]] | [[Cryptococcosis future or investigational therapies|Future therapies]]
[[Cryptococcosis medical therapy|Medical therapy]] | [[Cryptococcosis surgery|Surgical options]] | [[Cryptococcosis primary prevention|Primary prevention]]  | [[Cryptococcosis secondary prevention|Secondary prevention]] | [[Cryptococcosis cost-effectiveness of therapy|Financial costs]] | [[Cryptococcosis future or investigational therapies|Future therapies]]
== Etiology and Incidence ==
Cryptococcosis is a defining opportunistic infection for [[AIDS]], although patients with [[Hodgkin's]] or other [[lymphomas]] or [[sarcoidosis]] or those receiving long-term [[corticosteroid]] therapy are also at increased risk.
Distribution is worldwide. The prevalence of cryptococcosis has been increasing over the past 20 years for many reasons, including the increase in indicence of AIDS and the expanded use of immunosuppressive drugs.
In humans, ''C. neoformans'' causes three types of infections:
* Wound or [[cutaneous]] cryptococcosis
* [[Pulmonary]] cryptococcosis, and
* Cryptococcal [[meningitis]].
Cryptococcal meningitis (infection of the brain) is believed to result from dissemination of the fungus from either an observed or unappreciated pulmonary infection.  ''[[Cryptococcus gattii]]'' causes infections in immunocompetent people (those having a functioning [[immune system]]), but ''C. neoformans v. grubii'', and ''v. neoformans'' usually only cause clinically evident infections in persons who have some form of defect in their immune systems (immunocompromised persons).  People who have defects in their [[cell-mediated immunity]], for example, people with [[AIDS]], are especially susceptible to disseminated cryptococcosis. Cryptococcosis is often fatal, especially if untreated.


== Diagnosis ==
== Diagnosis ==

Revision as of 14:38, 3 February 2012

For patient information click here Template:DiseaseDisorder infobox

Cryptococcosis Microchapters

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Overview

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Classification

Pathophysiology

Causes

Differentiating Cryptococcosis from other Diseases

Epidemiology and Demographics

Risk Factors

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Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

Chest X Ray

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Risk calculators and risk factors for Cryptococcosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Historical Perspective

Pathophysiology

Epidemiology & Demographics

Risk Factors

Screening

Causes

Differentiating Cryptococcosis

Complications & Prognosis

Diagnosis

History and Symptoms | Physical Examination | Staging | Laboratory tests | Electrocardiogram | X Rays | CT | MRI Echocardiography or Ultrasound | Other images | Alternative diagnostics

Treatment

Medical therapy | Surgical options | Primary prevention | Secondary prevention | Financial costs | Future therapies

Diagnosis

Symptoms include chest pain, dry cough, swelling of abdomen, headache, blurred vision and confusion. Although symptoms may not be able to be detected.

Detection of cryptococcal antigen (capsular material) by culture of CSF, sputum and urine provides definitive diagnosis. Blood cultures may be positive in heavy infections.

Cerebrum: Cryptococcosis (PAS stain)

<youtube v=ZG0AcmtBLe4/>

Treatment

The standard regimen of treatment in non-AIDS patients intravenous Amphotericin B combined with oral flucytosine.

AIDS patients often have a reduced response to Amphotericin B and flucytosine, therefore after initial treatment as above, oral fluconazole can be used.

External links

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