Croup future or investigational therapies: Difference between revisions
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*[[Helium]] and [[oxygen]] combined into "[[heliox]]" breathing gas can be used to alleviate croup symptoms by reducing upper airway obstruction.<ref name="MoraaSturman2013">{{cite journal|last1=Moraa|first1=Irene|last2=Sturman|first2=Nancy|last3=McGuire|first3=Treasure|last4=van Driel|first4=Mieke L|last5=Moraa|first5=Irene|title=Heliox for croup in children|year=2013|doi=10.1002/14651858.CD006822.pub4}}</ref> | *[[Helium]] and [[oxygen]] combined into "[[heliox]]" breathing gas can be used to alleviate croup symptoms by reducing upper airway obstruction.<ref name="MoraaSturman2013">{{cite journal|last1=Moraa|first1=Irene|last2=Sturman|first2=Nancy|last3=McGuire|first3=Treasure|last4=van Driel|first4=Mieke L|last5=Moraa|first5=Irene|title=Heliox for croup in children|year=2013|doi=10.1002/14651858.CD006822.pub4}}</ref> | ||
**Upper airway resistance to gas flow is reduced to relieve [[respiratory distress]]. | **Upper airway resistance to gas flow is reduced to relieve [[respiratory distress]]. | ||
*There is evidence that [[heliox]] | *There is evidence that suggests [[heliox]] can be as effective as [[racemic]] [[epinephrine]] in relieving moderate to severe croup symptoms.<ref name="WeberChudnofsky2001">{{cite journal|last1=Weber|first1=J. E.|last2=Chudnofsky|first2=C. R.|last3=Younger|first3=J. G.|last4=Larkin|first4=G. L.|last5=Boczar|first5=M.|last6=Wilkerson|first6=M. D.|last7=Zuriekat|first7=G. Y.|last8=Nolan|first8=B.|last9=Eicke|first9=D. M.|title=A Randomized Comparison of Helium-Oxygen Mixture (Heliox) and Racemic Epinephrine for the Treatment of Moderate to Severe Croup|journal=PEDIATRICS|volume=107|issue=6|year=2001|pages=e96–e96|issn=0031-4005|doi=10.1542/peds.107.6.e96}}</ref> | ||
*Studies have not yet consistently determined if [[heliox]] is effective in treating all forms of croup and further investigational randomized trials are being pursued.<ref name="MoraaSturman2013">{{cite journal|last1=Moraa|first1=Irene|last2=Sturman|first2=Nancy|last3=McGuire|first3=Treasure|last4=van Driel|first4=Mieke L|last5=Moraa|first5=Irene|title=Heliox for croup in children|year=2013|doi=10.1002/14651858.CD006822.pub4}}</ref> | |||
==References== | ==References== | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Luke Rusowicz-Orazem, B.S.
Overview
Future or Investigational Therapies
Heliox
- Helium and oxygen combined into "heliox" breathing gas can be used to alleviate croup symptoms by reducing upper airway obstruction.[1]
- Upper airway resistance to gas flow is reduced to relieve respiratory distress.
- There is evidence that suggests heliox can be as effective as racemic epinephrine in relieving moderate to severe croup symptoms.[2]
- Studies have not yet consistently determined if heliox is effective in treating all forms of croup and further investigational randomized trials are being pursued.[1]
References
- ↑ 1.0 1.1 Moraa, Irene; Sturman, Nancy; McGuire, Treasure; van Driel, Mieke L; Moraa, Irene (2013). "Heliox for croup in children". doi:10.1002/14651858.CD006822.pub4.
- ↑ Weber, J. E.; Chudnofsky, C. R.; Younger, J. G.; Larkin, G. L.; Boczar, M.; Wilkerson, M. D.; Zuriekat, G. Y.; Nolan, B.; Eicke, D. M. (2001). "A Randomized Comparison of Helium-Oxygen Mixture (Heliox) and Racemic Epinephrine for the Treatment of Moderate to Severe Croup". PEDIATRICS. 107 (6): e96–e96. doi:10.1542/peds.107.6.e96. ISSN 0031-4005.