Critical illness-related corticosteroid insufficiency history and symptoms

Revision as of 15:18, 20 September 2012 by Aarti Narayan (talk | contribs)
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to navigation Jump to search

Critical illness-related corticosteroid insufficiency Microchapters

Home

Overview

Historical Perspective

Pathophysiology

Causes

Differentiating Critical illness-related corticosteroid insufficiency from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

CT

MRI

Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Critical illness-related corticosteroid insufficiency history and symptoms On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Critical illness-related corticosteroid insufficiency history and symptoms

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Critical illness-related corticosteroid insufficiency history and symptoms

CDC on Critical illness-related corticosteroid insufficiency history and symptoms

Critical illness-related corticosteroid insufficiency history and symptoms in the news

Blogs on Critical illness-related corticosteroid insufficiency history and symptoms

Directions to Hospitals Treating Critical illness-related corticosteroid insufficiency

Risk calculators and risk factors for Critical illness-related corticosteroid insufficiency history and symptoms

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

History

Symptoms

The best known feature that suggests a possible underlying adrenal insufficiency is low blood pressure despite resuscitation with intravenous fluids, requiring vasopressor drugs. These patients typically display tachycardia and other signs of hyperdynamic shock. Other symptoms include fever, purpura fulminans, and gastrointestinal or neurological disturbances. All these features are relatively non-specific in intensive care patients.

In some patients a specific reason for adrenal insufficiency can be suspected, such as prior intake of corticosteroids that suppressed the HPA axis, or use of enzyme inducing drugs such as phenytoin. Treatment with imidazole drugs such as etomidate, ketoconazole and miconazole can also suppress the HPA axis, as well as drugs used specifically for this purpose, such as metyrapone.Lamberts SW, Bons EG, Bruining HA, de Jong FH (1987). "Differential effects of the imidazole derivatives etomidate, ketoconazole and miconazole and of metyrapone on the secretion of cortisol and its precursors by human adrenocortical cells". J. Pharmacol. Exp. Ther. 240 (1): 259–64. PMID 3027305. Unknown parameter |month= ignored (help)</ref>

References

Template:WH Template:WS