Copper deficiency: Difference between revisions
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==Overview== | |||
'''[[Copper]] deficiency''' can cause a syndrome of [[anemia]] or [[pancytopenia]] and a neurodegeneration in humans or other mammals. The neurodegenerative syndrome of copper deficiency has been recognized for some time in ruminant animals, in which it is commonly known as “swayback.” Affected animals develop [[ataxia]] and [[spasticity]]. | '''[[Copper]] deficiency''' can cause a syndrome of [[anemia]] or [[pancytopenia]] and a neurodegeneration in humans or other mammals. The neurodegenerative syndrome of copper deficiency has been recognized for some time in ruminant animals, in which it is commonly known as “swayback.” Affected animals develop [[ataxia]] and [[spasticity]]. | ||
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Copper deficiency in ruminants can be caused by copper-poor grazing lands or copper-poor feed. In humans, copper deficiency can occur through copper-deficient [[parenteral nutrition]] or as a result of [[gastric bypass surgery]]. The recommended daily intake of elemental copper for an adult is 0.9 mg daily and typical American diets may be deficient in copper. [[Zinc]] competes with copper for absorption by the gut. Chronic excessive zinc consumption, such as may occur in those who overuse denture adhesive compounds, can cause copper deficiency. | Copper deficiency in ruminants can be caused by copper-poor grazing lands or copper-poor feed. In humans, copper deficiency can occur through copper-deficient [[parenteral nutrition]] or as a result of [[gastric bypass surgery]]. The recommended daily intake of elemental copper for an adult is 0.9 mg daily and typical American diets may be deficient in copper. [[Zinc]] competes with copper for absorption by the gut. Chronic excessive zinc consumption, such as may occur in those who overuse denture adhesive compounds, can cause copper deficiency. | ||
==Historical Perspective== | |||
==Classification== | |||
==Pathophysiology== | |||
==Causes== | |||
==Differentiating Copper Deficiency from other Diseases== | |||
==Epidemiology and Demographics== | |||
===Age=== | |||
===Gender=== | |||
===Race=== | |||
==Risk Factors== | |||
== Natural History, Complications and Prognosis== | |||
== Diagnosis == | |||
===Diagnostic Criteria=== | |||
=== Symptoms === | |||
=== Physical Examination === | |||
=== Laboratory Findings === | |||
===Imaging Findings=== | |||
=== Other Diagnostic Studies === | |||
== Treatment == | |||
=== Medical Therapy === | |||
=== Surgery === | |||
=== Prevention === | |||
==References== | ==References== | ||
{{reflist|2}} | |||
* {{cite journal | author = Pang Y, MacIntosh DL, Ryan PB |title = A longitudinal investigation of aggregate oral intake of copper. | year=2001 | journal = Journal of Nutrition | pmid = 11481413}} | * {{cite journal | author = Pang Y, MacIntosh DL, Ryan PB |title = A longitudinal investigation of aggregate oral intake of copper. | year=2001 | journal = Journal of Nutrition | pmid = 11481413}} | ||
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* {{cite journal | author = Kumar N |title = Copper deficiency myelopathy (human swayback). | year=2006 | journal = Mayo Clinic Proceedings | pmid = 17036563}} | * {{cite journal | author = Kumar N |title = Copper deficiency myelopathy (human swayback). | year=2006 | journal = Mayo Clinic Proceedings | pmid = 17036563}} | ||
[[Category:Hematology]] | [[Category:Hematology]] | ||
[[Category:Neurology]] | [[Category:Neurology]] | ||
{{WikiDoc Help Menu}} | {{WikiDoc Help Menu}} | ||
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Latest revision as of 18:55, 21 July 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Synonyms and keywords:
Overview
Copper deficiency can cause a syndrome of anemia or pancytopenia and a neurodegeneration in humans or other mammals. The neurodegenerative syndrome of copper deficiency has been recognized for some time in ruminant animals, in which it is commonly known as “swayback.” Affected animals develop ataxia and spasticity.
Cases of human anemia caused by copper deficiency are rare, but have been known of for many years. More recently, a syndrome similar to ruminant swayback has been seen. Affected persons develop progressive spasticity, ataxia, and a neuropathy. This may be accompanied by anemia as well. The clinical syndrome is nearly identical to subacute combined degeneration, a long-recognised and relatively common condition caused by vitamin B12 deficiency.
Copper deficiency in ruminants can be caused by copper-poor grazing lands or copper-poor feed. In humans, copper deficiency can occur through copper-deficient parenteral nutrition or as a result of gastric bypass surgery. The recommended daily intake of elemental copper for an adult is 0.9 mg daily and typical American diets may be deficient in copper. Zinc competes with copper for absorption by the gut. Chronic excessive zinc consumption, such as may occur in those who overuse denture adhesive compounds, can cause copper deficiency.
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Copper Deficiency from other Diseases
Epidemiology and Demographics
Age
Gender
Race
Risk Factors
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Criteria
Symptoms
Physical Examination
Laboratory Findings
Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Prevention
References
- Pang Y, MacIntosh DL, Ryan PB (2001). "A longitudinal investigation of aggregate oral intake of copper". Journal of Nutrition. PMID 11481413.