Congenital syphilis: Difference between revisions

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==Overview==
 
'''Congenital syphilis''' is [[syphilis]] present in utero and at birth, and occurs when a child is born to a mother with secondary or tertiary syphilis. Untreated syphilis results in a high risk of a bad outcome of pregnancy. Syphilis can cause [[miscarriages]], [[premature births]], [[stillbirths]], or death of newborn babies. Some infants with congenital syphilis have symptoms at birth, but most develop symptoms later. Untreated babies can have deformities, delays in development, or [[seizures]] along with many other problems such as rash, fever, swollen [[liver]] and [[spleen]], [[anemia]], and [[jaundice]]. Sores on infected babies are infectious. Rarely, the symptoms of syphilis go unseen in infants so that they develop the symptoms of late-stage syphilis, including damage to their bones, teeth, eyes, ears, and brain.<ref>http://www.niaid.nih.gov/factsheets/stdsyph.htm accessed 10/17/2006</ref>
==[[Congenital syphilis overview|Overview]]==
 
==[[Congenital syphilis historical perspective|Historical Perspective]]==
 
==[[Congenital syphilis pathophysiology|Pathophysiology]]==
 
==[[Congenital syphilis epidemiology and demographics|Epidemiology & Demographics]]==
 
==[[Congenital syphilis risk factors|Risk Factors]]==
 
==[[Congenital syphilis screening|Screening]]==
 
==[[Congenital syphilis causes|Causes]]==
 
==[[Congenital syphilis differential diagnosis|Differentiating Congenital syphilis]]==
 
==[[Congenital syphilis natural history|Complications & Prognosis]]==
 
==Diagnosis==
[[Congenital syphilis history and symptoms|History and Symptoms]] | [[Congenital syphilis physical examination|Physical Examination]] | [[Congenital syphilis staging|Staging]] | [[Congenital syphilis laboratory tests|Laboratory tests]] | [[Congenital syphilis electrocardiogram|Electrocardiogram]]  | [[Congenital syphilis x ray|X Rays]] | [[Congenital syphilis CT|CT]] | [[Congenital syphilis MRI|MRI]] [[Congenital syphilis echocardiography or ultrasound|Echocardiography or Ultrasound]] | [[Congenital syphilis other imaging findings|Other images]] | [[Congenital syphilis other diagnostic studies|Alternative diagnostics]]
 
==Treatment==
[[Congenital syphilis medical therapy|Medical therapy]] | [[Congenital syphilis surgery|Surgical options]] | [[Congenital syphilis primary prevention|Primary prevention]] | [[Congenital syphilis secondary prevention|Secondary prevention]] | [[Congenital syphilis cost-effectiveness of therapy|Financial costs]] | [[Congenital syphilis future or investigational therapies|Future therapies]]


==Epidemiology==
==Epidemiology==

Revision as of 15:34, 1 February 2012

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Congenital syphilis
ICD-10 A50
ICD-9 090
DiseasesDB 12744
MedlinePlus 001344
MeSH D013590

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Overview

Historical Perspective

Pathophysiology

Epidemiology & Demographics

Risk Factors

Screening

Causes

Differentiating Congenital syphilis

Complications & Prognosis

Diagnosis

History and Symptoms | Physical Examination | Staging | Laboratory tests | Electrocardiogram | X Rays | CT | MRI Echocardiography or Ultrasound | Other images | Alternative diagnostics

Treatment

Medical therapy | Surgical options | Primary prevention | Secondary prevention | Financial costs | Future therapies

Epidemiology

According to the CDC, 40% of births to syphilitic mothers are stillborn, 40-70% of the survivors will be infected, and 12% of these will subsequently die.

Early congenital syphilis

This is a subset of cases of congenital syphilis. Newborns may be asymptomatic and are only identified on routine prenatal screening. If not identified and treated, these newborns develop poor feeding and rhinorrhea. By definition, early congenital syphilis occurs in children between 0 and 2 years old[1]. After, they can develop late congenital syphilis.

Symptomatic newborns, if not stillborn, are born premature, with enlargement of the liver, spleen, skeletal abnormalities, pneumonia and a bullous skin disease known as pemphigus syphiliticus.

Manifestations of congenital syphilis

Notched incisors known as Hutchinson's teeth which are characteristic of congenital syphilis

Death from congenital syphilis is usually through pulmonary hemorrhage.

Treatment

If a pregnant mother is identified as being infected with syphilis, treatment can effectively prevent congenital syphilis from developing in the unborn child, especially if she is treated before the sixteenth week of pregnancy. The child is at greatest risk of contracting syphilis when the mother is in the early stages of infection, but the disease can be passed at any point during pregnancy, even during delivery (should the child have not contracted it already). However, a woman in the secondary stage of syphilis decreases her child's risk of developing congenital syphilis by 98% if she receives treatment before the last month of pregnancy[2]. An afflicted child can be treated using antibiotics much like an adult, however any developmental symptoms are likely to be permanent.

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