Colorectal cancer medical therapy: Difference between revisions
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{{Colon cancer}} | {{Colon cancer}} | ||
''' | To view the medical therapy of familial adenomatous polyposis (FAP), click [[Familial adenomatous polyposis medical therapy|'''here''']]<br> | ||
To view the medical therapy of hereditary nonpolyposis colorectal cancer (HNPCC), click [[Hereditary nonpolyposis colorectal cancer medical therapy|'''here''']]<br><br> | |||
{{CMG}} {{AE}} Elliot B. Tapper, M.D., Saarah T. Alkhairy, M.D. | |||
==Overview== | ==Overview== | ||
[[Chemotherapy]] is used to reduce the likelihood of metastasis developing, shrink tumor size, and slow tumor growth. Chemotherapy is often applied after surgery (adjuvant), before surgery (neo-adjuvant), or as the primary therapy if surgery is not indicated (palliative). Other therapies include radiation and support therapies. | |||
==Medical Therapy== | ==Medical Therapy== | ||
===Chemotherapy=== | ===Chemotherapy=== | ||
[[Chemotherapy]] is used to reduce the likelihood of metastasis developing, shrink tumor size, | [[Chemotherapy]] is used to reduce the likelihood of metastasis developing, shrink tumor size, and slow tumor growth. Chemotherapy is often applied after surgery (adjuvant), before surgery (neo-adjuvant), or as the primary therapy if surgery is not indicated (palliative). The treatments listed here have been shown in [[clinical trial]]s to improve survival and/or reduce mortality rate and have been approved for use by the US Food and Drug Administration. | ||
'''Adjuvant chemotherapy''' | |||
One regimen involves the combination of infusional [[5-fluorouracil]], [[leucovorin]], and [[oxaliplatin]] ([[FOLFOX]]) | |||
*[[5-fluorouracil]] (5-FU) or [[Capecitabine]] (Xeloda®) | |||
*[[Leucovorin]] (LV, Folinic Acid) | |||
*[[Oxaliplatin]] (Eloxatin®) | |||
'''Chemotherapy for metastatic disease''' | |||
Commonly used first line [[chemotherapy regimen]]s involve the combination of infusional [[5-fluorouracil]], [[leucovorin]], and [[oxaliplatin]] ([[FOLFOX]]) with [[bevacizumab]] OR infusional [[5-fluorouracil]], [[leucovorin]], and [[irinotecan]] ([[FOLFIRI]]) with [[bevacizumab]] | |||
*[[5-fluorouracil]] (5-FU) or Capecitabine | |||
*[[Leucovorin]] (LV, Folinic Acid) | |||
*[[Irinotecan]] (Camptosar®) | |||
*[[Oxaliplatin]] (Eloxatin®) | |||
*[[Bevacizumab]] (Avastin®) | |||
*[[Cetuximab]] (Erbitux®) | |||
*[[Panitumumab]] (Vectibix) | |||
'''In clinical trials for treated/untreated metastatic disease''' [http://saci.uthscsa.edu/ClinicalTrials/SelectedPhase1.html#PhINovel] | |||
*[[Bortezomib]] (Velcade®) | |||
*[[Oblimersen]] (Genasense®, G3139) | |||
*[[Gefitinib]] and [[Erlotinib]] (Tarceva®) | |||
*[[Topotecan]] (Hycamtin®) | |||
===Radiation therapy=== | ===Radiation therapy=== | ||
Radiotherapy is not used routinely in colon cancer | Radiotherapy is not used routinely in colon cancer since it could lead to [[radiation enteritis]]. It is also difficult to target specific portions of the colon. It is more commonly performed in rectal cancer since the rectum does not move as much as the colon and is easier to target. | ||
* Colon cancer | |||
Indications include: | |||
* Rectal cancer | *Colon cancer | ||
:*Pain relief and palliation | |||
:*Targeted at [[metastasis|metastatic]] tumor deposits if they compress vital structures and/or cause pain | |||
*Rectal cancer | |||
:*Neoadjuvant - given before surgery in patients with tumors that extend outside the rectum or have spread to regional lymph nodes in order to decrease the risk of recurrence following surgery or to allow for less invasive surgical approaches | |||
:*Adjuvant - where a tumor perforates the rectum or involves regional lymph nodes (AJCC T3 or T4 tumors or Duke's B or C tumors) | |||
:*Palliative - to decrease the tumor burden in order to relieve or prevent symptoms | |||
Sometimes chemotherapy agents are used to increase the effectiveness of radiation by sensitizing tumor cells if present. | Sometimes chemotherapy agents are used to increase the effectiveness of radiation by sensitizing tumor cells if present. | ||
===Support therapies=== | ===Support therapies=== | ||
Cancer diagnosis very often results in an enormous change in the patient's psychological wellbeing. Various support resources are available from hospitals and other agencies which provide [[counseling]], social service support, [[cancer support group]]s, and other services. These services help to mitigate some of the difficulties of integrating a patient's medical complications into other parts of their life. | Cancer diagnosis very often results in an enormous change in the patient's psychological wellbeing. Various support resources are available from hospitals and other agencies which provide [[counseling]], social service support, [[cancer support group]]s, and other services. These services help to mitigate some of the difficulties of integrating a patient's medical complications into other parts of their life. | ||
Revision as of 14:03, 15 July 2015
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Colorectal cancer Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Colorectal cancer medical therapy On the Web |
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American Roentgen Ray Society Images of Colorectal cancer medical therapy |
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Risk calculators and risk factors for Colorectal cancer medical therapy |
To view the medical therapy of familial adenomatous polyposis (FAP), click here
To view the medical therapy of hereditary nonpolyposis colorectal cancer (HNPCC), click here
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Elliot B. Tapper, M.D., Saarah T. Alkhairy, M.D.
Overview
Chemotherapy is used to reduce the likelihood of metastasis developing, shrink tumor size, and slow tumor growth. Chemotherapy is often applied after surgery (adjuvant), before surgery (neo-adjuvant), or as the primary therapy if surgery is not indicated (palliative). Other therapies include radiation and support therapies.
Medical Therapy
Chemotherapy
Chemotherapy is used to reduce the likelihood of metastasis developing, shrink tumor size, and slow tumor growth. Chemotherapy is often applied after surgery (adjuvant), before surgery (neo-adjuvant), or as the primary therapy if surgery is not indicated (palliative). The treatments listed here have been shown in clinical trials to improve survival and/or reduce mortality rate and have been approved for use by the US Food and Drug Administration.
Adjuvant chemotherapy One regimen involves the combination of infusional 5-fluorouracil, leucovorin, and oxaliplatin (FOLFOX)
- 5-fluorouracil (5-FU) or Capecitabine (Xeloda®)
- Leucovorin (LV, Folinic Acid)
- Oxaliplatin (Eloxatin®)
Chemotherapy for metastatic disease Commonly used first line chemotherapy regimens involve the combination of infusional 5-fluorouracil, leucovorin, and oxaliplatin (FOLFOX) with bevacizumab OR infusional 5-fluorouracil, leucovorin, and irinotecan (FOLFIRI) with bevacizumab
- 5-fluorouracil (5-FU) or Capecitabine
- Leucovorin (LV, Folinic Acid)
- Irinotecan (Camptosar®)
- Oxaliplatin (Eloxatin®)
- Bevacizumab (Avastin®)
- Cetuximab (Erbitux®)
- Panitumumab (Vectibix)
In clinical trials for treated/untreated metastatic disease [2]
- Bortezomib (Velcade®)
- Oblimersen (Genasense®, G3139)
- Gefitinib and Erlotinib (Tarceva®)
- Topotecan (Hycamtin®)
Radiation therapy
Radiotherapy is not used routinely in colon cancer since it could lead to radiation enteritis. It is also difficult to target specific portions of the colon. It is more commonly performed in rectal cancer since the rectum does not move as much as the colon and is easier to target.
Indications include:
- Colon cancer
- Pain relief and palliation
- Targeted at metastatic tumor deposits if they compress vital structures and/or cause pain
- Rectal cancer
- Neoadjuvant - given before surgery in patients with tumors that extend outside the rectum or have spread to regional lymph nodes in order to decrease the risk of recurrence following surgery or to allow for less invasive surgical approaches
- Adjuvant - where a tumor perforates the rectum or involves regional lymph nodes (AJCC T3 or T4 tumors or Duke's B or C tumors)
- Palliative - to decrease the tumor burden in order to relieve or prevent symptoms
Sometimes chemotherapy agents are used to increase the effectiveness of radiation by sensitizing tumor cells if present.
Support therapies
Cancer diagnosis very often results in an enormous change in the patient's psychological wellbeing. Various support resources are available from hospitals and other agencies which provide counseling, social service support, cancer support groups, and other services. These services help to mitigate some of the difficulties of integrating a patient's medical complications into other parts of their life.