Clostridium difficile infection classification: Difference between revisions
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{{Siren|Clostridium difficile infection}} | |||
{{Clostridium difficile}} | |||
{{CMG}}; {{AE}} {{YD}} | |||
==Overview== | |||
''C. difficile'' infection may be classified based on the clinical severity of the disease. The severity of the infection dictates the choice of [[Clostridium difficile infection medical therapy|antimicrobial therapy]] and the need for surgical consultation/management. Mild disease is defined as isolated [[diarrhea]], whereas severe/complicated disease is defined as either [[delirium]], [[shock]], [[organ failure]], [[high-grade fever]], or marked [[leukocytosis]]. | |||
==Classification== | |||
Shown below is a table that classifies ''C. difficile'' infection based on clinical features and lab findings. The severity of the infection dictates the choice of antimicrobial therapy. | |||
{| style="font-size: 85%;" | |||
! style="width: 80px; background: #4479BA; text-align: center;" |{{fontcolor|#FFF|Severity}} | |||
! style="width: 720px; background: #4479BA; text-align: center;" | {{fontcolor|#FFF|Criteria}} | |||
|- | |||
| style="background: #F5F5F5; padding: 5px; text-align: center;" | '''Mild''' | |||
| style="background: #DCDCDC; padding: 5px;" | [[Diarrhea]] as the only [[symptom]] | |||
|- | |||
| style="background: #F5F5F5; padding: 5px; text-align: center;" | '''Moderate''' | |||
| style="background: #DCDCDC; padding: 5px;" | Raised white cell count but <15,000 cells/mL and serum creatine <nowiki><1.5 times baseline</nowiki> | |||
|- | |||
| style="background: #F5F5F5; padding: 5px; text-align: center;" | '''Severe''' | |||
| style="background: #DCDCDC; padding: 5px;" | [[Leucocytosis]] <nowiki>>15,000 cells/mL OR serum creatinene level >1.5</nowiki> times baseline or abdominal tenderness and serum albumin < 3 g/dL | |||
|- | |||
| style="background: #F5F5F5; padding: 5px; text-align: center;" | '''Severe complicated''' | |||
| style="background: #DCDCDC; padding: 5px;" | [[Hypotension]] or [[shock]], [[ileus]], [[megacolon]], [[leucocytosis]] >20,000 cells/mL OR [[leucopenia]] <nowiki><2,000, lactate ></nowiki>2.2 mmol/L, [[delirium]], [[fever]] ≥ 38.5 °C, organ failure | |||
|} | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Disease]] | |||
[[Category:Gastroenterology]] | |||
[[Category:Infectious disease]] | |||
[[Category:Bacterial diseases]] | |||
{{WH}} | |||
{{WS}} | |||
Revision as of 17:02, 24 April 2015
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Clostridium difficile Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Clostridium difficile infection classification On the Web |
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American Roentgen Ray Society Images of Clostridium difficile infection classification |
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Risk calculators and risk factors for Clostridium difficile infection classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Yazan Daaboul, M.D.
Overview
C. difficile infection may be classified based on the clinical severity of the disease. The severity of the infection dictates the choice of antimicrobial therapy and the need for surgical consultation/management. Mild disease is defined as isolated diarrhea, whereas severe/complicated disease is defined as either delirium, shock, organ failure, high-grade fever, or marked leukocytosis.
Classification
Shown below is a table that classifies C. difficile infection based on clinical features and lab findings. The severity of the infection dictates the choice of antimicrobial therapy.
| Severity | Criteria |
|---|---|
| Mild | Diarrhea as the only symptom |
| Moderate | Raised white cell count but <15,000 cells/mL and serum creatine <1.5 times baseline |
| Severe | Leucocytosis >15,000 cells/mL OR serum creatinene level >1.5 times baseline or abdominal tenderness and serum albumin < 3 g/dL |
| Severe complicated | Hypotension or shock, ileus, megacolon, leucocytosis >20,000 cells/mL OR leucopenia <2,000, lactate >2.2 mmol/L, delirium, fever ≥ 38.5 °C, organ failure |