Clobutinol

Clobutinol
Clinical data
ATC code	R05DB03 (WHO) ;
Identifiers
	IUPAC name 1-(4-chlorophenyl)-4-dimethylamino-2,3-dimethyl-butan-2-ol;
CAS Number	14860-49-2;
PubChem CID	26937;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C14H22ClNO
Molar mass	255.783 g/mol

Clobutinol is a cough suppressant distributed by Boehringer-Ingelheim, Novartis's Hexal (Sandoz), Stada and possibly other companies.

Side effects and withdrawal

It was recently determined to cause cardiac arrhythmia in some patients.

Recent studies have indicated that clobutinol has the potential to prolong the QT interval.^[1]^[2].

Boehringer Ingelheim products containing clobutinol were withdrawn from sale in Germany, and the rest of the world, on August 31, 2007^[3] ^[4]^[5].

↑ Bellocq C, Wilders R, Schott JJ; et al. (2004). "A common antitussive drug, clobutinol, precipitates the long QT syndrome 2". Mol. Pharmacol. 66 (5): 1093–102. doi:10.1124/mol.104.001065. PMID 15280442.
↑ Expert statement on BfArM website: [1]. Retrieved 2007-SEP-01.
↑ Yahoo! News: Bundesinstitut ruft Hustenmittel zurück [in German]. Retrieved 2007-AUG-31.
↑ tagesschau.de: Bundesinstitut verbietet Hustenmittel Clobutinol [in German]. Retrieved 2007-AUG-31.
↑ Company Website:Boehringer Ingelheim voluntarily withdraws its clobutinol containing medications [English]. Retrieved 2007-Sep-01.

Clinical data

ATC code	R05DB03 (WHO)
Identifiers
IUPAC name 1-(4-chlorophenyl)-4-dimethylamino-2,3-dimethyl-butan-2-ol
CAS Number	14860-49-2
PubChem CID	26937
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₁₄H₂₂ClNO
Molar mass	255.783 g/mol