Chronic stable angina pathophysiology

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2]

Overview

The primary causes of myocardial ischemia are:

  • Fixed flow limiting stenosis,
  • Occlusive spasm and/or dynamic stenosis,
  • Microvascular dysfunction,
  • Non-obstructive thrombosis and
  • Extra coronary cardiac and non-cardiac causes of ischemia

These causes are not mutually exclusive and two or more causes may coexist in the same patient.

The Neural Basis or Mediators of Angina Pectoris

The aforemetnioned causes of myocardial ischemia lead to the activation of the chemo and mechanoreceptors and the release of substances like bradykinin and adenosine which in turn stimulate both sympathetic and vagal afferent fibers. Sympathetic afferent impulses converge with somatic sensory fibers from thoracic structures and travel to the thalamus and frontal cortex. Sympathetic activation is responsible for the perception of referred cardiac pain. Vagal afferent fibers synapse in the medulla and innervate the upper cervical spinothalamic tract, which gives rise to the pain in the neck and jaw.


Myocardial ischemia, whether silent or symptomatic, results from an imbalance between myocardial oxygen demand (consumption) and myocardial oxygen supply.

Angina Due to Increased Myocardial Oxygen Requirements: Demand Angina

Angina precipitated by increased myocardial oxygen requirements is sometimes referred to as demand angina or fixed threshold angina. In demand angina, evidence of increased cardiac oxygen requirements can be suspected in the following situations:

  • The factors mentioned below may trigger the release of norepinephrine, which increases myocardial oxygen requirements:

Demand angina has few dynamic (i.e. vasoconstrictor effects) components, and the amount of physical activity required to precipitate angina remains relatively constant.

Angina Due to Decreased Myocardial Oxygen Supply: Supply Angina

Angina that occurs secondary to a decrease in oxygen supply is sometimes referred to as supply angina or variable threshold angina.

  • Major determinants of myocardial oxygen consumption are:
  • Ventricular wall tension: intraventricular systolic pressure, ventricular volume, and ventricular wall thickness are the major determinants of left ventricular wall tension.
  • Heart rate: All kind of tachycardias and tachyarrhythmias also increase myocardial oxygen consumption and reduce myocardial perfusion by decreasing the duration of diastole. Therefore, reduction of heart rate is associated with a decrease in myocardial oxygen demand and improved left ventricular perfusion.
  • Myocardial contractility: adrenergic stimulation of the heart and tachycardia are the major determinants of contractility.
  • Myocardial oxygen extraction is almost at maximal level at rest and arterial oxygen content is usually stable, but anemia or marked hypoxia is an exception. Therefore, myocardial oxygen supply is mainly determined by coronary blood flow.
  • Coronary blood flow is a function of myocardial perfusion pressure (the difference between the diastolic pressure in aortic root and the right atrium). The duration of diastole has an inverse relation with the coronary vascular resistance. Coronary vascular resistance, in turn, is determined by the severity of epicardial coronary artery stenosis, the changes in epicardial coronary artery tone and by coronary arteriolar resistance; the latter is regulated by metabolic, neural, humoral, and autonomic activity.
  • Increased myocardial oxygen demand occurs during physical exertion. In normal physical conditions, this reduces coronary arteriolar resistance, which causes coronary blood flow to rise (autoregulatory reserve). This autoregulatory reserve progressively diminishes in order and parallel to increased severity of epicardial coronary artery stenosis. When coronary artery stenosis reaches about 90% of the luminal diameter, dilatation in coronary arteriolar bed arises to its maximum level and coronary blood flow becomes more dependent on perfusion pressure. Under these conditions, reduction of arterial pressure may increase in myocardial oxygen demand and induce myocardial ischemia.

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