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==Overview==
==Overview==
[[Chronic renal failure]] causes disturbances in not only the filtration function of the kidney, but also on normal functioning of virtually every organ in the body.
[[Chronic renal failure]] causes disturbances in not only the filtration function of the kidney, but also in the normal functioning of virtually every organ in the body. Symptoms and overt signs of kidney disease are often subtle or absent until renal failure ensues.
Thus, the diagnosis of [[chronic renal failure]] often take the patient by surprise.
==Physical Examination==
===General Appearance===
*Malaise
*In distress


==Signs==
===Vital signs===
{|style="width:80%; height:100px" border="1"
*Hypertension
|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" |                 
*[[Tachycardia]]
|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" | Improves with optimal program of dialysis and related therapy
*Reduced [[pulse pressure]]
|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" | Persists or worsens after optimal program of dialysis and related therapy
*Tachypnea
|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" | Develops only after initiation of dialysis therapy
*[[Hypothermia]]
|-
|-bgcolor="LightSteelBlue"
| '''Fluid and Electrolytes'''
|bgcolor="Beige"| [[Hypervolemia|Volume expansion]], [[Hyponatremia]], [[Hyperkalemia]], [[Hyperphosphatemia]] 
|bgcolor="Beige"|                                                                             
|bgcolor="Beige"|                                                                             
|-
|-bgcolor="LightSteelBlue"
| '''Endocrine-Metabolic disturbances'''
|bgcolor="Beige"| [[Secondary hyperparathyroidism]], Vitamin-D deficient [[osteomalacia]], Carbohydrate resistance, [[Hyperuricemia]], [[Hypertriglyceridemia]], [[Protein-energy malnutrition]], [[Amenorrhea]]
|bgcolor="Beige"| [[Secondary hyperparathyroidism]], [[Hyperuricemia]], [[Hypertriglyceridemia]], Increased [[lipoprotein A]] levels, Decreased [[HDL]] levels, [[Protein-energy malnutrition]], Impaired growth and development, [[Infertility]] and sexual dysfunction, [[Amenorrhea]], [[Beta 2 microglobulin]] associated [[amyloidosis]]
|bgcolor="Beige"| Adynamic bone, [[Beta 2 microglobulin]] associated [[amyloidosis]]
|-
|-bgcolor="LightSteelBlue"
| '''Neuromuscular disturbances'''
|bgcolor="Beige"| [[Fatigue]], Impaired mentation, [[Lethargy]], [[Asterixis]], [[Peripheral neuropathy]], [[Restless leg syndrome]], [[Myoclonus]], [[Seizures]], [[Coma]]
|bgcolor="Beige"| [[Sleep disorders]], [[Headache]], [[Peripheral neuropathy]], [[Restless leg syndrome]], [[Seizures]], [[Muscle cramps]], [[Myopathy]]
|bgcolor="Beige"| [[Muscle cramps]], [[Myopathy]]
|-
|-bgcolor="LightSteelBlue"
| '''Cardiovacsular and Pulmonary'''
|bgcolor="Beige"| [[Systemic hypertension]], [[Congestive heart failure]], [[Pulmonary edema]], [[Pericarditis]], [[Hypertrophic cardiomyopathy]], [[Dilated cardiopathy]], Uremic lung
|bgcolor="Beige"| [[Systemic hypertension]], [[Hypertrophic cardiomyopathy]], [[Dilated cardiomyopathy]], Accelerated [[atherosclerosis]]
|bgcolor="Beige"| [[Hypertrophic cardiomyopathy]], [[Dilated cardiomyopathy]], Accelerated [[atherosclerosis]], [[Hypotension]] and [[arrhythmia]]s
|-
|-bgcolor="LightSteelBlue"
| '''Dermatology'''
|bgcolor="Beige"| [[Pallor]], [[Hyperpigmentation]], [[Ecchymoses]], [[Uremic frost]]
|bgcolor="Beige"| [[Pruritis]], [[Hyperpigmentation]]
|bgcolor="Beige"| [[Hyperpigmentation]], Nephrogenic fibrosing dermopathy
|-
|-bgcolor="LightSteelBlue"
| '''Gastro-intestinal disturbances'''
|bgcolor="Beige"| [[Anorexia]], [[Nausea]] and [[vomiting]], [[Gastroenteritis]], [[Peptic ulcer]], [[Gastrointestinal bleeding]]
|bgcolor="Beige"| [[Peptic ulcer]], [[Gastrointestinal bleeding]]
|bgcolor="Beige"| [[Gastrointestinal bleeding]], Idiopathic [[ascites]], [[Peritonitis]]
|-
|-bgcolor="LightSteelBlue"
| '''Hematologic and immunologic disturbances'''
|bgcolor="Beige"| [[Anemia]], [[Bleeding diathesis]], Increased susceptibility to infections
|bgcolor="Beige"| [[Lymphocytopenia]], Increased susceptibility to infections
|bgcolor="Beige"| [[Bleeding diathesis]], [[Leukopenia]], [[Thrombocytopenia]]
|-
|}


===Skin===
*Uremic fetor (foul smell)
*Uremic frost on the face (deposits of tiny, white, friable, crystalline material)<ref name="pmid20696798">{{cite journal |author=Kuo CC, Hung JB, Tsai CW, Chen YM |title=Uremic frost |journal=[[CMAJ]] |volume=182 |issue=17 |pages=E800 |year=2010 |month=November |pmid=20696798 |pmc=2988568 |doi=10.1503/cmaj.091779 |url=}}</ref> <ref name="pmid16707817">{{cite journal |author=Udayakumar P, Balasubramanian S, Ramalingam KS, Lakshmi C, Srinivas CR, Mathew AC |title=Cutaneous manifestations in patients with chronic renal failure on hemodialysis |journal=[[Indian J Dermatol Venereol Leprol]] |volume=72 |issue=2 |pages=119–25 |year=2006 |pmid=16707817 |doi= |url=http://www.ijdvl.com/article.asp?issn=0378-6323;year=2006;volume=72;issue=2;spage=119;epage=125;aulast=Udayakumar}}</ref>
*Poor skin [[turgor]]
*[[Excoriations]] (scratching)<ref name="pmid17898101">{{cite journal| author=Meyer TW, Hostetter TH| title=Uremia. | journal=N Engl J Med | year= 2007 | volume= 357 | issue= 13 | pages= 1316-25 | pmid=17898101 | doi=10.1056/NEJMra071313 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17898101  }} </ref>
*Localized [[erythema]]
*[[Blister]]s<ref name="pmid17898101">{{cite journal| author=Meyer TW, Hostetter TH| title=Uremia. | journal=N Engl J Med | year= 2007 | volume= 357 | issue= 13 | pages= 1316-25 | pmid=17898101 | doi=10.1056/NEJMra071313 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17898101  }} </ref>
*[[Bruise]]s
*Lindsey's nails (half and half nails), where proximal half of nails is white (edema) and distal half is pink (normal)
===HEENT===
*Abnormal [[fundoscopic exam]] with evidence of [[diabetic retinopathy]] (among diabetic patients) or [[hypertensive retinopathy]] (among hypertensive patients)
*[[xerostomia]] (dry mucus membranes)
===Neck===
*Distended neck veins
*Carotid bruit (atherosclerosis)
===Cardiothoracic===
*Left ventricular [[heave]]
*Fourth heart sound [[Heart sounds#Fourth heart sound S4|S4]] (late diastolic low-pitched sound best heart at the apex in left lateral decubitus position)
*[[Pericardial friction rub]] ([[uremic pericarditis]])
*[[Crackles]] ([[pulmonary edema]])


==References==
==References==

Latest revision as of 15:05, 3 April 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Aarti Narayan, M.B.B.S [2]

Overview

Chronic renal failure causes disturbances in not only the filtration function of the kidney, but also in the normal functioning of virtually every organ in the body. Symptoms and overt signs of kidney disease are often subtle or absent until renal failure ensues. Thus, the diagnosis of chronic renal failure often take the patient by surprise.

Physical Examination

General Appearance

  • Malaise
  • In distress

Vital signs

Skin

  • Uremic fetor (foul smell)
  • Uremic frost on the face (deposits of tiny, white, friable, crystalline material)[1] [2]
  • Poor skin turgor
  • Excoriations (scratching)[3]
  • Localized erythema
  • Blisters[3]
  • Bruises
  • Lindsey's nails (half and half nails), where proximal half of nails is white (edema) and distal half is pink (normal)

HEENT

Neck

  • Distended neck veins
  • Carotid bruit (atherosclerosis)

Cardiothoracic

References

  1. Kuo CC, Hung JB, Tsai CW, Chen YM (2010). "Uremic frost". CMAJ. 182 (17): E800. doi:10.1503/cmaj.091779. PMC 2988568. PMID 20696798. Unknown parameter |month= ignored (help)
  2. Udayakumar P, Balasubramanian S, Ramalingam KS, Lakshmi C, Srinivas CR, Mathew AC (2006). "Cutaneous manifestations in patients with chronic renal failure on hemodialysis". Indian J Dermatol Venereol Leprol. 72 (2): 119–25. PMID 16707817.
  3. 3.0 3.1 Meyer TW, Hostetter TH (2007). "Uremia". N Engl J Med. 357 (13): 1316–25. doi:10.1056/NEJMra071313. PMID 17898101.

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