Difference between revisions of "Chronic pancreatitis"

Jump to: navigation, search
m (Bot: Automated text replacement (-{{SIB}} + & -{{EH}} + & -{{EJ}} + & -{{Editor Help}} + & -{{Editor Join}} +))
Line 1: Line 1:
 +
__NOTOC__
 
{{Infobox_Disease
 
{{Infobox_Disease
 
  | Name          = {{PAGENAME}}
 
  | Name          = {{PAGENAME}}
Line 9: Line 10:
 
  | OMIM          = 167800
 
  | OMIM          = 167800
 
  | MedlinePlus    = 000221
 
  | MedlinePlus    = 000221
  | eMedicineSubj  = med
+
  | eMedicineSubj  =
  | eMedicineTopic = 1721
+
  | eMedicineTopic =
 
  | MeshID        = D050500
 
  | MeshID        = D050500
 
}}
 
}}
 
'''For patient information click [[{{PAGENAME}} (patient information)|here]]'''
 
'''For patient information click [[{{PAGENAME}} (patient information)|here]]'''
  
{{SI}}
+
{{Chronic-pancreatitis}}
 
{{CMG}}
 
{{CMG}}
 
 
  
 
==Overview==
 
==Overview==
Line 116: Line 115:
 
{{Reflist|2}}
 
{{Reflist|2}}
  
== See also ==
+
== Related Chapters ==
  
 
* [[Acute pancreatitis]]
 
* [[Acute pancreatitis]]
 
* [[Exocrine pancreatic insufficiency]]
 
* [[Exocrine pancreatic insufficiency]]
 
==External links==
 
 
* [http://goldminer.arrs.org/search.php?query=chronic%20pancreatitis Goldminer: Chronic pancreatitis]
 
* [http://videos.med.wisc.edu/videoInfo.php?videoid=247 VIDEO - Chronic Pancreatitis: Recent Advances and Ongoing Challenges]
 
* [http://www.surgery.usc.edu/divisions/tumor/PancreasDiseases/web%20pages/PANCREATITIS/what%20is%20chronic%20pancreatit.html Medical Information and Treatment of Chronic Pancreatitis]
 
 
  
 
{{Gastroenterology}}
 
{{Gastroenterology}}

Revision as of 16:59, 5 September 2012

Chronic pancreatitis
Chronic-pancreatitis-006.jpg
Chronic pancreatitis.
Image courtesy of RadsWiki
ICD-10 K86.0-K86.1
ICD-9 577.1
OMIM 167800
DiseasesDB 9559
MedlinePlus 000221
MeSH D050500

For patient information click here

Chronic pancreatitis Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Chronic pancreatitis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

Diagnostic Criteria

History and Symptoms

Physical Examination

Laboratory Findings

Abdominal X Ray

CT

MRI

Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

American Pancreatic Association Practice Guidelines

APA Clinical Practice Guidelines for Chronic pancreatiits

Chronic pancreatitis On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Chronic pancreatitis

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Chronic pancreatitis

CDC on Chronic pancreatitis

Chronic pancreatitis in the news

Blogs on Chronic pancreatitis

Directions to Hospitals Treating Chronic pancreatitis

Risk calculators and risk factors for Chronic pancreatitis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Chronic pancreatitis is a long-standing inflammatory disease of the pancreas characterized by irreversible change to pancreatic structure and function related to inflammation and fibrosis. Pancreatitis presents as a complex of pain and poor quality of life[1] and, as it advances, develops symptoms related to exocrine and endocrine insufficiency, manifesting as malabsorption or diabetes.[2]

Causes

The causes of pancreatitis are many but at least 70% of adult cases are associated with chronic alcohol use, and most patients have consumed more than 80 g/day of alcohol over six to twelve years.[3]

  • Major Associations with Chronic Pancreatitis [4][5][6]
    • Alcohol
      • ≥80 g of ethanol consumption a day for at least 5 years.
    • Autoimmunity
      • Elevated blood levels of IgG4
    • Obstruction
      • Fibrotic stenosis of either the papilla of Vater or the main pancreatic duct
    • Anatomic variations
      • Pancreas divisum, Paraduodenal Pancreatitis (Cystic dystrophy of the duodenal wall/groove pancreatitis)
    • Metabolic
      • Hypercalcemia, Hypertryglyceridemia
    • Genetic
      • CFTR, SPINK1 or PRSS1 gene mutations
    • Idiopathic

Symptoms

Patients with chronic pancreatitis usually present with persistent abdominal pain or steatorrhea resulting from malabsorption of the fats in food (typically very bad-smelling and equally hard on the patient), as well as severe nausea. Diabetes is a common complication due to the chronic pancreatic damage and may require treatment with insulin. Some patients with chronic pancreatitis often look very sick, while others don't appear to be unhealthy at all.

Considerable weight loss, due to malabsorption, is evident in a high percentage of patients, and can continue to be a health problem as the condition progresses. The patient may also complain about pain related to their food intake, especially those meals containing a high percentage of fats and protein.

Diagnosis

The diagnosis of chronic pancreatitis is typically based on tests on pancreatic structure and function, as direct biopsy of the pancreas is considered excessively risky. Serum amylase and lipase may well not be elevated in cases of advanced chronic pancreatitis, but are often used as markers for detecting pancreatic inflammation in acute pancreatitis.

A secretin stimulation test is considered the gold standard functional test for diagnosis of chronic pancreatitis. The observation that bi-carbonate production is impaired early in chronic pancreatitis has led to the rationale of use of this test in early stages of disease (sensitivity of 95%). Other common tests used to determine chronic pancreatitis are faecal elastase measurement in stool, serum trypsinogen, Computed tomography (CT) scans, ultrasounds, EUS, MRI's, ERCP and MRCP's. Pancreatic calcification can often be seen on plain abdominal X-rays, as well as CT scans.

There are other non-specific laboratory studies useful in diagnosis of chronic pancreatitis. Serum bilirubin and alkaline phosphatase can be elevated, indicating stricturing of the common bile duct due to edema, fibrosis or cancer. When the chronic pancreatitis is due to an autoimmune process, elevations in ESR, IgG4, rheumatoid factor, ANA and antismooth muscle antibody may be seen.

The common symptom of chronic pancreatits, steatorrhea, can be diagnosed by two different studies: Sudden staining of feces or fecal fat excretion over 24hr on a 100g fat diet.

To check for pancreatic exocrine dysfunction, the most sensitive and specific test is the measurement of fecal elastase, which can be done with a single stool sample, and a value of less than 200 ug/g indicates pancreatic insufficiency.[7]abdominal pain.

Diagnostic Findings

Computed Tomography

  • Dilatation of the main pancreatic duct
  • Calcifications
  • Changes in pancreatic size, shape, and contour
  • Pancreatic pseudocysts

Patient #1

Images courtesy of RadsWiki

Patient #2

MR and CT demonstrate superior mesenteric vein thrombosis secondary to chronic pancreatitis:

Images courtesy of RadsWiki

Treatment

The different treatment modalities for management of chronic pancreatitis are medical measures, therapeutic endoscopy and surgery.[8] Treatment is directed, when possible, to the underlying cause, and to relief of the pain and malabsorption. Diabetes may occur and need long term insulin therapy. (Type 1 diabetes)

The abdominal pain can be very severe and require high doses of analgesics. Disability and mood problems are common, although early diagnosis and support can make these problems manageable.

Pancreatic Enzyme Supplementation

Replacement pancreatic enzymes are often effective in treating the malabsorption and steatorrhea. However, the outcome from 6 randomized trials has been inconclusive regarding pain reduction.[9]

While the outcome of trials regarding pain reduction with pancreatic enzyme replacement is inconclusive, some patients do have pain reduction with enzyme replacement and since they are relatively safe, giving enzyme replacement to a chronic pancreatitis patient is an acceptable step in treatment for most patients. Treatment may be more likely to be successful in those without involvement of large ducts and those with idiopathic pancreatitis. Patients with alcoholic pancreatitis may be less likely to respond. [7]

Surgery

Surgery for Chronic Pancreatitis tends to be divided into two areas - resectional and drainage procedures.[10]

References

  1. Pezilli et al. Pancreatectomy for Pancreatic Disease and Quality of Life. JOP. J Pancreas (Online) 2007; 8(1 Suppl.):118-131.
  2. Ammann RW. A clinically based classification system for alcoholic chronic pancreatitis: summary of an international workshop on chronic pancreatitis. Pancreas 1997; 14: 215–21.
  3. Nair RJ, Lawler L, Miller MR (2007). "Chronic pancreatitis". Am Fam Physician. 76 (11): 1679–88. PMID 18092710.
  4. Mitchell RMS et al. Pancreatitis. Lancet 2003; 361: 1447–55
  5. Frulloni et al. Chronic pancreatitis: Report from a multicenter Italian survey (PanCroInfAISP) on 893 patients. Dig Liver Dis. 2009 Apr;41(4):311-7
  6. Adsay NV et al. Paraduodenal pancreatitis: a clinico-pathologically distinct entity unifying "cystic dystrophy of heterotopic pancreas", "para-duodenal wall cyst", and "groove pancreatitis". Semin Diagn Pathol. 2004 Nov;21(4):247-54.
  7. 7.0 7.1 Freedman SD. "Clinical manifestations and diagnosis of chronic pancreatitis in adults". UpToDate.
  8. American Gastroenterological Association Medical Position Statement (1998). "American Gastroenterological Association Medical Position Statement: treatment of pain in chronic pancreatitis". Gastroenterology. 115 (3): 763–4. PMID 9721174.
  9. Warshaw AL, Banks PA, Fernández-Del Castillo C (1998). "AGA technical review: treatment of pain in chronic pancreatitis". Gastroenterology. 115 (3): 765–76. doi:10.1016/S0016-5085(98)70157-X. PMID 9721175.
  10. Society for Surgery of the Alimentary Tract (SSAT) (2004). "Operative treatment for chronic pancreatitis". Retrieved 2007-06-09.

Related Chapters

it:Pancreatite cronica fi:Krooninen haimatulehdus




Linked-in.jpg