Cholangitis laboratory findings: Difference between revisions

Jump to navigation Jump to search
m (Bot: Removing from Primary care)
 
(14 intermediate revisions by 6 users not shown)
Line 3: Line 3:
{{CMG}}; {{AE}} {{FH}}
{{CMG}}; {{AE}} {{FH}}
==Overview==
==Overview==
Laboratory tests provide useful clues in the diagnosis of [[cholangitis]]. Some commonly conducted tests are [[complete blood count]], [[basic metabolic panel]], [[liver function tests]], [[blood culture]], and other body fluid culture.
Certain laboratory tests may be helpful in the [[diagnosis]] of [[cholangitis]]. Some commonly conducted tests include [[complete blood count]], [[basic metabolic panel]], [[liver function tests]], [[blood culture]], and other body fluid cultures.


==Laboratory Findings==
==Laboratory Findings==
Laboratory test findings typically associated with cholangitis include:<ref name="book12">{{Citation
Laboratory findings typically associated with cholangitis include:<ref name="book12">{{Citation
| last1  = Liu
| last1  = Liu
| first1 = Chi-Leung.  
| first1 = Chi-Leung.  
Line 26: Line 26:
| place    = Philadelphia, PA  
| place    = Philadelphia, PA  
| year    = 2014
| year    = 2014
}}</ref>  
}}</ref>
*Neutrophilic [[leucocytosis]]
*Cultures should be obtained from [[bile]] aspirated through percutaneous biliary catheters, obtained during biliary drainage, or from indwelling biliary [[prostheses]].
*[[Blood cultures]]


===Cholestatic Pattern of Liver Function Tests===
==== Complete blood count (CBC): ====
Cholestatic patterns of liver function tests can indicate:<ref name="book12">{{Citation
*[[Neutrophilia|Neutrophilic]] [[leukocytosis]]
 
==== Liver function tests (LFTs): ====
Cholestatic patterns of [[liver function tests]] may be remarkable for:<ref name="book12">{{Citation
| last1  = Liu
| last1  = Liu
| first1 = Chi-Leung.  
| first1 = Chi-Leung.  
Line 42: Line 42:
| place    = Munich, Germany  
| place    = Munich, Germany  
| year    = 2001
| year    = 2001
}}</ref><ref name="pmid22086533">{{cite journal |vauthors=Andraus W, Haddad L, Nacif LS, Silva FD, Blasbalg R, D'Albuquerque LA |title=The best approach for diagnosing primary sclerosing cholangitis |journal=Clinics (Sao Paulo) |volume=66 |issue=11 |pages=1987–9 |year=2011 |pmid=22086533 |pmc=3203975 |doi= |url=}}</ref><ref name="pmid11148988">{{cite journal |vauthors=Björnsson ES, Kilander AF, Olsson RG |title=Bile duct bacterial isolates in primary sclerosing cholangitis and certain other forms of cholestasis--a study of bile cultures from ERCP |journal=Hepatogastroenterology |volume=47 |issue=36 |pages=1504–8 |year=2000 |pmid=11148988 |doi= |url=}}</ref>   
}}</ref><ref name="pmid22086533">{{cite journal |vauthors=Andraus W, Haddad L, Nacif LS, Silva FD, Blasbalg R, D'Albuquerque LA |title=The best approach for diagnosing primary sclerosing cholangitis |journal=Clinics (Sao Paulo) |volume=66 |issue=11 |pages=1987–9 |year=2011 |pmid=22086533 |pmc=3203975 |doi= |url=}}</ref><ref name="pmid11148988">{{cite journal |vauthors=Björnsson ES, Kilander AF, Olsson RG |title=Bile duct bacterial isolates in primary sclerosing cholangitis and certain other forms of cholestasis--a study of bile cultures from ERCP |journal=Hepatogastroenterology |volume=47 |issue=36 |pages=1504–8 |year=2000 |pmid=11148988 |doi= |url=}}</ref><ref name="pmid17252297">{{cite journal |vauthors=Wada K, Takada T, Kawarada Y, Nimura Y, Miura F, Yoshida M, Mayumi T, Strasberg S, Pitt HA, Gadacz TR, Büchler MW, Belghiti J, de Santibanes E, Gouma DJ, Neuhaus H, Dervenis C, Fan ST, Chen MF, Ker CG, Bornman PC, Hilvano SC, Kim SW, Liau KH, Kim MH |title=Diagnostic criteria and severity assessment of acute cholangitis: Tokyo Guidelines |journal=J Hepatobiliary Pancreat Surg |volume=14 |issue=1 |pages=52–8 |year=2007 |pmid=17252297 |pmc=2784515 |doi=10.1007/s00534-006-1156-7 |url=}}</ref>   
*Elevated serum [[alkaline phosphatase]]
*Elevated serum [[alkaline phosphatase]] ([[ALP]])
*Elevated gammaglutamyl transpeptidase (GGT)
*Elevated [[gamma-glutamyl transpeptidase]] ([[GGT]])
*Elevated conjugated (direct) [[bilirubin]]
*Elevated conjugated (direct) [[bilirubin]] (predominantly incase of obstruction)
*Elevated serum [[amylase]]
*Elevated serum [[amylase]] (7%)
**Levels may be as high as 3-4 times of normal, representing [[pancreatitis]].
**Levels may be as high as 3-4 times of normal, representing [[pancreatitis]].
*Culture from bile obtained during [[ERCP]] ([[endoscopic retrograde cholangiopancreatography]])
*Culture from [[bile]] obtained during [[ERCP]] ([[endoscopic retrograde cholangiopancreatography]])
*Elevated [[aminotransferases]] (as high as 1000 IU/L) reflecting [[hepatocytes]] injury and microabscess formation.
*Elevated [[aminotransferases]] (as high as 1000 IU/L), reflecting [[hepatocytes]] injury and microabscess formation
**Liver abscess is indicated in such cases.
**Liver abscess may be suspected in such cases.
*Liver enzyme abnormalities suggestive of [[cholestasis]]<ref name="book123">{{Citation
*Liver enzyme abnormalities suggestive of [[cholestasis]]<ref name="book123">{{Citation
| last1  = Cameron  
| last1  = Cameron  
Line 63: Line 63:
}}</ref>
}}</ref>


==== Blood cultures: ====
*Cultures are obtained from [[bile]] aspirated through percutaneous biliary catheters, obtained during biliary drainage, or from indwelling biliary [[prostheses]].
==References==
==References==
{{Reflist|2}}
{{Reflist|2}}


[[Category:Disease]]
{{WikiDoc Help Menu}}
{{WikiDoc Sources}}
 
[[Category:Gastroenterology]]
[[Category:Gastroenterology]]
[[Category:Emergency medicine]]
[[Category:Emergency medicine]]
 
[[Category:FinalQCRequired]]
{{WikiDoc Help Menu}}
[[Category:Disease]]
{{WikiDoc Sources}}
[[Category:Up-To-Date]]
[[Category:Infectious disease]]
[[Category:Surgery]]

Latest revision as of 20:55, 29 July 2020

Cholangitis Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Cholangitis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

Diagnostic Criteria

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X Ray

CT

MRI

Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Cholangitis laboratory findings On the Web

Most recent articles

cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Cholangitis laboratory findings

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Cholangitis laboratory findings

CDC on Cholangitis laboratory findings

Cholangitis laboratory findings in the news

Blogs on Cholangitis laboratory findings

Directions to Hospitals Treating Cholangitis

Risk calculators and risk factors for Cholangitis laboratory findings

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Farwa Haideri [2]

Overview

Certain laboratory tests may be helpful in the diagnosis of cholangitis. Some commonly conducted tests include complete blood count, basic metabolic panel, liver function tests, blood culture, and other body fluid cultures.

Laboratory Findings

Laboratory findings typically associated with cholangitis include:[1][2]

Complete blood count (CBC):

Liver function tests (LFTs):

Cholestatic patterns of liver function tests may be remarkable for:[1][3][4][5]

Blood cultures:

  • Cultures are obtained from bile aspirated through percutaneous biliary catheters, obtained during biliary drainage, or from indwelling biliary prostheses.

References

  1. 1.0 1.1 Liu, Chi-Leung. & Fan, Sheung-Tat. (2001), Surgical Treatment: Evidence-Based and Problem-Oriented., Munich, Germany: Zuckschwerdt Verlag
  2. 2.0 2.1 Cameron, John L. & Cameron, Andrew M. (2014), Current Surgical Therapy: Expert Consult, Philadelphia, PA: Elsevier, Inc.
  3. Andraus W, Haddad L, Nacif LS, Silva FD, Blasbalg R, D'Albuquerque LA (2011). "The best approach for diagnosing primary sclerosing cholangitis". Clinics (Sao Paulo). 66 (11): 1987–9. PMC 3203975. PMID 22086533.
  4. Björnsson ES, Kilander AF, Olsson RG (2000). "Bile duct bacterial isolates in primary sclerosing cholangitis and certain other forms of cholestasis--a study of bile cultures from ERCP". Hepatogastroenterology. 47 (36): 1504–8. PMID 11148988.
  5. Wada K, Takada T, Kawarada Y, Nimura Y, Miura F, Yoshida M, Mayumi T, Strasberg S, Pitt HA, Gadacz TR, Büchler MW, Belghiti J, de Santibanes E, Gouma DJ, Neuhaus H, Dervenis C, Fan ST, Chen MF, Ker CG, Bornman PC, Hilvano SC, Kim SW, Liau KH, Kim MH (2007). "Diagnostic criteria and severity assessment of acute cholangitis: Tokyo Guidelines". J Hepatobiliary Pancreat Surg. 14 (1): 52–8. doi:10.1007/s00534-006-1156-7. PMC 2784515. PMID 17252297.


Template:WikiDoc Sources