Chlorhexidine gluconate

Chlorhexidine gluconate
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Kiran Singh, M.D. [2]

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Overview

Chlorhexidine gluconate is an antibacterial that is FDA approved for the treatment of gingivitis, periodontitis, skin cleansing procedure. Common adverse reactions include staining of the teeth and other oral surfaces, calculus formation, an alteration in taste perception.

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Indication

• Treatment of gingivitis as characterized by redness and swelling of the gingivae, including gingival bleeding upon probing.

Dosage

• Recommended use is twice daily, oral rinsing 30 seconds, morning and evening after toothbrushing.

• Usual dosage is 15 mL of undiluted Paroex®.

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

Condition1

• Developed by:

• Class of Recommendation:

• Strength of Evidence:

• Dosing Information

• Dosage

Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Chlorhexidine gluconate in adult patients.

Non–Guideline-Supported Use

Condition1

• Dosing Information

• Dosage

Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Chlorhexidine gluconate in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

Condition1

• Dosing Information

• Dosage

Condition2

There is limited information regarding FDA-Labeled Use of Chlorhexidine gluconate in pediatric patients.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

Condition1

• Developed by:

• Class of Recommendation:

• Strength of Evidence:

• Dosing Information

• Dosage

Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Chlorhexidine gluconate in pediatric patients.

Non–Guideline-Supported Use

Condition1

• Dosing Information

• Dosage

Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Chlorhexidine gluconate in pediatric patients.

Contraindications

• Condition1

Warnings

• Description

Precautions

• Description

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Clinical Trial Experience of Chlorhexidine gluconate in the drug label.

Body as a Whole

Cardiovascular

Digestive

Endocrine

Hematologic and Lymphatic

Metabolic and Nutritional

Musculoskeletal

Neurologic

Respiratory

Skin and Hypersensitivy Reactions

Special Senses

Urogenital

Miscellaneous

Postmarketing Experience

There is limited information regarding Postmarketing Experience of Chlorhexidine gluconate in the drug label.

Body as a Whole

Cardiovascular

Digestive

Endocrine

Hematologic and Lymphatic

Metabolic and Nutritional

Musculoskeletal

Neurologic

Respiratory

Skin and Hypersensitivy Reactions

Special Senses

Urogenital

Miscellaneous

Drug Interactions

• Drug

• Description

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA):

• Pregnancy Category

Pregnancy Category (AUS):

• Australian Drug Evaluation Committee (ADEC) Pregnancy Category

There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Chlorhexidine gluconate in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Chlorhexidine gluconate during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Chlorhexidine gluconate with respect to nursing mothers.

Pediatric Use

There is no FDA guidance on the use of Chlorhexidine gluconate with respect to pediatric patients.

Geriatic Use

There is no FDA guidance on the use of Chlorhexidine gluconate with respect to geriatric patients.

Gender

There is no FDA guidance on the use of Chlorhexidine gluconate with respect to specific gender populations.

Race

There is no FDA guidance on the use of Chlorhexidine gluconate with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Chlorhexidine gluconate in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Chlorhexidine gluconate in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Chlorhexidine gluconate in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Chlorhexidine gluconate in patients who are immunocompromised.

Administration and Monitoring

Administration

• Oral

• Intravenous

Monitoring

There is limited information regarding Monitoring of Chlorhexidine gluconate in the drug label.

• Description

IV Compatibility

There is limited information regarding IV Compatibility of Chlorhexidine gluconate in the drug label.

Overdosage

Acute Overdose

Signs and Symptoms

• Description

Management

• Description

Chronic Overdose

There is limited information regarding Chronic Overdose of Chlorhexidine gluconate in the drug label.

Pharmacology

There is limited information regarding Chlorhexidine gluconate Pharmacology in the drug label.

Mechanism of Action

Structure

File:Chlorhexidine gluconate01.png

This image is provided by the National Library of Medicine.

Pharmacodynamics

There is limited information regarding Pharmacodynamics of Chlorhexidine gluconate in the drug label.

Pharmacokinetics

There is limited information regarding Pharmacokinetics of Chlorhexidine gluconate in the drug label.

Nonclinical Toxicology

There is limited information regarding Nonclinical Toxicology of Chlorhexidine gluconate in the drug label.

Clinical Studies

There is limited information regarding Clinical Studies of Chlorhexidine gluconate in the drug label.

How Supplied

Storage

There is limited information regarding Chlorhexidine gluconate Storage in the drug label.

Images

Drug Images

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Package and Label Display Panel

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Patient Counseling Information

• Patients should be instructed not to rinse with water, or other mouthwashes, brush teeth, or eat immediately after using Paroex®.

• Paroex® is not intended for ingestion and should be expectorated after rinsing.

Precautions with Alcohol

• Alcohol-Chlorhexidine gluconate interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

• ®

Look-Alike Drug Names

• A® — B®

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

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