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'''==[[Chancroid overview|Overview]]==


==[[Chancroid historical perspective|Historical Perspective]]==


'''Chancroid''' is a [[sexually transmitted infection]] characterized by painful sores on the genitalia. Chancroid is known to be spread from one to another individual through sexual contact.
==[[Chancroid classification|Classification]]==


==Causes==
==[[Chancroid pathophysiology|Pathophysiology]]==


Chancroid is a [[bacterium|bacteria]]l [[infection]] caused by the [[Growth medium|fastidious]] [[Gram-negative]] streptobacillus ''[[Haemophilus ducreyi]]''. It is a disease found primarily in developing countries, associated with commercial sex workers and their clientele.
==[[Chancroid causes|Causes]]==


Infection levels are low in the western world, typically around one case per two million of the population (Canada, France, UK and USA). Most individuals diagnosed with chancroid have visited countries or areas where the disease is known to occur frequently, although outbreaks have been observed in association with crack cocaine use and prostitution.
==[[Chancroid differential diagnosis|Differentiating Chancroid from other Diseases]]==


Uncircumcised men are at three times greater risk than [[circumcise]]d men for contracting chancroid from an infected partner. Chancroid is a risk factor for contracting [[HIV]], due to their ecological association or shared risk of exposure, and biologically facilitated transmission of one infection by the other.
==[[Chancroid epidemiology and demographics|Epidemiology and Demographics]]==


==Symptoms and signs==  
==[[Chancroid risk factors|Risk Factors]]==
After an incubation period of one day to two weeks, chancroid begins with a small bump that becomes an ulcer within a day of its appearance. The ulcer characteristically:


*Ranges in size dramatically from 3 to 50 mm (1/8 inch to two inches) across
==[[Chancroid screening|Screening]]==
*Is painful
*Has sharply defined, undermined borders
*Has irregular or ragged borders
*Has a base that is covered with a gray or yellowish-gray material
*Has a base that bleeds easily if traumatized or scraped


More specifically, the CDC's standard clinical definition for a probable case of chancroid includes all of the following:
==[[Chancroid natural history, complications and prognosis|Natural History, Complications and Prognosis]]==


*Patient has one or more painful genital ulcers. The combination of a painful ulcer with tender adenopathy is suggestive of chancroid; the presence of suppurative adenopathy is almost pathognomonic.
==Diagnosis==


*No evidence of ''[[Treponema pallidum]]'' is indicated by dark-field examination of ulcer or by a serologic test for [[Syphilis]] performed at least 7 days after the onset of ulcer.
[[Chancroid diagnostic criteria|Diagnostic Criteria]] | [[Chancroid history and symptoms|History and Symptoms]] | [[Chancroid physical examination|Physical Examination]] | [[Chancroid laboratory findings|Laboratory Findings]] | [[Chancroid electrocardiogram|EKG]] | [[Chancroid CT|CT]] | [[Chancroid MRI|MRI]] | [[Chancroid echocardiography or ultrasound|Echocardiography or Ultrasound]] | [[Chancroid other imaging findings|Other Imaging Findings]] | [[Chancroid other diagnostic studies|Other Diagnostic Studies]]
 
*The clinical presentation is not typical of disease caused by [[human herpesvirus 2]] ([[Herpes Simplex Virus]]), or result of culture for HSV is negative.
 
About half of infected men have only a single ulcer. Women frequently have four or more ulcers, with fewer symptoms. The ulcers appear in specific locations, such as the coronal sulcus of the uncircumcised glans penis in men, or the fourchette and labia minora in women.
 
==Common locations in men (from most common to least common)==
*[[Foreskin]] (prepuce) (most common)
*Groove behind the head of the penis ([[coronal sulcus]])
*Shaft of the penis
*Head of the penis ([[glans penis]])
*Opening of the penis (urethral meatus)
*[[Scrotum]] (least common)
 
==Common locations in women==
In women the most common location for ulcers is the [[labia majora]]. "Kissing ulcers" may develop. These are ulcers that occur on opposing surfaces of the labia. Other areas such as the [[labia minora]], [[perineum|perineal]] area, and inner thighs may also be involved. The most common symptoms in women are pain with urination and pain with intercourse.
 
The initial ulcer may be mistaken as a "hard" [[chancre]], the typical sore of primary [[syphilis]], as opposed to the "soft chancre" of chancroid.
 
Approximately one third of the infected individuals will develop enlargements of the [[inguinal]] [[lymph nodes]], the nodes located in the fold between the leg and the lower abdomen.
 
Half of those who develop swelling of the inguinal lymph nodes will progress to a point where the nodes rupture through the skin producing draining abscesses. The swollen lymph nodes and abscesses are often referred to as buboes.


==Treatment==
==Treatment==


The [[Centers for Disease Control and Prevention|CDC]] recommendation for chancroid is a single oral dose of [[Azythromicin]] or a single IM dose of [[Ceftriaxone]] or oral [[Erythromycin]] for seven days.
[[Chancroid medical therapy|Medical Therapy]] | [[Chancroid surgery|Surgery]] | [[Chancroid primary prevention|Primary Prevention]] | [[Chancroid secondary prevention|Secondary Prevention]] | [[Chancroid cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Chancroid future or investigational therapies|Future or Investigational Therapies]]


==External links==
==Case Studies==
[[Chancroid case study one|Case #1]]
'''==External links==
*[http://today.reuters.com/news/newsArticle.aspx?type=healthNews&storyID=2006-05-12T224644Z_01_DIS281852_RTRUKOC_0_US-CHANCROID-VACCINE.xml Chancroid vaccine promising in pigs] in Reuters Health  
*[http://today.reuters.com/news/newsArticle.aspx?type=healthNews&storyID=2006-05-12T224644Z_01_DIS281852_RTRUKOC_0_US-CHANCROID-VACCINE.xml Chancroid vaccine promising in pigs] in Reuters Health  


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Revision as of 20:58, 1 October 2012

Chancroid
Photomicrograph of H. ducreyi
ICD-10 A57
ICD-9 099.0
DiseasesDB 5563
MedlinePlus 000635
eMedicine [http://www.emedicine.com/eMedicineTopic =
 MeshID         = D002602/topic{{{eMedicineTopic}}}.htm eMedicineTopic =
 MeshID         = D002602/{{{eMedicineTopic}}}] 

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calculators and risk factors for Chancroid

==Overview==

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Chancroid from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Criteria | History and Symptoms | Physical Examination | Laboratory Findings | EKG | CT | MRI | Echocardiography or Ultrasound | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case #1 ==External links==


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