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{{Cervicitis}}
{{Cervicitis}}
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==Overview==
==Overview==
*Because cervicitis might be a sign of upper-genital–tract infection ([[endometritis]]), women who seek medical treatment for a new episode of cervicitis should be assessed for signs of PID and should be tested for C. trachomatis and for [[N. gonorrhoeae]] with the most sensitive and specific test available.  
Diagnosis of cervicitis is mostly clinical however, a finding of >10 [[WBC]] in vaginal fluid, in the absence of [[trichomoniasis]], may indicate [[endocervical]] [[inflammation]] caused specifically by [[C. trachomatis]] or [[N. gonorrhea]] although culture is more accurate for [[gonococcal]] cervicitis.<ref name="pmid6896368">{{cite journal| author=McLellan R, Spence MR, Brockman M, Raffel L, Smith JL| title=The clinical diagnosis of trichomoniasis. | journal=Obstet Gynecol | year= 1982 | volume= 60 | issue= 1 | pages= 30-4 | pmid=6896368 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6896368  }} </ref>
*Women with cervicitis also should be evaluated for the presence of BV and [[trichomoniasis]], and if these organisms are detected, they should be treated.
The use of nucleic acid amplification tests is very helpful for the diagnosis of trichomoniasis.<ref name="pmid26042815">{{cite journal| author=Workowski KA, Bolan GA, Centers for Disease Control and Prevention| title=Sexually transmitted diseases treatment guidelines, 2015. | journal=MMWR Recomm Rep | year= 2015 | volume= 64 | issue= RR-03 | pages= 1-137 | pmid=26042815 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26042815  }} </ref>
*Because the sensitivity of microscopy to detect T. vaginalis is relatively low (approximately 50%), symptomatic women with cervicitis and negative microscopy for trichomonads should receive further testing (i.e., culture or other FDA-cleared method).
Wet mount microscopy and direct visualisation have low sensitivity in detecting N. gonorrhea and T. vaginalis, because of this symptomatic women with cervicitis and negative microscopy should receive further testing (i.e., culture or other FDA-cleared method). Although [[HSV]]-2 infection has been associated with cervicitis, the utility of specific testing (i.e., culture or serologic testing) for [[HSV]]-2 is unknown. DNA amplification techniques has good sensitivity, but are not yet approved for diagnostic purposes of [[Trichomoniasis]].<ref name="pmid15054166">{{cite journal| author=Swygard H, Seña AC, Hobbs MM, Cohen MS| title=Trichomoniasis: clinical manifestations, diagnosis and management. | journal=Sex Transm Infect | year= 2004 | volume= 80 | issue= 2 | pages= 91-5 | pmid=15054166 | doi= | pmc=1744792 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15054166  }} </ref>
*Although HSV-2 infection has been associated with cervicitis, the utility of specific testing (i.e., culture or serologic testing) for HSV-2 in this setting is unknown. Standardized diagnostic tests for M. genitalium are not commercially available.<br>
Microscopy (wet prep) and vaginal pH are useful for identifying [[bacterial vaginosis]] which may show clue cells.<ref name="pmid20221621">{{cite journal| author=Storti-Filho A, Souza PC, Souza RJ, Pereira MW, Mello IC, Svidizinski TI et al.| title=Prevalence of clue cells suggestive for Gardnerella vaginalis in population-based cervical screening in the public versus private health care in Maringá, Paraná, Brazil. | journal=Arch Gynecol Obstet | year= 2011 | volume= 283 | issue= 4 | pages= 781-5 | pmid=20221621 | doi=10.1007/s00404-010-1400-x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20221621  }} </ref>
*NAAT should be used for diagnosing[[C. trachomatis]] and N. gonorrhoeae in women with cervicitis; this testing can be performed on either vaginal, cervical, or urine samples (197). A finding of >10 WBC in vaginal fluid, in the absence of trichomoniasis, might indicate endocervical inflammation caused specifically by C. trachomatis or N. gonorrhoeae (264,265).


==Laboratory Findings==
==Laboratory Findings==
Diagnosis of cervicitis is mostly clinical however, some laboratory findings consistent with cervicitis include :
* A finding of >10 [[WBC]] in vaginal fluid, in the absence of [[trichomoniasis]], may indicate [[endocervical]] [[inflammation]] caused specifically by [[C. trachomatis]] or [[N. gonorrhea]], however, culture is more accurate for [[gonococcal]] cervicitis.<ref name="pmid6896368">{{cite journal| author=McLellan R, Spence MR, Brockman M, Raffel L, Smith JL| title=The clinical diagnosis of trichomoniasis. | journal=Obstet Gynecol | year= 1982 | volume= 60 | issue= 1 | pages= 30-4 | pmid=6896368 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6896368  }} </ref>
 
*The use of nucleic acid amplification tests for the diagnosis of trichomoniasis.<ref name="pmid26042815">{{cite journal| author=Workowski KA, Bolan GA, Centers for Disease Control and Prevention| title=Sexually transmitted diseases treatment guidelines, 2015. | journal=MMWR Recomm Rep | year= 2015 | volume= 64 | issue= RR-03 | pages= 1-137 | pmid=26042815 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26042815  }} </ref>
*Wet mount microscopy and direct visualisation have low sensitivity in detecting N. gonorrhea and T. vaginalis, because of this symptomatic women with cervicitis and negative microscopy should receive further testing (i.e., culture or other FDA-cleared method).
*Although [[HSV]]-2 infection has been associated with cervicitis, the utility of specific testing (i.e., culture or serologic testing) for [[HSV]]-2 is unknown.
*DNA amplification techniques has good sensitivity, but are not yet approved for diagnostic purposes of [[Trichomoniasis]]<ref name="pmid15054166">{{cite journal| author=Swygard H, Seña AC, Hobbs MM, Cohen MS| title=Trichomoniasis: clinical manifestations, diagnosis and management. | journal=Sex Transm Infect | year= 2004 | volume= 80 | issue= 2 | pages= 91-5 | pmid=15054166 | doi= | pmc=1744792 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15054166  }} </ref>
*Microscopy (wet prep) and vaginal pH are useful for identifying [[bacterial vaginosis]] which may show clue cells.<ref name="pmid20221621">{{cite journal| author=Storti-Filho A, Souza PC, Souza RJ, Pereira MW, Mello IC, Svidizinski TI et al.| title=Prevalence of clue cells suggestive for Gardnerella vaginalis in population-based cervical screening in the public versus private health care in Maringá, Paraná, Brazil. | journal=Arch Gynecol Obstet | year= 2011 | volume= 283 | issue= 4 | pages= 781-5 | pmid=20221621 | doi=10.1007/s00404-010-1400-x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20221621  }} </ref>


==References==
==References==
{{Reflist|2}}
{{Reflist|2}}
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Latest revision as of 20:52, 29 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Prince Tano Djan, BSc, MBChB [2]

Overview

Diagnosis of cervicitis is mostly clinical however, a finding of >10 WBC in vaginal fluid, in the absence of trichomoniasis, may indicate endocervical inflammation caused specifically by C. trachomatis or N. gonorrhea although culture is more accurate for gonococcal cervicitis.[1] The use of nucleic acid amplification tests is very helpful for the diagnosis of trichomoniasis.[2] Wet mount microscopy and direct visualisation have low sensitivity in detecting N. gonorrhea and T. vaginalis, because of this symptomatic women with cervicitis and negative microscopy should receive further testing (i.e., culture or other FDA-cleared method). Although HSV-2 infection has been associated with cervicitis, the utility of specific testing (i.e., culture or serologic testing) for HSV-2 is unknown. DNA amplification techniques has good sensitivity, but are not yet approved for diagnostic purposes of Trichomoniasis.[3] Microscopy (wet prep) and vaginal pH are useful for identifying bacterial vaginosis which may show clue cells.[4]

Laboratory Findings

Diagnosis of cervicitis is mostly clinical however, some laboratory findings consistent with cervicitis include :

  • The use of nucleic acid amplification tests for the diagnosis of trichomoniasis.[2]
  • Wet mount microscopy and direct visualisation have low sensitivity in detecting N. gonorrhea and T. vaginalis, because of this symptomatic women with cervicitis and negative microscopy should receive further testing (i.e., culture or other FDA-cleared method).
  • Although HSV-2 infection has been associated with cervicitis, the utility of specific testing (i.e., culture or serologic testing) for HSV-2 is unknown.
  • DNA amplification techniques has good sensitivity, but are not yet approved for diagnostic purposes of Trichomoniasis[3]
  • Microscopy (wet prep) and vaginal pH are useful for identifying bacterial vaginosis which may show clue cells.[4]

References

  1. 1.0 1.1 McLellan R, Spence MR, Brockman M, Raffel L, Smith JL (1982). "The clinical diagnosis of trichomoniasis". Obstet Gynecol. 60 (1): 30–4. PMID 6896368.
  2. 2.0 2.1 Workowski KA, Bolan GA, Centers for Disease Control and Prevention (2015). "Sexually transmitted diseases treatment guidelines, 2015". MMWR Recomm Rep. 64 (RR-03): 1–137. PMID 26042815.
  3. 3.0 3.1 Swygard H, Seña AC, Hobbs MM, Cohen MS (2004). "Trichomoniasis: clinical manifestations, diagnosis and management". Sex Transm Infect. 80 (2): 91–5. PMC 1744792. PMID 15054166.
  4. 4.0 4.1 Storti-Filho A, Souza PC, Souza RJ, Pereira MW, Mello IC, Svidizinski TI; et al. (2011). "Prevalence of clue cells suggestive for Gardnerella vaginalis in population-based cervical screening in the public versus private health care in Maringá, Paraná, Brazil". Arch Gynecol Obstet. 283 (4): 781–5. doi:10.1007/s00404-010-1400-x. PMID 20221621.


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