Cerebral venous sinus thrombosis causes

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There are more than 100 different causes of cerebral venous sinus thrombosis (CVT). Virchow's principles (blood stasis, modification of vascular wall, and blood rheology) should be used to identify all the predisposing conditions for CVT. There are also some genetic and acquired causes leading to CVT. In the cohort of an International study of cerebral vein and dural sinus thrombosis(ISCVT), 34% of patients had thrombophilia while 22% of them had acquired thrombophilia.


Genetic prothrombotic causes:

- Antithrombin deficiency

- Protein C and S deficiency

- Factor v Leiden mutation

- Resistance to activated protein C

- prothrombin mutation (A–G at position 20210)

- mutations leading to homocysteinemia

- methylenetetrahydrofolate reductase (MTHFR)

Acquired Prothrombotic States

- pregnancy

- puerperium

- homocysteinemia

- antiphospholipid antibody

- nephrotic syndrome

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