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'''For patient information, click [[Cerebral aneurysm (patient information)|here]]'''
{{Infobox_Disease
{{Infobox_Disease
  | Name          = Cerebral aneurysm
  | Name          = Cerebral aneurysm
  | Image          = Cerebral aneurysm 2.jpeg
  | Image          = Cerebral aneurysm 2.jpeg
  | Caption        = Brain: Berry Aneurysm: Gross, natural color, close-up, an excellent view of typical berry aneurysm located on anterior cerebral artery <br> <small> [http://www.peir.net Image courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology] </small>
  | Caption        = Brain: Berry Aneurysm: Gross, natural color, close-up, an excellent view of typical berry aneurysm located on anterior cerebral artery <br> <small> [http://www.peir.net Image courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology] </small>
| DiseasesDB    = 1358
| ICD10          = {{ICD10|I|67|1|i|60}}
| ICD9          = {{ICD9|437.3}}
| ICDO          =
| OMIM          =
| MedlinePlus    = 001414
| MeshID        = D002532
}}
}}
{{SI}}
{{CMG}}; '''Associate Editor-In-Chief:''' {{CZ}}; {{KD}}


==Overview==
{{Cerebral aneurysm}}
A '''cerebral aneurysm''' or '''brain aneurysm''' is a [[cerebrovascular disease|cerebrovascular]] disorder in which weakness in the wall of a [[brain|cerebral]] [[artery]] or [[vein]] causes a localized [[vasodilation|dilation]] or ballooning of the blood vessel.
'''For patient information, click [[Cerebral aneurysm (patient information)|here]]'''


A common location of cerebral aneurysms is on the arteries at the base of the [[brain]], known as the [[Circle of Willis]]. Approximately 85% of cerebral aneurysms develop in the anterior part of the Circle of Willis, and involve the [[internal carotid arteries]] and their major branches that supply the anterior and middle sections of the brain. The most common sites include  the [[anterior communicating artery]] (30-35%), the bifurcation of the [[internal carotid]] and [[posterior communicating artery]] (30-35%), the  bifurcation of the [[middle cerebral artery]] (20%), the bifurcation of the [[basilar artery]], and the remaining posterior circulation arteries (5%).
{{CMG}}; {{AE}} {{CZ}}; {{KD}}
==Classification==
* Cerebral aneurysms are classified by size.
# Small aneurysms have a diameter of less than 15mm.
# Larger aneurysms include those classified as large (15 to 25mm)
# Giant (25 to 50mm)
# Super giant (over 50mm)
* Cerebral aneurysms are classified by shape.
# Saccular aneurysms are those with a saccular outpouching and are the most common form of cerebral aneurysm. [[Berry aneurysm|Berry aneurysms]] are saccular aneurysms with necks or stems resembling a berry.
# Fusiform aneurysms are aneurysms without stems.
==Causes==
[[Aneurysm]]s may result from
* [[congenital]] defects
* Preexisting conditions such as
** [[High blood pressure]]
** [[Atherosclerosis]]
** [[head (anatomy)|Head][[Physical trauma|trauma]].


The pursuit to identify Genetics of Intracranial Aneurysms has identified a number of locations, most recently 1p34-36, 2p14-15, 7q11, 11q25, and 19q13.1-13.3.
==[[Cerebral aneurysm overview|Overview]]==
==Epidemiology and demographics==
==[[Cerebral aneurysm historical perspective|Historical Perspective]]==
* About 5% of the population has some type of aneurysm in the brain, but only a small number of these aneurysms cause symptoms or rupture.
==[[Cerebral aneurysm classification|Classification]]==
* Cerebral aneurysms occur more commonly in adults than in children but they may occur at any age.
==[[Cerebral aneurysm pathophysiology |Pathophysiology]]==
* They are slightly more common in women than in men.
==[[Cerebral aneurysm causes |Causes]]==
==Risk Factors==
==[[Cerebral aneurysm differential diagnosis|Differentiating Cerebral aneurysm from other Diseases]]==
Following are risk factors for cerebral aneurysms:
* Family history of cerebral aneurysms
* Certain medical problems such as
** [[Polycystic kidney disease]]  
** [[Aortic coarctation]]  
** [[Hypertension]]  
==Natural history, complications and Prognosis==
* The [[prognosis]] for a patient with a ruptured cerebral aneurysm depends on the extent and location of the aneurysm, age , general health  and  neurological condition.
* Some individuals with a ruptured cerebral aneurysm die from the initial bleeding. Other individuals with cerebral aneurysm recover with  little or no neurological deficit.
* The most significant factors in determining outcome are grade (see Hunt and Hess grade above) and age.  Generally patients with Hunt and Hess grade I and II hemorrhage on admission to the emergency room and patients who are younger within the typical age range of vulnerability can anticipate a good outcome, without death or permanent disability.  Older patients and those with poorer Hunt and Hess grades on admission have a poor prognosis.  Generally, about two thirds of patients have a poor outcome, death, or permanent disability <ref name="Hop et al 1997">{{cite journal |last=Hop |first=Jeanette |coauthors=Gabriel Rinkel, Ale Algra, Jan van Gijn  |year=1997 |month=March |title=Case-Fatality Rates and Functional Outcome after Subarachnoid Hemorrhage: A Systematic Review. |journal=Stroke |volume=28 |issue=3 |pages=660-664 |id=PMID 11157554 }}</ref> <ref name="Ljunggren et al 1985">{{cite journal |last=Ljunggren  |first=B |coauthors=Sonesson B, Säveland H, Brandt L  |year=1985  |title= Cognitive impairment and adjustment in patients without neurological deficit after aneurysmal SAH and early operation. |journal=Journal of Neurosurgery |volume=62 |pages=673-679 |id=PMID 3989590 }}</ref>
==Diagnosis==
===History and Symptoms===
* A person may have an aneurysm without having any symptoms.
* Symptoms depend on the location of the aneurysm, whether it breaks open, and what part of the brain it is pushing on, but may include:
** Double vision
** Loss of vision
** Headaches
** Eye pain
** Neck pain
** Stiff neck
* Symptoms of an aneurysm rupture may include:
** [[Confusion]], [[lethargy]], [[sleepiness]], or stupor
** Eyelid drooping
** [[Headaches]] with [[nausea]] or [[vomiting]]
** [[Muscle weakness]] or difficulty moving any part of the body
** [[Numbness]] or decreased [[sensation]] in any part of the body
** [[Seizures]]
** [[Speech]] impairment
** [[Stiff neck]] (occasionally)
** [[Vision changes]] (double vision, loss of vision)
===Physical Examination===
===General===
Confusion, lethargy or stupor may be present.
===Neurologic Examination===
* Motor weakness may be present.
* Sensory abnormalities may be present.
* Neck stiffness may be present.


In outlining symptoms of ruptured cerebral aneurysm, it is useful to make use of the [[Hunt and Hess scale]] of subarachnoid [[hemorrhage]] severity:
==[[Cerebral aneurysm epidemiology and demographics|Epidemiology and Demographics]]==
 
==[[Cerebral aneurysm risk factors|Risk Factors]]==
* Grade 1: Asymptomatic; or minimal [[headache]] and slight [[nuchal rigidity]]. Approximate survival rate 70%.
==[[Cerebral aneurysm screening|Screening]]==
* Grade 2: Moderate to severe headache; nuchal rigidity; no [[neurology|neurologic]] deficit except [[cranial nerve]] [[palsy]]. 60%.
* Grade 3: Drowsy; minimal neurologic deficit. 50%.
* Grade 4: Stuporous; moderate to severe [[hemiparesis]]; possibly early [[decerebrate rigidity]] and vegetative disturbances. 20%.
* Grade 5: Deep [[coma]]; decerebrate rigidity; [[wiktionary:moribund|moribund]]. 10%.
===Multi Sliced CT===
The Fisher Grade classifies the appearance of subarachnoid hemorrhage on CT scan:
 
* Grade 1: No hemorrhage evident.
* Grade 2: Subarachnoid hemorrhage less than 1mm thick.
* Grade 3: Subarachnoid hemorrhage more than 1mm thick.
* Grade 4: Subarachnoid hemorrhage of any thickness with intra-ventricular hemorrhage (IVH) or parenchymal extension.
 
The Fisher Grade is most useful in communicating the description of SAH.  It is less useful prognostically than the Hunt-Hess scale.
 
Images shown below are courtesy of RadsWiki and copylefted.
 
<div align="left">
<gallery heights="175" widths="175">
Image:Basilar-artery-aneurysm-01.jpg|MSCT: A large basilar artery aneurysm
Image:Basilar-artery-aneurysm-02.jpg|MSCT: A large basilar artery aneurysm
</gallery>
</div>


 
==[[Cerebral aneurysm natural history, complications and prognosis|Natural History, Complications and Prognosis]]==
 
==Diagnosis==
<div align="left">
[[Cerebral aneurysm diagnostic criteria|Diagnostic Criteria]] | [[Cerebral aneurysm history and symptoms|History and Symptoms]] | [[Cerebral aneurysm physical examination|Physical Examination]] | [[Cerebral aneurysm laboratory findings|Laboratory Findings]] | [[Cerebral aneurysm CT|CT]] | [[Cerebral aneurysm MRI|MRI]] |[[Cerebral aneurysm other imaging findings|Other Imaging Findings]] | [[Cerebral aneurysm other diagnostic studies|Other Diagnostic Studies]]
<gallery heights="175" widths="175">
Image:Basilar-artery-aneurysm-03.jpg|MSCT: A large basilar artery aneurysm
Image:Basilar-artery-aneurysm-04.jpg|MSCT: A large basilar artery aneurysm
</gallery>
</div>
 
===MRI===
Images shown below are courtesy of RadsWiki and copylefted.
 
<div align="left">
<gallery heights="175" widths="175">
Image:Cavernous-sinus-aneurysm-001.jpg|MRI: A large cavernous sinus aneurysm
Image:Cavernous-sinus-aneurysm-002.jpg|MRI: A large cavernous sinus aneurysm
</gallery>
</div>
 
 
<div align="left">
<gallery heights="175" widths="175">
Image:Cavernous-sinus-aneurysm-003.jpg|MRI: A large cavernous sinus aneurysm
Image:Cavernous-sinus-aneurysm-004.jpg|MRI: A large cavernous sinus aneurysm
</gallery>
</div>
 
 
<div align="left">
<gallery heights="175" widths="175">
Image:Cavernous-sinus-aneurysm-005.jpg|MRI: A large cavernous sinus aneurysm
Image:Cavernous-sinus-aneurysm-006.jpg|MRI: A large cavernous sinus aneurysm
</gallery>
</div>
 
 
<div align="left">
<gallery heights="175" widths="175">
Image:Cavernous-sinus-aneurysm-007.jpg|MRI: A large cavernous sinus aneurysm
Image:Cavernous-sinus-aneurysm-008.jpg|MRI: A large cavernous sinus aneurysm
Image:Cavernous-sinus-aneurysm-009.jpg|MRI: A large cavernous sinus aneurysm
</gallery>
</div>
 
===Angiography===
 
Images shown below are courtesy of RadsWiki and copylefted.
 
<div align="left">
<gallery heights="175" widths="175">
Image:Basilar-artery-aneurysm-05.jpg|Cranial Angiography: Same case as in MSCT images. A large basilar artery aneurysm
Image:Basilar-artery-aneurysm-06.jpg|Cranial Angiography: Same case as in MSCT images. A large basilar artery aneurysm
</gallery>
</div>
 
===Pathological Findings===
 
[http://www.peir.net Image courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology]
 
<div align="left">
<gallery heights="175" widths="175">
Image:Cerebral aneurysm 2.jpeg|Brain: Berry Aneurysm: Gross, natural color, close-up, an excellent view of typical berry aneurysm located on anterior cerebral artery
Image:Cerebral aneurysm 1.jpeg|Brain: Berry Aneurysm Ruptured: Gross fixed tissue aneurysm at junction internal carotid and middle cerebral arteries (an excellent close-up view)
</gallery>
</div>
===Vasospasm===
One complication of aneurysmal subarachnoid hemorrhage is the development of [[vasospasm]].  Approximately 1 to 2 weeks following the initial hemorrhage, patients may experience 'spasm' of the cerebral arteries, which can result in stroke. The etiology of vasospasm is thought to be secondary to an inflammatory process that occurs as the blood in the subarachnoid space is resorbed. It appears that macrophages and neutrophils that enter the subarachnoid space to phagocytose senescent erythrocytes and clear extracorpuscular hemoglobin, remain trapped in the subarachnoid space, die and degranulate 3-4 days after their arrival, and release massive quantities of endothelins and free radicals that in turn induce vasospasm. <ref name="Gallia & Tamargo 1997">{{cite journal |last=Gallo |first=GL |coauthors=Rafael Tamargo  |year=2006 |month=October |title=Leukocyte-endothelial cell interactions in chronic vasospasm after subarachnoid hemorrhage. |journal=Neurol. Res |volume=28 |issue=7 |pages=750-758|id=PMID 17164038 }}</ref>. Vascular narrowing, however, is only one component of the transient inflammatory injury, which is extensive.
 
Vasospasm is monitored in a variety of ways.  Non-invasive methods include [[Transcranial doppler|transcranial Doppler]], which is a method of measuring the velocity of blood in the cerebral arteries using ultrasound. As the vessels narrow due to vasospasm, the velocity of blood increases.  The amount of blood reaching the brain can also be measured by [[CT scan|CT]] or [[MRI scan|MRI]] or [[radioisotope|nuclear]] [[perfusion]] scanning.
 
The definitive, but invasive method of detecting vasospasm is [[cerebral angiography]].  It is generally agreed that in order to prevent or reduce the risk of permanent neurological deficits, or even death, vasospasm should be treated aggressively.  This is usually performed by early delivery of drug and fluid therapy, or 'Triple H' (hypertensive-hypervolemic-hemodilution therapy) (which elevates [[blood pressure]], increases [[blood]] volume, and thins the blood) to drive blood flow through and around blocked arteries.  For patients who are refractive (resistant) to Triple H therapy, narrowed arteries in the brain can be treated with medication delivered into the arteries that are in spasm and with [[angioplasty|balloon angioplasty]] to widen the arteries and increase blood flow to the brain.  Although the effectiveness of these treatments is well established, angioplasty and other treatments delivered by interventional radiologists have been in evolution over the past several years.  It is generally recommended that aneurysms be evaluated at specialty centers which provide both neurosurgical and interventional radiology treatment and which also permit angioplasty, if needed, without transfer.


==Treatment==
==Treatment==
[[Cerebral aneurysm medical therapy|Medical Therapy]] | [[Cerebral aneurysm surgery|Surgery]] | [[Cerebral aneurysm primary prevention|Primary Prevention]] | [[Cerebral aneurysm secondary prevention|Secondary Prevention]] | [[Cerebral aneurysm cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Cerebral aneurysm future or investigational therapies|Future or Investigational Therapies]]


[[Emergency medicine|Emergency treatment]] for individuals with a ruptured cerebral aneurysm generally includes restoring deteriorating [[Respiration (physiology)|respiration]] and reducing [[intracranial pressure]]. Currently there are two treatment options for brain aneurysms.  Either surgical clipping or endovascular coiling is usually performed within the first three days to occlude the ruptured aneurysm and reduce the risk of rebleeding.
==Case Studies==
 
[[Cerebral aneurysm case study one|Case #1]]
'''Surgical clipping''':  Surgical clipping was introduced by [[Walter Dandy]] of the [[Johns Hopkins Hospital]] in 1937. It consists of performing a craniotomy, exposing the aneurysm, and closing the base of the aneurysm with a clip. The surgical technique has been modified and improved over the years. Surgical clipping has a lower rate of aneurysm recurrence after treatment. Either surgical clipping or endovascular coiling is usually performed within the first three days to occlude the ruptured aneurysm and reduce the risk of rebleeding.
 
'''Endovascular coiling''': This was introduced by Guido Guglielmi at UCLA in 1991. It consists of passing a catheter into the femoral artery in the groin, through the aorta, into the brain arteries, and finally into the aneurysm itself. Once the catheter is in the aneurysm, platinum coils are pushed into the aneurysm and released. These coils initiate a clotting or thrombotic reaction within the aneurysm that, if successful, will eliminate the aneurysm. In the case of broad-based aneurysms, a stent is passed first into the parent artery to serve as a scaffold for the coils ("stent-assisted coiling").Either surgical clipping or endovascular coiling is usually performed within the first three days to occlude the ruptured aneurysm and reduce the risk of rebleeding.
 
At this point it appears that the risks associated with surgical clipping and endovascular coiling, in terms of stroke or death from the procedure, are the same. The major problem associated with endovascular coiling, however, is a higher aneurysm recurrence rate. For instance, the most recent study by Jacques Moret and colleagues from Paris, France, (a group with one of the largest experiences in endovascular coiling) indicates that 28.6% of aneurysms recurred within one year of coiling, and that the recurrence rate increased with time. <ref name="Piotin et al 2007">{{cite journal |last=Piotin |first=M |coauthors=Spelle, L, Mounayer, C, Salles-Rezende, MT, Giansante-Abud, D, Vanzin-Santos, R, Moret, J  |year=2007 |month=May |title=Intracranial aneurysms: treatment with bare platinum coils--aneurysm packing, complex coils, and angiographic recurrence. |journal=Radiology |volume=243 |issue=2 |pages=500-8 |id=PMID 17293572 }}</ref> These results are similar to those previously reported by other endovascular groups. For instance Jean Raymond and colleagues from Montreal, Canada, (another group with a large experience in endovascular coiling) reported that 33.6% of aneurysms recurred within one year of coiling. <ref name="Raymond et al 2003">{{cite journal |last=Raymond |first=J |coauthors=Guilbert, F, Weill, A, Georganos, SA, Juravsky, L, Lambert, A, Lamoureux, J, Chagnon, M, Roy, D  |year=2003 |month=Jun |title= Long-term angiographic recurrences after selective endovascular treatment of aneurysms with detachable coils. |journal=Stroke |volume=34 |issue=6 |pages=1398-1403 |id=PMID 12775880 }}</ref> The long-term coiling results of one of the two prospective, randomized studies comparing surgical clipping versus endovascular coiling, namely the International Subarachnoid Aneurysm Trial (ISAT) are turning out to be similarly worrisome. In ISAT, the need for late retreatment of aneurysms was 6.9 times more likely for endovascular coiling as compared to surgical clipping.  <ref name="Campi et al 2007">{{cite journal |last=Campi  |first=A |coauthors=Ramzi N, Molyneaux AJ, Summers, PE, Kerr, RS, Sneade, M, Yarnold, JA, Rischmiller, J, Byrne, JV  |year=2007  |month=May  |title= Retreatment of ruptured cerebral aneurysms in patients randomized by coiling or
clipping in the International Subarachnoid Aneurysm Trial (ISAT).  |journal=Stroke |volume=38 |issue=5 |pages=1538-1544 |id=PMID 17395870 }}</ref>
 
Therefore it appears that although endovascular coiling is associated with a shorter recovery period as compared to surgical clipping, it is also associated with a significantly higher recurrence rate after treatment. It is unclear, however, whether the higher recurrence rate translates into a higher ''rebleeding'' rate, as the data thus far do not show a difference in the rate of recurrent hemorrhage in patients who had aneurysms clipped vs. coiled after rupture. <ref name="Campi et al 2007"/> The long-term data for ''unruptured'' aneurysms are still being gathered.
 
Patients who undergo endovascular coiling need to have annual studies (such as MRI/MRA, CTA, or angiography) indefinitely to detect early recurrences. If a recurrence is identified, the aneurysm needs to be retreated with either surgery or further coiling. The risks associated with surgical clipping of previously-coiled aneurysms are very high. Ultimately, the decision to treat with surgical clipping versus endovascular coiling should be made by a cerebrovascular team with extensive experience in both modalities.
 
==References==
{{reflist|2}}


== See also ==
== Related Chapters ==
*[[Charcot-Bouchard aneurysm]]
*[[Charcot-Bouchard aneurysm]]
*[[Intracranial berry aneurysm]]
*[[Intracranial berry aneurysm]]
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[[Category:Radiology]]
[[Category:Radiology]]
[[Category:Cardiology]]
[[Category:Cardiology]]
 
[[Category:Emergency medicine]]
[[ca:Aneurisma cerebral]]
[[Category:Disease]]
[[de:Aneurysma#Hirn-Aneurysmata]]
[[es:Aneurisma]]
[[fr:Anévrisme intra-crânien]]
[[ja:脳動脈瘤]]
[[pt:Aneurisma cerebral]]
[[fi:Aivoaneurysma]]


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Revision as of 16:46, 7 March 2013

Cerebral aneurysm
Brain: Berry Aneurysm: Gross, natural color, close-up, an excellent view of typical berry aneurysm located on anterior cerebral artery
Image courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Cafer Zorkun, M.D., Ph.D. [2]; Kalsang Dolma, M.B.B.S.[3]

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