Capillary leak syndrome: Difference between revisions

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==[[Capillary leak syndrome historical perspective|Historical Perspective]]==
==[[Capillary leak syndrome historical perspective|Historical Perspective]]==
Capillary leak syndrome was first described by B. Clarkson in 1960, and was named after him.
Numerous case reports on capillary leak [[syndrome]] are published since then.
Between 1960 to 2006, a hundred cases of capillary leak syndrome were reported in the world literature, and additional 26 cases were published since 2006.
==[[Capillary leak syndrome pathophysiology|Pathophysiology]]==
==[[Capillary leak syndrome pathophysiology|Pathophysiology]]==
The pathogenesis of capillary leak syndrome remain unclear, however, '''[https://www.wikidoc.org/index.php/Cytokines cytokines]''', '''[https://www.wikidoc.org/index.php/Vascular_endothelial_growth_factor vascular endothelial growth factor]''' (VEGF), '''[https://www.wikidoc.org/index.php/Leukotrienes leukotrienes]''', and '''complement''' play an important role.  During each episode of hyperpermeability of the vasculature, there is an increase of interleukin 2 receptor-positive peripheral blood M-cell count, as well as apoptosis of the endothelial cells.
The pathogenesis of capillary leak syndrome remain unclear, however, '''[https://www.wikidoc.org/index.php/Cytokines cytokines]''', '''[https://www.wikidoc.org/index.php/Vascular_endothelial_growth_factor vascular endothelial growth factor]''' (VEGF), '''[https://www.wikidoc.org/index.php/Leukotrienes leukotrienes]''', and '''complement''' play an important role.  During each episode of hyperpermeability of the vasculature, there is an increase of interleukin 2 receptor-positive peripheral blood M-cell count, as well as apoptosis of the endothelial cells.

Revision as of 07:23, 7 August 2022


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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: M. Hassan, M.B.B.S

Capillary leak syndrome Microchapters

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Synonyms and Keywords: Systemic capillary leak syndrome; SCLS; Clarkson's disease.

Overview

Historical Perspective

Pathophysiology

The pathogenesis of capillary leak syndrome remain unclear, however, cytokines, vascular endothelial growth factor (VEGF), leukotrienes, and complement play an important role. During each episode of hyperpermeability of the vasculature, there is an increase of interleukin 2 receptor-positive peripheral blood M-cell count, as well as apoptosis of the endothelial cells.

Causes

Differentiating Capillary leak syndrome from other Diseases

As capillary leak syndrome has overlapping clinical and laboratory findings with various other conditions, it should be considered as the diagnosis of exclusion. Several conditions that may be considered as the differential diagnoses of capillary leak syndrome include polycythemia vera, hereditary angioedema, Gleich syndrome, adrenal insufficiency, mast cell disease, acute gastroenteritis, carcinoid syndrome, primary amyloidosis, chronic heart failure, sepsis, and toxic shock syndrome.

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms | Physical Examination | Laboratory Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case #1


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