Capillary leak syndrome: Difference between revisions

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Latest revision as of 18:09, 16 November 2022

For patient information, click here

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: M. Hassan, M.B.B.S

Synonyms and Keywords: Systemic capillary leak syndrome; SCLS; Clarkson's disease.

Overview

Historical Perspective

Pathophysiology

Causes

Differentiating Capillary leak syndrome from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms | Physical Examination | Laboratory Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case #1

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-{{CMG}}
+__NOTOC__
-{{SI}}
+'''For patient information, click [[Capillary leak syndrome (patient information)|here]]'''
-{{EH}}
+{{CMG}}; '''Associate Editor(s)-In-Chief:''' [https://www.wikidoc.org/index.php/User:Hassan_M M. Hassan, M.B.B.S]
+{{Capillary leak syndrome}}
-==Overview==
+'''''Synonyms and Keywords:''''' Systemic capillary leak syndrome; SCLS; Clarkson's disease.
-'''Capillary Leak Syndrome''' or '''Systemic Capillary Leak Syndrome'''(SCLS).
-A rare [[medical condition]] where the number and size of the [[pore]]s in the [[capillaries]] are increased which leads to a leakage of [[fluid]] from the [[blood]] to the [[interstitial fluid]], resulting in dangerously low [[blood pressure]] ([[hypotension]]), [[edema]] and multiple [[Organ (anatomy)|organ]] failiure due to limited [[perfusion]].
-==History==
+==[[Capillary leak syndrome overview|Overview]]==
-The [[syndrome]] was first described by [[Clarkson]] in [[1960]].
-==Symptoms==
+==[[Capillary leak syndrome historical perspective|Historical Perspective]]==
-Edpisodes of
+==[[Capillary leak syndrome pathophysiology|Pathophysiology]]==
-* Low blood pressure ([[hypotension]])
+==[[Capillary leak syndrome causes|Causes]]==
-* Hemoconcentration
-* [[Hypoalbuminemia]] without [[albuminuria]]
-* Generalized [[edema]] or [[anasarca]]
-==Treatment==
+==[[Capillary leak syndrome differential diagnosis|Differentiating Capillary leak syndrome from other Diseases]]==
-The episode usually consists of two phases
+==[[Capillary leak syndrome epidemiology and demographics|Epidemiology and Demographics]]==
+==[[Capillary leak syndrome risk factors|Risk Factors]]==
+==[[Capillary leak syndrome natural history, complications and prognosis|Natural History, Complications and Prognosis]]==
+==Diagnosis==
-. The capillary leak phase (1-4 days)
+[[Capillary leak syndrome history and symptoms|History and Symptoms]] | [[Capillary leak syndrome physical examination|Physical Examination]] | [[Capillary leak syndrome laboratory findings|Laboratory Findings]] | [[Capillary leak syndrome other diagnostic studies|Other Diagnostic Studies]]
-The initial phase is the capillary leak phase, lasting from 1 to 4 days. Clinical features are [[abdomen|abdominal]] pain, [[nausea]], generalized edema and hypotension that may result in [[cardiopulmonary collapse]]. [[Acute renal failure]] is due to acute tubular [[necrosis]] consequent to [[hypovolemia]] and [[rhabdomyolysis]].
-. Recruitment of the interstitial fluid
+==Treatment==
-The second phase results in the recruitment of the initially extravasated fluid. Intravascular overload with polyuria and pulmonary edema often occur. Edema may be more severe due to massive fluid supply in the initial phase. It's necessary to monitor the patient in order to switch to [[depletion treatment]] with [[diuretics]] or [[hemofiltration]].
-==Prognosis==
+[[Capillary leak syndrome medical therapy|Medical Therapy]] | [[Capillary leak syndrome prevention|Prevention]] | [[Capillary leak syndrome cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Capillary leak syndrome future or investigational therapies|Future or Investigational Therapies]]
-Mortality is reported in 21% of the 57 cases described. However, better management of this condition has recently led to lower mortality. A few [[prophylactic]] treatments have been tried with variable results, principally [[terbutaline]] and [[theophyllin]]. Patients need to be monitored for monoclonal gammopathy since it may turn into multiple [[myeloma]].
-==References==
+==Case Studies==
-* Dorlands Medical Dictionary 30th Ed.
+[[Capillary leak syndrome case study one|Case #1]]
-* [http://www.cancer.gov/Templates/db_alpha.aspx?CdrID=426421 Cancer.gov]
-* [http://ndt.oxfordjournals.org/cgi/content/full/17/3/492 Case report in Oxford Journals]
-* [http://www.orpha.net/static/GB/capillary_leak_syndrome.html Orphanet (2003)]
 [[Category:Syndromes]]
 [[Category:Intensive care medicine]]
 [[Category:Emergency medicine]]
+[[Category:Disease]]
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Capillary leak syndrome: Difference between revisions

Latest revision as of 18:09, 16 November 2022

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