CYP4A11

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Cytochrome P450, family 4, subfamily A, polypeptide 11
Identifiers
Symbols CYP4A11 ; CP4Y; CYP4A2; CYP4AII
External IDs Template:OMIM5 Template:MGI HomoloGene88341
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

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Cytochrome P450, family 4, subfamily A, polypeptide 11, also known as CYP4A11, is a human gene.[1]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate.[1]

References

  1. 1.0 1.1 "Entrez Gene: CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11".

Further reading

  • Kawashima H, Kusunose E, Kubota I; et al. (1992). "Purification and NH2-terminal amino acid sequences of human and rat kidney fatty acid omega-hydroxylases". Biochim. Biophys. Acta. 1123 (2): 156–62. PMID 1739747.
  • Palmer CN, Richardson TH, Griffin KJ; et al. (1993). "Characterization of a cDNA encoding a human kidney, cytochrome P-450 4A fatty acid omega-hydroxylase and the cognate enzyme expressed in Escherichia coli". Biochim. Biophys. Acta. 1172 (1–2): 161–6. PMID 7679927.
  • Kawashima H, Kusunose E, Kikuta Y; et al. (1995). "Purification and cDNA cloning of human liver CYP4A fatty acid omega-hydroxylase". J. Biochem. 116 (1): 74–80. PMID 7798189.
  • Imaoka S, Ogawa H, Kimura S, Gonzalez FJ (1994). "Complete cDNA sequence and cDNA-directed expression of CYP4A11, a fatty acid omega-hydroxylase expressed in human kidney". DNA Cell Biol. 12 (10): 893–9. PMID 8274222.
  • Bell DR, Plant NJ, Rider CG; et al. (1993). "Species-specific induction of cytochrome P-450 4A RNAs: PCR cloning of partial guinea-pig, human and mouse CYP4A cDNAs". Biochem. J. 294 ( Pt 1): 173–80. PMID 8363569.
  • Powell PK, Wolf I, Lasker JM (1996). "Identification of CYP4A11 as the major lauric acid omega-hydroxylase in human liver microsomes". Arch. Biochem. Biophys. 335 (1): 219–26. doi:10.1006/abbi.1996.0501. PMID 8914854.
  • Powell PK, Wolf I, Jin R, Lasker JM (1998). "Metabolism of arachidonic acid to 20-hydroxy-5,8,11, 14-eicosatetraenoic acid by P450 enzymes in human liver: involvement of CYP4F2 and CYP4A11". J. Pharmacol. Exp. Ther. 285 (3): 1327–36. PMID 9618440.
  • Chang YT, Loew GH (1999). "Homology modeling and substrate binding study of human CYP4A11 enzyme". Proteins. 34 (3): 403–15. PMID 10024026.
  • Lasker JM, Chen WB, Wolf I; et al. (2000). "Formation of 20-hydroxyeicosatetraenoic acid, a vasoactive and natriuretic eicosanoid, in human kidney. Role of Cyp4F2 and Cyp4A11". J. Biol. Chem. 275 (6): 4118–26. PMID 10660572.
  • Kawashima H, Naganuma T, Kusunose E; et al. (2000). "Human fatty acid omega-hydroxylase, CYP4A11: determination of complete genomic sequence and characterization of purified recombinant protein". Arch. Biochem. Biophys. 378 (2): 333–9. doi:10.1006/abbi.2000.1831. PMID 10860550.
  • Hoch U, Ortiz De Montellano PR (2001). "Covalently linked heme in cytochrome p4504a fatty acid hydroxylases". J. Biol. Chem. 276 (14): 11339–46. doi:10.1074/jbc.M009969200. PMID 11139583.
  • Gonzalez MC, Marteau C, Franchi J, Migliore-Samour D (2001). "Cytochrome P450 4A11 expression in human keratinocytes: effects of ultraviolet irradiation". Br. J. Dermatol. 145 (5): 749–57. PMID 11736898.
  • LeBrun LA, Hoch U, Ortiz de Montellano PR (2002). "Autocatalytic mechanism and consequences of covalent heme attachment in the cytochrome P4504A family". J. Biol. Chem. 277 (15): 12755–61. doi:10.1074/jbc.M112155200. PMID 11821421.
  • Savas U, Hsu MH, Johnson EF (2003). "Differential regulation of human CYP4A genes by peroxisome proliferators and dexamethasone". Arch. Biochem. Biophys. 409 (1): 212–20. PMID 12464261.
  • Bellamine A, Wang Y, Waterman MR; et al. (2003). "Characterization of the CYP4A11 gene, a second CYP4A gene in humans". Arch. Biochem. Biophys. 409 (1): 221–7. PMID 12464262.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Jin P, Fu GK, Wilson AD; et al. (2004). "PCR isolation and cloning of novel splice variant mRNAs from known drug target genes". Genomics. 83 (4): 566–71. doi:10.1016/j.ygeno.2003.09.023. PMID 15028279.
  • Ramírez J, Innocenti F, Schuetz EG; et al. (2005). "CYP2B6, CYP3A4, and CYP2C19 are responsible for the in vitro N-demethylation of meperidine in human liver microsomes". Drug Metab. Dispos. 32 (9): 930–6. PMID 15319333.
  • Gainer JV, Bellamine A, Dawson EP; et al. (2005). "Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension". Circulation. 111 (1): 63–9. doi:10.1161/01.CIR.0000151309.82473.59. PMID 15611369.
  • Mayer B, Lieb W, Götz A; et al. (2005). "Association of the T8590C polymorphism of CYP4A11 with hypertension in the MONICA Augsburg echocardiographic substudy". Hypertension. 46 (4): 766–71. doi:10.1161/01.HYP.0000182658.04299.15. PMID 16144986.


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