CXCL2: Difference between revisions

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'''Chemokine (C-X-C motif) ligand 2''' (CXCL2) is a small [[cytokine]] belonging to the CXC [[chemokine]] family that is also called ''macrophage inflammatory protein 2-alpha'' (MIP2-alpha), ''Growth-regulated protein beta'' (Gro-beta) and ''Gro oncogene-2'' (Gro-2).  CXCL2 is 90% identical in [[amino acid]] sequence as a related chemokine, [[CXCL1]]. This chemokine is secreted by [[monocytes]] and [[macrophage]]s and is [[chemotactic]] for [[polymorphonuclear leukocyte]]s and [[hematopoietic stem cell]]s.<ref>Wolpe, S. D., Sherry, B., Juers, D., Davatelis, G., Yurt, R. W., [[Anthony Cerami|Cerami, A]]. Identification and characterization of macrophage inflammatory protein 2. Proc. Natl. Acad. Sci. 86: 612-616, 1989. {{PMID|2643119}}</ref><ref>Iida N., Grotendorst G.R. Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue. Mol. Cell. Biol. 10:5596-5599, 1990. {{PMID|2078213}}</ref><ref name = pelus>Pelus LM, Fukuda S. Peripheral blood stem cell mobilization: the CXCR2 ligand GRObeta rapidly mobilizes hematopoietic stem cells with enhanced engraftment properties. Exp Hematol. 2006 Aug;34(8):1010-20. {{PMID|16863907}}</ref> The gene for CXCL2 is located on human [[chromosome 4]] in a cluster of other CXC chemokines.<ref>O'Donovan, N., Galvin, M., Morgan, J. G. Physical mapping of the CXC chemokine locus on human chromosome 4. Cytogenet. Cell Genet. 84: 39-42, 1999. {{PMID|10343098}}</ref> CXCL2 mobilizes cells by interacting with a cell surface [[chemokine receptor]] called [[CXC chemokine receptors#CXCR1 and CXCR2|CXCR2]].<ref name = pelus/>
'''Chemokine (C-X-C motif) ligand 2''' (CXCL2) is a small [[cytokine]] belonging to the CXC [[chemokine]] family that is also called ''macrophage inflammatory protein 2-alpha'' (MIP2-alpha), ''Growth-regulated protein beta'' (Gro-beta) and ''Gro oncogene-2'' (Gro-2).  CXCL2 is 90% identical in [[amino acid]] sequence as a related chemokine, [[CXCL1]]. This chemokine is secreted by [[monocytes]] and [[macrophage]]s and is [[chemotactic]] for [[polymorphonuclear leukocyte]]s and [[hematopoietic stem cell]]s.<ref name="pmid2643119">{{cite journal | vauthors = Wolpe SD, Sherry B, Juers D, Davatelis G, Yurt RW, Cerami A | title = Identification and characterization of macrophage inflammatory protein 2 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 86 | issue = 2 | pages = 612–6 | date = January 1989 | pmid = 2643119 | pmc = 286522 | doi = }}</ref><ref name="pmid2078213">{{cite journal | vauthors = Iida N, Grotendorst GR | title = Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue | journal = Molecular and Cellular Biology | volume = 10 | issue = 10 | pages = 5596–9 | date = October 1990 | pmid = 2078213 | pmc = 361282 | doi = }}</ref><ref name = pelus>{{cite journal | vauthors = Pelus LM, Fukuda S | title = Peripheral blood stem cell mobilization: the CXCR2 ligand GRObeta rapidly mobilizes hematopoietic stem cells with enhanced engraftment properties | journal = Experimental Hematology | volume = 34 | issue = 8 | pages = 1010–20 | date = August 2006 | pmid = 16863907 | doi = 10.1016/j.exphem.2006.04.004 }}</ref> The gene for CXCL2 is located on human [[chromosome 4]] in a cluster of other CXC chemokines.<ref name="pmid10343098">{{cite journal | vauthors = O'Donovan N, Galvin M, Morgan JG | title = Physical mapping of the CXC chemokine locus on human chromosome 4 | journal = Cytogenetics and Cell Genetics | volume = 84 | issue = 1-2 | pages = 39–42 | date = 1999 | pmid = 10343098 | doi = 10.1159/000015209 }}</ref> CXCL2 mobilizes cells by interacting with a cell surface [[chemokine receptor]] called [[CXC chemokine receptors#CXCR1 and CXCR2|CXCR2]].<ref name = pelus/>
 
CXCL2, like related chemokines, is also a powerful neutrophil chemoattractant and is involved in many immune responses including wound healing, cancer metastasis, and angiogenesis.<ref name="Al-Alwan_2017" /> A study was published in 2013 testing the role of CXCL2, CXCL3, and CXCL1 in the migration of airway smooth muscle cells (ASMCs) migration which plays a significant role in asthma. The results of this study showed that CXCL2 and CXCL3 both help with the mediation of normal and asthmatic ASMC migration through different mechanisms.<ref name="Al-Alwan_2017">{{cite journal | vauthors = Al-Alwan LA, Chang Y, Mogas A, Halayko AJ, Baglole CJ, Martin JG, Rousseau S, Eidelman DH, Hamid Q | title = Differential roles of CXCL2 and CXCL3 and their receptors in regulating normal and asthmatic airway smooth muscle cell migration | journal = Journal of Immunology | volume = 191 | issue = 5 | pages = 2731–41 | date = September 2013 | pmid = 23904157 | pmc = 3748335 | doi = 10.4049/jimmunol.1203421 }}</ref>


==References==
==References==

Revision as of 12:55, 23 June 2018

chemokine (C-X-C motif) ligand 2
Identifiers
SymbolCXCL2
Alt. symbolsSCYB2, GRO2, GROb, MIP-2a, MGSA-b, CINC-2a
Entrez2920
HUGO4603
OMIM139110
RefSeqNM_002089
UniProtP19875
Other data
LocusChr. 4 q21

Chemokine (C-X-C motif) ligand 2 (CXCL2) is a small cytokine belonging to the CXC chemokine family that is also called macrophage inflammatory protein 2-alpha (MIP2-alpha), Growth-regulated protein beta (Gro-beta) and Gro oncogene-2 (Gro-2). CXCL2 is 90% identical in amino acid sequence as a related chemokine, CXCL1. This chemokine is secreted by monocytes and macrophages and is chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells.[1][2][3] The gene for CXCL2 is located on human chromosome 4 in a cluster of other CXC chemokines.[4] CXCL2 mobilizes cells by interacting with a cell surface chemokine receptor called CXCR2.[3]

CXCL2, like related chemokines, is also a powerful neutrophil chemoattractant and is involved in many immune responses including wound healing, cancer metastasis, and angiogenesis.[5] A study was published in 2013 testing the role of CXCL2, CXCL3, and CXCL1 in the migration of airway smooth muscle cells (ASMCs) migration which plays a significant role in asthma. The results of this study showed that CXCL2 and CXCL3 both help with the mediation of normal and asthmatic ASMC migration through different mechanisms.[5]

References

  1. ↑ Wolpe SD, Sherry B, Juers D, Davatelis G, Yurt RW, Cerami A (January 1989). "Identification and characterization of macrophage inflammatory protein 2". Proceedings of the National Academy of Sciences of the United States of America. 86 (2): 612–6. PMC 286522. PMID 2643119.
  2. ↑ Iida N, Grotendorst GR (October 1990). "Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue". Molecular and Cellular Biology. 10 (10): 5596–9. PMC 361282. PMID 2078213.
  3. ↑ 3.0 3.1 Pelus LM, Fukuda S (August 2006). "Peripheral blood stem cell mobilization: the CXCR2 ligand GRObeta rapidly mobilizes hematopoietic stem cells with enhanced engraftment properties". Experimental Hematology. 34 (8): 1010–20. doi:10.1016/j.exphem.2006.04.004. PMID 16863907.
  4. ↑ O'Donovan N, Galvin M, Morgan JG (1999). "Physical mapping of the CXC chemokine locus on human chromosome 4". Cytogenetics and Cell Genetics. 84 (1–2): 39–42. doi:10.1159/000015209. PMID 10343098.
  5. ↑ 5.0 5.1 Al-Alwan LA, Chang Y, Mogas A, Halayko AJ, Baglole CJ, Martin JG, Rousseau S, Eidelman DH, Hamid Q (September 2013). "Differential roles of CXCL2 and CXCL3 and their receptors in regulating normal and asthmatic airway smooth muscle cell migration". Journal of Immunology. 191 (5): 2731–41. doi:10.4049/jimmunol.1203421. PMC 3748335. PMID 23904157.


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