CTNND1
| Catenin (cadherin-associated protein), delta 1 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | CTNND1 ; CAS; CTNND; KIAA0384; P120CAS; P120CTN; p120 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 1017 | ||||||||||
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| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Catenin (cadherin-associated protein), delta 1, also known as CTNND1, is a human gene.
This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and althernative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined.[1]
See also
References
Further reading
- Wijnhoven BP, Dinjens WN, Pignatelli M (2000). "E-cadherin-catenin cell-cell adhesion complex and human cancer". The British journal of surgery. 87 (8): 992–1005. doi:10.1046/j.1365-2168.2000.01513.x. PMID 10931041.
- Thoreson MA, Reynolds AB (2003). "Altered expression of the catenin p120 in human cancer: implications for tumor progression". Differentiation. 70 (9–10): 583–9. PMID 12492499.
- Reynolds AB, Carnahan RH (2005). "Regulation of cadherin stability and turnover by p120ctn: implications in disease and cancer". Semin. Cell Dev. Biol. 15 (6): 657–63. doi:10.1016/j.semcdb.2004.09.003. PMID 15561585.
- Keil R, Wolf A, Hüttelmaier S, Hatzfeld M (2007). "Beyond regulation of cell adhesion: local control of RhoA at the cleavage furrow by the p0071 catenin". Cell Cycle. 6 (2): 122–7. PMID 17264675.
- Kinch MS, Clark GJ, Der CJ, Burridge K (1995). "Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia". J. Cell Biol. 130 (2): 461–71. PMID 7542250.
- Daniel JM, Reynolds AB (1995). "The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha-catenin". Mol. Cell. Biol. 15 (9): 4819–24. PMID 7651399.
- Shibamoto S, Hayakawa M, Takeuchi K; et al. (1995). "Association of p120, a tyrosine kinase substrate, with E-cadherin/catenin complexes". J. Cell Biol. 128 (5): 949–57. PMID 7876318.
- Reynolds AB, Daniel JM, Mo YY; et al. (1996). "The novel catenin p120cas binds classical cadherins and induces an unusual morphological phenotype in NIH3T3 fibroblasts". Exp. Cell Res. 225 (2): 328–37. doi:10.1006/excr.1996.0183. PMID 8660921.
- Reynolds AB, Jenkins NA, Gilbert DJ; et al. (1996). "The gene encoding p120cas, a novel catenin, localizes on human chromosome 11q11 (CTNND) and mouse chromosome 2 (Catns)". Genomics. 31 (1): 127–9. doi:10.1006/geno.1996.0020. PMID 8808291.
- Nagase T, Ishikawa K, Nakajima D; et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. PMID 9205841.
- Lampugnani MG, Corada M, Andriopoulou P; et al. (1997). "Cell confluence regulates tyrosine phosphorylation of adherens junction components in endothelial cells". J. Cell. Sci. 110 ( Pt 17): 2065–77. PMID 9378757.
- Hazan RB, Norton L (1998). "The epidermal growth factor receptor modulates the interaction of E-cadherin with the actin cytoskeleton". J. Biol. Chem. 273 (15): 9078–84. PMID 9535896.
- Keirsebilck A, Bonné S, Staes K; et al. (1998). "Molecular cloning of the human p120ctn catenin gene (CTNND1): expression of multiple alternatively spliced isoforms". Genomics. 50 (2): 129–46. doi:10.1006/geno.1998.5325. PMID 9653641.
- Bauer A, Lickert H, Kemler R, Stappert J (1998). "Modification of the E-cadherin-catenin complex in mitotic Madin-Darby canine kidney epithelial cells". J. Biol. Chem. 273 (43): 28314–21. PMID 9774455.
- Daniel JM, Reynolds AB (1999). "The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor". Mol. Cell. Biol. 19 (5): 3614–23. PMID 10207085.
- Aono S, Nakagawa S, Reynolds AB, Takeichi M (1999). "p120(ctn) acts as an inhibitory regulator of cadherin function in colon carcinoma cells". J. Cell Biol. 145 (3): 551–62. PMID 10225956.
- Aho S, Rothenberger K, Uitto J (1999). "Human p120ctn catenin: tissue-specific expression of isoforms and molecular interactions with BP180/type XVII collagen". J. Cell. Biochem. 73 (3): 390–9. PMID 10321838.
- van Hengel J, Vanhoenacker P, Staes K, van Roy F (1999). "Nuclear localization of the p120(ctn) Armadillo-like catenin is counteracted by a nuclear export signal and by E-cadherin expression". Proc. Natl. Acad. Sci. U.S.A. 96 (14): 7980–5. PMID 10393933.
- Ohkubo T, Ozawa M (1999). "p120(ctn) binds to the membrane-proximal region of the E-cadherin cytoplasmic domain and is involved in modulation of adhesion activity". J. Biol. Chem. 274 (30): 21409–15. PMID 10409703.
- Thoreson MA, Anastasiadis PZ, Daniel JM; et al. (2000). "Selective uncoupling of p120(ctn) from E-cadherin disrupts strong adhesion". J. Cell Biol. 148 (1): 189–202. PMID 10629228.
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