CTNND1: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Catenin delta-1''' is a [[protein]] that in humans is encoded by the ''CTNND1'' [[gene]].<ref name="pmid8808291">{{cite journal | vauthors = Reynolds AB, Jenkins NA, Gilbert DJ, Copeland NG, Shapiro DN, Wu J, Daniel JM | title = The gene encoding p120cas, a novel catenin, localizes on human chromosome 11q11 (CTNND) and mouse chromosome 2 (Catns) | journal = Genomics | volume = 31 | issue = 1 | pages = 127–9 | date = October 1996 | pmid = 8808291 | pmc = | doi = 10.1006/geno.1996.0020 }}</ref>
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| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Catenin (cadherin-associated protein), delta 1
| HGNCid = 2515
| Symbol = CTNND1
| AltSymbols =; CAS; CTNND; KIAA0384; P120CAS; P120CTN; p120
| OMIM = 601045
| ECnumber = 
| Homologene = 1017
| MGIid = 105100
| Function = {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0005488 |text = binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0030027 |text = lamellipodium}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0016055 |text = Wnt receptor signaling pathway}} {{GNF_GO|id=GO:0016337 |text = cell-cell adhesion}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1500
    | Hs_Ensembl = 
    | Hs_RefseqProtein = XP_001126721
    | Hs_RefseqmRNA = XM_001126721
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 12388
    | Mm_Ensembl = ENSMUSG00000034101
    | Mm_RefseqmRNA = NM_007615
    | Mm_RefseqProtein = NP_031641
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 84401622
    | Mm_GenLoc_end = 84451514
    | Mm_Uniprot = Q3TSU9
  }}
}}
'''Catenin (cadherin-associated protein), delta 1''', also known as '''CTNND1''', is a human [[gene]].


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and [[signal transduction]]. Multiple translation initiation codons and [[alternative splicing]] result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined.<ref>{{cite web | title = Entrez Gene: CTNND1 catenin (cadherin-associated protein), delta 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1500| accessdate = }}</ref>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and althernative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined.<ref>{{cite web | title = Entrez Gene: CTNND1 catenin (cadherin-associated protein), delta 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1500| accessdate = }}</ref>
}}


==See also==
== Interactions ==
CTNND1 has been shown to [[Protein-protein interaction|interact]] with:
{{div col|colwidth=20em}}
* [[Beta-catenin]],<ref name = pmid9535896>{{cite journal | vauthors = Hazan RB, Norton L | title = The epidermal growth factor receptor modulates the interaction of E-cadherin with the actin cytoskeleton | journal = J. Biol. Chem. | volume = 273 | issue = 15 | pages = 9078–84 | pmid = 9535896 | doi =  10.1074/jbc.273.15.9078 | date=April 1998}}</ref><ref name = pmid11712088>{{cite journal | vauthors = Kucerová D, Sloncová E, Tuhácková Z, Vojtechová M, Sovová V | title = Expression and interaction of different catenins in colorectal carcinoma cells | journal = Int. J. Mol. Med. | volume = 8 | issue = 6 | pages = 695–8 | pmid = 11712088 | doi =  10.3892/ijmm.8.6.695 | date=December 2001}}</ref>
* [[CDH1 (gene)|CDH1]],<ref name = pmid9535896/><ref name = pmid12640114/><ref name = pmid7651399>{{cite journal | vauthors = Daniel JM, Reynolds AB | title = The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha-catenin | journal = Mol. Cell. Biol. | volume = 15 | issue = 9 | pages = 4819–24 | pmid = 7651399 | pmc = 230726 | doi = 10.1128/mcb.15.9.4819| date=September 1995}}</ref><ref name = pmid12427869>{{cite journal | vauthors = Ireton RC, Davis MA, van Hengel J, Mariner DJ, Barnes K, Thoreson MA, Anastasiadis PZ, Matrisian L, Bundy LM, Sealy L, Gilbert B, van Roy F, Reynolds AB | title = A novel role for p120 catenin in E-cadherin function | journal = J. Cell Biol. | volume = 159 | issue = 3 | pages = 465–76 | pmid = 12427869 | pmc = 2173073 | doi = 10.1083/jcb.200205115 }}</ref><ref name = pmid7542250>{{cite journal | vauthors = Kinch MS, Clark GJ, Der CJ, Burridge K | title = Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia | journal = J. Cell Biol. | volume = 130 | issue = 2 | pages = 461–71 | pmid = 7542250 | pmc = 2199929 | doi =  10.1083/jcb.130.2.461}}</ref><ref name = pmid12707304>{{cite journal | vauthors = Bonné S, Gilbert B, Hatzfeld M, Chen X, Green KJ, van Roy F | title = Defining desmosomal plakophilin-3 interactions | journal = J. Cell Biol. | volume = 161 | issue = 2 | pages = 403–16 | pmid = 12707304 | pmc = 2172904 | doi = 10.1083/jcb.200303036 }}</ref><ref name = pmid7876318>{{cite journal | vauthors = Shibamoto S, Hayakawa M, Takeuchi K, Hori T, Miyazawa K, Kitamura N, Johnson KR, Wheelock MJ, Matsuyoshi N, Takeichi M | title = Association of p120, a tyrosine kinase substrate, with E-cadherin/catenin complexes | journal = J. Cell Biol. | volume = 128 | issue = 5 | pages = 949–57 | pmid = 7876318 | pmc = 2120395 | doi =  10.1083/jcb.128.5.949}}</ref><ref name = pmid10409703>{{cite journal | vauthors = Ohkubo T, Ozawa M | title = p120(ctn) binds to the membrane-proximal region of the E-cadherin cytoplasmic domain and is involved in modulation of adhesion activity | journal = J. Biol. Chem. | volume = 274 | issue = 30 | pages = 21409–15 | pmid = 10409703 | doi =  10.1074/jbc.274.30.21409 | date=July 1999}}</ref>
* [[CDH2]],<ref name = pmid14625392>{{cite journal | vauthors = Straub BK, Boda J, Kuhn C, Schnoelzer M, Korf U, Kempf T, Spring H, Hatzfeld M, Franke WW | title = A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells | journal = J. Cell Sci. | volume = 116 | issue = Pt 24 | pages = 4985–95 | pmid = 14625392 | doi = 10.1242/jcs.00815 | date=December 2003}}</ref><ref name = pmid12604612>{{cite journal | vauthors = Wahl JK, Kim YJ, Cullen JM, Johnson KR, Wheelock MJ | title = N-cadherin-catenin complexes form prior to cleavage of the proregion and transport to the plasma membrane | journal = J. Biol. Chem. | volume = 278 | issue = 19 | pages = 17269–76 | pmid = 12604612 | doi = 10.1074/jbc.M211452200 | date=May 2003}}</ref>
* [[Collagen, type XVII, alpha 1]],<ref name = pmid10321838>{{cite journal | vauthors = Aho S, Rothenberger K, Uitto J | title = Human p120ctn catenin: tissue-specific expression of isoforms and molecular interactions with BP180/type XVII collagen | journal = J. Cell. Biochem. | volume = 73 | issue = 3 | pages = 390–9 | year = 1999 | pmid = 10321838 | doi = 10.1002/(SICI)1097-4644(19990601)73:3<390::AID-JCB10>3.0.CO;2-1 }}</ref>
* [[Cortactin]],<ref name = pmid12835311/>
* [[FYN]],<ref name = pmid12640114>{{cite journal | vauthors = Piedra J, Miravet S, Castaño J, Pálmer HG, Heisterkamp N, García de Herreros A, Duñach M | title = p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction | journal = Mol. Cell. Biol. | volume = 23 | issue = 7 | pages = 2287–97 | pmid = 12640114 | pmc = 150740 | doi =  10.1128/MCB.23.7.2287-2297.2003}}</ref><ref name = pmid12835311>{{cite journal | vauthors = Martinez MC, Ochiishi T, Majewski M, Kosik KS | title = Dual regulation of neuronal morphogenesis by a delta-catenin-cortactin complex and Rho | journal = J. Cell Biol. | volume = 162 | issue = 1 | pages = 99–111 | pmid = 12835311 | pmc = 2172717 | doi = 10.1083/jcb.200211025 }}</ref>
* [[MUC1]],<ref name = pmid11181067>{{cite journal | vauthors = Li Y, Kufe D | title = The Human DF3/MUC1 carcinoma-associated antigen signals nuclear localization of the catenin p120(ctn) | journal = Biochem. Biophys. Res. Commun. | volume = 281 | issue = 2 | pages = 440–3 | pmid = 11181067 | doi = 10.1006/bbrc.2001.4383 | date=February 2001}}</ref>
* [[Nephrin]],<ref name = pmid15331416>{{cite journal | vauthors = Lehtonen S, Lehtonen E, Kudlicka K, Holthöfer H, Farquhar MG | title = Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin | journal = Am. J. Pathol. | volume = 165 | issue = 3 | pages = 923–36 | pmid = 15331416 | pmc = 1618613 | doi = 10.1016/S0002-9440(10)63354-8 }}</ref>
* [[PSEN1]],<ref name = pmid10208590>{{cite journal | vauthors = Tanahashi H, Tabira T | title = Isolation of human delta-catenin and its binding specificity with presenilin 1 | journal = NeuroReport | volume = 10 | issue = 3 | pages = 563–8 | pmid = 10208590 | doi =  10.1097/00001756-199902250-00022 | date=February 1999}}</ref>
* [[PTPN6]],<ref name = pmid10835420>{{cite journal | vauthors = Keilhack H, Hellman U, van Hengel J, van Roy F, Godovac-Zimmermann J, Böhmer FD | title = The protein-tyrosine phosphatase SHP-1 binds to and dephosphorylates p120 catenin | journal = J. Biol. Chem. | volume = 275 | issue = 34 | pages = 26376–84 | pmid = 10835420 | doi = 10.1074/jbc.M001315200 | date=August 2000}}</ref>
* [[PTPRJ]],<ref name = pmid12370829>{{cite journal | vauthors = Holsinger LJ, Ward K, Duffield B, Zachwieja J, Jallal B | title = The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn) | journal = Oncogene | volume = 21 | issue = 46 | pages = 7067–76 | pmid = 12370829 | doi = 10.1038/sj.onc.1205858 | date=October 2002}}</ref>
* [[PTPRM]],<ref name = pmid10753936>{{cite journal | vauthors = Zondag GC, Reynolds AB, Moolenaar WH | title = Receptor protein-tyrosine phosphatase RPTPmu binds to and dephosphorylates the catenin p120(ctn) | journal = J. Biol. Chem. | volume = 275 | issue = 15 | pages = 11264–9 | pmid = 10753936 | doi =  10.1074/jbc.275.15.11264 | date=April 2000}}</ref>
* [[VE-cadherin]],<ref name = pmid11855855>{{cite journal | vauthors = Ferber A, Yaen C, Sarmiento E, Martinez J | title = An octapeptide in the juxtamembrane domain of VE-cadherin is important for p120ctn binding and cell proliferation | journal = Exp. Cell Res. | volume = 274 | issue = 1 | pages = 35–44 | pmid = 11855855 | doi = 10.1006/excr.2001.5436 | date=March 2002}}</ref><ref name = pmid9378757>{{cite journal | vauthors = Lampugnani MG, Corada M, Andriopoulou P, Esser S, Risau W, Dejana E | title = Cell confluence regulates tyrosine phosphorylation of adherens junction components in endothelial cells | journal = J. Cell Sci. | volume = 110 | issue =  17| pages = 2065–77 | pmid = 9378757 | doi = | date=September 1997}}</ref>
* [[YES1]],<ref name = pmid12640114/>  and
* [[ZBTB33]]<ref name = pmid10207085>{{cite journal | vauthors = Daniel JM, Reynolds AB | title = The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor | journal = Mol. Cell. Biol. | volume = 19 | issue = 5 | pages = 3614–23 | pmid = 10207085 | pmc = 84161 | doi = 10.1128/mcb.19.5.3614| date=May 1999}}</ref>
{{Div col end}}
 
== See also ==
* [[Delta catenin]]
* [[Delta catenin]]
* [[Catenin]]
* [[Catenin]]
* [[CTNND2]]
{{Clear}}


==References==
== References ==
{{reflist|2}}
{{reflist|35em}}
==Further reading==
 
{{refbegin | 2}}
== Further reading ==
{{PBB_Further_reading
{{refbegin|35em}}
| citations =
* {{cite journal | vauthors = Wijnhoven BP, Dinjens WN, Pignatelli M | title = E-cadherin-catenin cell-cell adhesion complex and human cancer | journal = The British Journal of Surgery | volume = 87 | issue = 8 | pages = 992–1005 | year = 2000 | pmid = 10931041 | doi = 10.1046/j.1365-2168.2000.01513.x }}
*{{cite journal | author=Wijnhoven BP, Dinjens WN, Pignatelli M |title=E-cadherin-catenin cell-cell adhesion complex and human cancer. |journal=The British journal of surgery |volume=87 |issue= 8 |pages= 992-1005 |year= 2000 |pmid= 10931041 |doi= 10.1046/j.1365-2168.2000.01513.x }}
* {{cite journal | vauthors = Thoreson MA, Reynolds AB | title = Altered expression of the catenin p120 in human cancer: implications for tumor progression | journal = Differentiation | volume = 70 | issue = 9–10 | pages = 583–9 | year = 2003 | pmid = 12492499 | doi = 10.1046/j.1432-0436.2002.700911.x }}
*{{cite journal | author=Thoreson MA, Reynolds AB |title=Altered expression of the catenin p120 in human cancer: implications for tumor progression. |journal=Differentiation |volume=70 |issue= 9-10 |pages= 583-9 |year= 2003 |pmid= 12492499 |doi= }}
* {{cite journal | vauthors = Reynolds AB, Carnahan RH | title = Regulation of cadherin stability and turnover by p120ctn: implications in disease and cancer | journal = Semin. Cell Dev. Biol. | volume = 15 | issue = 6 | pages = 657–63 | year = 2005 | pmid = 15561585 | doi = 10.1016/j.semcdb.2004.09.003 }}
*{{cite journal | author=Reynolds AB, Carnahan RH |title=Regulation of cadherin stability and turnover by p120ctn: implications in disease and cancer. |journal=Semin. Cell Dev. Biol. |volume=15 |issue= 6 |pages= 657-63 |year= 2005 |pmid= 15561585 |doi= 10.1016/j.semcdb.2004.09.003 }}
* {{cite journal | vauthors = Keil R, Wolf A, Hüttelmaier S, Hatzfeld M | title = Beyond regulation of cell adhesion: local control of RhoA at the cleavage furrow by the p0071 catenin | journal = Cell Cycle | volume = 6 | issue = 2 | pages = 122–7 | year = 2007 | pmid = 17264675 | doi = 10.4161/cc.6.2.3741 }}
*{{cite journal | author=Keil R, Wolf A, Hüttelmaier S, Hatzfeld M |title=Beyond regulation of cell adhesion: local control of RhoA at the cleavage furrow by the p0071 catenin. |journal=Cell Cycle |volume=6 |issue= 2 |pages= 122-7 |year= 2007 |pmid= 17264675 |doi= }}
* {{cite journal | vauthors = Kinch MS, Clark GJ, Der CJ, Burridge K | title = Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia | journal = J. Cell Biol. | volume = 130 | issue = 2 | pages = 461–71 | year = 1995 | pmid = 7542250 | pmc = 2199929 | doi = 10.1083/jcb.130.2.461 }}
*{{cite journal | author=Kinch MS, Clark GJ, Der CJ, Burridge K |title=Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia. |journal=J. Cell Biol. |volume=130 |issue= 2 |pages= 461-71 |year= 1995 |pmid= 7542250 |doi= }}
* {{cite journal | vauthors = Daniel JM, Reynolds AB | title = The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha-catenin | journal = Mol. Cell. Biol. | volume = 15 | issue = 9 | pages = 4819–24 | year = 1995 | pmid = 7651399 | pmc = 230726 | doi =  10.1128/mcb.15.9.4819}}
*{{cite journal | author=Daniel JM, Reynolds AB |title=The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha-catenin. |journal=Mol. Cell. Biol. |volume=15 |issue= 9 |pages= 4819-24 |year= 1995 |pmid= 7651399 |doi=  }}
* {{cite journal | vauthors = Shibamoto S, Hayakawa M, Takeuchi K, Hori T, Miyazawa K, Kitamura N, Johnson KR, Wheelock MJ, Matsuyoshi N, Takeichi M | title = Association of p120, a tyrosine kinase substrate, with E- cadherin/catenin complexes | journal = J. Cell Biol. | volume = 128 | issue = 5 | pages = 949–57 | year = 1995 | pmid = 7876318 | pmc = 2120395 | doi = 10.1083/jcb.128.5.949 }}
*{{cite journal | author=Shibamoto S, Hayakawa M, Takeuchi K, ''et al.'' |title=Association of p120, a tyrosine kinase substrate, with E-cadherin/catenin complexes. |journal=J. Cell Biol. |volume=128 |issue= 5 |pages= 949-57 |year= 1995 |pmid= 7876318 |doi= }}
* {{cite journal | vauthors = Reynolds AB, Daniel JM, Mo YY, Wu J, Zhang Z | title = The novel catenin p120cas binds classical cadherins and induces an unusual morphological phenotype in NIH3T3 fibroblasts | journal = Exp. Cell Res. | volume = 225 | issue = 2 | pages = 328–37 | year = 1996 | pmid = 8660921 | doi = 10.1006/excr.1996.0183 }}
*{{cite journal | author=Reynolds AB, Daniel JM, Mo YY, ''et al.'' |title=The novel catenin p120cas binds classical cadherins and induces an unusual morphological phenotype in NIH3T3 fibroblasts. |journal=Exp. Cell Res. |volume=225 |issue= 2 |pages= 328-37 |year= 1996 |pmid= 8660921 |doi= 10.1006/excr.1996.0183 }}
* {{cite journal | vauthors = Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro | journal = DNA Res. | volume = 4 | issue = 2 | pages = 141–50 | year = 1997 | pmid = 9205841 | doi = 10.1093/dnares/4.2.141 }}
*{{cite journal | author=Reynolds AB, Jenkins NA, Gilbert DJ, ''et al.'' |title=The gene encoding p120cas, a novel catenin, localizes on human chromosome 11q11 (CTNND) and mouse chromosome 2 (Catns). |journal=Genomics |volume=31 |issue= 1 |pages= 127-9 |year= 1996 |pmid= 8808291 |doi= 10.1006/geno.1996.0020 }}
* {{cite journal | vauthors = Lampugnani MG, Corada M, Andriopoulou P, Esser S, Risau W, Dejana E | title = Cell confluence regulates tyrosine phosphorylation of adherens junction components in endothelial cells | journal = J. Cell Sci. | volume = 110 | issue = 17 | pages = 2065–77 | year = 1997 | pmid = 9378757 | doi =  }}
*{{cite journal | author=Nagase T, Ishikawa K, Nakajima D, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=4 |issue= 2 |pages= 141-50 |year= 1997 |pmid= 9205841 |doi=  }}
* {{cite journal | vauthors = Hazan RB, Norton L | title = The epidermal growth factor receptor modulates the interaction of E-cadherin with the actin cytoskeleton | journal = J. Biol. Chem. | volume = 273 | issue = 15 | pages = 9078–84 | year = 1998 | pmid = 9535896 | doi = 10.1074/jbc.273.15.9078 }}
*{{cite journal | author=Lampugnani MG, Corada M, Andriopoulou P, ''et al.'' |title=Cell confluence regulates tyrosine phosphorylation of adherens junction components in endothelial cells. |journal=J. Cell. Sci. |volume=110 ( Pt 17) |issue= |pages= 2065-77 |year= 1997 |pmid= 9378757 |doi= }}
* {{cite journal | vauthors = Keirsebilck A, Bonné S, Staes K, van Hengel J, Nollet F, Reynolds A, van Roy F | title = Molecular cloning of the human p120ctn catenin gene (CTNND1): expression of multiple alternatively spliced isoforms | journal = Genomics | volume = 50 | issue = 2 | pages = 129–46 | year = 1998 | pmid = 9653641 | doi = 10.1006/geno.1998.5325 }}
*{{cite journal | author=Hazan RB, Norton L |title=The epidermal growth factor receptor modulates the interaction of E-cadherin with the actin cytoskeleton. |journal=J. Biol. Chem. |volume=273 |issue= 15 |pages= 9078-84 |year= 1998 |pmid= 9535896 |doi= }}
* {{cite journal | vauthors = Bauer A, Lickert H, Kemler R, Stappert J | title = Modification of the E-cadherin-catenin complex in mitotic Madin-Darby canine kidney epithelial cells | journal = J. Biol. Chem. | volume = 273 | issue = 43 | pages = 28314–21 | year = 1998 | pmid = 9774455 | doi = 10.1074/jbc.273.43.28314 }}
*{{cite journal | author=Keirsebilck A, Bonné S, Staes K, ''et al.'' |title=Molecular cloning of the human p120ctn catenin gene (CTNND1): expression of multiple alternatively spliced isoforms. |journal=Genomics |volume=50 |issue= 2 |pages= 129-46 |year= 1998 |pmid= 9653641 |doi= 10.1006/geno.1998.5325 }}
* {{cite journal | vauthors = Daniel JM, Reynolds AB | title = The Catenin p120ctn Interacts with Kaiso, a Novel BTB/POZ Domain Zinc Finger Transcription Factor | journal = Mol. Cell. Biol. | volume = 19 | issue = 5 | pages = 3614–23 | year = 1999 | pmid = 10207085 | pmc = 84161 | doi =  10.1128/mcb.19.5.3614}}
*{{cite journal | author=Bauer A, Lickert H, Kemler R, Stappert J |title=Modification of the E-cadherin-catenin complex in mitotic Madin-Darby canine kidney epithelial cells. |journal=J. Biol. Chem. |volume=273 |issue= 43 |pages= 28314-21 |year= 1998 |pmid= 9774455 |doi=  }}
* {{cite journal | vauthors = Aono S, Nakagawa S, Reynolds AB, Takeichi M | title = p120ctn Acts as an Inhibitory Regulator of Cadherin Function in Colon Carcinoma Cells | journal = J. Cell Biol. | volume = 145 | issue = 3 | pages = 551–62 | year = 1999 | pmid = 10225956 | pmc = 2185070 | doi = 10.1083/jcb.145.3.551 }}
*{{cite journal | author=Daniel JM, Reynolds AB |title=The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor. |journal=Mol. Cell. Biol. |volume=19 |issue= 5 |pages= 3614-23 |year= 1999 |pmid= 10207085 |doi= }}
* {{cite journal | vauthors = Aho S, Rothenberger K, Uitto J | title = Human p120ctn catenin: tissue-specific expression of isoforms and molecular interactions with BP180/type XVII collagen | journal = J. Cell. Biochem. | volume = 73 | issue = 3 | pages = 390–9 | year = 1999 | pmid = 10321838 | doi = 10.1002/(SICI)1097-4644(19990601)73:3<390::AID-JCB10>3.0.CO;2-1 }}
*{{cite journal | author=Aono S, Nakagawa S, Reynolds AB, Takeichi M |title=p120(ctn) acts as an inhibitory regulator of cadherin function in colon carcinoma cells. |journal=J. Cell Biol. |volume=145 |issue= 3 |pages= 551-62 |year= 1999 |pmid= 10225956 |doi= }}
* {{cite journal | vauthors = van Hengel J, Vanhoenacker P, Staes K, van Roy F | title = Nuclear localization of the p120ctn Armadillo-like catenin is counteracted by a nuclear export signal and by E-cadherin expression | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 14 | pages = 7980–5 | year = 1999 | pmid = 10393933 | pmc = 22173 | doi = 10.1073/pnas.96.14.7980 }}
*{{cite journal | author=Aho S, Rothenberger K, Uitto J |title=Human p120ctn catenin: tissue-specific expression of isoforms and molecular interactions with BP180/type XVII collagen. |journal=J. Cell. Biochem. |volume=73 |issue= 3 |pages= 390-9 |year= 1999 |pmid= 10321838 |doi= }}
* {{cite journal | vauthors = Ohkubo T, Ozawa M | title = p120(ctn) binds to the membrane-proximal region of the E-cadherin cytoplasmic domain and is involved in modulation of adhesion activity | journal = J. Biol. Chem. | volume = 274 | issue = 30 | pages = 21409–15 | year = 1999 | pmid = 10409703 | doi = 10.1074/jbc.274.30.21409 }}
*{{cite journal | author=van Hengel J, Vanhoenacker P, Staes K, van Roy F |title=Nuclear localization of the p120(ctn) Armadillo-like catenin is counteracted by a nuclear export signal and by E-cadherin expression. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 14 |pages= 7980-5 |year= 1999 |pmid= 10393933 |doi= }}
* {{cite journal | vauthors = Thoreson MA, Anastasiadis PZ, Daniel JM, Ireton RC, Wheelock MJ, Johnson KR, Hummingbird DK, Reynolds AB | title = Selective Uncoupling of P120ctn from E-Cadherin Disrupts Strong Adhesion | journal = J. Cell Biol. | volume = 148 | issue = 1 | pages = 189–202 | year = 2000 | pmid = 10629228 | pmc = 2156209 | doi = 10.1083/jcb.148.1.189 }}
*{{cite journal | author=Ohkubo T, Ozawa M |title=p120(ctn) binds to the membrane-proximal region of the E-cadherin cytoplasmic domain and is involved in modulation of adhesion activity. |journal=J. Biol. Chem. |volume=274 |issue= 30 |pages= 21409-15 |year= 1999 |pmid= 10409703 |doi= }}
*{{cite journal  | author=Thoreson MA, Anastasiadis PZ, Daniel JM, ''et al.'' |title=Selective uncoupling of p120(ctn) from E-cadherin disrupts strong adhesion. |journal=J. Cell Biol. |volume=148 |issue= 1 |pages= 189-202 |year= 2000 |pmid= 10629228 |doi=  }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* {{UCSC gene info|CTNND1}}
 
[[Category:Catenins]]
[[Category:Armadillo-repeat-containing proteins]]

Latest revision as of 01:13, 3 October 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Catenin delta-1 is a protein that in humans is encoded by the CTNND1 gene.[1]

Function

This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined.[2]

Interactions

CTNND1 has been shown to interact with:

See also

References

  1. ↑ Reynolds AB, Jenkins NA, Gilbert DJ, Copeland NG, Shapiro DN, Wu J, Daniel JM (October 1996). "The gene encoding p120cas, a novel catenin, localizes on human chromosome 11q11 (CTNND) and mouse chromosome 2 (Catns)". Genomics. 31 (1): 127–9. doi:10.1006/geno.1996.0020. PMID 8808291.
  2. ↑ "Entrez Gene: CTNND1 catenin (cadherin-associated protein), delta 1".
  3. ↑ 3.0 3.1 Hazan RB, Norton L (April 1998). "The epidermal growth factor receptor modulates the interaction of E-cadherin with the actin cytoskeleton". J. Biol. Chem. 273 (15): 9078–84. doi:10.1074/jbc.273.15.9078. PMID 9535896.
  4. ↑ Kucerová D, Sloncová E, Tuhácková Z, Vojtechová M, Sovová V (December 2001). "Expression and interaction of different catenins in colorectal carcinoma cells". Int. J. Mol. Med. 8 (6): 695–8. doi:10.3892/ijmm.8.6.695. PMID 11712088.
  5. ↑ 5.0 5.1 5.2 Piedra J, Miravet S, Castaño J, Pálmer HG, Heisterkamp N, García de Herreros A, Duñach M. "p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction". Mol. Cell. Biol. 23 (7): 2287–97. doi:10.1128/MCB.23.7.2287-2297.2003. PMC 150740. PMID 12640114.
  6. ↑ Daniel JM, Reynolds AB (September 1995). "The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha-catenin". Mol. Cell. Biol. 15 (9): 4819–24. doi:10.1128/mcb.15.9.4819. PMC 230726. PMID 7651399.
  7. ↑ Ireton RC, Davis MA, van Hengel J, Mariner DJ, Barnes K, Thoreson MA, Anastasiadis PZ, Matrisian L, Bundy LM, Sealy L, Gilbert B, van Roy F, Reynolds AB. "A novel role for p120 catenin in E-cadherin function". J. Cell Biol. 159 (3): 465–76. doi:10.1083/jcb.200205115. PMC 2173073. PMID 12427869.
  8. ↑ Kinch MS, Clark GJ, Der CJ, Burridge K. "Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia". J. Cell Biol. 130 (2): 461–71. doi:10.1083/jcb.130.2.461. PMC 2199929. PMID 7542250.
  9. ↑ Bonné S, Gilbert B, Hatzfeld M, Chen X, Green KJ, van Roy F. "Defining desmosomal plakophilin-3 interactions". J. Cell Biol. 161 (2): 403–16. doi:10.1083/jcb.200303036. PMC 2172904. PMID 12707304.
  10. ↑ Shibamoto S, Hayakawa M, Takeuchi K, Hori T, Miyazawa K, Kitamura N, Johnson KR, Wheelock MJ, Matsuyoshi N, Takeichi M. "Association of p120, a tyrosine kinase substrate, with E-cadherin/catenin complexes". J. Cell Biol. 128 (5): 949–57. doi:10.1083/jcb.128.5.949. PMC 2120395. PMID 7876318.
  11. ↑ Ohkubo T, Ozawa M (July 1999). "p120(ctn) binds to the membrane-proximal region of the E-cadherin cytoplasmic domain and is involved in modulation of adhesion activity". J. Biol. Chem. 274 (30): 21409–15. doi:10.1074/jbc.274.30.21409. PMID 10409703.
  12. ↑ Straub BK, Boda J, Kuhn C, Schnoelzer M, Korf U, Kempf T, Spring H, Hatzfeld M, Franke WW (December 2003). "A novel cell-cell junction system: the cortex adhaerens mosaic of lens fiber cells". J. Cell Sci. 116 (Pt 24): 4985–95. doi:10.1242/jcs.00815. PMID 14625392.
  13. ↑ Wahl JK, Kim YJ, Cullen JM, Johnson KR, Wheelock MJ (May 2003). "N-cadherin-catenin complexes form prior to cleavage of the proregion and transport to the plasma membrane". J. Biol. Chem. 278 (19): 17269–76. doi:10.1074/jbc.M211452200. PMID 12604612.
  14. ↑ Aho S, Rothenberger K, Uitto J (1999). "Human p120ctn catenin: tissue-specific expression of isoforms and molecular interactions with BP180/type XVII collagen". J. Cell. Biochem. 73 (3): 390–9. doi:10.1002/(SICI)1097-4644(19990601)73:3<390::AID-JCB10>3.0.CO;2-1. PMID 10321838.
  15. ↑ 15.0 15.1 Martinez MC, Ochiishi T, Majewski M, Kosik KS. "Dual regulation of neuronal morphogenesis by a delta-catenin-cortactin complex and Rho". J. Cell Biol. 162 (1): 99–111. doi:10.1083/jcb.200211025. PMC 2172717. PMID 12835311.
  16. ↑ Li Y, Kufe D (February 2001). "The Human DF3/MUC1 carcinoma-associated antigen signals nuclear localization of the catenin p120(ctn)". Biochem. Biophys. Res. Commun. 281 (2): 440–3. doi:10.1006/bbrc.2001.4383. PMID 11181067.
  17. ↑ Lehtonen S, Lehtonen E, Kudlicka K, Holthöfer H, Farquhar MG. "Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin". Am. J. Pathol. 165 (3): 923–36. doi:10.1016/S0002-9440(10)63354-8. PMC 1618613. PMID 15331416.
  18. ↑ Tanahashi H, Tabira T (February 1999). "Isolation of human delta-catenin and its binding specificity with presenilin 1". NeuroReport. 10 (3): 563–8. doi:10.1097/00001756-199902250-00022. PMID 10208590.
  19. ↑ Keilhack H, Hellman U, van Hengel J, van Roy F, Godovac-Zimmermann J, Böhmer FD (August 2000). "The protein-tyrosine phosphatase SHP-1 binds to and dephosphorylates p120 catenin". J. Biol. Chem. 275 (34): 26376–84. doi:10.1074/jbc.M001315200. PMID 10835420.
  20. ↑ Holsinger LJ, Ward K, Duffield B, Zachwieja J, Jallal B (October 2002). "The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn)". Oncogene. 21 (46): 7067–76. doi:10.1038/sj.onc.1205858. PMID 12370829.
  21. ↑ Zondag GC, Reynolds AB, Moolenaar WH (April 2000). "Receptor protein-tyrosine phosphatase RPTPmu binds to and dephosphorylates the catenin p120(ctn)". J. Biol. Chem. 275 (15): 11264–9. doi:10.1074/jbc.275.15.11264. PMID 10753936.
  22. ↑ Ferber A, Yaen C, Sarmiento E, Martinez J (March 2002). "An octapeptide in the juxtamembrane domain of VE-cadherin is important for p120ctn binding and cell proliferation". Exp. Cell Res. 274 (1): 35–44. doi:10.1006/excr.2001.5436. PMID 11855855.
  23. ↑ Lampugnani MG, Corada M, Andriopoulou P, Esser S, Risau W, Dejana E (September 1997). "Cell confluence regulates tyrosine phosphorylation of adherens junction components in endothelial cells". J. Cell Sci. 110 (17): 2065–77. PMID 9378757.
  24. ↑ Daniel JM, Reynolds AB (May 1999). "The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor". Mol. Cell. Biol. 19 (5): 3614–23. doi:10.1128/mcb.19.5.3614. PMC 84161. PMID 10207085.

Further reading

External links

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