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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Cleavage and polyadenylation specificity factor subunit 6''' is a [[protein]] that in humans is encoded by the ''CPSF6'' [[gene]].<ref name="pmid9659921">{{cite journal | vauthors = Rüegsegger U, Blank D, Keller W | title = Human pre-mRNA cleavage factor Im is related to spliceosomal SR proteins and can be reconstituted in vitro from recombinant subunits | journal = Molecular Cell | volume = 1 | issue = 2 | pages = 243–53 | date = Jan 1998 | pmid = 9659921 | pmc =  | doi = 10.1016/S1097-2765(00)80025-8 }}</ref><ref name="pmid17267687">{{cite journal | vauthors = Cardinale S, Cisterna B, Bonetti P, Aringhieri C, Biggiogera M, Barabino SM | title = Subnuclear localization and dynamics of the Pre-mRNA 3' end processing factor mammalian cleavage factor I 68-kDa subunit | journal = Molecular Biology of the Cell | volume = 18 | issue = 4 | pages = 1282–92 | date = Apr 2007 | pmid = 17267687 | pmc = 1838998 | doi = 10.1091/mbc.E06-09-0846 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CPSF6 cleavage and polyadenylation specific factor 6, 68kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11052| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cleavage and polyadenylation specific factor 6, 68kDa
| HGNCid = 13871
| Symbol = CPSF6
| AltSymbols =; CFIM; CFIM68; HPBRII-4; HPBRII-7
| OMIM = 604979
| ECnumber = 
| Homologene = 5091
| MGIid = 1913948
| GeneAtlas_image1 = PBB_GE_CPSF6_202469_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CPSF6_202470_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005849 |text = mRNA cleavage factor complex}} {{GNF_GO|id=GO:0042382 |text = paraspeckles}}
| Process = {{GNF_GO|id=GO:0006397 |text = mRNA processing}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 11052
    | Hs_Ensembl = ENSG00000111605
    | Hs_RefseqProtein = NP_008938
    | Hs_RefseqmRNA = NM_007007
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 67919663
    | Hs_GenLoc_end = 67951290
    | Hs_Uniprot = Q16630
    | Mm_EntrezGene = 432508
    | Mm_Ensembl = ENSMUSG00000055531
    | Mm_RefseqmRNA = XM_984539
    | Mm_RefseqProtein = XP_989633
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 116751624
    | Mm_GenLoc_end = 116781080
    | Mm_Uniprot = Q6NVF9
  }}
}}
'''Cleavage and polyadenylation specific factor 6, 68kDa''', also known as '''CPSF6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CPSF6 cleavage and polyadenylation specific factor 6, 68kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11052| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitement of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitement of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins.<ref name="entrez">{{cite web | title = Entrez Gene: CPSF6 cleavage and polyadenylation specific factor 6, 68kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11052| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
CPSF6 has been shown to [[Protein-protein interaction|interact]] with [[WWP1]]<ref name=pmid16189514>{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | displayauthors = 6| title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}</ref> and [[PLSCR1]].<ref name=pmid16189514/>
 
== References ==
{{reflist}}
 
==External links==
* {{UCSC gene info|CPSF6}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | date = Jan 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
| citations =
* {{cite journal | vauthors = Rüegsegger U, Beyer K, Keller W | title = Purification and characterization of human cleavage factor Im involved in the 3' end processing of messenger RNA precursors | journal = The Journal of Biological Chemistry | volume = 271 | issue = 11 | pages = 6107–13 | date = Mar 1996 | pmid = 8626397 | doi = 10.1074/jbc.271.11.6107 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | date = Oct 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Rüegsegger U, Beyer K, Keller W |title=Purification and characterization of human cleavage factor Im involved in the 3' end processing of messenger RNA precursors. |journal=J. Biol. Chem. |volume=271 |issue= 11 |pages= 6107-13 |year= 1996 |pmid= 8626397 |doi= }}
* {{cite journal | vauthors = de Vries H, Rüegsegger U, Hübner W, Friedlein A, Langen H, Keller W | title = Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors | journal = The EMBO Journal | volume = 19 | issue = 21 | pages = 5895–904 | date = Nov 2000 | pmid = 11060040 | pmc = 305781 | doi = 10.1093/emboj/19.21.5895 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Awasthi S, Alwine JC | title = Association of polyadenylation cleavage factor I with U1 snRNP | journal = RNA | volume = 9 | issue = 11 | pages = 1400–9 | date = Nov 2003 | pmid = 14561889 | pmc = 1287061 | doi = 10.1261/rna.5104603 }}
*{{cite journal  | author=Rüegsegger U, Blank D, Keller W |title=Human pre-mRNA cleavage factor Im is related to spliceosomal SR proteins and can be reconstituted in vitro from recombinant subunits. |journal=Mol. Cell |volume=1 |issue= 2 |pages= 243-53 |year= 1998 |pmid= 9659921 |doi=  }}
* {{cite journal | vauthors = Brown KM, Gilmartin GM | title = A mechanism for the regulation of pre-mRNA 3' processing by human cleavage factor Im | journal = Molecular Cell | volume = 12 | issue = 6 | pages = 1467–76 | date = Dec 2003 | pmid = 14690600 | doi = 10.1016/S1097-2765(03)00453-2 }}
*{{cite journal | author=de Vries H, Rüegsegger U, Hübner W, ''et al.'' |title=Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors. |journal=EMBO J. |volume=19 |issue= 21 |pages= 5895-904 |year= 2000 |pmid= 11060040 |doi= 10.1093/emboj/19.21.5895 }}
* {{cite journal | vauthors = Dettwiler S, Aringhieri C, Cardinale S, Keller W, Barabino SM | title = Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization | journal = The Journal of Biological Chemistry | volume = 279 | issue = 34 | pages = 35788–97 | date = Aug 2004 | pmid = 15169763 | doi = 10.1074/jbc.M403927200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Venkataraman K, Brown KM, Gilmartin GM | title = Analysis of a noncanonical poly(A) site reveals a tripartite mechanism for vertebrate poly(A) site recognition | journal = Genes & Development | volume = 19 | issue = 11 | pages = 1315–27 | date = Jun 2005 | pmid = 15937220 | pmc = 1142555 | doi = 10.1101/gad.1298605 }}
*{{cite journal  | author=Awasthi S, Alwine JC |title=Association of polyadenylation cleavage factor I with U1 snRNP. |journal=RNA |volume=9 |issue= 11 |pages= 1400-9 |year= 2003 |pmid= 14561889 |doi= }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Brown KM, Gilmartin GM |title=A mechanism for the regulation of pre-mRNA 3' processing by human cleavage factor Im. |journal=Mol. Cell |volume=12 |issue= 6 |pages= 1467-76 |year= 2004 |pmid= 14690600 |doi= }}
* {{cite journal | vauthors = Millevoi S, Loulergue C, Dettwiler S, Karaa SZ, Keller W, Antoniou M, Vagner S | title = An interaction between U2AF 65 and CF I(m) links the splicing and 3' end processing machineries | journal = The EMBO Journal | volume = 25 | issue = 20 | pages = 4854–64 | date = Oct 2006 | pmid = 17024186 | pmc = 1618107 | doi = 10.1038/sj.emboj.7601331 }}
*{{cite journal | author=Dettwiler S, Aringhieri C, Cardinale S, ''et al.'' |title=Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization. |journal=J. Biol. Chem. |volume=279 |issue= 34 |pages= 35788-97 |year= 2005 |pmid= 15169763 |doi= 10.1074/jbc.M403927200 }}
* {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Venkataraman K, Brown KM, Gilmartin GM |title=Analysis of a noncanonical poly(A) site reveals a tripartite mechanism for vertebrate poly(A) site recognition. |journal=Genes Dev. |volume=19 |issue= 11 |pages= 1315-27 |year= 2005 |pmid= 15937220 |doi= 10.1101/gad.1298605 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal  | author=Millevoi S, Loulergue C, Dettwiler S, ''et al.'' |title=An interaction between U2AF 65 and CF I(m) links the splicing and 3' end processing machineries. |journal=EMBO J. |volume=25 |issue= 20 |pages= 4854-64 |year= 2006 |pmid= 17024186 |doi= 10.1038/sj.emboj.7601331 }}
*{{cite journal | author=Cardinale S, Cisterna B, Bonetti P, ''et al.'' |title=Subnuclear localization and dynamics of the Pre-mRNA 3' end processing factor mammalian cleavage factor I 68-kDa subunit. |journal=Mol. Biol. Cell |volume=18 |issue= 4 |pages= 1282-92 |year= 2007 |pmid= 17267687 |doi= 10.1091/mbc.E06-09-0846 }}
*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
{{refend}}
{{refend}}


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Revision as of 10:00, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Cleavage and polyadenylation specificity factor subunit 6 is a protein that in humans is encoded by the CPSF6 gene.[1][2][3]

Function

The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitement of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins.[3]

Interactions

CPSF6 has been shown to interact with WWP1[4] and PLSCR1.[4]

References

  1. ↑ Rüegsegger U, Blank D, Keller W (Jan 1998). "Human pre-mRNA cleavage factor Im is related to spliceosomal SR proteins and can be reconstituted in vitro from recombinant subunits". Molecular Cell. 1 (2): 243–53. doi:10.1016/S1097-2765(00)80025-8. PMID 9659921.
  2. ↑ Cardinale S, Cisterna B, Bonetti P, Aringhieri C, Biggiogera M, Barabino SM (Apr 2007). "Subnuclear localization and dynamics of the Pre-mRNA 3' end processing factor mammalian cleavage factor I 68-kDa subunit". Molecular Biology of the Cell. 18 (4): 1282–92. doi:10.1091/mbc.E06-09-0846. PMC 1838998. PMID 17267687.
  3. ↑ 3.0 3.1 "Entrez Gene: CPSF6 cleavage and polyadenylation specific factor 6, 68kDa".
  4. ↑ 4.0 4.1 Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

External links

Further reading

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