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| [[File:SARS-CoV-2 49534865371.jpg|thumb|Electron micrograph of SARS-CoV-2 virions with visible coronae]]
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| __NOTOC__
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| {{COVID-19}}
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| {{CMG}} ; {{AE}}[[User:DrMars|Mohammadmain Rezazadehsaatlou]] [2],
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| ==Overview==
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| ==Historical Perspective==
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| According to the WHO report<ref name="pmid7029452">{{cite journal |vauthors=Dahlström Y |title=[Literature retrieval with the aid of computers] |language=Swedish |journal=Nord Med |volume=96 |issue=10 |pages=247–9 |date=October 1981 |pmid=7029452 |doi= |url=}}</ref><ref name="pmid7031771">{{cite journal |vauthors=Matsukage A, Tanabe K, Yamaguchi M |title=[Structure and chain elongation mechanism of DNA polymerases from animal cells (author's transl)] |language=Japanese |journal=Tanpakushitsu Kakusan Koso |volume=26 |issue=10 |pages=1495–521 |date=August 1981 |pmid=7031771 |doi= |url=}}</ref><ref name="pmid7040011">{{cite journal |vauthors=Kaplan C, Hawley R |title=Dysgerminoma with giant cells. A case report with immunoperoxidase |journal=Diagn Gynecol Obstet |volume=3 |issue=4 |pages=325–9 |date=1981 |pmid=7040011 |doi= |url=}}</ref>, their office in china called "WHO China Country Office" on 31 December 2019, the WHO China Country Office was informed as a new type of pneumonia cases with unknown etiology at that time (31 December 2019) in Wuhan City, Hubei Province of China<ref name="pmid6995816">{{cite journal |vauthors=Al'-Nuri MA, Sattarova GB, Egorov NS |title=[Exoprotease biosynthesis by an Actinomyces spheroides culture on a medium with limited carbon, nitrogen and sulfur sources] |language=Russian |journal=Mikrobiologiia |volume=49 |issue=3 |pages=408–11 |date=1980 |pmid=6995816 |doi= |url=}}</ref>.
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| As of 3 January 2020, a total of 44 cases with that pneumonia due to the unknown etiology have been reported to WHO by the national authorities in China<ref name="pmid7014669">{{cite journal |vauthors=Prévost AP, Baltadjian H, Hélie P, Yergeau J |title=[Conservation of non-supportive enamel through the internal etching technique] |language=French |journal=J Dent Que |volume=18 |issue= |pages=39–41 |date=February 1981 |pmid=7014669 |doi= |url=}}</ref>:
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| * 11 case were severely ill.
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| * 33 remaining patients were stable.
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| Accordingly, the concerned market in Wuhan was closed on 1 January 2020 for environmental sanitation and disinfection. After that illness was not identified or confirmed. On 1 January 2020, then WHO requested further information from national authorities to assess the related risks and affect of this illness. The china reported to WHO that all patients were isolated and underwent medical treatment in Wuhan medical institutions. The related clinical signs and symptoms were consisted of<ref name="pmid6988271">{{cite journal |vauthors=Bolli G, Cartechini MG, Compagnucci P, Santeusanio F, Massi-Benedetti M, Calabrese G, Puxeddu A, Brunetti P |title=Modification of glycosylated haemoglobin concentration during artificial endocrine pancreas treatment of diabetics. Evidence for a short-term effect on HbA 1 (a+b+c) levels |journal=Diabetologia |volume=18 |issue=2 |pages=125–30 |date=1980 |pmid=6988271 |doi=10.1007/bf00290488 |url=}}</ref>:
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| * fever
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| * difficulty in breathing
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| * chest radiography showing invasive lesions of both lungs
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| In a recent study published by Xiaolu Tang et al <ref name="pmid10">{{cite journal |vauthors=Schmoldt A, Benthe HF, Haberland G, Fleet GH, Phaff HJ, Orskov ER, Fraser C |title=Digitoxin metabolism by rat liver microsomes |journal=Biochem. Pharmacol. |volume=24 |issue=17 |pages=1639–41 |date=September 1975 |pmid=10 |doi=10.1016/0005-2744(75)90234-x |url=}}</ref> on 03 March 2020 at Peking University's School of Life Sciences and the Institut Pasteur of Shanghai, they have mentioned that they have concluded that there is a more aggressive type of the new coronavirus had responsible for around 70% of analyzed strains, while the remain 30% had been linked to a less aggressive type of the coronavirus. The aggressive type of the coronavirus was prevalent in the early outbreak in Wuhan — the Chinese city where COVID-19 was first detected on 31 December 2019, but the frequency of this type of virus has since decreased from the beginning of this outbreak. and the Xiaolu Tang et al concluded that this aggresive type of this disease could be caused by mutations and natural selection of the spike in COVID-19. And more studies were recommended by those researchers.
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| ==References==
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| [[Category: Infectious disease]]
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