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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''UMP-CMP kinase''' is an [[enzyme]] that in humans is encoded by the ''CMPK1'' [[gene]].<ref name="pmid10462544">{{cite journal | vauthors = Van Rompay AR, Johansson M, Karlsson A | title = Phosphorylation of deoxycytidine analog monophosphates by UMP-CMP kinase: molecular characterization of the human enzyme | journal = Molecular Pharmacology | volume = 56 | issue = 3 | pages = 562–9 | year = 1999 | pmid = 10462544 }}</ref><ref name="entrez">{{EntrezGene|51727}}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_CMPK_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1tev.
| PDB = {{PDB2|1tev}}
| Name = Cytidylate kinase
| HGNCid = 18170
| Symbol = CMPK
| AltSymbols =; UMPK; RP11-511I2.1; UMP-CMPK
| OMIM = 191710
| ECnumber = 
| Homologene = 32308
| MGIid = 1913838
| GeneAtlas_image1 = PBB_GE_CMPK_217870_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004127 |text = cytidylate kinase activity}} {{GNF_GO|id=GO:0004849 |text = uridine kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016301 |text = kinase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0016776 |text = phosphotransferase activity, phosphate group as acceptor}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006139 |text = nucleobase, nucleoside, nucleotide and nucleic acid metabolic process}} {{GNF_GO|id=GO:0009220 |text = pyrimidine ribonucleotide biosynthetic process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 51727
    | Hs_Ensembl = ENSG00000162368
    | Hs_RefseqProtein = NP_057392
    | Hs_RefseqmRNA = NM_016308
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 47572068
    | Hs_GenLoc_end = 47617098
    | Hs_Uniprot = P30085
    | Mm_EntrezGene = 66588
    | Mm_Ensembl = ENSMUSG00000028719
    | Mm_RefseqmRNA = NM_025647
    | Mm_RefseqProtein = NP_079923
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 114458570
    | Mm_GenLoc_end = 114485078
    | Mm_Uniprot = Q8BK17
  }}
}}
'''Cytidylate kinase''', also known as '''CMPK''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CMPK cytidylate kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51727| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Uridine monophosphate (UMP)/cytidine monophosphate (CMP) kinase (EC 2.7.4.4) catalyzes the phosphoryl transfer from ATP to UMP, CMP, and deoxy-CMP (dCMP), resulting in the formation of ADP and the corresponding nucleoside diphosphate. These nucleoside diphosphates are required for cellular nucleic acid synthesis.<ref name="entrez"/><ref>{{cite journal | vauthors = Liou JY, Dutschman GE, Lam W, Jiang Z, Cheng YC | title = Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates | journal = Cancer Research | volume = 62 | issue = 6 | pages = 1624–31 | year = 2002 | pmid = 11912132 }}
{{PBB_Summary
</ref>
| section_title =
| summary_text = Uridine monophosphate (UMP)/cytidine monophosphate (CMP) kinase (EC 2.7.4.4) catalyzes the phosphoryl transfer from ATP to UMP, CMP, and deoxy-CMP (dCMP), resulting in the formation of ADP and the corresponding nucleoside diphosphate. These nucleoside diphosphates are required for cellular nucleic acid synthesis (Liou et al., 2002).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: CMPK cytidylate kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51727| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|CMPK1}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Hochstrasser DF, Frutiger S, Paquet N, Bairoch A, Ravier F, Pasquali C, Sanchez JC, Tissot JD, Bjellqvist B, Vargas R | title = Human liver protein map: A reference database established by microsequencing and gel comparison | journal = Electrophoresis | volume = 13 | issue = 12 | pages = 992–1001 | year = 1992 | pmid = 1286669 | doi = 10.1002/elps.11501301201 }}
| citations =
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Hochstrasser DF, Frutiger S, Paquet N, ''et al.'' |title=Human liver protein map: a reference database established by microsequencing and gel comparison. |journal=Electrophoresis |volume=13 |issue= 12 |pages= 992-1001 |year= 1993 |pmid= 1286669 |doi= }}
* {{cite journal | vauthors = Hughes GJ, Frutiger S, Paquet N, Pasquali C, Sanchez JC, Tissot JD, Bairoch A, Appel RD, Hochstrasser DF | title = Human liver protein map: Update 1993 | journal = Electrophoresis | volume = 14 | issue = 11 | pages = 1216–22 | year = 1993 | pmid = 8313870 | doi = 10.1002/elps.11501401181 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5′-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Hughes GJ, Frutiger S, Paquet N, ''et al.'' |title=Human liver protein map: update 1993. |journal=Electrophoresis |volume=14 |issue= 11 |pages= 1216-22 |year= 1994 |pmid= 8313870 |doi= }}
* {{cite journal | vauthors = Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, Gu YJ, Huang CH, Li YB, Jiang CL, Fu G, Zhang QH, Gu BW, Dai M, Mao YF, Gao GF, Rong R, Ye M, Zhou J, Xu SH, Gu J, Shi JX, Jin WR, Zhang CK, Wu TM, Huang GY, Chen Z, Chen MD, Chen JL | title = Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning | journal = Proceedings of the National Academy of Sciences | volume = 97 | issue = 17 | pages = 9543–8 | year = 2000 | pmid = 10931946 | pmc = 16901 | doi = 10.1073/pnas.160270997 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Pearman AT, Castro-Faria-Neto HC, McIntyre TM, Prescott SM, Stafforini DM | title = Characterization of human UMP-CMP kinase enzymatic activity and 5′ untranslated region | journal = Life Sciences | volume = 69 | issue = 20 | pages = 2361–70 | year = 2001 | pmid = 11681623 | doi = 10.1016/S0024-3205(01)01322-4 }}
*{{cite journal  | author=Van Rompay AR, Johansson M, Karlsson A |title=Phosphorylation of deoxycytidine analog monophosphates by UMP-CMP kinase: molecular characterization of the human enzyme. |journal=Mol. Pharmacol. |volume=56 |issue= 3 |pages= 562-9 |year= 1999 |pmid= 10462544 |doi=  }}
* {{cite journal | vauthors = Liou JY, Dutschman GE, Lam W, Jiang Z, Cheng YC | title = Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates | journal = Cancer Research | volume = 62 | issue = 6 | pages = 1624–31 | year = 2002 | pmid = 11912132 }}
*{{cite journal | author=Hu RM, Han ZG, Song HD, ''et al.'' |title=Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 17 |pages= 9543-8 |year= 2000 |pmid= 10931946 |doi= 10.1073/pnas.160270997 }}
* {{cite journal | vauthors = Pasti C, Gallois-Montbrun S, Munier-Lehmann H, Veron M, Gilles AM, Deville-Bonne D | title = Reaction of human UMP-CMP kinase with natural and analog substrates | journal = European Journal of Biochemistry | volume = 270 | issue = 8 | pages = 1784–90 | year = 2003 | pmid = 12694191 | doi = 10.1046/j.1432-1033.2003.03537.x }}
*{{cite journal | author=Pearman AT, Castro-Faria-Neto HC, McIntyre TM, ''et al.'' |title=Characterization of human UMP-CMP kinase enzymatic activity and 5' untranslated region. |journal=Life Sci. |volume=69 |issue= 20 |pages= 2361-70 |year= 2001 |pmid= 11681623 |doi= }}
* {{cite journal | vauthors = Segura-Peña D, Sekulic N, Ort S, Konrad M, Lavie A | title = Substrate-induced Conformational Changes in Human UMP/CMP Kinase | journal = Journal of Biological Chemistry | volume = 279 | issue = 32 | pages = 33882–9 | year = 2004 | pmid = 15163660 | doi = 10.1074/jbc.M401989200 }}
*{{cite journal | author=Liou JY, Dutschman GE, Lam W, ''et al.'' |title=Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates. |journal=Cancer Res. |volume=62 |issue= 6 |pages= 1624-31 |year= 2002 |pmid= 11912132 |doi=  }}
* {{cite journal | vauthors = Hsu CH, Liou JY, Dutschman GE, Cheng YC | title = Phosphorylation of Cytidine, Deoxycytidine, and Their Analog Monophosphates by Human UMP/CMP Kinase is Differentially Regulated by ATP and Magnesium | journal = Molecular Pharmacology | volume = 67 | issue = 3 | pages = 806–14 | year = 2004 | pmid = 15550676 | doi = 10.1124/mol.104.006098 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Wickham L, Benjannet S, Marcinkiewicz E, Chretien M, Seidah NG | title = Beta-Amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin | journal = Journal of Neurochemistry | volume = 92 | issue = 1 | pages = 93–102 | year = 2005 | pmid = 15606899 | doi = 10.1111/j.1471-4159.2004.02840.x }}
*{{cite journal | author=Pasti C, Gallois-Montbrun S, Munier-Lehmann H, ''et al.'' |title=Reaction of human UMP-CMP kinase with natural and analog substrates. |journal=Eur. J. Biochem. |volume=270 |issue= 8 |pages= 1784-90 |year= 2003 |pmid= 12694191 |doi= }}
* {{cite journal | vauthors = Topalis D, Kumamoto H, Amaya Velasco MF, Dugué L, Haouz A, Alexandre JA, Gallois-Montbrun S, Alzari PM, Pochet S, Agrofoglio LA, Deville-Bonne D | title = Nucleotide binding to human UMP-CMP kinase using fluorescent derivatives – a screening based on affinity for the UMP-CMP binding site | journal = FEBS Journal | volume = 274 | issue = 14 | pages = 3704–14 | year = 2007 | pmid = 17608725 | doi = 10.1111/j.1742-4658.2007.05902.x }}
*{{cite journal | author=Segura-Peña D, Sekulic N, Ort S, ''et al.'' |title=Substrate-induced conformational changes in human UMP/CMP kinase. |journal=J. Biol. Chem. |volume=279 |issue= 32 |pages= 33882-9 |year= 2004 |pmid= 15163660 |doi= 10.1074/jbc.M401989200 }}
* {{cite journal | vauthors = Gagyi C, Bucurenci N, Sîrbu O, Labesse G, Ionescu M, Ofiteru A, Assairi L, Landais S, Danchin A, Bârzu O, Gilles AM | title = UMP kinase from the Gram-positive bacterium Bacillus subtilis is strongly dependent on GTP for optimal activity | journal = European Journal of Biochemistry | volume = 270 | issue = 15 | pages = 3196–204 | year = 2003 | pmid = 12869195 | doi = 10.1046/j.1432-1033.2003.03702.x }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Ofiteru A, Bucurenci N, Alexov E, Bertrand T, Briozzo P, Munier-Lehmann H, Gilles AM | title = Structural and functional consequences of single amino acid substitutions in the pyrimidine base binding pocket of Escherichia coli CMP kinase | journal = The FEBS Journal | volume = 274 | issue = 13 | pages = 3363–73 | year = 2007 | pmid = 17542990 | doi = 10.1111/j.1742-4658.2007.05870.x }}
*{{cite journal  | author=Hsu CH, Liou JY, Dutschman GE, Cheng YC |title=Phosphorylation of Cytidine, Deoxycytidine, and Their Analog Monophosphates by Human UMP/CMP Kinase Is Differentially Regulated by ATP and Magnesium. |journal=Mol. Pharmacol. |volume=67 |issue= 3 |pages= 806-14 |year= 2005 |pmid= 15550676 |doi= 10.1124/mol.104.006098 }}
*{{cite journal | author=Wickham L, Benjannet S, Marcinkiewicz E, ''et al.'' |title=Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin. |journal=J. Neurochem. |volume=92 |issue= 1 |pages= 93-102 |year= 2005 |pmid= 15606899 |doi= 10.1111/j.1471-4159.2004.02840.x }}
*{{cite journal | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal | author=Topalis D, Kumamoto H, Amaya Velasco MF, ''et al.'' |title=Nucleotide binding to human UMP-CMP kinase using fluorescent derivatives -- a screening based on affinity for the UMP-CMP binding site. |journal=FEBS J. |volume=274 |issue= 14 |pages= 3704-14 |year= 2007 |pmid= 17608725 |doi= 10.1111/j.1742-4658.2007.05902.x }}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=51727}}
[[Category:Genes on human chromosome 1]]


{{protein-stub}}
{{gene-1-stub}}
{{WikiDoc Sources}}

Latest revision as of 00:27, 20 June 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

UMP-CMP kinase is an enzyme that in humans is encoded by the CMPK1 gene.[1][2]

Function

Uridine monophosphate (UMP)/cytidine monophosphate (CMP) kinase (EC 2.7.4.4) catalyzes the phosphoryl transfer from ATP to UMP, CMP, and deoxy-CMP (dCMP), resulting in the formation of ADP and the corresponding nucleoside diphosphate. These nucleoside diphosphates are required for cellular nucleic acid synthesis.[2][3]

References

  1. ↑ Van Rompay AR, Johansson M, Karlsson A (1999). "Phosphorylation of deoxycytidine analog monophosphates by UMP-CMP kinase: molecular characterization of the human enzyme". Molecular Pharmacology. 56 (3): 562–9. PMID 10462544.
  2. ↑ 2.0 2.1 EntrezGene 51727
  3. ↑ Liou JY, Dutschman GE, Lam W, Jiang Z, Cheng YC (2002). "Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates". Cancer Research. 62 (6): 1624–31. PMID 11912132.

External links

Further reading

  • Hochstrasser DF, Frutiger S, Paquet N, Bairoch A, Ravier F, Pasquali C, Sanchez JC, Tissot JD, Bjellqvist B, Vargas R (1992). "Human liver protein map: A reference database established by microsequencing and gel comparison". Electrophoresis. 13 (12): 992–1001. doi:10.1002/elps.11501301201. PMID 1286669.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Hughes GJ, Frutiger S, Paquet N, Pasquali C, Sanchez JC, Tissot JD, Bairoch A, Appel RD, Hochstrasser DF (1993). "Human liver protein map: Update 1993". Electrophoresis. 14 (11): 1216–22. doi:10.1002/elps.11501401181. PMID 8313870.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5′-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, Gu YJ, Huang CH, Li YB, Jiang CL, Fu G, Zhang QH, Gu BW, Dai M, Mao YF, Gao GF, Rong R, Ye M, Zhou J, Xu SH, Gu J, Shi JX, Jin WR, Zhang CK, Wu TM, Huang GY, Chen Z, Chen MD, Chen JL (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proceedings of the National Academy of Sciences. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
  • Pearman AT, Castro-Faria-Neto HC, McIntyre TM, Prescott SM, Stafforini DM (2001). "Characterization of human UMP-CMP kinase enzymatic activity and 5′ untranslated region". Life Sciences. 69 (20): 2361–70. doi:10.1016/S0024-3205(01)01322-4. PMID 11681623.
  • Liou JY, Dutschman GE, Lam W, Jiang Z, Cheng YC (2002). "Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates". Cancer Research. 62 (6): 1624–31. PMID 11912132.
  • Pasti C, Gallois-Montbrun S, Munier-Lehmann H, Veron M, Gilles AM, Deville-Bonne D (2003). "Reaction of human UMP-CMP kinase with natural and analog substrates". European Journal of Biochemistry. 270 (8): 1784–90. doi:10.1046/j.1432-1033.2003.03537.x. PMID 12694191.
  • Segura-Peña D, Sekulic N, Ort S, Konrad M, Lavie A (2004). "Substrate-induced Conformational Changes in Human UMP/CMP Kinase". Journal of Biological Chemistry. 279 (32): 33882–9. doi:10.1074/jbc.M401989200. PMID 15163660.
  • Hsu CH, Liou JY, Dutschman GE, Cheng YC (2004). "Phosphorylation of Cytidine, Deoxycytidine, and Their Analog Monophosphates by Human UMP/CMP Kinase is Differentially Regulated by ATP and Magnesium". Molecular Pharmacology. 67 (3): 806–14. doi:10.1124/mol.104.006098. PMID 15550676.
  • Wickham L, Benjannet S, Marcinkiewicz E, Chretien M, Seidah NG (2005). "Beta-Amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin". Journal of Neurochemistry. 92 (1): 93–102. doi:10.1111/j.1471-4159.2004.02840.x. PMID 15606899.
  • Topalis D, Kumamoto H, Amaya Velasco MF, Dugué L, Haouz A, Alexandre JA, Gallois-Montbrun S, Alzari PM, Pochet S, Agrofoglio LA, Deville-Bonne D (2007). "Nucleotide binding to human UMP-CMP kinase using fluorescent derivatives – a screening based on affinity for the UMP-CMP binding site". FEBS Journal. 274 (14): 3704–14. doi:10.1111/j.1742-4658.2007.05902.x. PMID 17608725.
  • Gagyi C, Bucurenci N, Sîrbu O, Labesse G, Ionescu M, Ofiteru A, Assairi L, Landais S, Danchin A, Bârzu O, Gilles AM (2003). "UMP kinase from the Gram-positive bacterium Bacillus subtilis is strongly dependent on GTP for optimal activity". European Journal of Biochemistry. 270 (15): 3196–204. doi:10.1046/j.1432-1033.2003.03702.x. PMID 12869195.
  • Ofiteru A, Bucurenci N, Alexov E, Bertrand T, Briozzo P, Munier-Lehmann H, Gilles AM (2007). "Structural and functional consequences of single amino acid substitutions in the pyrimidine base binding pocket of Escherichia coli CMP kinase". The FEBS Journal. 274 (13): 3363–73. doi:10.1111/j.1742-4658.2007.05870.x. PMID 17542990.


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