CLCN2
| Chloride channel 2 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | CLCN2 ; CIC-2; CLC2; ECA3; EGI3; EGMA | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 3213 | ||||||||||
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| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
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Chloride channel 2, also known as CLCN2, is a human gene.[1]
References
Further reading
- Cid LP, Montrose-Rafizadeh C, Smith DI; et al. (1995). "Cloning of a putative human voltage-gated chloride channel (CIC-2) cDNA widely expressed in human tissues". Hum. Mol. Genet. 4 (3): 407–13. PMID 7795595.
- Lamb FS, Clayton GH, Liu BX; et al. (1999). "Expression of CLCN voltage-gated chloride channel genes in human blood vessels". J. Mol. Cell. Cardiol. 31 (3): 657–66. doi:10.1006/jmcc.1998.0901. PMID 10198195.
- Sander T, Schulz H, Saar K; et al. (2000). "Genome search for susceptibility loci of common idiopathic generalised epilepsies". Hum. Mol. Genet. 9 (10): 1465–72. PMID 10888596.
- Lamb FS, Graeff RW, Clayton GH; et al. (2001). "Ontogeny of CLCN3 chloride channel gene expression in human pulmonary epithelium". Am. J. Respir. Cell Mol. Biol. 24 (4): 376–81. PMID 11306429.
- Lipecka J, Bali M, Thomas A; et al. (2002). "Distribution of ClC-2 chloride channel in rat and human epithelial tissues". Am. J. Physiol., Cell Physiol. 282 (4): C805–16. doi:10.1152/ajpcell.00291.2001. PMID 11880269.
- Nehrke K, Arreola J, Nguyen HV; et al. (2002). "Loss of hyperpolarization-activated Cl(-) current in salivary acinar cells from Clcn2 knockout mice". J. Biol. Chem. 277 (26): 23604–11. doi:10.1074/jbc.M202900200. PMID 11976342.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Dhani SU, Mohammad-Panah R, Ahmed N; et al. (2003). "Evidence for a functional interaction between the ClC-2 chloride channel and the retrograde motor dynein complex". J. Biol. Chem. 278 (18): 16262–70. doi:10.1074/jbc.M209828200. PMID 12601004.
- Haug K, Warnstedt M, Alekov AK; et al. (2003). "Mutations in CLCN2 encoding a voltage-gated chloride channel are associated with idiopathic generalized epilepsies". Nat. Genet. 33 (4): 527–32. doi:10.1038/ng1121. PMID 12612585.
- Olsen ML, Schade S, Lyons SA; et al. (2003). "Expression of voltage-gated chloride channels in human glioma cells". J. Neurosci. 23 (13): 5572–82. PMID 12843258.
- Cuppoletti J, Tewari KP, Sherry AM; et al. (2004). "Sites of protein kinase A activation of the human ClC-2 Cl(-) channel". J. Biol. Chem. 279 (21): 21849–56. doi:10.1074/jbc.M312567200. PMID 15010473.
- Niemeyer MI, Yusef YR, Cornejo I; et al. (2005). "Functional evaluation of human ClC-2 chloride channel mutations associated with idiopathic generalized epilepsies". Physiol. Genomics. 19 (1): 74–83. doi:10.1152/physiolgenomics.00070.2004. PMID 15252188.
- Huber SM, Duranton C, Henke G; et al. (2004). "Plasmodium induces swelling-activated ClC-2 anion channels in the host erythrocyte". J. Biol. Chem. 279 (40): 41444–52. doi:10.1074/jbc.M407618200. PMID 15272009.
- Hori K, Takahashi Y, Horikawa N; et al. (2004). "Is the ClC-2 chloride channel involved in the Cl- secretory mechanism of gastric parietal cells?". FEBS Lett. 575 (1–3): 105–8. doi:10.1016/j.febslet.2004.08.044. PMID 15388342.
- Chu S, Blaisdell CJ, Bamford P, Ferro TJ (2004). "Interferon-gamma regulates ClC-2 chloride channel in lung epithelial cells". Biochem. Biophys. Res. Commun. 324 (1): 31–9. doi:10.1016/j.bbrc.2004.09.026. PMID 15464978.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- D'Agostino D, Bertelli M, Gallo S; et al. (2006). "Mutations and polymorphisms of the CLCN2 gene in idiopathic epilepsy". Neurology. 63 (8): 1500–2. PMID 15505175.
- Blaisdell CJ, Howard TD, Stern A; et al. (2004). "CLC-2 single nucleotide polymorphisms (SNPs) as potential modifiers of cystic fibrosis disease severity". BMC Med. Genet. 5: 26. doi:10.1186/1471-2350-5-26. PMID 15507145.
- Heils A (2004). "CLCN2 and idiopathic generalized epilepsy". Advances in neurology. 95: 265–71. PMID 15508929.
- Hinzpeter A, Lipecka J, Brouillard F; et al. (2006). "Association between Hsp90 and the ClC-2 chloride channel upregulates channel function". Am. J. Physiol., Cell Physiol. 290 (1): C45–56. doi:10.1152/ajpcell.00209.2005. PMID 16049054.
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