CISH
| Cytokine inducible SH2-containing protein | |||||||||||
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| Identifiers | |||||||||||
| Symbols | CISH ; CIS; CIS-1; G18; SOCS | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 7667 | ||||||||||
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| Species | Human | Mouse | |||||||||
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Cytokine inducible SH2-containing protein, also known as CISH, is a human gene.[1]
The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor.[1]
References
Further reading
- Kile BT, Schulman BA, Alexander WS; et al. (2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem. Sci. 27 (5): 235–41. PMID 12076535.
- Yoshimura A, Ohkubo T, Kiguchi T; et al. (1995). "A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors". EMBO J. 14 (12): 2816–26. PMID 7796808.
- Uchida K, Yoshimura A, Inazawa J; et al. (1998). "Molecular cloning of CISH, chromosome assignment to 3p21.3, and analysis of expression in fetal and adult tissues". Cytogenet. Cell Genet. 78 (3–4): 209–12. PMID 9465889.
- Verdier F, Chrétien S, Muller O; et al. (1998). "Proteasomes regulate erythropoietin receptor and signal transducer and activator of transcription 5 (STAT5) activation. Possible involvement of the ubiquitinated Cis protein". J. Biol. Chem. 273 (43): 28185–90. PMID 9774439.
- Aman MJ, Migone TS, Sasaki A; et al. (1999). "CIS associates with the interleukin-2 receptor beta chain and inhibits interleukin-2-dependent signaling". J. Biol. Chem. 274 (42): 30266–72. PMID 10514520.
- Okabe S, Tauchi T, Morita H; et al. (1999). "Thrombopoietin induces an SH2-containing protein, CIS1, which binds to Mpl: involvement of the ubiquitin proteosome pathway". Exp. Hematol. 27 (10): 1542–7. PMID 10517496.
- Jiang C, Yu L, Zhao Y; et al. (2000). "Cloning and characterization of CIS 1b (cytokine inducible SH2-containing protein 1b), an alternative splicing form of CIS 1 gene". DNA Seq. 11 (1–2): 149–54. PMID 10902923.
- Dogusan Z, Hooghe-Peters EL, Berus D; et al. (2000). "Expression of SOCS genes in normal and leukemic human leukocytes stimulated by prolactin, growth hormone and cytokines". J. Neuroimmunol. 109 (1): 34–9. PMID 10969179.
- Yousefi S, Cooper PR, Mueck B; et al. (2000). "cDNA representational difference analysis of human neutrophils stimulated by GM-CSF". Biochem. Biophys. Res. Commun. 277 (2): 401–9. doi:10.1006/bbrc.2000.3678. PMID 11032736.
- Dif F, Saunier E, Demeneix B; et al. (2001). "Cytokine-inducible SH2-containing protein suppresses PRL signaling by binding the PRL receptor". Endocrinology. 142 (12): 5286–93. PMID 11713228.
- Federici M, Giustizieri ML, Scarponi C; et al. (2002). "Impaired IFN-gamma-dependent inflammatory responses in human keratinocytes overexpressing the suppressor of cytokine signaling 1". J. Immunol. 169 (1): 434–42. PMID 12077274.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Du L, Frick GP, Tai LR; et al. (2003). "Interaction of the growth hormone receptor with cytokine-induced Src homology domain 2 protein in rat adipocytes". Endocrinology. 144 (3): 868–76. PMID 12586763.
- Chen S, Anderson PO, Li L; et al. (2003). "Functional association of cytokine-induced SH2 protein and protein kinase C in activated T cells". Int. Immunol. 15 (3): 403–9. PMID 12618484.
- Yamasaki K, Hanakawa Y, Tokumaru S; et al. (2003). "Suppressor of cytokine signaling 1/JAB and suppressor of cytokine signaling 3/cytokine-inducible SH2 containing protein 3 negatively regulate the signal transducers and activators of transcription signaling pathway in normal human epidermal keratinocytes". J. Invest. Dermatol. 120 (4): 571–80. doi:10.1046/j.1523-1747.2003.12100.x. PMID 12648219.
- Cheng J, Zhang D, Zhou C, Marasco WA (2004). "Down-regulation of SHP1 and up-regulation of negative regulators of JAK/STAT signaling in HTLV-1 transformed cell lines and freshly transformed human peripheral blood CD4+ T-cells". Leuk. Res. 28 (1): 71–82. PMID 14630083.
- Bayle J, Letard S, Frank R; et al. (2004). "Suppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signaling". J. Biol. Chem. 279 (13): 12249–59. doi:10.1074/jbc.M313381200. PMID 14707129.
- Colland F, Jacq X, Trouplin V; et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.
- Hunter MG, Jacob A, O'donnell LC; et al. (2004). "Loss of SHIP and CIS recruitment to the granulocyte colony-stimulating factor receptor contribute to hyperproliferative responses in severe congenital neutropenia/acute myelogenous leukemia". J. Immunol. 173 (8): 5036–45. PMID 15470047.
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