CHD4: Difference between revisions

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Latest revision as of 01:59, 27 October 2017

Chromodomain-helicase-DNA-binding protein 4 is an enzyme that in humans is encoded by the CHD4 gene.^[1]^[2]^[3]

Function

The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein.^[3]

Interactions

CHD4 has been shown to interact with HDAC1,^[4]^[5]^[6] Histone deacetylase 2,^[6]^[7]^[8] MTA2,^[4] SATB1^[9] and Ataxia telangiectasia and Rad3 related.^[8]

References

↑ Seelig HP, Moosbrugger I, Ehrfeld H, Fink T, Renz M, Genth E (Oct 1995). "The major dermatomyositis-specific Mi-2 autoantigen is a presumed helicase involved in transcriptional activation". Arthritis and Rheumatism. 38 (10): 1389–99. doi:10.1002/art.1780381006. PMID 7575689.
↑ Seelig HP, Renz M, Targoff IN, Ge Q, Frank MB (Oct 1996). "Two forms of the major antigenic protein of the dermatomyositis-specific Mi-2 autoantigen". Arthritis and Rheumatism. 39 (10): 1769–71. doi:10.1002/art.1780391029. PMID 8843877.
↑ ^3.0 ^3.1 "Entrez Gene: CHD4 chromodomain helicase DNA binding protein 4".
↑ ^4.0 ^4.1 Yao YL, Yang WM (Oct 2003). "The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity". The Journal of Biological Chemistry. 278 (43): 42560–8. doi:10.1074/jbc.M302955200. PMID 12920132.
↑ Grozinger CM, Hassig CA, Schreiber SL (Apr 1999). "Three proteins define a class of human histone deacetylases related to yeast Hda1p". Proceedings of the National Academy of Sciences of the United States of America. 96 (9): 4868–73. doi:10.1073/pnas.96.9.4868. PMC 21783. PMID 10220385.
↑ ^6.0 ^6.1 Tong JK, Hassig CA, Schnitzler GR, Kingston RE, Schreiber SL (Oct 1998). "Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex". Nature. 395 (6705): 917–21. doi:10.1038/27699. PMID 9804427.
↑ Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R (Feb 2003). "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes". The Journal of Biological Chemistry. 278 (9): 7234–9. doi:10.1074/jbc.M208992200. PMID 12493763.
↑ ^8.0 ^8.1 Schmidt DR, Schreiber SL (Nov 1999). "Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4". Biochemistry. 38 (44): 14711–7. doi:10.1021/bi991614n. PMID 10545197.
↑ Yasui D, Miyano M, Cai S, Varga-Weisz P, Kohwi-Shigematsu T (Oct 2002). "SATB1 targets chromatin remodelling to regulate genes over long distances". Nature. 419 (6907): 641–5. doi:10.1038/nature01084. PMID 12374985.

External links

Human CHD4 genome location and CHD4 gene details page in the UCSC Genome Browser.

Denslow SA, Wade PA (Aug 2007). "The human Mi-2/NuRD complex and gene regulation". Oncogene. 26 (37): 5433–8. doi:10.1038/sj.onc.1210611. PMID 17694084.
Ge Q, Nilasena DS, O'Brien CA, Frank MB, Targoff IN (Oct 1995). "Molecular analysis of a major antigenic region of the 240-kD protein of Mi-2 autoantigen". The Journal of Clinical Investigation. 96 (4): 1730–7. doi:10.1172/JCI118218. PMC 185809. PMID 7560064.
Woodage T, Basrai MA, Baxevanis AD, Hieter P, Collins FS (Oct 1997). "Characterization of the CHD family of proteins". Proceedings of the National Academy of Sciences of the United States of America. 94 (21): 11472–7. doi:10.1073/pnas.94.21.11472. PMC 23509. PMID 9326634.
Zhang Y, LeRoy G, Seelig HP, Lane WS, Reinberg D (Oct 1998). "The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities". Cell. 95 (2): 279–89. doi:10.1016/S0092-8674(00)81758-4. PMID 9790534.
Tong JK, Hassig CA, Schnitzler GR, Kingston RE, Schreiber SL (Oct 1998). "Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex". Nature. 395 (6705): 917–21. doi:10.1038/27699. PMID 9804427.
Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D (Aug 1999). "Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation". Genes & Development. 13 (15): 1924–35. doi:10.1101/gad.13.15.1924. PMC 316920. PMID 10444591.
Schmidt DR, Schreiber SL (Nov 1999). "Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4". Biochemistry. 38 (44): 14711–7. doi:10.1021/bi991614n. PMID 10545197.
Humphrey GW, Wang Y, Russanova VR, Hirai T, Qin J, Nakatani Y, Howard BH (Mar 2001). "Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1". The Journal of Biological Chemistry. 276 (9): 6817–24. doi:10.1074/jbc.M007372200. PMID 11102443.
Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (Jan 2002). "Directed proteomic analysis of the human nucleolus". Current Biology. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
Koipally J, Georgopoulos K (Aug 2002). "A molecular dissection of the repression circuitry of Ikaros". The Journal of Biological Chemistry. 277 (31): 27697–705. doi:10.1074/jbc.M201694200. PMID 12015313.
Saito M, Ishikawa F (Sep 2002). "The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2". The Journal of Biological Chemistry. 277 (38): 35434–9. doi:10.1074/jbc.M203455200. PMID 12124384.
Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R (Feb 2003). "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes". The Journal of Biological Chemistry. 278 (9): 7234–9. doi:10.1074/jbc.M208992200. PMID 12493763.
Kwan AH, Gell DA, Verger A, Crossley M, Matthews JM, Mackay JP (Jul 2003). "Engineering a protein scaffold from a PHD finger". Structure. 11 (7): 803–13. doi:10.1016/S0969-2126(03)00122-9. PMID 12842043.
Shimono Y, Murakami H, Kawai K, Wade PA, Shimokata K, Takahashi M (Dec 2003). "Mi-2 beta associates with BRG1 and RET finger protein at the distinct regions with transcriptional activating and repressing abilities". The Journal of Biological Chemistry. 278 (51): 51638–45. doi:10.1074/jbc.M309198200. PMID 14530259.
Williams CJ, Naito T, Arco PG, Seavitt JR, Cashman SM, De Souza B, Qi X, Keables P, Von Andrian UH, Georgopoulos K (Jun 2004). "The chromatin remodeler Mi-2beta is required for CD4 expression and T cell development". Immunity. 20 (6): 719–33. doi:10.1016/j.immuni.2004.05.005. PMID 15189737.
Lehner B, Sanderson CM (Jul 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

[pmid7575689-1] Seelig HP, Moosbrugger I, Ehrfeld H, Fink T, Renz M, Genth E (Oct 1995). "The major dermatomyositis-specific Mi-2 autoantigen is a presumed helicase involved in transcriptional activation". Arthritis and Rheumatism. 38 (10): 1389–99. doi:10.1002/art.1780381006. PMID 7575689.

[pmid8843877-2] Seelig HP, Renz M, Targoff IN, Ge Q, Frank MB (Oct 1996). "Two forms of the major antigenic protein of the dermatomyositis-specific Mi-2 autoantigen". Arthritis and Rheumatism. 39 (10): 1769–71. doi:10.1002/art.1780391029. PMID 8843877.

[entrez-3] 3.0 ^3.1 "Entrez Gene: CHD4 chromodomain helicase DNA binding protein 4".

[pmid12920132-4] 4.0 ^4.1 Yao YL, Yang WM (Oct 2003). "The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity". The Journal of Biological Chemistry. 278 (43): 42560–8. doi:10.1074/jbc.M302955200. PMID 12920132.

[pmid10220385-5] Grozinger CM, Hassig CA, Schreiber SL (Apr 1999). "Three proteins define a class of human histone deacetylases related to yeast Hda1p". Proceedings of the National Academy of Sciences of the United States of America. 96 (9): 4868–73. doi:10.1073/pnas.96.9.4868. PMC 21783. PMID 10220385.

[pmid9804427-6] 6.0 ^6.1 Tong JK, Hassig CA, Schnitzler GR, Kingston RE, Schreiber SL (Oct 1998). "Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex". Nature. 395 (6705): 917–21. doi:10.1038/27699. PMID 9804427.

[pmid12493763-7] Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R (Feb 2003). "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes". The Journal of Biological Chemistry. 278 (9): 7234–9. doi:10.1074/jbc.M208992200. PMID 12493763.

[pmid10545197-8] 8.0 ^8.1 Schmidt DR, Schreiber SL (Nov 1999). "Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4". Biochemistry. 38 (44): 14711–7. doi:10.1021/bi991614n. PMID 10545197.

[pmid12374985-9] Yasui D, Miyano M, Cai S, Varga-Weisz P, Kohwi-Shigematsu T (Oct 2002). "SATB1 targets chromatin remodelling to regulate genes over long distances". Nature. 419 (6907): 641–5. doi:10.1038/nature01084. PMID 12374985.

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@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{For|the TC LID|Thamesford (Harydale Farms) Aerodrome}}
-{{PBB_Controls
+{{Infobox_gene}}
-| update_page = yes
+'''Chromodomain-helicase-DNA-binding protein 4''' is an [[enzyme]] that in humans is encoded by the ''CHD4'' [[gene]].<ref name="pmid7575689">{{cite journal | vauthors = Seelig HP, Moosbrugger I, Ehrfeld H, Fink T, Renz M, Genth E | title = The major dermatomyositis-specific Mi-2 autoantigen is a presumed helicase involved in transcriptional activation | journal = Arthritis and Rheumatism | volume = 38 | issue = 10 | pages = 1389–99 | date = Oct 1995 | pmid = 7575689 | pmc =  | doi = 10.1002/art.1780381006 }}</ref><ref name="pmid8843877">{{cite journal | vauthors = Seelig HP, Renz M, Targoff IN, Ge Q, Frank MB | title = Two forms of the major antigenic protein of the dermatomyositis-specific Mi-2 autoantigen | journal = Arthritis and Rheumatism | volume = 39 | issue = 10 | pages = 1769–71 | date = Oct 1996 | pmid = 8843877 | pmc =  | doi = 10.1002/art.1780391029 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CHD4 chromodomain helicase DNA binding protein 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1108| accessdate = }}</ref>
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Function ==
-{{GNF_Protein_box
- | image = PBB_Protein_CHD4_image.jpg
- | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1mm2.
- | PDB = {{PDB2|1mm2}}
- | Name = Chromodomain helicase DNA binding protein 4
- | HGNCid = 1919
- | Symbol = CHD4
- | AltSymbols =; DKFZp686E06161; Mi-2b; Mi2-BETA
- | OMIM = 603277
- | ECnumber =
- | Homologene = 68175
- | MGIid = 1344380
- | GeneAtlas_image1 = PBB_GE_CHD4_201183_s_at_tn.png
- | GeneAtlas_image2 = PBB_GE_CHD4_201182_s_at_tn.png
- | GeneAtlas_image3 = PBB_GE_CHD4_201184_s_at_tn.png
- | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003682 |text = chromatin binding}} {{GNF_GO|id=GO:0004003 |text = ATP-dependent DNA helicase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
- | Component = {{GNF_GO|id=GO:0000785 |text = chromatin}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
- | Process = {{GNF_GO|id=GO:0006333 |text = chromatin assembly or disassembly}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0007001 |text = chromosome organization and biogenesis (sensu Eukaryota)}} {{GNF_GO|id=GO:0016568 |text = chromatin modification}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 1108
-    | Hs_Ensembl = ENSG00000111642
-    | Hs_RefseqProtein = NP_001264
-    | Hs_RefseqmRNA = NM_001273
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 12
-    | Hs_GenLoc_start = 6549510
-    | Hs_GenLoc_end = 6586812
-    | Hs_Uniprot = Q14839
-    | Mm_EntrezGene = 107932
-    | Mm_Ensembl = ENSMUSG00000063870
-    | Mm_RefseqmRNA = NM_145979
-    | Mm_RefseqProtein = NP_666091
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 6
-    | Mm_GenLoc_start = 125061782
-    | Mm_GenLoc_end = 125096133
-    | Mm_Uniprot = Q3U582
-  }}
-}}
-'''Chromodomain helicase DNA binding protein 4''', also known as '''CHD4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CHD4 chromodomain helicase DNA binding protein 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1108| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein.<ref name="entrez" />
-{{PBB_Summary
-| section_title =
-| summary_text = The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein.<ref name="entrez">{{cite web | title = Entrez Gene: CHD4 chromodomain helicase DNA binding protein 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1108| accessdate = }}</ref>
-}}
-==References==
+== Interactions ==
-{{reflist|2}}
-==Further reading==
+CHD4 has been shown to [[Protein-protein interaction|interact]] with [[HDAC1]],<ref name=pmid12920132>{{cite journal | vauthors = Yao YL, Yang WM | title = The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity | journal = The Journal of Biological Chemistry | volume = 278 | issue = 43 | pages = 42560–8 | date = Oct 2003 | pmid = 12920132 | doi = 10.1074/jbc.M302955200 }}</ref><ref name=pmid10220385>{{cite journal | vauthors = Grozinger CM, Hassig CA, Schreiber SL | title = Three proteins define a class of human histone deacetylases related to yeast Hda1p | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 9 | pages = 4868–73 | date = Apr 1999 | pmid = 10220385 | pmc = 21783 | doi = 10.1073/pnas.96.9.4868 }}</ref><ref name=pmid9804427>{{cite journal | vauthors = Tong JK, Hassig CA, Schnitzler GR, Kingston RE, Schreiber SL | title = Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex | journal = Nature | volume = 395 | issue = 6705 | pages = 917–21 | date = Oct 1998 | pmid = 9804427 | doi = 10.1038/27699 }}</ref> [[Histone deacetylase 2]],<ref name=pmid9804427/><ref name=pmid12493763>{{cite journal | vauthors = Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R | title = A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes | journal = The Journal of Biological Chemistry | volume = 278 | issue = 9 | pages = 7234–9 | date = Feb 2003 | pmid = 12493763 | doi = 10.1074/jbc.M208992200 }}</ref><ref name=pmid10545197>{{cite journal | vauthors = Schmidt DR, Schreiber SL | title = Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4 | journal = Biochemistry | volume = 38 | issue = 44 | pages = 14711–7 | date = Nov 1999 | pmid = 10545197 | doi = 10.1021/bi991614n }}</ref> [[MTA2]],<ref name=pmid12920132/> [[SATB1]]<ref name=pmid12374985>{{cite journal | vauthors = Yasui D, Miyano M, Cai S, Varga-Weisz P, Kohwi-Shigematsu T | title = SATB1 targets chromatin remodelling to regulate genes over long distances | journal = Nature | volume = 419 | issue = 6907 | pages = 641–5 | date = Oct 2002 | pmid = 12374985 | doi = 10.1038/nature01084 }}</ref> and [[Ataxia telangiectasia and Rad3 related]].<ref name=pmid10545197/>
+== References ==
+{{reflist}}
+==External links==
+* {{UCSC gene info|CHD4}}
+== Further reading ==
 {{refbegin | 2}}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Denslow SA, Wade PA | title = The human Mi-2/NuRD complex and gene regulation | journal = Oncogene | volume = 26 | issue = 37 | pages = 5433–8 | date = Aug 2007 | pmid = 17694084 | doi = 10.1038/sj.onc.1210611 }}
-| citations =
+* {{cite journal | vauthors = Ge Q, Nilasena DS, O'Brien CA, Frank MB, Targoff IN | title = Molecular analysis of a major antigenic region of the 240-kD protein of Mi-2 autoantigen | journal = The Journal of Clinical Investigation | volume = 96 | issue = 4 | pages = 1730–7 | date = Oct 1995 | pmid = 7560064 | pmc = 185809 | doi = 10.1172/JCI118218 }}
-*{{cite journal  | author=Denslow SA, Wade PA |title=The human Mi-2/NuRD complex and gene regulation. |journal=Oncogene |volume=26 |issue= 37 |pages= 5433-8 |year= 2007 |pmid= 17694084 |doi= 10.1038/sj.onc.1210611 }}
+* {{cite journal | vauthors = Woodage T, Basrai MA, Baxevanis AD, Hieter P, Collins FS | title = Characterization of the CHD family of proteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 94 | issue = 21 | pages = 11472–7 | date = Oct 1997 | pmid = 9326634 | pmc = 23509 | doi = 10.1073/pnas.94.21.11472 }}
-*{{cite journal  | author=Ge Q, Nilasena DS, O'Brien CA, ''et al.'' |title=Molecular analysis of a major antigenic region of the 240-kD protein of Mi-2 autoantigen. |journal=J. Clin. Invest. |volume=96 |issue= 4 |pages= 1730-7 |year= 1995 |pmid= 7560064 |doi=  }}
+* {{cite journal | vauthors = Zhang Y, LeRoy G, Seelig HP, Lane WS, Reinberg D | title = The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities | journal = Cell | volume = 95 | issue = 2 | pages = 279–89 | date = Oct 1998 | pmid = 9790534 | doi = 10.1016/S0092-8674(00)81758-4 }}
-*{{cite journal  | author=Seelig HP, Moosbrugger I, Ehrfeld H, ''et al.'' |title=The major dermatomyositis-specific Mi-2 autoantigen is a presumed helicase involved in transcriptional activation. |journal=Arthritis Rheum. |volume=38 |issue= 10 |pages= 1389-99 |year= 1995 |pmid= 7575689 |doi=  }}
+* {{cite journal | vauthors = Tong JK, Hassig CA, Schnitzler GR, Kingston RE, Schreiber SL | title = Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex | journal = Nature | volume = 395 | issue = 6705 | pages = 917–21 | date = Oct 1998 | pmid = 9804427 | doi = 10.1038/27699 }}
-*{{cite journal  | author=Seelig HP, Renz M, Targoff IN, ''et al.'' |title=Two forms of the major antigenic protein of the dermatomyositis-specific Mi-2 autoantigen. |journal=Arthritis Rheum. |volume=39 |issue= 10 |pages= 1769-71 |year= 1996 |pmid= 8843877 |doi=  }}
+* {{cite journal | vauthors = Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D | title = Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation | journal = Genes & Development | volume = 13 | issue = 15 | pages = 1924–35 | date = Aug 1999 | pmid = 10444591 | pmc = 316920 | doi = 10.1101/gad.13.15.1924 }}
-*{{cite journal  | author=Woodage T, Basrai MA, Baxevanis AD, ''et al.'' |title=Characterization of the CHD family of proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 21 |pages= 11472-7 |year= 1997 |pmid= 9326634 |doi=  }}
+* {{cite journal | vauthors = Schmidt DR, Schreiber SL | title = Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4 | journal = Biochemistry | volume = 38 | issue = 44 | pages = 14711–7 | date = Nov 1999 | pmid = 10545197 | doi = 10.1021/bi991614n }}
-*{{cite journal  | author=Zhang Y, LeRoy G, Seelig HP, ''et al.'' |title=The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities. |journal=Cell |volume=95 |issue= 2 |pages= 279-89 |year= 1998 |pmid= 9790534 |doi=  }}
+* {{cite journal | vauthors = Humphrey GW, Wang Y, Russanova VR, Hirai T, Qin J, Nakatani Y, Howard BH | title = Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1 | journal = The Journal of Biological Chemistry | volume = 276 | issue = 9 | pages = 6817–24 | date = Mar 2001 | pmid = 11102443 | doi = 10.1074/jbc.M007372200 }}
-*{{cite journal  | author=Tong JK, Hassig CA, Schnitzler GR, ''et al.'' |title=Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex. |journal=Nature |volume=395 |issue= 6705 |pages= 917-21 |year= 1998 |pmid= 9804427 |doi= 10.1038/27699 }}
+* {{cite journal | vauthors = Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI | title = Directed proteomic analysis of the human nucleolus | journal = Current Biology | volume = 12 | issue = 1 | pages = 1–11 | date = Jan 2002 | pmid = 11790298 | doi = 10.1016/S0960-9822(01)00650-9 }}
-*{{cite journal  | author=Zhang Y, Ng HH, Erdjument-Bromage H, ''et al.'' |title=Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. |journal=Genes Dev. |volume=13 |issue= 15 |pages= 1924-35 |year= 1999 |pmid= 10444591 |doi=  }}
+* {{cite journal | vauthors = Koipally J, Georgopoulos K | title = A molecular dissection of the repression circuitry of Ikaros | journal = The Journal of Biological Chemistry | volume = 277 | issue = 31 | pages = 27697–705 | date = Aug 2002 | pmid = 12015313 | doi = 10.1074/jbc.M201694200 }}
-*{{cite journal  | author=Schmidt DR, Schreiber SL |title=Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4. |journal=Biochemistry |volume=38 |issue= 44 |pages= 14711-7 |year= 1999 |pmid= 10545197 |doi=  }}
+* {{cite journal | vauthors = Saito M, Ishikawa F | title = The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 38 | pages = 35434–9 | date = Sep 2002 | pmid = 12124384 | doi = 10.1074/jbc.M203455200 }}
-*{{cite journal  | author=Humphrey GW, Wang Y, Russanova VR, ''et al.'' |title=Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1. |journal=J. Biol. Chem. |volume=276 |issue= 9 |pages= 6817-24 |year= 2001 |pmid= 11102443 |doi= 10.1074/jbc.M007372200 }}
+* {{cite journal | vauthors = Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R | title = A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes | journal = The Journal of Biological Chemistry | volume = 278 | issue = 9 | pages = 7234–9 | date = Feb 2003 | pmid = 12493763 | doi = 10.1074/jbc.M208992200 }}
-*{{cite journal  | author=Andersen JS, Lyon CE, Fox AH, ''et al.'' |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1-11 |year= 2002 |pmid= 11790298 |doi=  }}
+* {{cite journal | vauthors = Kwan AH, Gell DA, Verger A, Crossley M, Matthews JM, Mackay JP | title = Engineering a protein scaffold from a PHD finger | journal = Structure | volume = 11 | issue = 7 | pages = 803–13 | date = Jul 2003 | pmid = 12842043 | doi = 10.1016/S0969-2126(03)00122-9 }}
-*{{cite journal  | author=Koipally J, Georgopoulos K |title=A molecular dissection of the repression circuitry of Ikaros. |journal=J. Biol. Chem. |volume=277 |issue= 31 |pages= 27697-705 |year= 2002 |pmid= 12015313 |doi= 10.1074/jbc.M201694200 }}
+* {{cite journal | vauthors = Shimono Y, Murakami H, Kawai K, Wade PA, Shimokata K, Takahashi M | title = Mi-2 beta associates with BRG1 and RET finger protein at the distinct regions with transcriptional activating and repressing abilities | journal = The Journal of Biological Chemistry | volume = 278 | issue = 51 | pages = 51638–45 | date = Dec 2003 | pmid = 14530259 | doi = 10.1074/jbc.M309198200 }}
-*{{cite journal  | author=Saito M, Ishikawa F |title=The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2. |journal=J. Biol. Chem. |volume=277 |issue= 38 |pages= 35434-9 |year= 2002 |pmid= 12124384 |doi= 10.1074/jbc.M203455200 }}
+* {{cite journal | vauthors = Williams CJ, Naito T, Arco PG, Seavitt JR, Cashman SM, De Souza B, Qi X, Keables P, Von Andrian UH, Georgopoulos K | title = The chromatin remodeler Mi-2beta is required for CD4 expression and T cell development | journal = Immunity | volume = 20 | issue = 6 | pages = 719–33 | date = Jun 2004 | pmid = 15189737 | doi = 10.1016/j.immuni.2004.05.005 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+* {{cite journal | vauthors = Lehner B, Sanderson CM | title = A protein interaction framework for human mRNA degradation | journal = Genome Research | volume = 14 | issue = 7 | pages = 1315–23 | date = Jul 2004 | pmid = 15231747 | pmc = 442147 | doi = 10.1101/gr.2122004 }}
-*{{cite journal  | author=Hakimi MA, Dong Y, Lane WS, ''et al.'' |title=A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes. |journal=J. Biol. Chem. |volume=278 |issue= 9 |pages= 7234-9 |year= 2003 |pmid= 12493763 |doi= 10.1074/jbc.M208992200 }}
-*{{cite journal  | author=Kwan AH, Gell DA, Verger A, ''et al.'' |title=Engineering a protein scaffold from a PHD finger. |journal=Structure |volume=11 |issue= 7 |pages= 803-13 |year= 2004 |pmid= 12842043 |doi=  }}
-*{{cite journal  | author=Shimono Y, Murakami H, Kawai K, ''et al.'' |title=Mi-2 beta associates with BRG1 and RET finger protein at the distinct regions with transcriptional activating and repressing abilities. |journal=J. Biol. Chem. |volume=278 |issue= 51 |pages= 51638-45 |year= 2004 |pmid= 14530259 |doi= 10.1074/jbc.M309198200 }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
-*{{cite journal  | author=Williams CJ, Naito T, Arco PG, ''et al.'' |title=The chromatin remodeler Mi-2beta is required for CD4 expression and T cell development. |journal=Immunity |volume=20 |issue= 6 |pages= 719-33 |year= 2004 |pmid= 15189737 |doi= 10.1016/j.immuni.2004.05.005 }}
-*{{cite journal  | author=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315-23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004 }}
-}}
 {{refend}}
-{{protein-stub}}
+{{PDB Gallery|geneid=1108}}
-{{WikiDoc Sources}}
+{{gene-12-stub}}

CHD4: Difference between revisions

Latest revision as of 01:59, 27 October 2017

Contents

Function

Interactions

References

External links

Further reading

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