CDKN2D: Difference between revisions

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Revision as of 09:54, 30 August 2017

Cyclin-dependent kinase 4 inhibitor D is an enzyme that in humans is encoded by the CDKN2D gene.^[1]^[2]

The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported.^[2]

Note, this protein should not be confused with p19-ARF (mouse) or the human equivalent p14-ARF, which are alternative products of the CDKN2a gene.

References

↑ Okuda T, Hirai H, Valentine VA, Shurtleff SA, Kidd VJ, Lahti JM, Sherr CJ, Downing JR (Mar 1996). "Molecular cloning, expression pattern, and chromosomal localization of human CDKN2D/INK4d, an inhibitor of cyclin D-dependent kinases". Genomics. 29 (3): 623–30. doi:10.1006/geno.1995.9957. PMID 8575754.
↑ ^2.0 ^2.1 "Entrez Gene: CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)".

Hirai H, Roussel MF, Kato JY, et al. (1995). "Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6". Mol. Cell. Biol. 15 (5): 2672–81. PMC 230497. PMID 7739547.
Chan FK, Zhang J, Cheng L, et al. (1995). "Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4". Mol. Cell. Biol. 15 (5): 2682–8. PMC 230498. PMID 7739548.
Guan KL, Jenkins CW, Li Y, et al. (1996). "Isolation and characterization of p19INK4d, a p16-related inhibitor specific to CDK6 and CDK4". Mol. Biol. Cell. 7 (1): 57–70. doi:10.1091/mbc.7.1.57. PMC 278612. PMID 8741839.
Schwaller J, Pabst T, Koeffler HP, et al. (1997). "Expression and regulation of G1 cell-cycle inhibitors (p16INK4A, p15INK4B, p18INK4C, p19INK4D) in human acute myeloid leukemia and normal myeloid cells". Leukemia. 11 (1): 54–63. doi:10.1038/sj.leu.2400522. PMID 9001419.
Russo AA, Tong L, Lee JO, et al. (1998). "Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a". Nature. 395 (6699): 237–43. doi:10.1038/26155. PMID 9751050.
Brotherton DH, Dhanaraj V, Wick S, et al. (1998). "Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d". Nature. 395 (6699): 244–50. doi:10.1038/26164. PMID 9751051.
Baumgartner R, Fernandez-Catalan C, Winoto A, et al. (1998). "Structure of human cyclin-dependent kinase inhibitor p19INK4d: comparison to known ankyrin-repeat-containing structures and implications for the dysfunction of tumor suppressor p16INK4a". Structure. 6 (10): 1279–90. doi:10.1016/S0969-2126(98)00128-2. PMID 9782052.
Schreiber M, Muller WJ, Singh G, Graham FL (1999). "Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity". Oncogene. 18 (9): 1663–76. doi:10.1038/sj.onc.1202466. PMID 10208428.
Newton Bishop JA, Harland M, Bennett DC, et al. (1999). "Mutation testing in melanoma families: INK4A, CDK4 and INK4D". Br. J. Cancer. 80 (1–2): 295–300. doi:10.1038/sj.bjc.6690354. PMC 2363010. PMID 10390011.
Zindy F, Cunningham JJ, Sherr CJ, et al. (1999). "Postnatal neuronal proliferation in mice lacking Ink4d and Kip1 inhibitors of cyclin-dependent kinases". Proc. Natl. Acad. Sci. U.S.A. 96 (23): 13462–7. doi:10.1073/pnas.96.23.13462. PMC 23970. PMID 10557343.
Thullberg M, Bartkova J, Khan S, et al. (2000). "Distinct versus redundant properties among members of the INK4 family of cyclin-dependent kinase inhibitors". FEBS Lett. 470 (2): 161–6. doi:10.1016/S0014-5793(00)01307-7. PMID 10734227.
Bartkova J, Thullberg M, Rajpert-De Meyts E, et al. (2000). "Lack of p19INK4d in human testicular germ-cell tumours contrasts with high expression during normal spermatogenesis". Oncogene. 19 (36): 4146–50. doi:10.1038/sj.onc.1203769. PMID 10962575.
Fink JR, LeBien TW (2001). "Novel expression of cyclin-dependent kinase inhibitors in human B-cell precursors". Exp. Hematol. 29 (4): 490–8. doi:10.1016/S0301-472X(01)00619-1. PMID 11301189.
Zeeb M, Rösner H, Zeslawski W, et al. (2002). "Protein folding and stability of human CDK inhibitor p19(INK4d)". J. Mol. Biol. 315 (3): 447–57. doi:10.1006/jmbi.2001.5242. PMID 11786024.
Matsuzaki Y, Miyazawa K, Yokota T, et al. (2002). "Molecular cloning and characterization of the human p19(INK4d) gene promoter". FEBS Lett. 517 (1–3): 272–6. doi:10.1016/S0014-5793(02)02647-9. PMID 12062451.
Arcellana-Panlilio MY, Egeler RM, Ujack E, et al. (2002). "Evidence of a role for the INK4 family of cyclin-dependent kinase inhibitors in ovarian granulosa cell tumors". Genes Chromosomes Cancer. 35 (2): 176–81. doi:10.1002/gcc.10108. PMID 12203782.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
Komata T, Kanzawa T, Takeuchi H, et al. (2004). "Antitumour effect of cyclin-dependent kinase inhibitors (p16(INK4A), p18(INK4C), p19(INK4D), p21(WAF1/CIP1) and p27(KIP1)) on malignant glioma cells". Br. J. Cancer. 88 (8): 1277–80. doi:10.1038/sj.bjc.6600862. PMC 2747579. PMID 12698196.

External links

CDKN2D human gene location in the UCSC Genome Browser.
CDKN2D human gene details in the UCSC Genome Browser.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[pmid8575754-1] Okuda T, Hirai H, Valentine VA, Shurtleff SA, Kidd VJ, Lahti JM, Sherr CJ, Downing JR (Mar 1996). "Molecular cloning, expression pattern, and chromosomal localization of human CDKN2D/INK4d, an inhibitor of cyclin D-dependent kinases". Genomics. 29 (3): 623–30. doi:10.1006/geno.1995.9957. PMID 8575754.

[entrez-2] 2.0 ^2.1 "Entrez Gene: CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)".

[1]

[2]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Underlinked|date=March 2014}}
-{{PBB_Controls
+{{Infobox_gene}}
-| update_page = yes
+'''Cyclin-dependent kinase 4 inhibitor D''' is an [[enzyme]] that in humans is encoded by the ''CDKN2D'' [[gene]].<ref name="pmid8575754">{{cite journal | vauthors = Okuda T, Hirai H, Valentine VA, Shurtleff SA, Kidd VJ, Lahti JM, Sherr CJ, Downing JR | title = Molecular cloning, expression pattern, and chromosomal localization of human CDKN2D/INK4d, an inhibitor of cyclin D-dependent kinases | journal = Genomics | volume = 29 | issue = 3 | pages = 623–30 |date=Mar 1996 | pmid = 8575754 | pmc =  | doi = 10.1006/geno.1995.9957 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1032| accessdate = }}</ref>
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image = PBB_Protein_CDKN2D_image.jpg
- | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1bd8.
- | PDB = {{PDB2|1bd8}}, {{PDB2|1bi8}}
- | Name = Cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
- | HGNCid = 1790
- | Symbol = CDKN2D
- | AltSymbols =; p19; INK4D; p19-INK4D
- | OMIM = 600927
- | ECnumber =
- | Homologene = 36081
- | MGIid = 105387
- | GeneAtlas_image1 = PBB_GE_CDKN2D_210240_s_at_tn.png
- | Function = {{GNF_GO|id=GO:0004861 |text = cyclin-dependent protein kinase inhibitor activity}}
- | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
- | Process = {{GNF_GO|id=GO:0000079 |text = regulation of cyclin-dependent protein kinase activity}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007050 |text = cell cycle arrest}} {{GNF_GO|id=GO:0007605 |text = sensory perception of sound}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}}
-  | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 1032
-    | Hs_Ensembl = ENSG00000129355
-    | Hs_RefseqProtein = NP_001791
-    | Hs_RefseqmRNA = NM_001800
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 19
-    | Hs_GenLoc_start = 10538139
-    | Hs_GenLoc_end = 10540655
-    | Hs_Uniprot = P55273
-    | Mm_EntrezGene = 12581
-    | Mm_Ensembl = ENSMUSG00000066860
-    | Mm_RefseqmRNA = NM_009878
-    | Mm_RefseqProtein = NP_034008
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 9
-    | Mm_GenLoc_start = 21038861
-    | Mm_GenLoc_end = 21041429
-    | Mm_Uniprot = Q3US51
-  }}
-}}
-'''Cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)''', also known as '''CDKN2D''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1032| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
-| summary_text = The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported.<ref name="entrez">{{cite web | title = Entrez Gene: CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1032| accessdate = }}</ref>
+| summary_text = The [[protein]] encoded by this [[gene]] is a member of the [[INK4|INK4 family]] of cyclin-dependent kinase [[Enzyme inhibitor|inhibitor]]s. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK [[kinases]], thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as [[spermatogenesis]]. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported.<ref name="entrez"/>
 }}
+Note, this protein should not be confused with p19-ARF (mouse) or the human equivalent p14-ARF, which are alternative products of the CDKN2a gene.
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Hirai H, Roussel MF, Kato JY, ''et al.'' |title=Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6. |journal=Mol. Cell. Biol. |volume=15 |issue= 5 |pages= 2672-81 |year= 1995 |pmid= 7739547 |doi=  }}
+*{{cite journal  | vauthors=Hirai H, Roussel MF, Kato JY |title=Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6. |journal=Mol. Cell. Biol. |volume=15 |issue= 5 |pages= 2672–81 |year= 1995 |pmid= 7739547 |doi=  | pmc=230497  |display-authors=etal}}
-*{{cite journal  | author=Chan FK, Zhang J, Cheng L, ''et al.'' |title=Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4. |journal=Mol. Cell. Biol. |volume=15 |issue= 5 |pages= 2682-8 |year= 1995 |pmid= 7739548 |doi=  }}
+*{{cite journal  | vauthors=Chan FK, Zhang J, Cheng L |title=Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4. |journal=Mol. Cell. Biol. |volume=15 |issue= 5 |pages= 2682–8 |year= 1995 |pmid= 7739548 |doi=  | pmc=230498  |display-authors=etal}}
-*{{cite journal  | author=Okuda T, Hirai H, Valentine VA, ''et al.'' |title=Molecular cloning, expression pattern, and chromosomal localization of human CDKN2D/INK4d, an inhibitor of cyclin D-dependent kinases. |journal=Genomics |volume=29 |issue= 3 |pages= 623-30 |year= 1996 |pmid= 8575754 |doi= 10.1006/geno.1995.9957 }}
+*{{cite journal  | vauthors=Guan KL, Jenkins CW, Li Y |title=Isolation and characterization of p19INK4d, a p16-related inhibitor specific to CDK6 and CDK4. |journal=Mol. Biol. Cell |volume=7 |issue= 1 |pages= 57–70 |year= 1996 |pmid= 8741839 |doi=  10.1091/mbc.7.1.57| pmc=278612  |display-authors=etal}}
-*{{cite journal  | author=Guan KL, Jenkins CW, Li Y, ''et al.'' |title=Isolation and characterization of p19INK4d, a p16-related inhibitor specific to CDK6 and CDK4. |journal=Mol. Biol. Cell |volume=7 |issue= 1 |pages= 57-70 |year= 1996 |pmid= 8741839 |doi=  }}
+*{{cite journal  | vauthors=Schwaller J, Pabst T, Koeffler HP |title=Expression and regulation of G1 cell-cycle inhibitors (p16INK4A, p15INK4B, p18INK4C, p19INK4D) in human acute myeloid leukemia and normal myeloid cells. |journal=Leukemia |volume=11 |issue= 1 |pages= 54–63 |year= 1997 |pmid= 9001419 |doi=10.1038/sj.leu.2400522  |display-authors=etal}}
-*{{cite journal  | author=Schwaller J, Pabst T, Koeffler HP, ''et al.'' |title=Expression and regulation of G1 cell-cycle inhibitors (p16INK4A, p15INK4B, p18INK4C, p19INK4D) in human acute myeloid leukemia and normal myeloid cells. |journal=Leukemia |volume=11 |issue= 1 |pages= 54-63 |year= 1997 |pmid= 9001419 |doi=  }}
+*{{cite journal  | vauthors=Russo AA, Tong L, Lee JO |title=Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a. |journal=Nature |volume=395 |issue= 6699 |pages= 237–43 |year= 1998 |pmid= 9751050 |doi= 10.1038/26155 |display-authors=etal}}
-*{{cite journal  | author=Russo AA, Tong L, Lee JO, ''et al.'' |title=Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a. |journal=Nature |volume=395 |issue= 6699 |pages= 237-43 |year= 1998 |pmid= 9751050 |doi= 10.1038/26155 }}
+*{{cite journal  | vauthors=Brotherton DH, Dhanaraj V, Wick S |title=Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d. |journal=Nature |volume=395 |issue= 6699 |pages= 244–50 |year= 1998 |pmid= 9751051 |doi= 10.1038/26164 |display-authors=etal}}
-*{{cite journal  | author=Brotherton DH, Dhanaraj V, Wick S, ''et al.'' |title=Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d. |journal=Nature |volume=395 |issue= 6699 |pages= 244-50 |year= 1998 |pmid= 9751051 |doi= 10.1038/26164 }}
+*{{cite journal  | vauthors=Baumgartner R, Fernandez-Catalan C, Winoto A |title=Structure of human cyclin-dependent kinase inhibitor p19INK4d: comparison to known ankyrin-repeat-containing structures and implications for the dysfunction of tumor suppressor p16INK4a. |journal=Structure |volume=6 |issue= 10 |pages= 1279–90 |year= 1998 |pmid= 9782052 |doi=10.1016/S0969-2126(98)00128-2  |display-authors=etal}}
-*{{cite journal  | author=Baumgartner R, Fernandez-Catalan C, Winoto A, ''et al.'' |title=Structure of human cyclin-dependent kinase inhibitor p19INK4d: comparison to known ankyrin-repeat-containing structures and implications for the dysfunction of tumor suppressor p16INK4a. |journal=Structure |volume=6 |issue= 10 |pages= 1279-90 |year= 1998 |pmid= 9782052 |doi=  }}
+*{{cite journal  | vauthors=Schreiber M, Muller WJ, Singh G, Graham FL |title=Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity. |journal=Oncogene |volume=18 |issue= 9 |pages= 1663–76 |year= 1999 |pmid= 10208428 |doi= 10.1038/sj.onc.1202466 }}
-*{{cite journal  | author=Schreiber M, Muller WJ, Singh G, Graham FL |title=Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity. |journal=Oncogene |volume=18 |issue= 9 |pages= 1663-76 |year= 1999 |pmid= 10208428 |doi= 10.1038/sj.onc.1202466 }}
+*{{cite journal  | vauthors=Newton Bishop JA, Harland M, Bennett DC |title=Mutation testing in melanoma families: INK4A, CDK4 and INK4D. |journal=Br. J. Cancer |volume=80 |issue= 1-2 |pages= 295–300 |year= 1999 |pmid= 10390011 |doi= 10.1038/sj.bjc.6690354  | pmc=2363010 |display-authors=etal}}
-*{{cite journal  | author=Newton Bishop JA, Harland M, Bennett DC, ''et al.'' |title=Mutation testing in melanoma families: INK4A, CDK4 and INK4D. |journal=Br. J. Cancer |volume=80 |issue= 1-2 |pages= 295-300 |year= 1999 |pmid= 10390011 |doi= 10.1038/sj.bjc.6690354 }}
+*{{cite journal  | vauthors=Zindy F, Cunningham JJ, Sherr CJ |title=Postnatal neuronal proliferation in mice lacking Ink4d and Kip1 inhibitors of cyclin-dependent kinases. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 23 |pages= 13462–7 |year= 1999 |pmid= 10557343 |doi=10.1073/pnas.96.23.13462  | pmc=23970  |display-authors=etal}}
-*{{cite journal  | author=Zindy F, Cunningham JJ, Sherr CJ, ''et al.'' |title=Postnatal neuronal proliferation in mice lacking Ink4d and Kip1 inhibitors of cyclin-dependent kinases. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 23 |pages= 13462-7 |year= 1999 |pmid= 10557343 |doi=  }}
+*{{cite journal  | vauthors=Thullberg M, Bartkova J, Khan S |title=Distinct versus redundant properties among members of the INK4 family of cyclin-dependent kinase inhibitors. |journal=FEBS Lett. |volume=470 |issue= 2 |pages= 161–6 |year= 2000 |pmid= 10734227 |doi=10.1016/S0014-5793(00)01307-7  |display-authors=etal}}
-*{{cite journal  | author=Thullberg M, Bartkova J, Khan S, ''et al.'' |title=Distinct versus redundant properties among members of the INK4 family of cyclin-dependent kinase inhibitors. |journal=FEBS Lett. |volume=470 |issue= 2 |pages= 161-6 |year= 2000 |pmid= 10734227 |doi=  }}
+*{{cite journal  | vauthors=Bartkova J, Thullberg M, Rajpert-De Meyts E |title=Lack of p19INK4d in human testicular germ-cell tumours contrasts with high expression during normal spermatogenesis. |journal=Oncogene |volume=19 |issue= 36 |pages= 4146–50 |year= 2000 |pmid= 10962575 |doi= 10.1038/sj.onc.1203769 |display-authors=etal}}
-*{{cite journal  | author=Bartkova J, Thullberg M, Rajpert-De Meyts E, ''et al.'' |title=Lack of p19INK4d in human testicular germ-cell tumours contrasts with high expression during normal spermatogenesis. |journal=Oncogene |volume=19 |issue= 36 |pages= 4146-50 |year= 2000 |pmid= 10962575 |doi= 10.1038/sj.onc.1203769 }}
+*{{cite journal  | vauthors=Fink JR, LeBien TW |title=Novel expression of cyclin-dependent kinase inhibitors in human B-cell precursors. |journal=Exp. Hematol. |volume=29 |issue= 4 |pages= 490–8 |year= 2001 |pmid= 11301189 |doi=10.1016/S0301-472X(01)00619-1  }}
-*{{cite journal  | author=Fink JR, LeBien TW |title=Novel expression of cyclin-dependent kinase inhibitors in human B-cell precursors. |journal=Exp. Hematol. |volume=29 |issue= 4 |pages= 490-8 |year= 2001 |pmid= 11301189 |doi=  }}
+*{{cite journal  | vauthors=Zeeb M, Rösner H, Zeslawski W |title=Protein folding and stability of human CDK inhibitor p19(INK4d). |journal=J. Mol. Biol. |volume=315 |issue= 3 |pages= 447–57 |year= 2002 |pmid= 11786024 |doi= 10.1006/jmbi.2001.5242 |display-authors=etal}}
-*{{cite journal  | author=Zeeb M, Rösner H, Zeslawski W, ''et al.'' |title=Protein folding and stability of human CDK inhibitor p19(INK4d). |journal=J. Mol. Biol. |volume=315 |issue= 3 |pages= 447-57 |year= 2002 |pmid= 11786024 |doi= 10.1006/jmbi.2001.5242 }}
+*{{cite journal  | vauthors=Matsuzaki Y, Miyazawa K, Yokota T |title=Molecular cloning and characterization of the human p19(INK4d) gene promoter. |journal=FEBS Lett. |volume=517 |issue= 1-3 |pages= 272–6 |year= 2002 |pmid= 12062451 |doi=10.1016/S0014-5793(02)02647-9  |display-authors=etal}}
-*{{cite journal  | author=Matsuzaki Y, Miyazawa K, Yokota T, ''et al.'' |title=Molecular cloning and characterization of the human p19(INK4d) gene promoter. |journal=FEBS Lett. |volume=517 |issue= 1-3 |pages= 272-6 |year= 2002 |pmid= 12062451 |doi=  }}
+*{{cite journal  | vauthors=Arcellana-Panlilio MY, Egeler RM, Ujack E |title=Evidence of a role for the INK4 family of cyclin-dependent kinase inhibitors in ovarian granulosa cell tumors. |journal=Genes Chromosomes Cancer |volume=35 |issue= 2 |pages= 176–81 |year= 2002 |pmid= 12203782 |doi= 10.1002/gcc.10108 |display-authors=etal}}
-*{{cite journal  | author=Arcellana-Panlilio MY, Egeler RM, Ujack E, ''et al.'' |title=Evidence of a role for the INK4 family of cyclin-dependent kinase inhibitors in ovarian granulosa cell tumors. |journal=Genes Chromosomes Cancer |volume=35 |issue= 2 |pages= 176-81 |year= 2002 |pmid= 12203782 |doi= 10.1002/gcc.10108 }}
+*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal  | vauthors=Gevaert K, Goethals M, Martens L |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 |display-authors=etal}}
-*{{cite journal  | author=Gevaert K, Goethals M, Martens L, ''et al.'' |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566-9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }}
+*{{cite journal  | vauthors=Komata T, Kanzawa T, Takeuchi H |title=Antitumour effect of cyclin-dependent kinase inhibitors (p16(INK4A), p18(INK4C), p19(INK4D), p21(WAF1/CIP1) and p27(KIP1)) on malignant glioma cells. |journal=Br. J. Cancer |volume=88 |issue= 8 |pages= 1277–80 |year= 2004 |pmid= 12698196 |doi= 10.1038/sj.bjc.6600862  | pmc=2747579 |display-authors=etal}}
-*{{cite journal  | author=Komata T, Kanzawa T, Takeuchi H, ''et al.'' |title=Antitumour effect of cyclin-dependent kinase inhibitors (p16(INK4A), p18(INK4C), p19(INK4D), p21(WAF1/CIP1) and p27(KIP1)) on malignant glioma cells. |journal=Br. J. Cancer |volume=88 |issue= 8 |pages= 1277-80 |year= 2004 |pmid= 12698196 |doi= 10.1038/sj.bjc.6600862 }}
 }}
 {{refend}}
-{{protein-stub}}
+==External links==
-{{WikiDoc Sources}}
+* {{UCSC genome browser|CDKN2D}}
+* {{UCSC gene details|CDKN2D}}
+{{PDB Gallery|geneid=1032}}
+{{Cell cycle proteins}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
+{{gene-19-stub}}

CDKN2D: Difference between revisions

Revision as of 09:54, 30 August 2017

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