CCL21: Difference between revisions

Jump to navigation Jump to search
(→‎References: Adding link to CCL21 gene details page and display in UCSC genome browser.)
 
m (1 revision imported)
 
(One intermediate revision by one other user not shown)
Line 1: Line 1:
{{Infobox_gene}}
{{Infobox_gene}}


'''Chemokine (C-C motif) ligand 21''' (CCL21) is a small [[cytokine]] belonging to the CC [[chemokine]] family.  This chemokine is also known as 6Ckine (because it has six conserved [[cysteine]] residues instead of the four cysteines typical to chemokines), exodus-2, and secondary lymphoid-tissue chemokine (SLC).<ref name="pmid9257816">{{cite journal | vauthors = Hedrick JA, Zlotnik A | title = Identification and characterization of a novel beta chemokine containing six conserved cysteines | journal = J. Immunol. | volume = 159 | issue = 4 | pages = 1589–93 | year = 1997 | pmid = 9257816 | doi = | issn = | url = http://www.jimmunol.org/cgi/content/abstract/159/4/1589 }}</ref><ref name="pmid9300671">{{cite journal | vauthors = Hromas R, Kim CH, Klemsz M, Krathwohl M, Fife K, Cooper S, Schnizlein-Bick C, Broxmeyer HE | title = Isolation and characterization of Exodus-2, a novel C-C chemokine with a unique 37-amino acid carboxyl-terminal extension | journal = J. Immunol. | volume = 159 | issue = 6 | pages = 2554–8 | year = 1997 | pmid = 9300671 | doi = | issn = | url = http://www.jimmunol.org/cgi/content/abstract/159/6/2554 }}</ref><ref name="pmid9235955">{{cite journal | vauthors = Nagira M, Imai T, Hieshima K, Kusuda J, Ridanpää M, Takagi S, Nishimura M, Kakizaki M, Nomiyama H, Yoshie O | title = Molecular cloning of a novel human CC chemokine secondary lymphoid-tissue chemokine that is a potent chemoattractant for lymphocytes and mapped to chromosome 9p13 | journal = J. Biol. Chem. | volume = 272 | issue = 31 | pages = 19518–24 | year = 1997 | pmid = 9235955 | doi = 10.1074/jbc.272.31.19518 }}</ref>  The [[gene]] for CCL21 is located on human [[chromosome 9]].  CCL21 elicits its effects by binding to a cell surface [[chemokine receptor]] known as [[CC chemokine receptors#CCR7|CCR7]].<ref name="pmid9507024">{{cite journal | vauthors = Yoshida R, Nagira M, Kitaura M, Imagawa N, Imai T, Yoshie O | title = Secondary lymphoid-tissue chemokine is a functional ligand for the CC chemokine receptor CCR7 | journal = J. Biol. Chem. | volume = 273 | issue = 12 | pages = 7118–22 | year = 1998 | pmid = 9507024 | doi = 10.1074/jbc.273.12.7118 }}</ref>
'''Chemokine (C-C motif) ligand 21''' (CCL21) is a small [[cytokine]] belonging to the CC [[chemokine]] family.  This chemokine is also known as 6Ckine (because it has six conserved [[cysteine]] residues instead of the four cysteines typical to chemokines), exodus-2, and secondary lymphoid-tissue chemokine (SLC).<ref name="pmid9257816">{{cite journal | vauthors = Hedrick JA, Zlotnik A | title = Identification and characterization of a novel beta chemokine containing six conserved cysteines | journal = Journal of Immunology | volume = 159 | issue = 4 | pages = 1589–93 | date = August 1997 | pmid = 9257816 | doi = | url = http://www.jimmunol.org/cgi/content/abstract/159/4/1589 }}</ref><ref name="pmid9300671">{{cite journal | vauthors = Hromas R, Kim CH, Klemsz M, Krathwohl M, Fife K, Cooper S, Schnizlein-Bick C, Broxmeyer HE | title = Isolation and characterization of Exodus-2, a novel C-C chemokine with a unique 37-amino acid carboxyl-terminal extension | journal = Journal of Immunology | volume = 159 | issue = 6 | pages = 2554–8 | date = September 1997 | pmid = 9300671 | doi = | url = http://www.jimmunol.org/cgi/content/abstract/159/6/2554 }}</ref><ref name="pmid9235955">{{cite journal | vauthors = Nagira M, Imai T, Hieshima K, Kusuda J, Ridanpää M, Takagi S, Nishimura M, Kakizaki M, Nomiyama H, Yoshie O | title = Molecular cloning of a novel human CC chemokine secondary lymphoid-tissue chemokine that is a potent chemoattractant for lymphocytes and mapped to chromosome 9p13 | journal = The Journal of Biological Chemistry | volume = 272 | issue = 31 | pages = 19518–24 | date = August 1997 | pmid = 9235955 | doi = 10.1074/jbc.272.31.19518 }}</ref>  The [[gene]] for CCL21 is located on human [[chromosome 9]].  CCL21 elicits its effects by binding to a cell surface [[chemokine receptor]] known as [[CC chemokine receptors#CCR7|CCR7]].<ref name="pmid9507024">{{cite journal | vauthors = Yoshida R, Nagira M, Kitaura M, Imagawa N, Imai T, Yoshie O | title = Secondary lymphoid-tissue chemokine is a functional ligand for the CC chemokine receptor CCR7 | journal = The Journal of Biological Chemistry | volume = 273 | issue = 12 | pages = 7118–22 | date = March 1998 | pmid = 9507024 | doi = 10.1074/jbc.273.12.7118 }}</ref>


==References==
In human lymph nodes, the fibroblastic reticular cells (FRCs) express CCL21 as a chemoattractant to guide naive, CCR7 expressing T cells to the T cell zone. <ref>{{cite journal | vauthors = Mueller SN, Germain RN | title = Stromal cell contributions to the homeostasis and functionality of the immune system | journal = Nature Reviews. Immunology | volume = 9 | issue = 9 | pages = 618–29 | date = September 2009 | pmid = 19644499 | doi = 10.1038/nri2588 }}</ref><ref>{{cite journal | vauthors = Mueller SN, Germain RN | title = Stromal cell contributions to the homeostasis and functionality of the immune system | journal = Nature Reviews. Immunology | volume = 9 | issue = 9 | pages = 618–29 | date = September 2009 | pmid = 19644499 | pmc = 2785037 | doi = 10.1038/nri2588 }}</ref>
 
== References ==
{{Reflist|2}}
{{Reflist|2}}


==External links==
== External links ==
* {{UCSC gene info|CCL21}}
* {{UCSC gene info|CCL21}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Nagira M, Imai T, Hieshima K, Kusuda J, Ridanpää M, Takagi S, Nishimura M, Kakizaki M, Nomiyama H, Yoshie O | title = Molecular cloning of a novel human CC chemokine secondary lymphoid-tissue chemokine that is a potent chemoattractant for lymphocytes and mapped to chromosome 9p13 | journal = The Journal of Biological Chemistry | volume = 272 | issue = 31 | pages = 19518–24 | date = August 1997 | pmid = 9235955 | doi = 10.1074/jbc.272.31.19518 }}
| citations =
* {{cite journal | vauthors = Hedrick JA, Zlotnik A | title = Identification and characterization of a novel beta chemokine containing six conserved cysteines | journal = Journal of Immunology | volume = 159 | issue = 4 | pages = 1589–93 | date = August 1997 | pmid = 9257816 | doi =  }}
*{{cite journal | vauthors=Nagira M, Imai T, Hieshima K |title=Molecular cloning of a novel human CC chemokine secondary lymphoid-tissue chemokine that is a potent chemoattractant for lymphocytes and mapped to chromosome 9p13. |journal=J. Biol. Chem. |volume=272 |issue= 31 |pages= 19518–24 |year= 1997 |pmid= 9235955 |doi=10.1074/jbc.272.31.19518 |display-authors=etal}}
* {{cite journal | vauthors = Hromas R, Kim CH, Klemsz M, Krathwohl M, Fife K, Cooper S, Schnizlein-Bick C, Broxmeyer HE | title = Isolation and characterization of Exodus-2, a novel C-C chemokine with a unique 37-amino acid carboxyl-terminal extension | journal = Journal of Immunology | volume = 159 | issue = 6 | pages = 2554–8 | date = September 1997 | pmid = 9300671 | doi =  }}
*{{cite journal | vauthors=Hedrick JA, Zlotnik A |title=Identification and characterization of a novel beta chemokine containing six conserved cysteines. |journal=J. Immunol. |volume=159 |issue= 4 |pages= 1589–93 |year= 1997 |pmid= 9257816 |doi=  }}
* {{cite journal | vauthors = Gunn MD, Tangemann K, Tam C, Cyster JG, Rosen SD, Williams LT | title = A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 1 | pages = 258–63 | date = January 1998 | pmid = 9419363 | pmc = 18193 | doi = 10.1073/pnas.95.1.258 }}
*{{cite journal | vauthors=Hromas R, Kim CH, Klemsz M |title=Isolation and characterization of Exodus-2, a novel C-C chemokine with a unique 37-amino acid carboxyl-terminal extension. |journal=J. Immunol. |volume=159 |issue= 6 |pages= 2554–8 |year= 1997 |pmid= 9300671 |doi=  |display-authors=etal}}
* {{cite journal | vauthors = Yoshida R, Nagira M, Kitaura M, Imagawa N, Imai T, Yoshie O | title = Secondary lymphoid-tissue chemokine is a functional ligand for the CC chemokine receptor CCR7 | journal = The Journal of Biological Chemistry | volume = 273 | issue = 12 | pages = 7118–22 | date = March 1998 | pmid = 9507024 | doi = 10.1074/jbc.273.12.7118 }}
*{{cite journal | vauthors=Gunn MD, Tangemann K, Tam C |title=A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 1 |pages= 258–63 |year= 1998 |pmid= 9419363 |doi=10.1073/pnas.95.1.258 | pmc=18193  |display-authors=etal}}
* {{cite journal | vauthors = Campbell JJ, Bowman EP, Murphy K, Youngman KR, Siani MA, Thompson DA, Wu L, Zlotnik A, Butcher EC | title = 6-C-kine (SLC), a lymphocyte adhesion-triggering chemokine expressed by high endothelium, is an agonist for the MIP-3beta receptor CCR7 | journal = The Journal of Cell Biology | volume = 141 | issue = 4 | pages = 1053–9 | date = May 1998 | pmid = 9585422 | pmc = 2132769 | doi = 10.1083/jcb.141.4.1053 }}
*{{cite journal | vauthors=Yoshida R, Nagira M, Kitaura M |title=Secondary lymphoid-tissue chemokine is a functional ligand for the CC chemokine receptor CCR7. |journal=J. Biol. Chem. |volume=273 |issue= 12 |pages= 7118–22 |year= 1998 |pmid= 9507024 |doi=10.1074/jbc.273.12.7118 |display-authors=etal}}
* {{cite journal | vauthors = Jenh CH, Cox MA, Kaminski H, Zhang M, Byrnes H, Fine J, Lundell D, Chou CC, Narula SK, Zavodny PJ | title = Cutting edge: species specificity of the CC chemokine 6Ckine signaling through the CXC chemokine receptor CXCR3: human 6Ckine is not a ligand for the human or mouse CXCR3 receptors | journal = Journal of Immunology | volume = 162 | issue = 7 | pages = 3765–9 | date = April 1999 | pmid = 10201891 | doi =  }}
*{{cite journal | vauthors=Campbell JJ, Bowman EP, Murphy K |title=6-C-kine (SLC), a lymphocyte adhesion-triggering chemokine expressed by high endothelium, is an agonist for the MIP-3beta receptor CCR7. |journal=J. Cell Biol. |volume=141 |issue= 4 |pages= 1053–9 |year= 1998 |pmid= 9585422 |doi=10.1083/jcb.141.4.1053 | pmc=2132769  |display-authors=etal}}
* {{cite journal | vauthors = Gosling J, Dairaghi DJ, Wang Y, Hanley M, Talbot D, Miao Z, Schall TJ | title = Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK | journal = Journal of Immunology | volume = 164 | issue = 6 | pages = 2851–6 | date = March 2000 | pmid = 10706668 | doi = 10.4049/jimmunol.164.6.2851 }}
*{{cite journal | vauthors=Jenh CH, Cox MA, Kaminski H |title=Cutting edge: species specificity of the CC chemokine 6Ckine signaling through the CXC chemokine receptor CXCR3: human 6Ckine is not a ligand for the human or mouse CXCR3 receptors. |journal=J. Immunol. |volume=162 |issue= 7 |pages= 3765–9 |year= 1999 |pmid= 10201891 |doi=  |display-authors=etal}}
* {{cite journal | vauthors = Annunziato F, Romagnani P, Cosmi L, Beltrame C, Steiner BH, Lazzeri E, Raport CJ, Galli G, Manetti R, Mavilia C, Vanini V, Chantry D, Maggi E, Romagnani S | title = Macrophage-derived chemokine and EBI1-ligand chemokine attract human thymocytes in different stage of development and are produced by distinct subsets of medullary epithelial cells: possible implications for negative selection | journal = Journal of Immunology | volume = 165 | issue = 1 | pages = 238–46 | date = July 2000 | pmid = 10861057 | doi = 10.4049/jimmunol.165.1.238 }}
*{{cite journal | vauthors=Gosling J, Dairaghi DJ, Wang Y |title=Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK. |journal=J. Immunol. |volume=164 |issue= 6 |pages= 2851–6 |year= 2000 |pmid= 10706668 |doi= 10.4049/jimmunol.164.6.2851|display-authors=etal}}
* {{cite journal | vauthors = Hirose J, Kawashima H, Yoshie O, Tashiro K, Miyasaka M | title = Versican interacts with chemokines and modulates cellular responses | journal = The Journal of Biological Chemistry | volume = 276 | issue = 7 | pages = 5228–34 | date = February 2001 | pmid = 11083865 | doi = 10.1074/jbc.M007542200 }}
*{{cite journal | vauthors=Annunziato F, Romagnani P, Cosmi L |title=Macrophage-derived chemokine and EBI1-ligand chemokine attract human thymocytes in different stage of development and are produced by distinct subsets of medullary epithelial cells: possible implications for negative selection. |journal=J. Immunol. |volume=165 |issue= 1 |pages= 238–46 |year= 2000 |pmid= 10861057 |doi= 10.4049/jimmunol.165.1.238|display-authors=etal}}
* {{cite journal | vauthors = Till KJ, Lin K, Zuzel M, Cawley JC | title = The chemokine receptor CCR7 and alpha4 integrin are important for migration of chronic lymphocytic leukemia cells into lymph nodes | journal = Blood | volume = 99 | issue = 8 | pages = 2977–84 | date = April 2002 | pmid = 11929789 | doi = 10.1182/blood.V99.8.2977 }}
*{{cite journal | vauthors=Hirose J, Kawashima H, Yoshie O |title=Versican interacts with chemokines and modulates cellular responses. |journal=J. Biol. Chem. |volume=276 |issue= 7 |pages= 5228–34 |year= 2001 |pmid= 11083865 |doi= 10.1074/jbc.M007542200 |display-authors=etal}}
* {{cite journal | vauthors = Grant AJ, Goddard S, Ahmed-Choudhury J, Reynolds G, Jackson DG, Briskin M, Wu L, Hübscher SG, Adams DH | title = Hepatic expression of secondary lymphoid chemokine (CCL21) promotes the development of portal-associated lymphoid tissue in chronic inflammatory liver disease | journal = The American Journal of Pathology | volume = 160 | issue = 4 | pages = 1445–55 | date = April 2002 | pmid = 11943728 | pmc = 1867219 | doi = 10.1016/S0002-9440(10)62570-9 }}
*{{cite journal | vauthors=Till KJ, Lin K, Zuzel M, Cawley JC |title=The chemokine receptor CCR7 and alpha4 integrin are important for migration of chronic lymphocytic leukemia cells into lymph nodes. |journal=Blood |volume=99 |issue= 8 |pages= 2977–84 |year= 2002 |pmid= 11929789 |doi=10.1182/blood.V99.8.2977 }}
* {{cite journal | vauthors = Banas B, Wörnle M, Berger T, Nelson PJ, Cohen CD, Kretzler M, Pfirstinger J, Mack M, Lipp M, Gröne HJ, Schlöndorff D | title = Roles of SLC/CCL21 and CCR7 in human kidney for mesangial proliferation, migration, apoptosis, and tissue homeostasis | journal = Journal of Immunology | volume = 168 | issue = 9 | pages = 4301–7 | date = May 2002 | pmid = 11970971 | doi = 10.4049/jimmunol.168.9.4301 }}
*{{cite journal | vauthors=Grant AJ, Goddard S, Ahmed-Choudhury J |title=Hepatic expression of secondary lymphoid chemokine (CCL21) promotes the development of portal-associated lymphoid tissue in chronic inflammatory liver disease. |journal=Am. J. Pathol. |volume=160 |issue= 4 |pages= 1445–55 |year= 2002 |pmid= 11943728 |doi= 10.1016/S0002-9440(10)62570-9| pmc=1867219  |display-authors=etal}}
* {{cite journal | vauthors = Christopherson KW, Hood AF, Travers JB, Ramsey H, Hromas RA | title = Endothelial induction of the T-cell chemokine CCL21 in T-cell autoimmune diseases | journal = Blood | volume = 101 | issue = 3 | pages = 801–6 | date = February 2003 | pmid = 12393410 | doi = 10.1182/blood-2002-05-1586 }}
*{{cite journal | vauthors=Banas B, Wörnle M, Berger T |title=Roles of SLC/CCL21 and CCR7 in human kidney for mesangial proliferation, migration, apoptosis, and tissue homeostasis. |journal=J. Immunol. |volume=168 |issue= 9 |pages= 4301–7 |year= 2002 |pmid= 11970971 |doi= 10.4049/jimmunol.168.9.4301|display-authors=etal}}
* {{cite journal | vauthors = Stein JV, Soriano SF, M'rini C, Nombela-Arrieta C, de Buitrago GG, Rodríguez-Frade JM, Mellado M, Girard JP, Martínez-A C | title = CCR7-mediated physiological lymphocyte homing involves activation of a tyrosine kinase pathway | journal = Blood | volume = 101 | issue = 1 | pages = 38–44 | date = January 2003 | pmid = 12393730 | doi = 10.1182/blood-2002-03-0841 }}
*{{cite journal | vauthors=Christopherson KW, Hood AF, Travers JB |title=Endothelial induction of the T-cell chemokine CCL21 in T-cell autoimmune diseases. |journal=Blood |volume=101 |issue= 3 |pages= 801–6 |year= 2003 |pmid= 12393410 |doi= 10.1182/blood-2002-05-1586 |display-authors=etal}}
* {{cite journal | vauthors = Wolf M, Clark-Lewis I, Buri C, Langen H, Lis M, Mazzucchelli L | title = Cathepsin D specifically cleaves the chemokines macrophage inflammatory protein-1 alpha, macrophage inflammatory protein-1 beta, and SLC that are expressed in human breast cancer | journal = The American Journal of Pathology | volume = 162 | issue = 4 | pages = 1183–90 | date = April 2003 | pmid = 12651610 | pmc = 1851240 | doi = 10.1016/S0002-9440(10)63914-4 }}
*{{cite journal | vauthors=Stein JV, Soriano SF, M'rini C |title=CCR7-mediated physiological lymphocyte homing involves activation of a tyrosine kinase pathway. |journal=Blood |volume=101 |issue= 1 |pages= 38–44 |year= 2003 |pmid= 12393730 |doi= 10.1182/blood-2002-03-0841 |display-authors=etal}}
* {{cite journal | vauthors = Weninger W, Carlsen HS, Goodarzi M, Moazed F, Crowley MA, Baekkevold ES, Cavanagh LL, von Andrian UH | title = Naive T cell recruitment to nonlymphoid tissues: a role for endothelium-expressed CC chemokine ligand 21 in autoimmune disease and lymphoid neogenesis | journal = Journal of Immunology | volume = 170 | issue = 9 | pages = 4638–48 | date = May 2003 | pmid = 12707342 | doi = 10.4049/jimmunol.170.9.4638 }}
*{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
* {{cite journal | vauthors = Nagakubo D, Murai T, Tanaka T, Usui T, Matsumoto M, Sekiguchi K, Miyasaka M | title = A high endothelial venule secretory protein, mac25/angiomodulin, interacts with multiple high endothelial venule-associated molecules including chemokines | journal = Journal of Immunology | volume = 171 | issue = 2 | pages = 553–61 | date = July 2003 | pmid = 12847218 | doi = 10.4049/jimmunol.171.2.553 }}
*{{cite journal | vauthors=Wolf M, Clark-Lewis I, Buri C |title=Cathepsin D specifically cleaves the chemokines macrophage inflammatory protein-1 alpha, macrophage inflammatory protein-1 beta, and SLC that are expressed in human breast cancer. |journal=Am. J. Pathol. |volume=162 |issue= 4 |pages= 1183–90 |year= 2003 |pmid= 12651610 |doi= 10.1016/S0002-9440(10)63914-4| pmc=1851240  |display-authors=etal}}
*{{cite journal | vauthors=Weninger W, Carlsen HS, Goodarzi M |title=Naive T cell recruitment to nonlymphoid tissues: a role for endothelium-expressed CC chemokine ligand 21 in autoimmune disease and lymphoid neogenesis. |journal=J. Immunol. |volume=170 |issue= 9 |pages= 4638–48 |year= 2003 |pmid= 12707342 |doi= 10.4049/jimmunol.170.9.4638|display-authors=etal}}
*{{cite journal  | vauthors=Nagakubo D, Murai T, Tanaka T |title=A high endothelial venule secretory protein, mac25/angiomodulin, interacts with multiple high endothelial venule-associated molecules including chemokines. |journal=J. Immunol. |volume=171 |issue= 2 |pages= 553–61 |year= 2003 |pmid= 12847218 |doi=  10.4049/jimmunol.171.2.553|display-authors=etal}}
*{{cite journal  | vauthors=Clark HF, Gurney AL, Abaya E |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003  | pmc=403697 |display-authors=etal}}
}}
{{refend}}
{{refend}}


{{Chemokines}}
{{Chemokines}}
{{Chemokine receptor modulators}}
{{Chemokine receptor modulators}}


<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = no
| update_citations = yes
}}


[[Category:Cytokines]]
[[Category:Cytokines]]


{{gene-9-stub}}
{{gene-9-stub}}

Latest revision as of 07:44, 10 January 2019

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Chemokine (C-C motif) ligand 21 (CCL21) is a small cytokine belonging to the CC chemokine family. This chemokine is also known as 6Ckine (because it has six conserved cysteine residues instead of the four cysteines typical to chemokines), exodus-2, and secondary lymphoid-tissue chemokine (SLC).[1][2][3] The gene for CCL21 is located on human chromosome 9. CCL21 elicits its effects by binding to a cell surface chemokine receptor known as CCR7.[4]

In human lymph nodes, the fibroblastic reticular cells (FRCs) express CCL21 as a chemoattractant to guide naive, CCR7 expressing T cells to the T cell zone. [5][6]

References

  1. Hedrick JA, Zlotnik A (August 1997). "Identification and characterization of a novel beta chemokine containing six conserved cysteines". Journal of Immunology. 159 (4): 1589–93. PMID 9257816.
  2. Hromas R, Kim CH, Klemsz M, Krathwohl M, Fife K, Cooper S, Schnizlein-Bick C, Broxmeyer HE (September 1997). "Isolation and characterization of Exodus-2, a novel C-C chemokine with a unique 37-amino acid carboxyl-terminal extension". Journal of Immunology. 159 (6): 2554–8. PMID 9300671.
  3. Nagira M, Imai T, Hieshima K, Kusuda J, Ridanpää M, Takagi S, Nishimura M, Kakizaki M, Nomiyama H, Yoshie O (August 1997). "Molecular cloning of a novel human CC chemokine secondary lymphoid-tissue chemokine that is a potent chemoattractant for lymphocytes and mapped to chromosome 9p13". The Journal of Biological Chemistry. 272 (31): 19518–24. doi:10.1074/jbc.272.31.19518. PMID 9235955.
  4. Yoshida R, Nagira M, Kitaura M, Imagawa N, Imai T, Yoshie O (March 1998). "Secondary lymphoid-tissue chemokine is a functional ligand for the CC chemokine receptor CCR7". The Journal of Biological Chemistry. 273 (12): 7118–22. doi:10.1074/jbc.273.12.7118. PMID 9507024.
  5. Mueller SN, Germain RN (September 2009). "Stromal cell contributions to the homeostasis and functionality of the immune system". Nature Reviews. Immunology. 9 (9): 618–29. doi:10.1038/nri2588. PMID 19644499.
  6. Mueller SN, Germain RN (September 2009). "Stromal cell contributions to the homeostasis and functionality of the immune system". Nature Reviews. Immunology. 9 (9): 618–29. doi:10.1038/nri2588. PMC 2785037. PMID 19644499.

External links

Further reading